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Fusion gene ID: 4574 |
FusionGeneSummary for BTRC_HIF1AN |
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Fusion gene information | Fusion gene name: BTRC_HIF1AN | Fusion gene ID: 4574 | Hgene | Tgene | Gene symbol | BTRC | HIF1AN | Gene ID | 8945 | 55662 |
Gene name | beta-transducin repeat containing E3 ubiquitin protein ligase | hypoxia inducible factor 1 subunit alpha inhibitor | |
Synonyms | BETA-TRCP|FBW1A|FBXW1|FBXW1A|FWD1|bTrCP|bTrCP1|betaTrCP | FIH1 | |
Cytomap | 10q24.32 | 10q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | F-box/WD repeat-containing protein 1AE3RSIkappaBF-box and WD repeats protein beta-TrCPF-box and WD-repeat protein 1Bbeta-TrCP1epididymis tissue protein Li 2apIkappaBalpha-E3 receptor subunit | hypoxia-inducible factor 1-alpha inhibitorFIH-1factor inhibiting HIF-1factor inhibiting HIF1hypoxia inducible factor 1 alpha subunit inhibitorhypoxia-inducible factor asparagine hydroxylasepeptide-aspartate beta-dioxygenase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9Y297 | Q9NWT6 | |
Ensembl transtripts involved in fusion gene | ENST00000370187, ENST00000393441, ENST00000408038, ENST00000493877, | ENST00000299163, ENST00000528044, | |
Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 3 X 2 X 3=18 |
# samples | 5 | 3 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BTRC [Title/Abstract] AND HIF1AN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BTRC | GO:0000209 | protein polyubiquitination | 12820959 |
Hgene | BTRC | GO:0006511 | ubiquitin-dependent protein catabolic process | 15448698 |
Hgene | BTRC | GO:0016567 | protein ubiquitination | 16885022 |
Hgene | BTRC | GO:0042752 | regulation of circadian rhythm | 15917222 |
Hgene | BTRC | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 15917222 |
Tgene | HIF1AN | GO:0036138 | peptidyl-histidine hydroxylation | 21251231 |
Tgene | HIF1AN | GO:0042264 | peptidyl-aspartic acid hydroxylation | 21177872 |
Tgene | HIF1AN | GO:0042265 | peptidyl-asparagine hydroxylation | 12080085|12215170|14734545|21177872 |
Tgene | HIF1AN | GO:0045663 | positive regulation of myoblast differentiation | 18299578 |
Tgene | HIF1AN | GO:0045746 | negative regulation of Notch signaling pathway | 18299578 |
Tgene | HIF1AN | GO:0055114 | oxidation-reduction process | 12080085|12215170 |
Tgene | HIF1AN | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | 11641274 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRC | TCGA-BP-5202-01A | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000370187 | ENST00000299163 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
5CDS-3UTR | ENST00000370187 | ENST00000528044 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
In-frame | ENST00000393441 | ENST00000299163 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
5CDS-3UTR | ENST00000393441 | ENST00000528044 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
intron-3CDS | ENST00000408038 | ENST00000299163 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
intron-3UTR | ENST00000408038 | ENST00000528044 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
intron-3CDS | ENST00000493877 | ENST00000299163 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
intron-3UTR | ENST00000493877 | ENST00000528044 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
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FusionProtFeatures for BTRC_HIF1AN |
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Hgene | Tgene |
BTRC | HIF1AN |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation oftarget proteins. Recognizes and binds to phosphorylated targetproteins (PubMed:10066435, PubMed:10497169, PubMed:10644755,PubMed:10835356, PubMed:11238952, PubMed:11359933,PubMed:11994270, PubMed:12791267, PubMed:12902344,PubMed:14603323, PubMed:14681206, PubMed:14988407,PubMed:15448698, PubMed:15917222, PubMed:16371461,PubMed:25503564, PubMed:25704143, PubMed:9859996). SCF(BTRC)mediates the ubiquitination of CTNNB1 and participates in Wntsignaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediatesthe ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1,FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2(PubMed:10835356, PubMed:11238952, PubMed:14681206,PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA,NFKBIB and NFKBIE; the degradation frees the associated NFKB1 totranslocate into the nucleus and to activate transcription(PubMed:10066435, PubMed:10497169, PubMed:10644755).Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'(PubMed:10066435). SCF(BTRC) mediates the ubiquitination of CEP68;this is required for centriole separation during mitosis(PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates theubiquitination and subsequent degradation of nuclear NFE2L1 (Bysimilarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 andPER2 (PubMed:15917222). May be involved in ubiquitination andsubsequent proteasomal degradation through a DBB1-CUL4 E3ubiquitin-protein ligase. Required for activation of NFKB-mediatedtranscription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Requiredfor proteolytic processing of GLI3 (PubMed:16371461).