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Fusion gene ID: 4578 |
FusionGeneSummary for BUB1B_PCM1 |
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Fusion gene information | Fusion gene name: BUB1B_PCM1 | Fusion gene ID: 4578 | Hgene | Tgene | Gene symbol | BUB1B | PCM1 | Gene ID | 701 | 5108 |
Gene name | BUB1 mitotic checkpoint serine/threonine kinase B | pericentriolar material 1 | |
Synonyms | BUB1beta|BUBR1|Bub1A|MAD3L|MVA1|SSK1|hBUBR1 | PTC4|RET/PCM-1 | |
Cytomap | 15q15.1 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | mitotic checkpoint serine/threonine-protein kinase BUB1 betaBUB1B, mitotic checkpoint serine/threonine kinaseMAD3/BUB1-related protein kinasebudding uninhibited by benzimidazoles 1 homolog betamitotic checkpoint kinase MAD3L | pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60566 | Q15154 | |
Ensembl transtripts involved in fusion gene | ENST00000287598, ENST00000412359, ENST00000560120, | ENST00000325083, ENST00000519253, ENST00000524226, ENST00000518537, ENST00000518936, ENST00000327578, | |
Fusion gene scores | * DoF score | 2 X 3 X 3=18 | 5 X 5 X 3=75 |
# samples | 3 | 5 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BUB1B [Title/Abstract] AND PCM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-O2-A5IB-01A | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
TCGA | LD | LUSC | TCGA-O2-A5IB-01A | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000287598 | ENST00000325083 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000519253 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000524226 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000518537 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000518936 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000327578 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000325083 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000519253 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000524226 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000518537 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000518936 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000327578 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
3UTR-3CDS | ENST00000560120 | ENST00000325083 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
3UTR-3CDS | ENST00000560120 | ENST00000519253 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
3UTR-3CDS | ENST00000560120 | ENST00000524226 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
3UTR-intron | ENST00000560120 | ENST00000518537 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
3UTR-intron | ENST00000560120 | ENST00000518936 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
3UTR-intron | ENST00000560120 | ENST00000327578 | BUB1B | chr15 | 40462882 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000325083 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000519253 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000524226 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000518537 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000518936 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000327578 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000325083 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000519253 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000524226 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000518537 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000518936 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000327578 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-3CDS | ENST00000560120 | ENST00000325083 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-3CDS | ENST00000560120 | ENST00000519253 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-3CDS | ENST00000560120 | ENST00000524226 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-intron | ENST00000560120 | ENST00000518537 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-intron | ENST00000560120 | ENST00000518936 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-intron | ENST00000560120 | ENST00000327578 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