{ECO:0000250|UniProtKB:Q3ULA2, ECO:0000269|PubMed:10066435,ECO:0000269|PubMed:10497169, ECO:0000269|PubMed:10644755,ECO:0000269|PubMed:10835356, ECO:0000269|PubMed:11238952,ECO:0000269|PubMed:11359933, ECO:0000269|PubMed:11994270,ECO:0000269|PubMed:12077367, ECO:0000269|PubMed:12791267,ECO:0000269|PubMed:12820959, ECO:0000269|PubMed:12902344,ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:14681206,ECO:0000269|PubMed:14988407, ECO:0000269|PubMed:15448698,ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16371461,ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143,ECO:0000269|PubMed:9859996}. | Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repressionthrough interaction with HIF1A, VHL and histone deacetylases.Hydroxylates specific Asn residues within ankyrin repeat domains(ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several otherARD-containing proteins. Also hydroxylates Asp and His residueswithin ARDs of ANK1 and TNKS2, respectively. Negatively regulatesNOTCH1 activity, accelerating myogenic differentiation. Positivelyregulates ASB4 activity, promoting vascular differentiation.{ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085,ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339,ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366,ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 142_312 | 59 | 350 | Domain | JmjC |
Tgene | >HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 181_183 | 59 | 350 | Region | Substrate binding |
Tgene | >HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 201_203 | 59 | 350 | Region | Substrate binding |
Tgene | >HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 238_239 | 59 | 350 | Region | Substrate binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 128_177 | 52 | 1939 | Region | Note=Homodimerization domain D |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 190_228 | 52 | 1939 | Region | Note=Required for down-regulation of SNAI1 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 128_177 | -25 | 1918 | Region | Note=Homodimerization domain D |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 190_228 | -25 | 1918 | Region | Note=Required for down-regulation of SNAI1 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 301_338 | 52 | 1939 | Repeat | Note=WD 1 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 341_378 | 52 | 1939 | Repeat | Note=WD 2 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 381_418 | 52 | 1939 | Repeat | Note=WD 3 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 424_461 | 52 | 1939 | Repeat | Note=WD 4 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 464_503 | 52 | 1939 | Repeat | Note=WD 5 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 505_541 | 52 | 1939 | Repeat | Note=WD 6 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 553_590 | 52 | 1939 | Repeat | Note=WD 7 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 301_338 | -25 | 1918 | Repeat | Note=WD 1 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 341_378 | -25 | 1918 | Repeat | Note=WD 2 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 381_418 | -25 | 1918 | Repeat | Note=WD 3 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 424_461 | -25 | 1918 | Repeat | Note=WD 4 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 464_503 | -25 | 1918 | Repeat | Note=WD 5 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 505_541 | -25 | 1918 | Repeat | Note=WD 6 |
Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 553_590 | -25 | 1918 | Repeat | Note=WD 7 |
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FusionGeneSequence for BTRC_HIF1AN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_BTRC_ENST00000370187_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_343aa MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSAST HKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLL LIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYW >In-frame_BTRC_ENST00000393441_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_328aa MCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQ NFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDE QQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITIT |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_BTRC_ENST00000370187_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_1029nt ATGGACCCGGCCGAGGCGGTGCTGCAAGAGAAGGCACTCAAGTTTATGTGCTCTATGCCCAGGTCTCTGTGGCTGGGCTGCTCCAGCCTG GCGGACAGCATGCCTTCGCTGCGATGCCTGTATAACCCAGGGACTGGCGCACTCACAGCTTTCCAGGAGCCTGTGGTGCTGACCGACACA AATCTTGTGTATCCTGCCCTGAAATGGGACCTTGAATACCTGCAAGAGAATATTGGCAATGGAGACTTCTCTGTGTACAGTGCCAGCACC CACAAGTTCTTGTACTATGATGAGAAGAAGATGGCCAATTTCCAGAACTTTAAGCCGAGGTCCAACAGGGAAGAAATGAAATTTCATGAG TTCGTTGAGAAACTGCAGGATATACAGCAGCGAGGAGGGGAAGAGAGGTTGTATCTGCAGCAAACGCTCAATGACACTGTGGGCAGGAAG ATTGTCATGGACTTCTTAGGTTTTAACTGGAACTGGATTAATAAGCAACAGGGAAAGCGTGGCTGGGGGCAGCTTACCTCTAACCTGCTG CTCATTGGCATGGAAGGAAATGTGACACCTGCTCACTATGATGAGCAGCAGAACTTTTTTGCTCAGATAAAAGGTTACAAACGATGCATC TTATTCCCTCCGGATCAGTTCGAGTGCCTCTACCCATACCCTGTTCATCACCCATGTGACAGACAGAGCCAGGTGGACTTTGACAATCCC GACTACGAGAGGTTCCCTAATTTCCAAAATGTGGTTGGTTACGAAACAGTGGTTGGCCCTGGTGATGTTCTTTACATCCCAATGTACTGG TGGCATCACATAGAGTCATTACTAAATGGGGGGATTACCATCACTGTGAACTTCTGGTATAAGGGGGCTCCCACCCCTAAGAGAATTGAA TATCCTCTCAAAGCTCATCAGAAAGTGGCCATAATGAGAAACATTGAGAAGATGCTTGGAGAGGCCTTGGGGAACCCACAAGAGGTGGGG >In-frame_BTRC_ENST00000393441_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_984nt ATGTGCTCTATGCCCAGGTCTCTGTGGCTGGGCTGCTCCAGCCTGGCGGACAGCATGCCTTCGCTGCGATGCCTGTATAACCCAGGGACT GGCGCACTCACAGCTTTCCAGGAGCCTGTGGTGCTGACCGACACAAATCTTGTGTATCCTGCCCTGAAATGGGACCTTGAATACCTGCAA GAGAATATTGGCAATGGAGACTTCTCTGTGTACAGTGCCAGCACCCACAAGTTCTTGTACTATGATGAGAAGAAGATGGCCAATTTCCAG AACTTTAAGCCGAGGTCCAACAGGGAAGAAATGAAATTTCATGAGTTCGTTGAGAAACTGCAGGATATACAGCAGCGAGGAGGGGAAGAG AGGTTGTATCTGCAGCAAACGCTCAATGACACTGTGGGCAGGAAGATTGTCATGGACTTCTTAGGTTTTAACTGGAACTGGATTAATAAG CAACAGGGAAAGCGTGGCTGGGGGCAGCTTACCTCTAACCTGCTGCTCATTGGCATGGAAGGAAATGTGACACCTGCTCACTATGATGAG CAGCAGAACTTTTTTGCTCAGATAAAAGGTTACAAACGATGCATCTTATTCCCTCCGGATCAGTTCGAGTGCCTCTACCCATACCCTGTT CATCACCCATGTGACAGACAGAGCCAGGTGGACTTTGACAATCCCGACTACGAGAGGTTCCCTAATTTCCAAAATGTGGTTGGTTACGAA ACAGTGGTTGGCCCTGGTGATGTTCTTTACATCCCAATGTACTGGTGGCATCACATAGAGTCATTACTAAATGGGGGGATTACCATCACT GTGAACTTCTGGTATAAGGGGGCTCCCACCCCTAAGAGAATTGAATATCCTCTCAAAGCTCATCAGAAAGTGGCCATAATGAGAAACATT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_BTRC_ENST00000370187_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_13008nt AGAGGTAAGAGAGGGCGGGGGGAAGGAAGAGGAGGCGGGATCCGGGCGCTGCGTTGGCTGCGGCCTGGCACCAAAGGGGCGGCCCCGGCG GAGAGCGGACCCAGTGGCCTCGGCGATTATGGACCCGGCCGAGGCGGTGCTGCAAGAGAAGGCACTCAAGTTTATGTGCTCTATGCCCAG GTCTCTGTGGCTGGGCTGCTCCAGCCTGGCGGACAGCATGCCTTCGCTGCGATGCCTGTATAACCCAGGGACTGGCGCACTCACAGCTTT CCAGGAGCCTGTGGTGCTGACCGACACAAATCTTGTGTATCCTGCCCTGAAATGGGACCTTGAATACCTGCAAGAGAATATTGGCAATGG AGACTTCTCTGTGTACAGTGCCAGCACCCACAAGTTCTTGTACTATGATGAGAAGAAGATGGCCAATTTCCAGAACTTTAAGCCGAGGTC CAACAGGGAAGAAATGAAATTTCATGAGTTCGTTGAGAAACTGCAGGATATACAGCAGCGAGGAGGGGAAGAGAGGTTGTATCTGCAGCA AACGCTCAATGACACTGTGGGCAGGAAGATTGTCATGGACTTCTTAGGTTTTAACTGGAACTGGATTAATAAGCAACAGGGAAAGCGTGG CTGGGGGCAGCTTACCTCTAACCTGCTGCTCATTGGCATGGAAGGAAATGTGACACCTGCTCACTATGATGAGCAGCAGAACTTTTTTGC TCAGATAAAAGGTTACAAACGATGCATCTTATTCCCTCCGGATCAGTTCGAGTGCCTCTACCCATACCCTGTTCATCACCCATGTGACAG ACAGAGCCAGGTGGACTTTGACAATCCCGACTACGAGAGGTTCCCTAATTTCCAAAATGTGGTTGGTTACGAAACAGTGGTTGGCCCTGG TGATGTTCTTTACATCCCAATGTACTGGTGGCATCACATAGAGTCATTACTAAATGGGGGGATTACCATCACTGTGAACTTCTGGTATAA GGGGGCTCCCACCCCTAAGAGAATTGAATATCCTCTCAAAGCTCATCAGAAAGTGGCCATAATGAGAAACATTGAGAAGATGCTTGGAGA GGCCTTGGGGAACCCACAAGAGGTGGGGCCCTTGTTGAACACAATGATCAAGGGCCGATACAACTAGCCTGCCAGGGGTCAAGGCCTCCT GCCAGGTGACTGCTATCCCGTCCACACCGCTTCATTGATGAGGACAGGAGACTCCAAGCGCTAGTATTGCACGCTGCACTTAATGGACTG GACTCTTGCCATGGCCCAGGAGTCAGGTGTTTGGAGCGAGGCAGGGCAGTTGGCACTCCACTCCTATTTGGAGGGACTTCATACCCTTGC CTCTTGTGCCCCAGCACCTTCTCTCTCTGCCCCCCGCCTAAAGTCCTGCATTCAGTGTGTGGAGTCCCAGCTTTTGGTTGTCATCATGTC TGTGTGTATGTTAGTCTGTCAACTTCGGAATGTGTGCGTGTGTGTGCATGCACACGCATGTATGTATCTGTTCCCTGTTCCTTCTGGGTC AGGCTGTCACTTCCGGCTCTCAGCCCTATCTCCTGCAACCTCAGTGCCTCAGCCTGAGAGAGAGATGAGATGCTCTTGGACTCCCCACTG CATCTGGGCTGCAGGGCCAGAGCTAGTCTGACCATTAGGTCAGTCTGCCTCCTGACAGTTTTTGCGTAGTCAAGCTCTAGGCGGTATGGG AATGGCTACCGGGACTCTAATGGGGTGAAAGAGAGGGGAGGCTTGCCTTTGAGAGCCTATATAGCCTTCCTGTGAGAGAGGATTAGATAG GGTTCCAACTGGGCCTACAAGCTCAAGCCATACATAAAAGGACCTTGGGACATAAGAACCAATGATTGTGCATAAGTTCTAAATTAGAGA CACATATAGTTTCTCTCTTTCAGCACCAGCTCTTGCCCCTATGCTGGGTACCAAGGGAGTTCTCCTAGCTGTGGCTTCTCTAGGTTCTAG GGGTGCAAGCCTCTGTGTGTTTGTTTGTGTGTGTCTGTGTGTGCGTATCCACACTAGGGGTGCAAGCCTCTGGGTGTGTGTGTGTGTGTG CGTGCGTGTGTGTGTGTGTGTCCGTGTGTGTGTGTGTGTGTGTCCACACTGGCCAGCCTCCCTACTTACCAAGGTTCTCCACTGCTTACC TTTTCCAGTGGGACAGTACAGTGTGAGCCCCCGGGAAGTACTGCCTGACCTATCCTAAGCTTTTACACTTGGATTTTAGCCATCATATGT TGGCCAGGTCTCACTGCAGCCTGCCCGAGGCTAACTGGCTAGAGCCTCCAGGCCCTATGATGCTCCCTGCCCAGGCCATATCCTTTATTC CTGCTGAGCTTCCTGGCTGAATAGATGAAATGGGGTCAAGCCCAGGCAGCTCATTCACTACCTGTGATCCACCTCAGGGCACGGGCAAAC ACATAGGCTTGCGTCTTAAAGCCAGCTCCTCTGCCAGACCCCGTTGTAATGTGCCACAACACCCTCAATAGTCAGGGCAACTGGTGGAGC ATGGAAGTCGAATTTCCTTTTCTGTTAGGAGCTACTCCTGGGAACCCCTCTCAGGGCTGCAGCTTACAGGTGGGCAGCTGTGATTGCACA ACTTGAAGGGCCATCATTCACATCTATTCAGTGGGAGTGGGGTCCCTGGGATTGGGCAGTGTGGTGGCCCTGTGTCTCCTCACCTCTGCT CCTGTCTTCATCACCTTCTCTCTGGAAGGGAAGAGGAGTTGGAAGGTCTCTGGTTTTCTTTTCTTTTTTTTTTTTTTTGCCAAAGGTTTA CTTCCAGCATCTGAGCTCTGGCTCTCACCCCTGAAGCTCAGTTATAGTGCACTGATGAACTGAGAGGATGCGTGTGGATGTGTGTGCATG CCTGAGTGCGTTTTTTGGGGAGGGGTGTTTATTTTTAGTACCCCATTCTGGGGTTCTCTGATGCAGTGTGGATGTGAAGATATGGTACCT TCTCAAGTGTAGCTCTTTCAAATATAGTCAATGCTGGGAAATGTGATTGCAGTGATCTCTATCTCTCCACTTCTTTTGGGAAAGAGGAGC ACAGGAGCGGAGGAAAAACTTGGCCACAGTCACACTTGGAAAGATAGTAGATTATTTTCGTTCTCCTCAGCAGGTCTGCTGTATTCCTCG CTCAGCGCTCAAAGATGTGGGTGATGTGTCAAGGAGGCATGCACTCAGCTGGTCCTTGCTGAGTTATTTGCTGACACAGGTCTCACTAAG GTGGCTGAGGGGTGGGAGGGAGAAGGCTAATCTTGGAACCTTCACAGGATTGGCCTTGATCCTTGGGTAACACAAGAGTGATTCCTGATT TTTAGACACCTAATATGTGCCTAGTGCTTTTCTCTTTGTTCCTCACTATCCTGCAAGGTAGGTATTCTCACTTACAGATGAATAAATGGG CTCAGAGAGATTAGGTGATTAGTGACAATCAGTTGTAACTTAGCACTGTTAGGCTGCAAACCCCTTGCTCCTTCCTTTCCACCAAACTAT GTTGATTTTCCTTCCTTACCTCCCTCCTTGTACCACAGGTTCTGTCCTCAAGATATCACCCCACTGGGCAGTATCTGAAGGCAGACCCAG CCCAAGATGGTGCAGAATATACAGCTCAGGGTGAAAGTTCTTCTGGGCTCCTGCTAACAAAGTCTTGGAAAAACTGCCTGGGAAGCCATA TTATGAATTAGTGCTAGAAGAAGCTGTGGGGGGAACTGAGTTCTGTGTCTAATTGCATTACTTATGTGTCCTTGAATAGGACCCATAACT CCTCCCGGCATGCTTTTGCATCTATAGAACTGAAGCTGTAGTTCTAGATGGCACTAAGGGTCTTGGTTCATATTCAGCTGCTGCTTCCCC CCAAGGAAAAGATGAGGTTTTTCCCCTTCGATTACCTTTTGAGGGATGTTTAGGCTCAAATTCTGCTTGCCACAGAGGAAACATTTCTGC