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FusionProtFeatures for BUB1B_PCM1 |
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Hgene | Tgene |
BUB1B | PCM1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BUB1B_PCM1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BUB1B_PCM1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BUB1B | HDAC1, BRCA2, SNCG, CDC20, BUB3, MAD2L1, CENPE, AP2B1, APC, CDC27, CDC16, ANAPC7, UBE2C, PARP1, KAT2B, ANAPC4, BUB1, MIS12, ZWINT, BUB1B, NSL1, DNMBP, MXI1, MDM2, MAD2L1BP, PLK1, TUBB, CASC5, TP73, AJUBA, AURKB, PLK3, PTTG1, SGOL1, DAXX, FZR1, TRIM33, COMMD4, GANAB, PRKCSH, PNMA2, UGP2, TRIP13, SUMO1, ANAPC1, ANAPC2, BAG2, DSN1, ZFC3H1, CCT2, EEF2, HSPB1, HSPH1, NDC80, NUF2, PMF1, PSMA3, PSMA4, PSMA6, PSMB5, PSMD6, RPL39, SKIV2L2, RAE1, UBR5, CCNA2, FBXW7, BTRC, MED4, XPO1, CD14, CDC23, SMEK1, CERK, ANAPC10, NEK2, SNW1, CDC5L, PPP2R5A, TYW3, HDAC2, HDAC3 | PCM1 | BBS4, KRT15, ING5, KIAA0368, KRT19, CCDC53, ABI2, EXOC8, EPS8, CEP72, PCNT, HAP1, EWSR1, HNRNPUL1, CLTC, MIB1, FUS, CEP131, PPIB, SIRT7, NEURL4, PAN2, CASK, E2F4, YWHAQ, LATS2, SAV1, CEP250, HAUS2, OBSL1, CCDC8, CSPP1, CCDC183, SLC25A41, SSFA2, RASSF8, RASSF7, IFT81, NTRK1, BTRC, MED4, HERC2, AHI1, CEP162, RPGRIP1L, CC2D2A, CEP128, LCA5, OFD1, CCDC138, CEP170, PIBF1, SSX2IP, WRAP73, HAUS1, HAUS4, KIAA0753, CCDC77, CCNB2, CEP350, CEP95, CSNK1A1, DSP, KIF20A, LUZP1, MCM10, MCRS1, MPRIP, NDC80, SMARCD2, TPGS1, SUPT5H, SSBP1, KIF7, SKA1, TSPYL1, SREK1IP1, CSNK1D, IFT172, CEP55, IFT20, CCDC14, HMMR, CFAP97, IPO5, KCTD12, SNRPE, SPICE1, ABCD3, ACOT9, ATP5L, CAMSAP1, CC2D1A, CCDC66, CEP120, CKAP2, FGFR1OP, HAUS3, HAUS5, HAUS6, HAUS7, HAUS8, IDH3B, IFT57, IFT74, NCKAP5L, RAE1, STAU1, TP53BP2, TTK, TXLNA, TXLNG, TBC1D31, WDR83, XRN1, ZNF280C, ACTR2, ANKRD26, BAIAP2, BICD1, BICD2, BTF3, C11orf49, KNSTRN, C2CD3, CAMSAP2, CCDC112, CCDC18, CCDC22, CCDC85C, CCDC92, CCNB1, CCP110, CDC123, CEP164, CEP192, CEP57L1, CEP63, CEP85, CEP89, CEP97, CKAP2L, CNOT10, COMMD2, COMMD4, CSNK1E, DAPK3, DIAPH3, ERC1, EXOC4, FOPNL, GNAO1, GPATCH1, IBTK, IQCB1, KIAA1328, KIF14, LRRC49, LRRCC1, MAGED1, MAP7D3, MED29, MIS18A, MIS18BP1, MOB4, MPHOSPH9, MYO9A, NAV1, NEDD1, NME7, NOL11, NUF2, ODF2L, ODF2, PCBP3, PKN2, PLK1, KIZ, PPP1R9B, IFT22, RRM2, SCLT1, SDCCAG3, SECISBP2, SMG5, SMG7, SPATA24, SPATS2, SPC24, SRGAP2, STRN4, TANC1, TCHP, TEX9, TNIP1, TRAF3IP1, TTC12, TTF2, TTLL4, TTLL5, CEP104, CEP290, CEP152, CEP135, CNTRL, FBF1, NINL, NIN, POC5, SASS6, RPGRIP1, STIL, CENPJ, CENPE, PPP2CA, PRKAR2B, DYNLL1, MAPRE1, SLAIN2, CEP170P1, PPP2R3C, YWHAE, YWHAZ, MTMR7, C6orf118, BIN3, CCDC172, LPXN, FAM81B, COG5, ING2, CCDC65, LCA5L, CCDC40, DKK3, NECAB2, ATG14, TSC1, RNF168 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BUB1B_PCM1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BUB1B_PCM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BUB1B | C0018273 | Growth Disorders | 1 | CTD_human |
Hgene | BUB1B | C0025958 | Microcephaly | 1 | CTD_human |
Hgene | BUB1B | C0206656 | Rhabdomyosarcoma, Embryonal | 1 | CTD_human |
Hgene | BUB1B | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | BUB1B | C1850343 | MOSAIC VARIEGATED ANEUPLOIDY SYNDROME | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | BUB1B | C1864389 | PREMATURE CHROMATID SEPARATION TRAIT | 1 | CTD_human;UNIPROT |
Tgene | PCM1 | C0036341 | Schizophrenia | 1 | CTD_human |