TGTAGTTGTTTACCTCCATCCTAGCTGGCAGTGTGGGACACACACATACAGCAAGTGAAGGTGGGGGTTTGGGCCTGTATAGAGGTCAGC TACGCTGCAGGCTCATCTATTCACACCAGCAGGTACAGAGAAAACTAGTGTTTTGTAAAGTCAAATATTTGTTGGGGGTTGGAGTTCTGG GGTTGGAGGAGGGGCTGTTCTGGGCATCAGTTGAGCAGATGCCCAGGATGCCTGGGGGAGACCAGCTTCCCCTACAAATCAGAGCTCTAA ATTACAAGGTTTTTACCAACGTGAACAGTTGGGGGAAGTCGTCTGCTCTCATTTGCGTAATGGTTTCTGTCACTGGTGATTAGACACAGG ATGAAGGAAAAGAAATTTGACAATTAGGAATGAGCGATCATTAATCTGAATCTGTTAGGAGACAGAGAGGGGAAGGATCCTTATCAGTGG GCCAGCCCAGTATGGGGAGACACTCCCTCCCTCTGCCCCCAGAGACTCCTGGGCTACATCCTCTTTCAGTATTGCCACAAGTGGGCAGAG CTTGTATTTCTTAACAAAGATTAGGGACCCAGTTGCCAGCCTGAGATGGATATAGGAACAGACATCTTTGGGCATGAGCCAACAAAGATA GAAATAGATGAGTGTCAGGTACAAGCTATAAGGCAAAGAATAACAGTGGAAAAGTTTTGACATGTGTTTGCCATTTGTGGAAAATGTTTT TGTAATAGTCAACACCCCTCATAGCCCACCTGTGACAAGTACTTGTTACATTCCAGCACTGTAGGGCGTGAGGAAAATCTGGTCCTTATC AAATCCCAGGAGCTTCTGCTTAGTTGGGGAAGAAATTACATGAAGCAACCAGAGGTTATAAGGCCACACTTGTATATCGTGCACCCTGTG TGGACAAGATTAGGGACTGTTGAGAGAGGAGGAAACCAGTAGAGAGCAAAGCTCTACCCAGGCTCCTTGTAAGCCTCTGGGCTCCCCCGA GAGGGCCTCGCTACTCTACGCTTCCTAGCAACGTTGATGTCCCCACAACCCCACATCAGTGCAGCTGTGGCTGTGTGGAGGGGCTCTGAG GCCTCTGAGGCCAGATGTGTAAACAGTGCTGAGGTTCAGTAATAGGATGAGTCTTCAGGTGTGGAGCAGCCCACCTTGGCTCTTCCCATG TCTCTGTGTTACTTCTCATATTCTGCTGTCCTTTCAAACTTCAAGGACAGTATTAATTTATACTAGTATTTCTTCCTCAGTTTTGTGACT TGAATGCAGTGAGTGCCTTAGAGGATCCAAGGATGAAGGAATGCGGGTTGGTGGTTCTCTCTTTCAGAATGGGAACTTCCCAAAAATGGG GCTGCGTCTCGCCTCTCAGTAGGTTCCCTACCTCTGGGTCTTCCACCCTTCAAAATCTGGTACAGAATTTAGCAGGGGCTGCAGGGAATG ACCCTCAGGGACCAGTTTCACCCAGATGGGGTAGATGATGAGGTATACCTAGAAGTAGCTCAGGGCTCCAGAGTCTGGCCTTTCAGCTGG TGTCTTACTCCCCTTTGAGACCTTCAGCTGCTTGTCTTCCACTGCCTGCATACTTCTCTGATGTCTTCTCAAACTGTTGGCTCTAAAGGG ATGTTCCAGCCTCCCTCTCCAGAGCTGCCTGCAGTTTCCCTTATTCAGCTGTCTCCTGCCTAGTCTCTCCAGCGGCCTCCTTACCAAGAC CCTTTTTCCTAAACAGTTGTCCTTCCCTCAGAAACTCCATGGCTGCAAGTGTGAATAGACTTGTCTTTAGGATCCCTCTCTCTGGTCATC CCTGATCATCTTAGGGCCGTCTCCCTTTTCTGATTTTTGACAGCTCTGTTTATTTTGCCCATGGCTAGTCCTCTTGTTTTGTGTCTGCTG TGTGTTCTTGCCCTTCCATTGTCAGTTCTGTACATCCTGGTTCAGCTTGTCTCACTGTGGTAGCCCCTTCTGCTTGTCTTCAGCCATCTT GGTTTAATCCTCATAGGTCATGGATGAATGGAGCCTTGCTGAGCACTTTGAGGGCATTTCTGTTGGGCACAACCTCAGAAACGGGAAGTC TTGAGGCCTGGGGGCGTGTGGTCAGTGAGGCCTCCAGAGGTGGGTTAGGGGTGGGCACCTACAAGGGCCAGTTGAGGGGAGAGGTGCAGG GATTGCTGAGGAGACTTTGTGAGAATGATGTCAGGCCCGGGAAGCTGGTGTGGAAGAACTGAGCTGTCAGAAGGAGATACCAATATCCCC TTTGCAGGGTGGTGATGGGCATCAAACATGACGTGGAACATGTCCCCTTCATGGAGGGTTTCCATCTAAATGCATCTGTGTGCCTTAGGG ATCAGTAGTTCAGGGGTGGTGGACTTTTTTGAGTGTCTCCTAATTTCTCTGAGGTGTCTTTGGCTCTGTGTCACCAAATGTGCCTGACCT CTGCATCCCAGTGGTTGCTGAAAGGGAAACAGTATATTGCGTAGTCAGATGTCAGGAGTAGAGATCTTAATGAGAAAGGCCCTGGCAGCT GGAGAGATGAGAGGACCTAGTGGTCAGCTTATACCCAGACTATCTCTCCACTCCTCCAAGAGTTTGAGTCCCATAGCTGATGAAAGAATT TACATATGGGCTCCCCCCTGCTTTCCCACTGAAAATCTATTCTCATATTTTGGGAAGGAGCATATGTCCTTTAACTTTCAATGGTAAACA ATCTAGGATAGTGTTTAAAGGCATGGATTTTGGAGTCACATATAGTTGGTTTGAATTTCTAGCTTCACTACTTACCAGCTGGGTTTGACC TTGGTTGATTTACTTAACCTCTCTGAGCCTCAGTTTCCTCAACTATAATAACATGGGTGGAGGGAGGCATGTTGAAAATATCTACCTCAG GGTTGTTGGAATAACTGAAACAATGTTTGTAAAGCTTTAGCACAGTGCCTGGCAAGCACTTAATAAATGGCTGTGGTGGTGGTGGTTATA TTTATTATGTGATTTATTCAGAAACTTGGTTTCAGTGATCTCTAAACAGATTTCCAGTGGTTCTTTCTCTCTCAAGAAAAGCATAGGGAA AAACGAGAAACACCTTAGATAAACCATATTGAGTTGAGGGTAGACAGAAGAGTCTAGTACCTAAACTCACCCTAGAGGAAGAGAAACAGG AAGTGTCTTATGCCTCTTCTGCCTGGGCAGCCAGACTTTACTGCTGTACTACCAGCCCAGGGCCTTGGGTGAGAAGGTTTCAGGTCTGAG CTCCCCTTGCACTGTGTGAGAGGCCGTGGAGCCGAATGAGTCCTTATTATACCTGGAGAAGCTGTTGTCTCCTCACACCATGAAATGTAA TAGCAGTCAAATCAGGCCCCTCTTGATTCAATTTTAGTCCATGCCTTTCCATGTATTTAAATTATATAAGTGTTGGCCAGGTGTGGTGGC TCACACCTGTAATCCCAGCACTTCGGGAGGCTGAGGCAGGAGGATCACTTGAGCCCAGGAGTTCGAACCAACCTTGGGCAGCATAGTGAG ACCCCTTCTCTTAATAATTTTTTTTGAAAATAATTTTTTAAAAATTACAAATATGGACCAGACACCTGGGAGGATTACCTCACGCCTGTA ATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACTATCCTGGCCAACATGGTGAAACCCTGTCTCT ACTAAAAATACAAAAATTAGCCAGATGTGGTGGTGGGTACCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCACTTGAACCT GGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGTCATTGCACTCCAGCCTGGGTGACTACAGTGAGACTCCCTCTCAAAAAAAAAAAAAA AAAATTATGAGTATGTTAAGATTGTTCTAGGGGAGAAGGGCAATCAAAATTCAGAAAAATATGAGTGGGATGTTAATAGCTACCATTTGT TGAACACTTCTGTTCCAGGCACTGTATTAGTTCGTCCCCATGTGGTGCTCTCAGATCAGTAGGGGAGACAGGCAGGCAGTTAGAATTATG GTGTATAGAGGAGAAGCATTGCACTATGTCCAGTTTTTTATGGTAGGCTTCCTGCAGAAAGTGATAAGTCCAAGCTGATATGTGGAAGAT GAATAATTAACCAGAGGTTGGGGGATTTCCCCCTTAGCTTCTCTTTCTTCCAGTCCAGCAGTCCAAAACAAACACTGCTTCCCAATGCCT AAGGGTTTTGTCGTACCTTACTCCAGGGAATGGGTGAGACAGTAGATCCCAAGAAGAAAACCCTTTGGTTAGTCACAGAAATCTGAAAGT CTTGGTTGCTGGCTCAGATTTGTCCTGGAGTGGACGTAGATTGGACTTGCTTATTTGTAGCCCTCCACCGTTCTCATTTGTGTTCTGGCC TCTGGAGCCACCCTGCCAGACCCTACTTGGAAGAAATGTTGAATCAAGCTACTCAGACTTCAGCCTGAGATGTATTATGGCTGGCTGGAA TTCTCAGCCCTTTCCACATCATGATCCCATTAATCTCTTGGGTCTATCCCCACGCCCAGCCACCTCTCCTCCTCACTATAAGCCAAGTCT CCCTGCAGTTCTCTATAAATACTCAGATCCTCTTGCCTCAGACCCTGGTCCCTAGCTTTGTGGGTGAAGAAGATACCTCTTTAGCTTGTG CCAACCCATCCCTCTGGGCTACAGGCCATTCTGTAGTCACCTTGCAGTCACGTCTTTCCTTCTAGATAACTGGCTCTGGGCCTTGGAAAC CTTCTCTTTGGCTCTAGCTAATTTTGCTGTTTTATTCCGTTTACTTAAAACCTATTCACTTGGTCATTGAGGTCAGAACTATCAGGAAAG CTGTGCTCCTTAACCCATCATCTAAGCTAAGCTTGGGCCAGGTTTTTATTACCTCTTGAATATATATAGTGCAATATAGTGTAGTGGTTG AGAGTGGAGTCTGCATACCTGGATCTGCCATTCTGCATGACTTTGGGCAAATGGACAAACTGCCCGAAACTTGACTTGTTTATATGTATG GGGAAGACATCATTTACATTGTCAGGGTAAGGCTTAGCAGAATGACCGGTCCATAGCAAGGGCTCAGTCTTTCTGTGTCTCTCAGTCTTT ACCTCTCTTCCCCATCTAGCTTTCTGTCTAAGTTCCTGTTTCTAGTCTCAGGGCATATCTAGTTGTCAGCTCCTGAGCAGAGCAGAGGTA TAAGTGTCAACTCATGCTTGTGTTACCAGTTCCTACCCCTGTCAGTAACCTCTGATGCTTACAAGGATACTATCACCTATGCCATCAGTG GGGAATGACCTTCCAAAAATATTTTTAACAATACTAAAAATACCTGAAACATACTGGGTGAAAATAAGACATTGGAGCTGCTGCTCCCCA AGGAGATAAAAGGACAGTTCCTAAAGAGGCATTGAAGGTTTGTATGAGCCAGCAGCACAGTCAGAAGGCAAGAAGGAGACCCTGGGATGT GCACAAGGATGCAGGAGACGAGATTGTCACAGAGGCTGTCATGCTAGTAAGAGTCAGAGGTTACTGATGGGTAGAGATTGTCAGAGTCTG CCTTGCTAGTCTAGAGGTAGGACCATGGATTTAAGAACGTTGCCTCCAAGTTTTTGAATTGTGAATTTTTGATCATATTTGAACAAAACC CCACCTACAGTCTGCATGGTCATTGTTCTCACAAGGGTTTGTGTGATGCACTGACAAGAACAGAGGCTTTGGAGGTGACTCCTGGGTTTG AATCACCATTTGCCACTAGCTAATTCTAACCTTAGGTAAGTCAGTGTCTCTGGGTCTCAACCTCTTCCTCTGTGAGGGGTAGGAAATAGC ACATAACTTGTAGCATTGTTATAAGGGCTCGTGATAATGTTTTTAAAACACCTGGCTCAAGCACTCAGGAAAATGTTTTATTATGAAGAC CAAGTGTCTCTGAAAAGTGTTTCCTTAGTGTCTGGAGAGACTACAGCAGCAAGGCTTTTCTGATCCTACTCTGACTCTCAAGATAATGGT GCTTGAAGTGAAATCACAGAAGAGATGACTGGGGCAGGAAAAGCAAGATGGAAAAGATAAAGTTGTGGAAGGGACTGAAAGTCCATGAAG TGCTGGGCTGGGGACAGAAAGGGTTTAATAGGGCAGGGTCTTGAGGAACAGGAACAGAGACCTTGGTTCTGGGTTGCCATCTGATTCCCA GAAGAGTAAAGGAAATGGGGCAGGAGGATGTCTGTGGAGGACACAGTGTGGCTGAGTGGAGAGAACACAAGCTTCTGGCCAGTGAACCTA AGTGAGAATGTCAGTGGACTTTGCACAGGCTGGGTGCCTTTGGGGGTGTTCATCTCGCTATGCTTCGGTCCCCTCATTTAAAAAAATTGG TTAATAATATGATGACCTGCCAATGTGTGTGGAAATACTATGTAAACTGAGCACTATATAAATGCTGGTTGTTGAGATATTGGGAGTGGG GGTTTCGGGAGATTTTGTTTGTTTGTTTTTTTGAGATGGAGTTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTC ACTGCAACCTCCACCTCCTCCAGGTTCAAGCAATTCTGCCTCAGCCTCCCGAGTAGCTGGGACTCAGGCGTGCGCCACCATGCCTGGCTA ATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTTGGCCT CCCAAAGTGCTGGGATTACAGGTGCGAGCTACCACACCTGGCCCTGGATTTCTTAATAGGTCCTCTTATGTGGCTATTGAGAATGAATGA GACAACTCATTAACTAACTAAGTTAATTCAGAACTTAGTGCCTAGTAAGTGCTCAGTAAATGTTAGTTTCTTTTCCTCCATTTCTTCTTA GGAAGCATCGTTTACCCAGCATAAACAGGAGGACTCAACTGTGCATGTCTTAGTGTGAACAAGTAACATCAGATTTCCCTTTTCTGAGGA GAGATCAGTTCTGTAAGAGGGAGCATGAGTGTGAATGGGGAAGAATCATGGAGAAGGGAGCAGGACTCCACAGTACTGGAGATGGAGTAG GGACCTCTGGGAATCGTTGGCATGGGGGTGTGGTGCAGAAAGGGTGATGCTAAGAGGTGAGAGTCTCAAGAAAGAAGATGGGTGTTCTAG AGGGGAAAGCTAAACGATGATAGGCAATGAGGAGCGGAGGACAAGACCCTGAACTAAGGGTGAGGAGGCCAGCATTCTGTCAGGAGAACC TTAGGAATTGTGACCAGAAGTCAAAGTTGTTACAGCAATCCTGCATTCAACCAGGTTTCATCTGAAAAACTTAAGAGTTGCTAGGCACAG TCGTGCACACTTGTAATCCCAACACTTTGGGAGGCTTGAGTCAGGAGGAAGCTTGAGGCCAGGAGTTTGAGATCAGCCTAGGCAGCATAG TGACACCCCATCTCTTGAAAAAACAAACACTCTTAAGAGCAGTGGTTCACCTAGAAATAAAAAGCAGAAATCATCAAGATGAGAAGACAT TTTGTGTTTTGACAGCCAAGGAAATTTGCCACTGAGACAAGGTATCTGACAGCCTAGATGGGATTCTAGACTTCTGTGAGAAAGTGCAGT TAGGCCCTGAATAGCGTCAAACTCAGGGATGTGAGCTGACTGACTGCCTTTTTATGTAATGGAGGCCATGTGATAGGGCTTTATGAGGCC ACAAATAGCACTTTCTGGGTCCTTTCACAGTCTAGTCAGTGGCCCAACCAACATATCTGGTTGTTCTGCAATCTCAGTCATCTGAGAAGA TAACCTCCAAAATACATGCAGTGGCATCAGGTGTTTCCTTGGTAGGTGTGCATCTTTTAATGATGGAGGACTTAGGATGAAGAACAGGTG TGTTTAAAAACATCAAACCCCCACATCATTACTATTTGCTGTAAGGATCTATGCAGTTTGTATTTTAAGTCCTTGACATATGGAAGAGCA TTTGTGAGAGTAACAGGTTTGCTTTGTAATGCCAACTAAAAAGTGTGTATTTATACTCGAATTTTAAGTTGAAATTTTGCTAAGTTTCTT TTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAGTACAGTGGTACAATCATTGCTAAGTCTTTCTGTAGTTTTAGAAC ATTTAGAACAACTTAAGATTTCCTGTATTTATAAACTTAATTTATTGGAAATATAAGTACTTGATCAGGTTTTGTCTTGGTCAGATAAAT TAAGTACTTAAGGAAATCAAATACATTAATCATATAAATGCCATTTAAGTGTTTAAAGGAGTTTAGTTAAATGTAAGTTGGATCAAACAT TAAACTTTTTTGTTTTATAAGCAAAATAATAAGATTTGTTAGCAGAACTTAAAAGCTTAGAAAAGAGAGGATTTTGGATATGTAACTTTG AAGAGGTGAATAGTTTGCTCTTTTCTGAGACAGGGCATTGCTTTTCGACGCAGGCTGGAGTGCAGTGGGGCAAGCATGGCTCACTGCAGC CTCAACCTCCTGGACTCAAGTGATCCTCCTGCCTCAGCCTCCCATGTAGCTGGGATCACAGGCACATGCCACCACACCTGGCTAATTTTT TATTTTTTGTAGAGACAGGGGCCTCACTTCATTGCCCAGGCGGATCTCGAACACCTGGGCTCAAGCAGTCCTGCCTCAGCCTCCCAAAGT TCTGGGATTACAGGCATAAGCCACTGTGCCTGGCCTTGAATATATTTTTTAACCAAAGTAATTTATGAATATAAATTGTTTCTATATAAC CCAAAGTCACTCTCATTGACATTAAGAAACTCAGAGAGTGGGTTCTAAATGTAATATTACCACACACCCAAGTCACTTAGCCTCTACAAG TACCACGTAACTAGCAGCCGTTAAAAGATGGCCACCGCTAGTCCAGTCGGCCACAGACATGGTTTTGTTTGGCCAATACAAGTTTTTGAA >In-frame_BTRC_ENST00000393441_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_12969nt ATCCGGGCGCTGCGTTGGCTGCGGCCTGGCACCAAAGGGGCGGCCCCGGCGGAGAGCGGACCCAGTGGCCTCGGCGATTATGGACCCGGC CGAGGCGGTGCTGCAAGAGAAGGCACTCAAGTTTATGTGCTCTATGCCCAGGTCTCTGTGGCTGGGCTGCTCCAGCCTGGCGGACAGCAT GCCTTCGCTGCGATGCCTGTATAACCCAGGGACTGGCGCACTCACAGCTTTCCAGGAGCCTGTGGTGCTGACCGACACAAATCTTGTGTA TCCTGCCCTGAAATGGGACCTTGAATACCTGCAAGAGAATATTGGCAATGGAGACTTCTCTGTGTACAGTGCCAGCACCCACAAGTTCTT GTACTATGATGAGAAGAAGATGGCCAATTTCCAGAACTTTAAGCCGAGGTCCAACAGGGAAGAAATGAAATTTCATGAGTTCGTTGAGAA ACTGCAGGATATACAGCAGCGAGGAGGGGAAGAGAGGTTGTATCTGCAGCAAACGCTCAATGACACTGTGGGCAGGAAGATTGTCATGGA CTTCTTAGGTTTTAACTGGAACTGGATTAATAAGCAACAGGGAAAGCGTGGCTGGGGGCAGCTTACCTCTAACCTGCTGCTCATTGGCAT GGAAGGAAATGTGACACCTGCTCACTATGATGAGCAGCAGAACTTTTTTGCTCAGATAAAAGGTTACAAACGATGCATCTTATTCCCTCC GGATCAGTTCGAGTGCCTCTACCCATACCCTGTTCATCACCCATGTGACAGACAGAGCCAGGTGGACTTTGACAATCCCGACTACGAGAG GTTCCCTAATTTCCAAAATGTGGTTGGTTACGAAACAGTGGTTGGCCCTGGTGATGTTCTTTACATCCCAATGTACTGGTGGCATCACAT AGAGTCATTACTAAATGGGGGGATTACCATCACTGTGAACTTCTGGTATAAGGGGGCTCCCACCCCTAAGAGAATTGAATATCCTCTCAA AGCTCATCAGAAAGTGGCCATAATGAGAAACATTGAGAAGATGCTTGGAGAGGCCTTGGGGAACCCACAAGAGGTGGGGCCCTTGTTGAA CACAATGATCAAGGGCCGATACAACTAGCCTGCCAGGGGTCAAGGCCTCCTGCCAGGTGACTGCTATCCCGTCCACACCGCTTCATTGAT GAGGACAGGAGACTCCAAGCGCTAGTATTGCACGCTGCACTTAATGGACTGGACTCTTGCCATGGCCCAGGAGTCAGGTGTTTGGAGCGA GGCAGGGCAGTTGGCACTCCACTCCTATTTGGAGGGACTTCATACCCTTGCCTCTTGTGCCCCAGCACCTTCTCTCTCTGCCCCCCGCCT AAAGTCCTGCATTCAGTGTGTGGAGTCCCAGCTTTTGGTTGTCATCATGTCTGTGTGTATGTTAGTCTGTCAACTTCGGAATGTGTGCGT GTGTGTGCATGCACACGCATGTATGTATCTGTTCCCTGTTCCTTCTGGGTCAGGCTGTCACTTCCGGCTCTCAGCCCTATCTCCTGCAAC CTCAGTGCCTCAGCCTGAGAGAGAGATGAGATGCTCTTGGACTCCCCACTGCATCTGGGCTGCAGGGCCAGAGCTAGTCTGACCATTAGG TCAGTCTGCCTCCTGACAGTTTTTGCGTAGTCAAGCTCTAGGCGGTATGGGAATGGCTACCGGGACTCTAATGGGGTGAAAGAGAGGGGA GGCTTGCCTTTGAGAGCCTATATAGCCTTCCTGTGAGAGAGGATTAGATAGGGTTCCAACTGGGCCTACAAGCTCAAGCCATACATAAAA GGACCTTGGGACATAAGAACCAATGATTGTGCATAAGTTCTAAATTAGAGACACATATAGTTTCTCTCTTTCAGCACCAGCTCTTGCCCC TATGCTGGGTACCAAGGGAGTTCTCCTAGCTGTGGCTTCTCTAGGTTCTAGGGGTGCAAGCCTCTGTGTGTTTGTTTGTGTGTGTCTGTG TGTGCGTATCCACACTAGGGGTGCAAGCCTCTGGGTGTGTGTGTGTGTGTGCGTGCGTGTGTGTGTGTGTGTCCGTGTGTGTGTGTGTGT GTGTCCACACTGGCCAGCCTCCCTACTTACCAAGGTTCTCCACTGCTTACCTTTTCCAGTGGGACAGTACAGTGTGAGCCCCCGGGAAGT ACTGCCTGACCTATCCTAAGCTTTTACACTTGGATTTTAGCCATCATATGTTGGCCAGGTCTCACTGCAGCCTGCCCGAGGCTAACTGGC TAGAGCCTCCAGGCCCTATGATGCTCCCTGCCCAGGCCATATCCTTTATTCCTGCTGAGCTTCCTGGCTGAATAGATGAAATGGGGTCAA GCCCAGGCAGCTCATTCACTACCTGTGATCCACCTCAGGGCACGGGCAAACACATAGGCTTGCGTCTTAAAGCCAGCTCCTCTGCCAGAC CCCGTTGTAATGTGCCACAACACCCTCAATAGTCAGGGCAACTGGTGGAGCATGGAAGTCGAATTTCCTTTTCTGTTAGGAGCTACTCCT GGGAACCCCTCTCAGGGCTGCAGCTTACAGGTGGGCAGCTGTGATTGCACAACTTGAAGGGCCATCATTCACATCTATTCAGTGGGAGTG GGGTCCCTGGGATTGGGCAGTGTGGTGGCCCTGTGTCTCCTCACCTCTGCTCCTGTCTTCATCACCTTCTCTCTGGAAGGGAAGAGGAGT TGGAAGGTCTCTGGTTTTCTTTTCTTTTTTTTTTTTTTTGCCAAAGGTTTACTTCCAGCATCTGAGCTCTGGCTCTCACCCCTGAAGCTC AGTTATAGTGCACTGATGAACTGAGAGGATGCGTGTGGATGTGTGTGCATGCCTGAGTGCGTTTTTTGGGGAGGGGTGTTTATTTTTAGT ACCCCATTCTGGGGTTCTCTGATGCAGTGTGGATGTGAAGATATGGTACCTTCTCAAGTGTAGCTCTTTCAAATATAGTCAATGCTGGGA AATGTGATTGCAGTGATCTCTATCTCTCCACTTCTTTTGGGAAAGAGGAGCACAGGAGCGGAGGAAAAACTTGGCCACAGTCACACTTGG AAAGATAGTAGATTATTTTCGTTCTCCTCAGCAGGTCTGCTGTATTCCTCGCTCAGCGCTCAAAGATGTGGGTGATGTGTCAAGGAGGCA TGCACTCAGCTGGTCCTTGCTGAGTTATTTGCTGACACAGGTCTCACTAAGGTGGCTGAGGGGTGGGAGGGAGAAGGCTAATCTTGGAAC CTTCACAGGATTGGCCTTGATCCTTGGGTAACACAAGAGTGATTCCTGATTTTTAGACACCTAATATGTGCCTAGTGCTTTTCTCTTTGT TCCTCACTATCCTGCAAGGTAGGTATTCTCACTTACAGATGAATAAATGGGCTCAGAGAGATTAGGTGATTAGTGACAATCAGTTGTAAC TTAGCACTGTTAGGCTGCAAACCCCTTGCTCCTTCCTTTCCACCAAACTATGTTGATTTTCCTTCCTTACCTCCCTCCTTGTACCACAGG TTCTGTCCTCAAGATATCACCCCACTGGGCAGTATCTGAAGGCAGACCCAGCCCAAGATGGTGCAGAATATACAGCTCAGGGTGAAAGTT CTTCTGGGCTCCTGCTAACAAAGTCTTGGAAAAACTGCCTGGGAAGCCATATTATGAATTAGTGCTAGAAGAAGCTGTGGGGGGAACTGA GTTCTGTGTCTAATTGCATTACTTATGTGTCCTTGAATAGGACCCATAACTCCTCCCGGCATGCTTTTGCATCTATAGAACTGAAGCTGT AGTTCTAGATGGCACTAAGGGTCTTGGTTCATATTCAGCTGCTGCTTCCCCCCAAGGAAAAGATGAGGTTTTTCCCCTTCGATTACCTTT TGAGGGATGTTTAGGCTCAAATTCTGCTTGCCACAGAGGAAACATTTCTGCTGTAGTTGTTTACCTCCATCCTAGCTGGCAGTGTGGGAC ACACACATACAGCAAGTGAAGGTGGGGGTTTGGGCCTGTATAGAGGTCAGCTACGCTGCAGGCTCATCTATTCACACCAGCAGGTACAGA GAAAACTAGTGTTTTGTAAAGTCAAATATTTGTTGGGGGTTGGAGTTCTGGGGTTGGAGGAGGGGCTGTTCTGGGCATCAGTTGAGCAGA TGCCCAGGATGCCTGGGGGAGACCAGCTTCCCCTACAAATCAGAGCTCTAAATTACAAGGTTTTTACCAACGTGAACAGTTGGGGGAAGT CGTCTGCTCTCATTTGCGTAATGGTTTCTGTCACTGGTGATTAGACACAGGATGAAGGAAAAGAAATTTGACAATTAGGAATGAGCGATC ATTAATCTGAATCTGTTAGGAGACAGAGAGGGGAAGGATCCTTATCAGTGGGCCAGCCCAGTATGGGGAGACACTCCCTCCCTCTGCCCC CAGAGACTCCTGGGCTACATCCTCTTTCAGTATTGCCACAAGTGGGCAGAGCTTGTATTTCTTAACAAAGATTAGGGACCCAGTTGCCAG CCTGAGATGGATATAGGAACAGACATCTTTGGGCATGAGCCAACAAAGATAGAAATAGATGAGTGTCAGGTACAAGCTATAAGGCAAAGA ATAACAGTGGAAAAGTTTTGACATGTGTTTGCCATTTGTGGAAAATGTTTTTGTAATAGTCAACACCCCTCATAGCCCACCTGTGACAAG TACTTGTTACATTCCAGCACTGTAGGGCGTGAGGAAAATCTGGTCCTTATCAAATCCCAGGAGCTTCTGCTTAGTTGGGGAAGAAATTAC ATGAAGCAACCAGAGGTTATAAGGCCACACTTGTATATCGTGCACCCTGTGTGGACAAGATTAGGGACTGTTGAGAGAGGAGGAAACCAG TAGAGAGCAAAGCTCTACCCAGGCTCCTTGTAAGCCTCTGGGCTCCCCCGAGAGGGCCTCGCTACTCTACGCTTCCTAGCAACGTTGATG TCCCCACAACCCCACATCAGTGCAGCTGTGGCTGTGTGGAGGGGCTCTGAGGCCTCTGAGGCCAGATGTGTAAACAGTGCTGAGGTTCAG TAATAGGATGAGTCTTCAGGTGTGGAGCAGCCCACCTTGGCTCTTCCCATGTCTCTGTGTTACTTCTCATATTCTGCTGTCCTTTCAAAC TTCAAGGACAGTATTAATTTATACTAGTATTTCTTCCTCAGTTTTGTGACTTGAATGCAGTGAGTGCCTTAGAGGATCCAAGGATGAAGG AATGCGGGTTGGTGGTTCTCTCTTTCAGAATGGGAACTTCCCAAAAATGGGGCTGCGTCTCGCCTCTCAGTAGGTTCCCTACCTCTGGGT CTTCCACCCTTCAAAATCTGGTACAGAATTTAGCAGGGGCTGCAGGGAATGACCCTCAGGGACCAGTTTCACCCAGATGGGGTAGATGAT GAGGTATACCTAGAAGTAGCTCAGGGCTCCAGAGTCTGGCCTTTCAGCTGGTGTCTTACTCCCCTTTGAGACCTTCAGCTGCTTGTCTTC CACTGCCTGCATACTTCTCTGATGTCTTCTCAAACTGTTGGCTCTAAAGGGATGTTCCAGCCTCCCTCTCCAGAGCTGCCTGCAGTTTCC CTTATTCAGCTGTCTCCTGCCTAGTCTCTCCAGCGGCCTCCTTACCAAGACCCTTTTTCCTAAACAGTTGTCCTTCCCTCAGAAACTCCA TGGCTGCAAGTGTGAATAGACTTGTCTTTAGGATCCCTCTCTCTGGTCATCCCTGATCATCTTAGGGCCGTCTCCCTTTTCTGATTTTTG ACAGCTCTGTTTATTTTGCCCATGGCTAGTCCTCTTGTTTTGTGTCTGCTGTGTGTTCTTGCCCTTCCATTGTCAGTTCTGTACATCCTG GTTCAGCTTGTCTCACTGTGGTAGCCCCTTCTGCTTGTCTTCAGCCATCTTGGTTTAATCCTCATAGGTCATGGATGAATGGAGCCTTGC TGAGCACTTTGAGGGCATTTCTGTTGGGCACAACCTCAGAAACGGGAAGTCTTGAGGCCTGGGGGCGTGTGGTCAGTGAGGCCTCCAGAG GTGGGTTAGGGGTGGGCACCTACAAGGGCCAGTTGAGGGGAGAGGTGCAGGGATTGCTGAGGAGACTTTGTGAGAATGATGTCAGGCCCG GGAAGCTGGTGTGGAAGAACTGAGCTGTCAGAAGGAGATACCAATATCCCCTTTGCAGGGTGGTGATGGGCATCAAACATGACGTGGAAC ATGTCCCCTTCATGGAGGGTTTCCATCTAAATGCATCTGTGTGCCTTAGGGATCAGTAGTTCAGGGGTGGTGGACTTTTTTGAGTGTCTC CTAATTTCTCTGAGGTGTCTTTGGCTCTGTGTCACCAAATGTGCCTGACCTCTGCATCCCAGTGGTTGCTGAAAGGGAAACAGTATATTG CGTAGTCAGATGTCAGGAGTAGAGATCTTAATGAGAAAGGCCCTGGCAGCTGGAGAGATGAGAGGACCTAGTGGTCAGCTTATACCCAGA CTATCTCTCCACTCCTCCAAGAGTTTGAGTCCCATAGCTGATGAAAGAATTTACATATGGGCTCCCCCCTGCTTTCCCACTGAAAATCTA TTCTCATATTTTGGGAAGGAGCATATGTCCTTTAACTTTCAATGGTAAACAATCTAGGATAGTGTTTAAAGGCATGGATTTTGGAGTCAC ATATAGTTGGTTTGAATTTCTAGCTTCACTACTTACCAGCTGGGTTTGACCTTGGTTGATTTACTTAACCTCTCTGAGCCTCAGTTTCCT CAACTATAATAACATGGGTGGAGGGAGGCATGTTGAAAATATCTACCTCAGGGTTGTTGGAATAACTGAAACAATGTTTGTAAAGCTTTA GCACAGTGCCTGGCAAGCACTTAATAAATGGCTGTGGTGGTGGTGGTTATATTTATTATGTGATTTATTCAGAAACTTGGTTTCAGTGAT CTCTAAACAGATTTCCAGTGGTTCTTTCTCTCTCAAGAAAAGCATAGGGAAAAACGAGAAACACCTTAGATAAACCATATTGAGTTGAGG GTAGACAGAAGAGTCTAGTACCTAAACTCACCCTAGAGGAAGAGAAACAGGAAGTGTCTTATGCCTCTTCTGCCTGGGCAGCCAGACTTT ACTGCTGTACTACCAGCCCAGGGCCTTGGGTGAGAAGGTTTCAGGTCTGAGCTCCCCTTGCACTGTGTGAGAGGCCGTGGAGCCGAATGA GTCCTTATTATACCTGGAGAAGCTGTTGTCTCCTCACACCATGAAATGTAATAGCAGTCAAATCAGGCCCCTCTTGATTCAATTTTAGTC CATGCCTTTCCATGTATTTAAATTATATAAGTGTTGGCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTCGGGAGGCTGAGGCAG GAGGATCACTTGAGCCCAGGAGTTCGAACCAACCTTGGGCAGCATAGTGAGACCCCTTCTCTTAATAATTTTTTTTGAAAATAATTTTTT AAAAATTACAAATATGGACCAGACACCTGGGAGGATTACCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCT GAGGTCAGGAGTTTGAGACTATCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGATGTGGTGGTGGGTA CCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGTCATTG CACTCCAGCCTGGGTGACTACAGTGAGACTCCCTCTCAAAAAAAAAAAAAAAAAATTATGAGTATGTTAAGATTGTTCTAGGGGAGAAGG GCAATCAAAATTCAGAAAAATATGAGTGGGATGTTAATAGCTACCATTTGTTGAACACTTCTGTTCCAGGCACTGTATTAGTTCGTCCCC ATGTGGTGCTCTCAGATCAGTAGGGGAGACAGGCAGGCAGTTAGAATTATGGTGTATAGAGGAGAAGCATTGCACTATGTCCAGTTTTTT ATGGTAGGCTTCCTGCAGAAAGTGATAAGTCCAAGCTGATATGTGGAAGATGAATAATTAACCAGAGGTTGGGGGATTTCCCCCTTAGCT TCTCTTTCTTCCAGTCCAGCAGTCCAAAACAAACACTGCTTCCCAATGCCTAAGGGTTTTGTCGTACCTTACTCCAGGGAATGGGTGAGA CAGTAGATCCCAAGAAGAAAACCCTTTGGTTAGTCACAGAAATCTGAAAGTCTTGGTTGCTGGCTCAGATTTGTCCTGGAGTGGACGTAG ATTGGACTTGCTTATTTGTAGCCCTCCACCGTTCTCATTTGTGTTCTGGCCTCTGGAGCCACCCTGCCAGACCCTACTTGGAAGAAATGT TGAATCAAGCTACTCAGACTTCAGCCTGAGATGTATTATGGCTGGCTGGAATTCTCAGCCCTTTCCACATCATGATCCCATTAATCTCTT GGGTCTATCCCCACGCCCAGCCACCTCTCCTCCTCACTATAAGCCAAGTCTCCCTGCAGTTCTCTATAAATACTCAGATCCTCTTGCCTC AGACCCTGGTCCCTAGCTTTGTGGGTGAAGAAGATACCTCTTTAGCTTGTGCCAACCCATCCCTCTGGGCTACAGGCCATTCTGTAGTCA CCTTGCAGTCACGTCTTTCCTTCTAGATAACTGGCTCTGGGCCTTGGAAACCTTCTCTTTGGCTCTAGCTAATTTTGCTGTTTTATTCCG TTTACTTAAAACCTATTCACTTGGTCATTGAGGTCAGAACTATCAGGAAAGCTGTGCTCCTTAACCCATCATCTAAGCTAAGCTTGGGCC AGGTTTTTATTACCTCTTGAATATATATAGTGCAATATAGTGTAGTGGTTGAGAGTGGAGTCTGCATACCTGGATCTGCCATTCTGCATG ACTTTGGGCAAATGGACAAACTGCCCGAAACTTGACTTGTTTATATGTATGGGGAAGACATCATTTACATTGTCAGGGTAAGGCTTAGCA GAATGACCGGTCCATAGCAAGGGCTCAGTCTTTCTGTGTCTCTCAGTCTTTACCTCTCTTCCCCATCTAGCTTTCTGTCTAAGTTCCTGT TTCTAGTCTCAGGGCATATCTAGTTGTCAGCTCCTGAGCAGAGCAGAGGTATAAGTGTCAACTCATGCTTGTGTTACCAGTTCCTACCCC TGTCAGTAACCTCTGATGCTTACAAGGATACTATCACCTATGCCATCAGTGGGGAATGACCTTCCAAAAATATTTTTAACAATACTAAAA ATACCTGAAACATACTGGGTGAAAATAAGACATTGGAGCTGCTGCTCCCCAAGGAGATAAAAGGACAGTTCCTAAAGAGGCATTGAAGGT TTGTATGAGCCAGCAGCACAGTCAGAAGGCAAGAAGGAGACCCTGGGATGTGCACAAGGATGCAGGAGACGAGATTGTCACAGAGGCTGT CATGCTAGTAAGAGTCAGAGGTTACTGATGGGTAGAGATTGTCAGAGTCTGCCTTGCTAGTCTAGAGGTAGGACCATGGATTTAAGAACG TTGCCTCCAAGTTTTTGAATTGTGAATTTTTGATCATATTTGAACAAAACCCCACCTACAGTCTGCATGGTCATTGTTCTCACAAGGGTT TGTGTGATGCACTGACAAGAACAGAGGCTTTGGAGGTGACTCCTGGGTTTGAATCACCATTTGCCACTAGCTAATTCTAACCTTAGGTAA GTCAGTGTCTCTGGGTCTCAACCTCTTCCTCTGTGAGGGGTAGGAAATAGCACATAACTTGTAGCATTGTTATAAGGGCTCGTGATAATG TTTTTAAAACACCTGGCTCAAGCACTCAGGAAAATGTTTTATTATGAAGACCAAGTGTCTCTGAAAAGTGTTTCCTTAGTGTCTGGAGAG ACTACAGCAGCAAGGCTTTTCTGATCCTACTCTGACTCTCAAGATAATGGTGCTTGAAGTGAAATCACAGAAGAGATGACTGGGGCAGGA AAAGCAAGATGGAAAAGATAAAGTTGTGGAAGGGACTGAAAGTCCATGAAGTGCTGGGCTGGGGACAGAAAGGGTTTAATAGGGCAGGGT CTTGAGGAACAGGAACAGAGACCTTGGTTCTGGGTTGCCATCTGATTCCCAGAAGAGTAAAGGAAATGGGGCAGGAGGATGTCTGTGGAG GACACAGTGTGGCTGAGTGGAGAGAACACAAGCTTCTGGCCAGTGAACCTAAGTGAGAATGTCAGTGGACTTTGCACAGGCTGGGTGCCT TTGGGGGTGTTCATCTCGCTATGCTTCGGTCCCCTCATTTAAAAAAATTGGTTAATAATATGATGACCTGCCAATGTGTGTGGAAATACT ATGTAAACTGAGCACTATATAAATGCTGGTTGTTGAGATATTGGGAGTGGGGGTTTCGGGAGATTTTGTTTGTTTGTTTTTTTGAGATGG AGTTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCTCCAGGTTCAAGCAATTCTGC CTCAGCCTCCCGAGTAGCTGGGACTCAGGCGTGCGCCACCATGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTG GTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGCGAGCTACCACACCT GGCCCTGGATTTCTTAATAGGTCCTCTTATGTGGCTATTGAGAATGAATGAGACAACTCATTAACTAACTAAGTTAATTCAGAACTTAGT GCCTAGTAAGTGCTCAGTAAATGTTAGTTTCTTTTCCTCCATTTCTTCTTAGGAAGCATCGTTTACCCAGCATAAACAGGAGGACTCAAC TGTGCATGTCTTAGTGTGAACAAGTAACATCAGATTTCCCTTTTCTGAGGAGAGATCAGTTCTGTAAGAGGGAGCATGAGTGTGAATGGG GAAGAATCATGGAGAAGGGAGCAGGACTCCACAGTACTGGAGATGGAGTAGGGACCTCTGGGAATCGTTGGCATGGGGGTGTGGTGCAGA AAGGGTGATGCTAAGAGGTGAGAGTCTCAAGAAAGAAGATGGGTGTTCTAGAGGGGAAAGCTAAACGATGATAGGCAATGAGGAGCGGAG GACAAGACCCTGAACTAAGGGTGAGGAGGCCAGCATTCTGTCAGGAGAACCTTAGGAATTGTGACCAGAAGTCAAAGTTGTTACAGCAAT CCTGCATTCAACCAGGTTTCATCTGAAAAACTTAAGAGTTGCTAGGCACAGTCGTGCACACTTGTAATCCCAACACTTTGGGAGGCTTGA GTCAGGAGGAAGCTTGAGGCCAGGAGTTTGAGATCAGCCTAGGCAGCATAGTGACACCCCATCTCTTGAAAAAACAAACACTCTTAAGAG CAGTGGTTCACCTAGAAATAAAAAGCAGAAATCATCAAGATGAGAAGACATTTTGTGTTTTGACAGCCAAGGAAATTTGCCACTGAGACA AGGTATCTGACAGCCTAGATGGGATTCTAGACTTCTGTGAGAAAGTGCAGTTAGGCCCTGAATAGCGTCAAACTCAGGGATGTGAGCTGA CTGACTGCCTTTTTATGTAATGGAGGCCATGTGATAGGGCTTTATGAGGCCACAAATAGCACTTTCTGGGTCCTTTCACAGTCTAGTCAG TGGCCCAACCAACATATCTGGTTGTTCTGCAATCTCAGTCATCTGAGAAGATAACCTCCAAAATACATGCAGTGGCATCAGGTGTTTCCT TGGTAGGTGTGCATCTTTTAATGATGGAGGACTTAGGATGAAGAACAGGTGTGTTTAAAAACATCAAACCCCCACATCATTACTATTTGC TGTAAGGATCTATGCAGTTTGTATTTTAAGTCCTTGACATATGGAAGAGCATTTGTGAGAGTAACAGGTTTGCTTTGTAATGCCAACTAA AAAGTGTGTATTTATACTCGAATTTTAAGTTGAAATTTTGCTAAGTTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAG GCTGGAGTACAGTGGTACAATCATTGCTAAGTCTTTCTGTAGTTTTAGAACATTTAGAACAACTTAAGATTTCCTGTATTTATAAACTTA ATTTATTGGAAATATAAGTACTTGATCAGGTTTTGTCTTGGTCAGATAAATTAAGTACTTAAGGAAATCAAATACATTAATCATATAAAT GCCATTTAAGTGTTTAAAGGAGTTTAGTTAAATGTAAGTTGGATCAAACATTAAACTTTTTTGTTTTATAAGCAAAATAATAAGATTTGT TAGCAGAACTTAAAAGCTTAGAAAAGAGAGGATTTTGGATATGTAACTTTGAAGAGGTGAATAGTTTGCTCTTTTCTGAGACAGGGCATT GCTTTTCGACGCAGGCTGGAGTGCAGTGGGGCAAGCATGGCTCACTGCAGCCTCAACCTCCTGGACTCAAGTGATCCTCCTGCCTCAGCC TCCCATGTAGCTGGGATCACAGGCACATGCCACCACACCTGGCTAATTTTTTATTTTTTGTAGAGACAGGGGCCTCACTTCATTGCCCAG GCGGATCTCGAACACCTGGGCTCAAGCAGTCCTGCCTCAGCCTCCCAAAGTTCTGGGATTACAGGCATAAGCCACTGTGCCTGGCCTTGA ATATATTTTTTAACCAAAGTAATTTATGAATATAAATTGTTTCTATATAACCCAAAGTCACTCTCATTGACATTAAGAAACTCAGAGAGT GGGTTCTAAATGTAATATTACCACACACCCAAGTCACTTAGCCTCTACAAGTACCACGTAACTAGCAGCCGTTAAAAGATGGCCACCGCT AGTCCAGTCGGCCACAGACATGGTTTTGTTTGGCCAATACAAGTTTTTGAAAGTTTTAAAAAATTGACAACATTAAAGATCAGAAACTTG |
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FusionGenePPI for BTRC_HIF1AN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BTRC | TRIM9, TBK1, SMAD4, SMAD3, DLG1, CUL1, SKP1, IKBKB, NFKB1, NFKBIB, BTRC, FBXW11, NFKBIA, UBE2R2, CDC34, RELA, JUP, NFKB2, UBE2D2, HIPK2, PTTG1, BORA, PDCD4, TP63, EPOR, PHLPP1, AMER1, GHR, APC, CDC25A, HIVEP1, HIVEP2, IGHM, NRD1, PRKACA, SERPINB4, OGT, KEAP1, TUBGCP3, NUDC, TUBGCP2, CLPX, SUN2, COPS4, USP47, GPRASP2, KRT79, CLSPN, CTNNB1, EP300, ATF4, PER1, SNAI1, FBXO5, GLI3, WEE1, TNF, SNRNP70, AXIN1, GSK3B, HEY2, CASP3, MYC, RASA1, CDC25B, CLU, UBC, YAP1, TP53, IKBKG, IFNAR1, BST2, DEPTOR, SP1, PSMD4, UBE2D1, BMI1, MDM2, FBXW8, HNRNPU, MAPK14, CSNK2B, DBN1, RASSF1, ZC3H12A, ICE1, PCDH8, KDR, NEDD8, HRAS, CTTN, FAF1, IL10RA, TAZ, PRLR, EEF2K, RNF7, RBX1, BCL2L11, FGD1, AGO2, DDB1, CUL4A, IGF2BP1, FOXO3, WWTR1, ELF3, REST, CDC20, HSF1, CCNE1, BCL10, RCAN1, CCND1, IRAK1, MCL1, PLK4, CHUK, USP37, BTG1, BTG2, FGD3, SKP2, ELAVL1, UHRF1, DDIT4, HSP90AA1, SMURF1, AURKA, CCDC22, TERF1, CRY1, CRY2, PER2, TRIB2, NCOR2, CHPF, HNRNPK, CP, HNRNPC, PRDX1, PSMA3, FZR1, VCP, MAP2K1, MTSS1, UFD1L, NPLOC4, EZH2, SUZ12, OIP5, TFAP4, NEDD4, KRAS, SMURF2, NUAK1, NUAK2, ASF1A, UBE2D3, TIAM1, CDK1, CCNB1, RASSF5, BHLHE40, RAP1GAP, RAPGEF2, TBC1D4, SKP1P2, NFE2, TACC1, ENO1, MOV10, NXF1, E2F1, NFKBIE, AATF, ARIH1, CAND1, CPVL, DAP3, DOCK1, EGFLAM, ELMO2, GPATCH8, HNRNPA3, HNRNPAB, HNRNPD, HNRNPUL2, MRPL12, MRPL15, MRPL21, MRPL24, MRPL37, MRPL38, MRPL4, MRPL40, MRPL41, MRPL44, MRPL47, MRPL48, MRPL49, MRPS18A, MRPS22, MRPS27, MRPS31, MRPS34, MRPS35, YWHAB, YWHAE, YWHAG, YWHAZ, CSNK1A1, CTNNA1, GBF1, HCFC1, HSPB1, NFE2L1, PPP1R15B, PRKAR1A, RBMXL2, REL, STK3, STK4, DLD, TSC22D4, WBP1, SPANXN3, FAM219A, ZBTB46, NFE2L2, UBE4B, ZNF395, ZNF704, PRRC2A, AEBP2, GGNBP2, ALDH2, CEP44, DACT1, FNIP1, RIPK4, RASSF3, CEP68, WWC1, GLI1, SOX9, ALDH1A2, C11orf49, C1orf226, CCDC138, CEP55, DCP1A, DCP1B, DPCD, DVL1, EMG1, LRRC49, NEDD1, NOL10, NOS1AP, NSFL1C, OFD1, PCM1, PDLIM5, PFDN1, PFDN4, PFDN5, PFDN6, PPM1G, RAB5A, RPS10, RPS18, SMG5, SSX2IP, TCP11L2, TJP1, TPGS1, TXNL1, WWOX, ABCD3, ACBD5, BOP1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, COL10A1, KANK2, LRRC47, MDN1, PFDN2, SIRT2, SMG7, TNRC6A, TWISTNB, USMG5, VBP1, VCPIP1, WDR12, AFG3L2, AKAP2, ALDH3A2, ALMS1, BAG2, BUB1B, CNOT11, CCDC50, CKAP5, CLTCL1, CNOT1, CNOT10, CREBRF, DLG5, ERBB2IP, FAM21A, FLCN, GOPC, MAGED1, MAP1S, MAST2, MAST3, MTR, NME7, RGAG1, RQCD1, SPATA5, TCHP, TNRC6B, USP54, YTHDF3, STIL, COPS6, HINT1, CREB3L3, FOXN2, GADD45A, TWIST1, PAQR3, FANCM, LPCAT1, MAP3K2, USP15, FBXW2, LPIN1, ALPP, MTDH, PRKRA, CTNND1, DYRK1A, COPS7A, COPS7B, CHD1, MLPH, KHDRBS2, MYO10, MPRIP, DHX38, EML5, LSP1, PLEKHG5, SH3BP5L, ACOT7, GPR161, IL17RD, BTG3, TUBGCP5, SPATA20, KIF20A, EED, PRICKLE3, FOXN3, RAI14, APBA2, TUBGCP6, RALGAPB, TUBGCP4, CACHD1, MXI1, TNKS1BP1, CNOT2, INTU, CUL5, TRIM25, CENPW | HIF1AN | ASB9, FBF1, ASB13, INVS, HIF1A, VHL, HDAC1, HDAC2, HDAC3, SIAH1, ASB4, OTUD7B, ELAVL1, UBE3A, HIF1AN, NFKB1, FEM1B, UACA, ASB5, ASB6, ASB7, ASB8, ASB16, ANKRD44, CLDN20, KLHL20, CCDC94, NFKBIA, ANKRD12, ANKRD55, NFKBIB, ANKDD1A, XPO1, OTUB1, APBA3, CASKIN1, ANKRD49, TNKS2, ANKRD27, FYCO1, NOTCH3, ANKRD52, RNASEL, ANKS1A, TNKS, USP24, RIPK4, RPRD2, TXLNG, PIP4K2B, REL, ANK3, OSBPL1A, PIP4K2C, C2orf44, ANKFY1, GMDS, TXLNA, MLLT4, NFKB2, EIF4ENIF1, ANK2, ASB10, ZFP36L2, KIAA1804, OSBPL3, ASB3, TBK1, HECTD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 2_125 | 59 | 350 | VHL |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BTRC_HIF1AN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BTRC_HIF1AN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |