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Fusion gene ID: 4574 |
FusionGeneSummary for BTRC_HIF1AN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BTRC_HIF1AN | Fusion gene ID: 4574 | Hgene | Tgene | Gene symbol | BTRC | HIF1AN | Gene ID | 8945 | 55662 |
| Gene name | beta-transducin repeat containing E3 ubiquitin protein ligase | hypoxia inducible factor 1 subunit alpha inhibitor | |
| Synonyms | BETA-TRCP|FBW1A|FBXW1|FBXW1A|FWD1|bTrCP|bTrCP1|betaTrCP | FIH1 | |
| Cytomap | 10q24.32 | 10q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/WD repeat-containing protein 1AE3RSIkappaBF-box and WD repeats protein beta-TrCPF-box and WD-repeat protein 1Bbeta-TrCP1epididymis tissue protein Li 2apIkappaBalpha-E3 receptor subunit | hypoxia-inducible factor 1-alpha inhibitorFIH-1factor inhibiting HIF-1factor inhibiting HIF1hypoxia inducible factor 1 alpha subunit inhibitorhypoxia-inducible factor asparagine hydroxylasepeptide-aspartate beta-dioxygenase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y297 | Q9NWT6 | |
| Ensembl transtripts involved in fusion gene | ENST00000370187, ENST00000393441, ENST00000408038, ENST00000493877, | ENST00000299163, ENST00000528044, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 3 X 2 X 3=18 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BTRC [Title/Abstract] AND HIF1AN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BTRC | GO:0000209 | protein polyubiquitination | 12820959 |
| Hgene | BTRC | GO:0006511 | ubiquitin-dependent protein catabolic process | 15448698 |
| Hgene | BTRC | GO:0016567 | protein ubiquitination | 16885022 |
| Hgene | BTRC | GO:0042752 | regulation of circadian rhythm | 15917222 |
| Hgene | BTRC | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 15917222 |
| Tgene | HIF1AN | GO:0036138 | peptidyl-histidine hydroxylation | 21251231 |
| Tgene | HIF1AN | GO:0042264 | peptidyl-aspartic acid hydroxylation | 21177872 |
| Tgene | HIF1AN | GO:0042265 | peptidyl-asparagine hydroxylation | 12080085|12215170|14734545|21177872 |
| Tgene | HIF1AN | GO:0045663 | positive regulation of myoblast differentiation | 18299578 |
| Tgene | HIF1AN | GO:0045746 | negative regulation of Notch signaling pathway | 18299578 |
| Tgene | HIF1AN | GO:0055114 | oxidation-reduction process | 12080085|12215170 |
| Tgene | HIF1AN | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | 11641274 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRC | TCGA-BP-5202-01A | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000370187 | ENST00000299163 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
| 5CDS-3UTR | ENST00000370187 | ENST00000528044 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
| In-frame | ENST00000393441 | ENST00000299163 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
| 5CDS-3UTR | ENST00000393441 | ENST00000528044 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
| intron-3CDS | ENST00000408038 | ENST00000299163 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
| intron-3UTR | ENST00000408038 | ENST00000528044 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
| intron-3CDS | ENST00000493877 | ENST00000299163 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
| intron-3UTR | ENST00000493877 | ENST00000528044 | BTRC | chr10 | 103190209 | + | HIF1AN | chr10 | 102296168 | + |
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FusionProtFeatures for BTRC_HIF1AN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BTRC | HIF1AN |
| Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation oftarget proteins. Recognizes and binds to phosphorylated targetproteins (PubMed:10066435, PubMed:10497169, PubMed:10644755,PubMed:10835356, PubMed:11238952, PubMed:11359933,PubMed:11994270, PubMed:12791267, PubMed:12902344,PubMed:14603323, PubMed:14681206, PubMed:14988407,PubMed:15448698, PubMed:15917222, PubMed:16371461,PubMed:25503564, PubMed:25704143, PubMed:9859996). SCF(BTRC)mediates the ubiquitination of CTNNB1 and participates in Wntsignaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediatesthe ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1,FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2(PubMed:10835356, PubMed:11238952, PubMed:14681206,PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA,NFKBIB and NFKBIE; the degradation frees the associated NFKB1 totranslocate into the nucleus and to activate transcription(PubMed:10066435, PubMed:10497169, PubMed:10644755).Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'(PubMed:10066435). SCF(BTRC) mediates the ubiquitination of CEP68;this is required for centriole separation during mitosis(PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates theubiquitination and subsequent degradation of nuclear NFE2L1 (Bysimilarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 andPER2 (PubMed:15917222). May be involved in ubiquitination andsubsequent proteasomal degradation through a DBB1-CUL4 E3ubiquitin-protein ligase. Required for activation of NFKB-mediatedtranscription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Requiredfor proteolytic processing of GLI3 (PubMed:16371461).{ECO:0000250|UniProtKB:Q3ULA2, ECO:0000269|PubMed:10066435,ECO:0000269|PubMed:10497169, ECO:0000269|PubMed:10644755,ECO:0000269|PubMed:10835356, ECO:0000269|PubMed:11238952,ECO:0000269|PubMed:11359933, ECO:0000269|PubMed:11994270,ECO:0000269|PubMed:12077367, ECO:0000269|PubMed:12791267,ECO:0000269|PubMed:12820959, ECO:0000269|PubMed:12902344,ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:14681206,ECO:0000269|PubMed:14988407, ECO:0000269|PubMed:15448698,ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16371461,ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143,ECO:0000269|PubMed:9859996}. | Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repressionthrough interaction with HIF1A, VHL and histone deacetylases.Hydroxylates specific Asn residues within ankyrin repeat domains(ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several otherARD-containing proteins. Also hydroxylates Asp and His residueswithin ARDs of ANK1 and TNKS2, respectively. Negatively regulatesNOTCH1 activity, accelerating myogenic differentiation. Positivelyregulates ASB4 activity, promoting vascular differentiation.{ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085,ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339,ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366,ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 142_312 | 59 | 350 | Domain | JmjC |
| Tgene | >HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 181_183 | 59 | 350 | Region | Substrate binding |
| Tgene | >HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 201_203 | 59 | 350 | Region | Substrate binding |
| Tgene | >HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 238_239 | 59 | 350 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 128_177 | 52 | 1939 | Region | Note=Homodimerization domain D |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 190_228 | 52 | 1939 | Region | Note=Required for down-regulation of SNAI1 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 128_177 | -25 | 1918 | Region | Note=Homodimerization domain D |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 190_228 | -25 | 1918 | Region | Note=Required for down-regulation of SNAI1 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 301_338 | 52 | 1939 | Repeat | Note=WD 1 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 341_378 | 52 | 1939 | Repeat | Note=WD 2 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 381_418 | 52 | 1939 | Repeat | Note=WD 3 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 424_461 | 52 | 1939 | Repeat | Note=WD 4 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 464_503 | 52 | 1939 | Repeat | Note=WD 5 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 505_541 | 52 | 1939 | Repeat | Note=WD 6 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000370187 | + | 2 | 15 | 553_590 | 52 | 1939 | Repeat | Note=WD 7 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 301_338 | -25 | 1918 | Repeat | Note=WD 1 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 341_378 | -25 | 1918 | Repeat | Note=WD 2 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 381_418 | -25 | 1918 | Repeat | Note=WD 3 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 424_461 | -25 | 1918 | Repeat | Note=WD 4 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 464_503 | -25 | 1918 | Repeat | Note=WD 5 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 505_541 | -25 | 1918 | Repeat | Note=WD 6 |
| Hgene | >BTRC | chr10:103190209 | chr10:102296168 | ENST00000408038 | + | 1 | 14 | 553_590 | -25 | 1918 | Repeat | Note=WD 7 |
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FusionGeneSequence for BTRC_HIF1AN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BTRC_ENST00000370187_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_343aa MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSAST HKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLL LIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYW >In-frame_BTRC_ENST00000393441_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_328aa MCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQ NFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDE QQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITIT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BTRC_ENST00000370187_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_1029nt ATGGACCCGGCCGAGGCGGTGCTGCAAGAGAAGGCACTCAAGTTTATGTGCTCTATGCCCAGGTCTCTGTGGCTGGGCTGCTCCAGCCTG GCGGACAGCATGCCTTCGCTGCGATGCCTGTATAACCCAGGGACTGGCGCACTCACAGCTTTCCAGGAGCCTGTGGTGCTGACCGACACA AATCTTGTGTATCCTGCCCTGAAATGGGACCTTGAATACCTGCAAGAGAATATTGGCAATGGAGACTTCTCTGTGTACAGTGCCAGCACC CACAAGTTCTTGTACTATGATGAGAAGAAGATGGCCAATTTCCAGAACTTTAAGCCGAGGTCCAACAGGGAAGAAATGAAATTTCATGAG TTCGTTGAGAAACTGCAGGATATACAGCAGCGAGGAGGGGAAGAGAGGTTGTATCTGCAGCAAACGCTCAATGACACTGTGGGCAGGAAG ATTGTCATGGACTTCTTAGGTTTTAACTGGAACTGGATTAATAAGCAACAGGGAAAGCGTGGCTGGGGGCAGCTTACCTCTAACCTGCTG CTCATTGGCATGGAAGGAAATGTGACACCTGCTCACTATGATGAGCAGCAGAACTTTTTTGCTCAGATAAAAGGTTACAAACGATGCATC TTATTCCCTCCGGATCAGTTCGAGTGCCTCTACCCATACCCTGTTCATCACCCATGTGACAGACAGAGCCAGGTGGACTTTGACAATCCC GACTACGAGAGGTTCCCTAATTTCCAAAATGTGGTTGGTTACGAAACAGTGGTTGGCCCTGGTGATGTTCTTTACATCCCAATGTACTGG TGGCATCACATAGAGTCATTACTAAATGGGGGGATTACCATCACTGTGAACTTCTGGTATAAGGGGGCTCCCACCCCTAAGAGAATTGAA TATCCTCTCAAAGCTCATCAGAAAGTGGCCATAATGAGAAACATTGAGAAGATGCTTGGAGAGGCCTTGGGGAACCCACAAGAGGTGGGG >In-frame_BTRC_ENST00000393441_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_984nt ATGTGCTCTATGCCCAGGTCTCTGTGGCTGGGCTGCTCCAGCCTGGCGGACAGCATGCCTTCGCTGCGATGCCTGTATAACCCAGGGACT GGCGCACTCACAGCTTTCCAGGAGCCTGTGGTGCTGACCGACACAAATCTTGTGTATCCTGCCCTGAAATGGGACCTTGAATACCTGCAA GAGAATATTGGCAATGGAGACTTCTCTGTGTACAGTGCCAGCACCCACAAGTTCTTGTACTATGATGAGAAGAAGATGGCCAATTTCCAG AACTTTAAGCCGAGGTCCAACAGGGAAGAAATGAAATTTCATGAGTTCGTTGAGAAACTGCAGGATATACAGCAGCGAGGAGGGGAAGAG AGGTTGTATCTGCAGCAAACGCTCAATGACACTGTGGGCAGGAAGATTGTCATGGACTTCTTAGGTTTTAACTGGAACTGGATTAATAAG CAACAGGGAAAGCGTGGCTGGGGGCAGCTTACCTCTAACCTGCTGCTCATTGGCATGGAAGGAAATGTGACACCTGCTCACTATGATGAG CAGCAGAACTTTTTTGCTCAGATAAAAGGTTACAAACGATGCATCTTATTCCCTCCGGATCAGTTCGAGTGCCTCTACCCATACCCTGTT CATCACCCATGTGACAGACAGAGCCAGGTGGACTTTGACAATCCCGACTACGAGAGGTTCCCTAATTTCCAAAATGTGGTTGGTTACGAA ACAGTGGTTGGCCCTGGTGATGTTCTTTACATCCCAATGTACTGGTGGCATCACATAGAGTCATTACTAAATGGGGGGATTACCATCACT GTGAACTTCTGGTATAAGGGGGCTCCCACCCCTAAGAGAATTGAATATCCTCTCAAAGCTCATCAGAAAGTGGCCATAATGAGAAACATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BTRC_ENST00000370187_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_13008nt AGAGGTAAGAGAGGGCGGGGGGAAGGAAGAGGAGGCGGGATCCGGGCGCTGCGTTGGCTGCGGCCTGGCACCAAAGGGGCGGCCCCGGCG GAGAGCGGACCCAGTGGCCTCGGCGATTATGGACCCGGCCGAGGCGGTGCTGCAAGAGAAGGCACTCAAGTTTATGTGCTCTATGCCCAG GTCTCTGTGGCTGGGCTGCTCCAGCCTGGCGGACAGCATGCCTTCGCTGCGATGCCTGTATAACCCAGGGACTGGCGCACTCACAGCTTT CCAGGAGCCTGTGGTGCTGACCGACACAAATCTTGTGTATCCTGCCCTGAAATGGGACCTTGAATACCTGCAAGAGAATATTGGCAATGG AGACTTCTCTGTGTACAGTGCCAGCACCCACAAGTTCTTGTACTATGATGAGAAGAAGATGGCCAATTTCCAGAACTTTAAGCCGAGGTC CAACAGGGAAGAAATGAAATTTCATGAGTTCGTTGAGAAACTGCAGGATATACAGCAGCGAGGAGGGGAAGAGAGGTTGTATCTGCAGCA AACGCTCAATGACACTGTGGGCAGGAAGATTGTCATGGACTTCTTAGGTTTTAACTGGAACTGGATTAATAAGCAACAGGGAAAGCGTGG CTGGGGGCAGCTTACCTCTAACCTGCTGCTCATTGGCATGGAAGGAAATGTGACACCTGCTCACTATGATGAGCAGCAGAACTTTTTTGC TCAGATAAAAGGTTACAAACGATGCATCTTATTCCCTCCGGATCAGTTCGAGTGCCTCTACCCATACCCTGTTCATCACCCATGTGACAG ACAGAGCCAGGTGGACTTTGACAATCCCGACTACGAGAGGTTCCCTAATTTCCAAAATGTGGTTGGTTACGAAACAGTGGTTGGCCCTGG TGATGTTCTTTACATCCCAATGTACTGGTGGCATCACATAGAGTCATTACTAAATGGGGGGATTACCATCACTGTGAACTTCTGGTATAA GGGGGCTCCCACCCCTAAGAGAATTGAATATCCTCTCAAAGCTCATCAGAAAGTGGCCATAATGAGAAACATTGAGAAGATGCTTGGAGA GGCCTTGGGGAACCCACAAGAGGTGGGGCCCTTGTTGAACACAATGATCAAGGGCCGATACAACTAGCCTGCCAGGGGTCAAGGCCTCCT GCCAGGTGACTGCTATCCCGTCCACACCGCTTCATTGATGAGGACAGGAGACTCCAAGCGCTAGTATTGCACGCTGCACTTAATGGACTG GACTCTTGCCATGGCCCAGGAGTCAGGTGTTTGGAGCGAGGCAGGGCAGTTGGCACTCCACTCCTATTTGGAGGGACTTCATACCCTTGC CTCTTGTGCCCCAGCACCTTCTCTCTCTGCCCCCCGCCTAAAGTCCTGCATTCAGTGTGTGGAGTCCCAGCTTTTGGTTGTCATCATGTC TGTGTGTATGTTAGTCTGTCAACTTCGGAATGTGTGCGTGTGTGTGCATGCACACGCATGTATGTATCTGTTCCCTGTTCCTTCTGGGTC AGGCTGTCACTTCCGGCTCTCAGCCCTATCTCCTGCAACCTCAGTGCCTCAGCCTGAGAGAGAGATGAGATGCTCTTGGACTCCCCACTG CATCTGGGCTGCAGGGCCAGAGCTAGTCTGACCATTAGGTCAGTCTGCCTCCTGACAGTTTTTGCGTAGTCAAGCTCTAGGCGGTATGGG AATGGCTACCGGGACTCTAATGGGGTGAAAGAGAGGGGAGGCTTGCCTTTGAGAGCCTATATAGCCTTCCTGTGAGAGAGGATTAGATAG GGTTCCAACTGGGCCTACAAGCTCAAGCCATACATAAAAGGACCTTGGGACATAAGAACCAATGATTGTGCATAAGTTCTAAATTAGAGA CACATATAGTTTCTCTCTTTCAGCACCAGCTCTTGCCCCTATGCTGGGTACCAAGGGAGTTCTCCTAGCTGTGGCTTCTCTAGGTTCTAG GGGTGCAAGCCTCTGTGTGTTTGTTTGTGTGTGTCTGTGTGTGCGTATCCACACTAGGGGTGCAAGCCTCTGGGTGTGTGTGTGTGTGTG CGTGCGTGTGTGTGTGTGTGTCCGTGTGTGTGTGTGTGTGTGTCCACACTGGCCAGCCTCCCTACTTACCAAGGTTCTCCACTGCTTACC TTTTCCAGTGGGACAGTACAGTGTGAGCCCCCGGGAAGTACTGCCTGACCTATCCTAAGCTTTTACACTTGGATTTTAGCCATCATATGT TGGCCAGGTCTCACTGCAGCCTGCCCGAGGCTAACTGGCTAGAGCCTCCAGGCCCTATGATGCTCCCTGCCCAGGCCATATCCTTTATTC CTGCTGAGCTTCCTGGCTGAATAGATGAAATGGGGTCAAGCCCAGGCAGCTCATTCACTACCTGTGATCCACCTCAGGGCACGGGCAAAC ACATAGGCTTGCGTCTTAAAGCCAGCTCCTCTGCCAGACCCCGTTGTAATGTGCCACAACACCCTCAATAGTCAGGGCAACTGGTGGAGC ATGGAAGTCGAATTTCCTTTTCTGTTAGGAGCTACTCCTGGGAACCCCTCTCAGGGCTGCAGCTTACAGGTGGGCAGCTGTGATTGCACA ACTTGAAGGGCCATCATTCACATCTATTCAGTGGGAGTGGGGTCCCTGGGATTGGGCAGTGTGGTGGCCCTGTGTCTCCTCACCTCTGCT CCTGTCTTCATCACCTTCTCTCTGGAAGGGAAGAGGAGTTGGAAGGTCTCTGGTTTTCTTTTCTTTTTTTTTTTTTTTGCCAAAGGTTTA CTTCCAGCATCTGAGCTCTGGCTCTCACCCCTGAAGCTCAGTTATAGTGCACTGATGAACTGAGAGGATGCGTGTGGATGTGTGTGCATG CCTGAGTGCGTTTTTTGGGGAGGGGTGTTTATTTTTAGTACCCCATTCTGGGGTTCTCTGATGCAGTGTGGATGTGAAGATATGGTACCT TCTCAAGTGTAGCTCTTTCAAATATAGTCAATGCTGGGAAATGTGATTGCAGTGATCTCTATCTCTCCACTTCTTTTGGGAAAGAGGAGC ACAGGAGCGGAGGAAAAACTTGGCCACAGTCACACTTGGAAAGATAGTAGATTATTTTCGTTCTCCTCAGCAGGTCTGCTGTATTCCTCG CTCAGCGCTCAAAGATGTGGGTGATGTGTCAAGGAGGCATGCACTCAGCTGGTCCTTGCTGAGTTATTTGCTGACACAGGTCTCACTAAG GTGGCTGAGGGGTGGGAGGGAGAAGGCTAATCTTGGAACCTTCACAGGATTGGCCTTGATCCTTGGGTAACACAAGAGTGATTCCTGATT TTTAGACACCTAATATGTGCCTAGTGCTTTTCTCTTTGTTCCTCACTATCCTGCAAGGTAGGTATTCTCACTTACAGATGAATAAATGGG CTCAGAGAGATTAGGTGATTAGTGACAATCAGTTGTAACTTAGCACTGTTAGGCTGCAAACCCCTTGCTCCTTCCTTTCCACCAAACTAT GTTGATTTTCCTTCCTTACCTCCCTCCTTGTACCACAGGTTCTGTCCTCAAGATATCACCCCACTGGGCAGTATCTGAAGGCAGACCCAG CCCAAGATGGTGCAGAATATACAGCTCAGGGTGAAAGTTCTTCTGGGCTCCTGCTAACAAAGTCTTGGAAAAACTGCCTGGGAAGCCATA TTATGAATTAGTGCTAGAAGAAGCTGTGGGGGGAACTGAGTTCTGTGTCTAATTGCATTACTTATGTGTCCTTGAATAGGACCCATAACT CCTCCCGGCATGCTTTTGCATCTATAGAACTGAAGCTGTAGTTCTAGATGGCACTAAGGGTCTTGGTTCATATTCAGCTGCTGCTTCCCC CCAAGGAAAAGATGAGGTTTTTCCCCTTCGATTACCTTTTGAGGGATGTTTAGGCTCAAATTCTGCTTGCCACAGAGGAAACATTTCTGC TGTAGTTGTTTACCTCCATCCTAGCTGGCAGTGTGGGACACACACATACAGCAAGTGAAGGTGGGGGTTTGGGCCTGTATAGAGGTCAGC TACGCTGCAGGCTCATCTATTCACACCAGCAGGTACAGAGAAAACTAGTGTTTTGTAAAGTCAAATATTTGTTGGGGGTTGGAGTTCTGG GGTTGGAGGAGGGGCTGTTCTGGGCATCAGTTGAGCAGATGCCCAGGATGCCTGGGGGAGACCAGCTTCCCCTACAAATCAGAGCTCTAA ATTACAAGGTTTTTACCAACGTGAACAGTTGGGGGAAGTCGTCTGCTCTCATTTGCGTAATGGTTTCTGTCACTGGTGATTAGACACAGG ATGAAGGAAAAGAAATTTGACAATTAGGAATGAGCGATCATTAATCTGAATCTGTTAGGAGACAGAGAGGGGAAGGATCCTTATCAGTGG GCCAGCCCAGTATGGGGAGACACTCCCTCCCTCTGCCCCCAGAGACTCCTGGGCTACATCCTCTTTCAGTATTGCCACAAGTGGGCAGAG CTTGTATTTCTTAACAAAGATTAGGGACCCAGTTGCCAGCCTGAGATGGATATAGGAACAGACATCTTTGGGCATGAGCCAACAAAGATA GAAATAGATGAGTGTCAGGTACAAGCTATAAGGCAAAGAATAACAGTGGAAAAGTTTTGACATGTGTTTGCCATTTGTGGAAAATGTTTT TGTAATAGTCAACACCCCTCATAGCCCACCTGTGACAAGTACTTGTTACATTCCAGCACTGTAGGGCGTGAGGAAAATCTGGTCCTTATC AAATCCCAGGAGCTTCTGCTTAGTTGGGGAAGAAATTACATGAAGCAACCAGAGGTTATAAGGCCACACTTGTATATCGTGCACCCTGTG TGGACAAGATTAGGGACTGTTGAGAGAGGAGGAAACCAGTAGAGAGCAAAGCTCTACCCAGGCTCCTTGTAAGCCTCTGGGCTCCCCCGA GAGGGCCTCGCTACTCTACGCTTCCTAGCAACGTTGATGTCCCCACAACCCCACATCAGTGCAGCTGTGGCTGTGTGGAGGGGCTCTGAG GCCTCTGAGGCCAGATGTGTAAACAGTGCTGAGGTTCAGTAATAGGATGAGTCTTCAGGTGTGGAGCAGCCCACCTTGGCTCTTCCCATG TCTCTGTGTTACTTCTCATATTCTGCTGTCCTTTCAAACTTCAAGGACAGTATTAATTTATACTAGTATTTCTTCCTCAGTTTTGTGACT TGAATGCAGTGAGTGCCTTAGAGGATCCAAGGATGAAGGAATGCGGGTTGGTGGTTCTCTCTTTCAGAATGGGAACTTCCCAAAAATGGG GCTGCGTCTCGCCTCTCAGTAGGTTCCCTACCTCTGGGTCTTCCACCCTTCAAAATCTGGTACAGAATTTAGCAGGGGCTGCAGGGAATG ACCCTCAGGGACCAGTTTCACCCAGATGGGGTAGATGATGAGGTATACCTAGAAGTAGCTCAGGGCTCCAGAGTCTGGCCTTTCAGCTGG TGTCTTACTCCCCTTTGAGACCTTCAGCTGCTTGTCTTCCACTGCCTGCATACTTCTCTGATGTCTTCTCAAACTGTTGGCTCTAAAGGG ATGTTCCAGCCTCCCTCTCCAGAGCTGCCTGCAGTTTCCCTTATTCAGCTGTCTCCTGCCTAGTCTCTCCAGCGGCCTCCTTACCAAGAC CCTTTTTCCTAAACAGTTGTCCTTCCCTCAGAAACTCCATGGCTGCAAGTGTGAATAGACTTGTCTTTAGGATCCCTCTCTCTGGTCATC CCTGATCATCTTAGGGCCGTCTCCCTTTTCTGATTTTTGACAGCTCTGTTTATTTTGCCCATGGCTAGTCCTCTTGTTTTGTGTCTGCTG TGTGTTCTTGCCCTTCCATTGTCAGTTCTGTACATCCTGGTTCAGCTTGTCTCACTGTGGTAGCCCCTTCTGCTTGTCTTCAGCCATCTT GGTTTAATCCTCATAGGTCATGGATGAATGGAGCCTTGCTGAGCACTTTGAGGGCATTTCTGTTGGGCACAACCTCAGAAACGGGAAGTC TTGAGGCCTGGGGGCGTGTGGTCAGTGAGGCCTCCAGAGGTGGGTTAGGGGTGGGCACCTACAAGGGCCAGTTGAGGGGAGAGGTGCAGG GATTGCTGAGGAGACTTTGTGAGAATGATGTCAGGCCCGGGAAGCTGGTGTGGAAGAACTGAGCTGTCAGAAGGAGATACCAATATCCCC TTTGCAGGGTGGTGATGGGCATCAAACATGACGTGGAACATGTCCCCTTCATGGAGGGTTTCCATCTAAATGCATCTGTGTGCCTTAGGG ATCAGTAGTTCAGGGGTGGTGGACTTTTTTGAGTGTCTCCTAATTTCTCTGAGGTGTCTTTGGCTCTGTGTCACCAAATGTGCCTGACCT CTGCATCCCAGTGGTTGCTGAAAGGGAAACAGTATATTGCGTAGTCAGATGTCAGGAGTAGAGATCTTAATGAGAAAGGCCCTGGCAGCT GGAGAGATGAGAGGACCTAGTGGTCAGCTTATACCCAGACTATCTCTCCACTCCTCCAAGAGTTTGAGTCCCATAGCTGATGAAAGAATT TACATATGGGCTCCCCCCTGCTTTCCCACTGAAAATCTATTCTCATATTTTGGGAAGGAGCATATGTCCTTTAACTTTCAATGGTAAACA ATCTAGGATAGTGTTTAAAGGCATGGATTTTGGAGTCACATATAGTTGGTTTGAATTTCTAGCTTCACTACTTACCAGCTGGGTTTGACC TTGGTTGATTTACTTAACCTCTCTGAGCCTCAGTTTCCTCAACTATAATAACATGGGTGGAGGGAGGCATGTTGAAAATATCTACCTCAG GGTTGTTGGAATAACTGAAACAATGTTTGTAAAGCTTTAGCACAGTGCCTGGCAAGCACTTAATAAATGGCTGTGGTGGTGGTGGTTATA TTTATTATGTGATTTATTCAGAAACTTGGTTTCAGTGATCTCTAAACAGATTTCCAGTGGTTCTTTCTCTCTCAAGAAAAGCATAGGGAA AAACGAGAAACACCTTAGATAAACCATATTGAGTTGAGGGTAGACAGAAGAGTCTAGTACCTAAACTCACCCTAGAGGAAGAGAAACAGG AAGTGTCTTATGCCTCTTCTGCCTGGGCAGCCAGACTTTACTGCTGTACTACCAGCCCAGGGCCTTGGGTGAGAAGGTTTCAGGTCTGAG CTCCCCTTGCACTGTGTGAGAGGCCGTGGAGCCGAATGAGTCCTTATTATACCTGGAGAAGCTGTTGTCTCCTCACACCATGAAATGTAA TAGCAGTCAAATCAGGCCCCTCTTGATTCAATTTTAGTCCATGCCTTTCCATGTATTTAAATTATATAAGTGTTGGCCAGGTGTGGTGGC TCACACCTGTAATCCCAGCACTTCGGGAGGCTGAGGCAGGAGGATCACTTGAGCCCAGGAGTTCGAACCAACCTTGGGCAGCATAGTGAG ACCCCTTCTCTTAATAATTTTTTTTGAAAATAATTTTTTAAAAATTACAAATATGGACCAGACACCTGGGAGGATTACCTCACGCCTGTA ATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACTATCCTGGCCAACATGGTGAAACCCTGTCTCT ACTAAAAATACAAAAATTAGCCAGATGTGGTGGTGGGTACCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCACTTGAACCT GGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGTCATTGCACTCCAGCCTGGGTGACTACAGTGAGACTCCCTCTCAAAAAAAAAAAAAA AAAATTATGAGTATGTTAAGATTGTTCTAGGGGAGAAGGGCAATCAAAATTCAGAAAAATATGAGTGGGATGTTAATAGCTACCATTTGT TGAACACTTCTGTTCCAGGCACTGTATTAGTTCGTCCCCATGTGGTGCTCTCAGATCAGTAGGGGAGACAGGCAGGCAGTTAGAATTATG GTGTATAGAGGAGAAGCATTGCACTATGTCCAGTTTTTTATGGTAGGCTTCCTGCAGAAAGTGATAAGTCCAAGCTGATATGTGGAAGAT GAATAATTAACCAGAGGTTGGGGGATTTCCCCCTTAGCTTCTCTTTCTTCCAGTCCAGCAGTCCAAAACAAACACTGCTTCCCAATGCCT AAGGGTTTTGTCGTACCTTACTCCAGGGAATGGGTGAGACAGTAGATCCCAAGAAGAAAACCCTTTGGTTAGTCACAGAAATCTGAAAGT CTTGGTTGCTGGCTCAGATTTGTCCTGGAGTGGACGTAGATTGGACTTGCTTATTTGTAGCCCTCCACCGTTCTCATTTGTGTTCTGGCC TCTGGAGCCACCCTGCCAGACCCTACTTGGAAGAAATGTTGAATCAAGCTACTCAGACTTCAGCCTGAGATGTATTATGGCTGGCTGGAA TTCTCAGCCCTTTCCACATCATGATCCCATTAATCTCTTGGGTCTATCCCCACGCCCAGCCACCTCTCCTCCTCACTATAAGCCAAGTCT CCCTGCAGTTCTCTATAAATACTCAGATCCTCTTGCCTCAGACCCTGGTCCCTAGCTTTGTGGGTGAAGAAGATACCTCTTTAGCTTGTG CCAACCCATCCCTCTGGGCTACAGGCCATTCTGTAGTCACCTTGCAGTCACGTCTTTCCTTCTAGATAACTGGCTCTGGGCCTTGGAAAC CTTCTCTTTGGCTCTAGCTAATTTTGCTGTTTTATTCCGTTTACTTAAAACCTATTCACTTGGTCATTGAGGTCAGAACTATCAGGAAAG CTGTGCTCCTTAACCCATCATCTAAGCTAAGCTTGGGCCAGGTTTTTATTACCTCTTGAATATATATAGTGCAATATAGTGTAGTGGTTG AGAGTGGAGTCTGCATACCTGGATCTGCCATTCTGCATGACTTTGGGCAAATGGACAAACTGCCCGAAACTTGACTTGTTTATATGTATG GGGAAGACATCATTTACATTGTCAGGGTAAGGCTTAGCAGAATGACCGGTCCATAGCAAGGGCTCAGTCTTTCTGTGTCTCTCAGTCTTT ACCTCTCTTCCCCATCTAGCTTTCTGTCTAAGTTCCTGTTTCTAGTCTCAGGGCATATCTAGTTGTCAGCTCCTGAGCAGAGCAGAGGTA TAAGTGTCAACTCATGCTTGTGTTACCAGTTCCTACCCCTGTCAGTAACCTCTGATGCTTACAAGGATACTATCACCTATGCCATCAGTG GGGAATGACCTTCCAAAAATATTTTTAACAATACTAAAAATACCTGAAACATACTGGGTGAAAATAAGACATTGGAGCTGCTGCTCCCCA AGGAGATAAAAGGACAGTTCCTAAAGAGGCATTGAAGGTTTGTATGAGCCAGCAGCACAGTCAGAAGGCAAGAAGGAGACCCTGGGATGT GCACAAGGATGCAGGAGACGAGATTGTCACAGAGGCTGTCATGCTAGTAAGAGTCAGAGGTTACTGATGGGTAGAGATTGTCAGAGTCTG CCTTGCTAGTCTAGAGGTAGGACCATGGATTTAAGAACGTTGCCTCCAAGTTTTTGAATTGTGAATTTTTGATCATATTTGAACAAAACC CCACCTACAGTCTGCATGGTCATTGTTCTCACAAGGGTTTGTGTGATGCACTGACAAGAACAGAGGCTTTGGAGGTGACTCCTGGGTTTG AATCACCATTTGCCACTAGCTAATTCTAACCTTAGGTAAGTCAGTGTCTCTGGGTCTCAACCTCTTCCTCTGTGAGGGGTAGGAAATAGC ACATAACTTGTAGCATTGTTATAAGGGCTCGTGATAATGTTTTTAAAACACCTGGCTCAAGCACTCAGGAAAATGTTTTATTATGAAGAC CAAGTGTCTCTGAAAAGTGTTTCCTTAGTGTCTGGAGAGACTACAGCAGCAAGGCTTTTCTGATCCTACTCTGACTCTCAAGATAATGGT GCTTGAAGTGAAATCACAGAAGAGATGACTGGGGCAGGAAAAGCAAGATGGAAAAGATAAAGTTGTGGAAGGGACTGAAAGTCCATGAAG TGCTGGGCTGGGGACAGAAAGGGTTTAATAGGGCAGGGTCTTGAGGAACAGGAACAGAGACCTTGGTTCTGGGTTGCCATCTGATTCCCA GAAGAGTAAAGGAAATGGGGCAGGAGGATGTCTGTGGAGGACACAGTGTGGCTGAGTGGAGAGAACACAAGCTTCTGGCCAGTGAACCTA AGTGAGAATGTCAGTGGACTTTGCACAGGCTGGGTGCCTTTGGGGGTGTTCATCTCGCTATGCTTCGGTCCCCTCATTTAAAAAAATTGG TTAATAATATGATGACCTGCCAATGTGTGTGGAAATACTATGTAAACTGAGCACTATATAAATGCTGGTTGTTGAGATATTGGGAGTGGG GGTTTCGGGAGATTTTGTTTGTTTGTTTTTTTGAGATGGAGTTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTC ACTGCAACCTCCACCTCCTCCAGGTTCAAGCAATTCTGCCTCAGCCTCCCGAGTAGCTGGGACTCAGGCGTGCGCCACCATGCCTGGCTA ATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTTGGCCT CCCAAAGTGCTGGGATTACAGGTGCGAGCTACCACACCTGGCCCTGGATTTCTTAATAGGTCCTCTTATGTGGCTATTGAGAATGAATGA GACAACTCATTAACTAACTAAGTTAATTCAGAACTTAGTGCCTAGTAAGTGCTCAGTAAATGTTAGTTTCTTTTCCTCCATTTCTTCTTA GGAAGCATCGTTTACCCAGCATAAACAGGAGGACTCAACTGTGCATGTCTTAGTGTGAACAAGTAACATCAGATTTCCCTTTTCTGAGGA GAGATCAGTTCTGTAAGAGGGAGCATGAGTGTGAATGGGGAAGAATCATGGAGAAGGGAGCAGGACTCCACAGTACTGGAGATGGAGTAG GGACCTCTGGGAATCGTTGGCATGGGGGTGTGGTGCAGAAAGGGTGATGCTAAGAGGTGAGAGTCTCAAGAAAGAAGATGGGTGTTCTAG AGGGGAAAGCTAAACGATGATAGGCAATGAGGAGCGGAGGACAAGACCCTGAACTAAGGGTGAGGAGGCCAGCATTCTGTCAGGAGAACC TTAGGAATTGTGACCAGAAGTCAAAGTTGTTACAGCAATCCTGCATTCAACCAGGTTTCATCTGAAAAACTTAAGAGTTGCTAGGCACAG TCGTGCACACTTGTAATCCCAACACTTTGGGAGGCTTGAGTCAGGAGGAAGCTTGAGGCCAGGAGTTTGAGATCAGCCTAGGCAGCATAG TGACACCCCATCTCTTGAAAAAACAAACACTCTTAAGAGCAGTGGTTCACCTAGAAATAAAAAGCAGAAATCATCAAGATGAGAAGACAT TTTGTGTTTTGACAGCCAAGGAAATTTGCCACTGAGACAAGGTATCTGACAGCCTAGATGGGATTCTAGACTTCTGTGAGAAAGTGCAGT TAGGCCCTGAATAGCGTCAAACTCAGGGATGTGAGCTGACTGACTGCCTTTTTATGTAATGGAGGCCATGTGATAGGGCTTTATGAGGCC ACAAATAGCACTTTCTGGGTCCTTTCACAGTCTAGTCAGTGGCCCAACCAACATATCTGGTTGTTCTGCAATCTCAGTCATCTGAGAAGA TAACCTCCAAAATACATGCAGTGGCATCAGGTGTTTCCTTGGTAGGTGTGCATCTTTTAATGATGGAGGACTTAGGATGAAGAACAGGTG TGTTTAAAAACATCAAACCCCCACATCATTACTATTTGCTGTAAGGATCTATGCAGTTTGTATTTTAAGTCCTTGACATATGGAAGAGCA TTTGTGAGAGTAACAGGTTTGCTTTGTAATGCCAACTAAAAAGTGTGTATTTATACTCGAATTTTAAGTTGAAATTTTGCTAAGTTTCTT TTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAGTACAGTGGTACAATCATTGCTAAGTCTTTCTGTAGTTTTAGAAC ATTTAGAACAACTTAAGATTTCCTGTATTTATAAACTTAATTTATTGGAAATATAAGTACTTGATCAGGTTTTGTCTTGGTCAGATAAAT TAAGTACTTAAGGAAATCAAATACATTAATCATATAAATGCCATTTAAGTGTTTAAAGGAGTTTAGTTAAATGTAAGTTGGATCAAACAT TAAACTTTTTTGTTTTATAAGCAAAATAATAAGATTTGTTAGCAGAACTTAAAAGCTTAGAAAAGAGAGGATTTTGGATATGTAACTTTG AAGAGGTGAATAGTTTGCTCTTTTCTGAGACAGGGCATTGCTTTTCGACGCAGGCTGGAGTGCAGTGGGGCAAGCATGGCTCACTGCAGC CTCAACCTCCTGGACTCAAGTGATCCTCCTGCCTCAGCCTCCCATGTAGCTGGGATCACAGGCACATGCCACCACACCTGGCTAATTTTT TATTTTTTGTAGAGACAGGGGCCTCACTTCATTGCCCAGGCGGATCTCGAACACCTGGGCTCAAGCAGTCCTGCCTCAGCCTCCCAAAGT TCTGGGATTACAGGCATAAGCCACTGTGCCTGGCCTTGAATATATTTTTTAACCAAAGTAATTTATGAATATAAATTGTTTCTATATAAC CCAAAGTCACTCTCATTGACATTAAGAAACTCAGAGAGTGGGTTCTAAATGTAATATTACCACACACCCAAGTCACTTAGCCTCTACAAG TACCACGTAACTAGCAGCCGTTAAAAGATGGCCACCGCTAGTCCAGTCGGCCACAGACATGGTTTTGTTTGGCCAATACAAGTTTTTGAA >In-frame_BTRC_ENST00000393441_chr10_103190209_+_HIF1AN_ENST00000299163_chr10_102296168_+_12969nt ATCCGGGCGCTGCGTTGGCTGCGGCCTGGCACCAAAGGGGCGGCCCCGGCGGAGAGCGGACCCAGTGGCCTCGGCGATTATGGACCCGGC CGAGGCGGTGCTGCAAGAGAAGGCACTCAAGTTTATGTGCTCTATGCCCAGGTCTCTGTGGCTGGGCTGCTCCAGCCTGGCGGACAGCAT GCCTTCGCTGCGATGCCTGTATAACCCAGGGACTGGCGCACTCACAGCTTTCCAGGAGCCTGTGGTGCTGACCGACACAAATCTTGTGTA TCCTGCCCTGAAATGGGACCTTGAATACCTGCAAGAGAATATTGGCAATGGAGACTTCTCTGTGTACAGTGCCAGCACCCACAAGTTCTT GTACTATGATGAGAAGAAGATGGCCAATTTCCAGAACTTTAAGCCGAGGTCCAACAGGGAAGAAATGAAATTTCATGAGTTCGTTGAGAA ACTGCAGGATATACAGCAGCGAGGAGGGGAAGAGAGGTTGTATCTGCAGCAAACGCTCAATGACACTGTGGGCAGGAAGATTGTCATGGA CTTCTTAGGTTTTAACTGGAACTGGATTAATAAGCAACAGGGAAAGCGTGGCTGGGGGCAGCTTACCTCTAACCTGCTGCTCATTGGCAT GGAAGGAAATGTGACACCTGCTCACTATGATGAGCAGCAGAACTTTTTTGCTCAGATAAAAGGTTACAAACGATGCATCTTATTCCCTCC GGATCAGTTCGAGTGCCTCTACCCATACCCTGTTCATCACCCATGTGACAGACAGAGCCAGGTGGACTTTGACAATCCCGACTACGAGAG GTTCCCTAATTTCCAAAATGTGGTTGGTTACGAAACAGTGGTTGGCCCTGGTGATGTTCTTTACATCCCAATGTACTGGTGGCATCACAT AGAGTCATTACTAAATGGGGGGATTACCATCACTGTGAACTTCTGGTATAAGGGGGCTCCCACCCCTAAGAGAATTGAATATCCTCTCAA AGCTCATCAGAAAGTGGCCATAATGAGAAACATTGAGAAGATGCTTGGAGAGGCCTTGGGGAACCCACAAGAGGTGGGGCCCTTGTTGAA CACAATGATCAAGGGCCGATACAACTAGCCTGCCAGGGGTCAAGGCCTCCTGCCAGGTGACTGCTATCCCGTCCACACCGCTTCATTGAT GAGGACAGGAGACTCCAAGCGCTAGTATTGCACGCTGCACTTAATGGACTGGACTCTTGCCATGGCCCAGGAGTCAGGTGTTTGGAGCGA GGCAGGGCAGTTGGCACTCCACTCCTATTTGGAGGGACTTCATACCCTTGCCTCTTGTGCCCCAGCACCTTCTCTCTCTGCCCCCCGCCT AAAGTCCTGCATTCAGTGTGTGGAGTCCCAGCTTTTGGTTGTCATCATGTCTGTGTGTATGTTAGTCTGTCAACTTCGGAATGTGTGCGT GTGTGTGCATGCACACGCATGTATGTATCTGTTCCCTGTTCCTTCTGGGTCAGGCTGTCACTTCCGGCTCTCAGCCCTATCTCCTGCAAC CTCAGTGCCTCAGCCTGAGAGAGAGATGAGATGCTCTTGGACTCCCCACTGCATCTGGGCTGCAGGGCCAGAGCTAGTCTGACCATTAGG TCAGTCTGCCTCCTGACAGTTTTTGCGTAGTCAAGCTCTAGGCGGTATGGGAATGGCTACCGGGACTCTAATGGGGTGAAAGAGAGGGGA GGCTTGCCTTTGAGAGCCTATATAGCCTTCCTGTGAGAGAGGATTAGATAGGGTTCCAACTGGGCCTACAAGCTCAAGCCATACATAAAA GGACCTTGGGACATAAGAACCAATGATTGTGCATAAGTTCTAAATTAGAGACACATATAGTTTCTCTCTTTCAGCACCAGCTCTTGCCCC TATGCTGGGTACCAAGGGAGTTCTCCTAGCTGTGGCTTCTCTAGGTTCTAGGGGTGCAAGCCTCTGTGTGTTTGTTTGTGTGTGTCTGTG TGTGCGTATCCACACTAGGGGTGCAAGCCTCTGGGTGTGTGTGTGTGTGTGCGTGCGTGTGTGTGTGTGTGTCCGTGTGTGTGTGTGTGT GTGTCCACACTGGCCAGCCTCCCTACTTACCAAGGTTCTCCACTGCTTACCTTTTCCAGTGGGACAGTACAGTGTGAGCCCCCGGGAAGT ACTGCCTGACCTATCCTAAGCTTTTACACTTGGATTTTAGCCATCATATGTTGGCCAGGTCTCACTGCAGCCTGCCCGAGGCTAACTGGC TAGAGCCTCCAGGCCCTATGATGCTCCCTGCCCAGGCCATATCCTTTATTCCTGCTGAGCTTCCTGGCTGAATAGATGAAATGGGGTCAA GCCCAGGCAGCTCATTCACTACCTGTGATCCACCTCAGGGCACGGGCAAACACATAGGCTTGCGTCTTAAAGCCAGCTCCTCTGCCAGAC CCCGTTGTAATGTGCCACAACACCCTCAATAGTCAGGGCAACTGGTGGAGCATGGAAGTCGAATTTCCTTTTCTGTTAGGAGCTACTCCT GGGAACCCCTCTCAGGGCTGCAGCTTACAGGTGGGCAGCTGTGATTGCACAACTTGAAGGGCCATCATTCACATCTATTCAGTGGGAGTG GGGTCCCTGGGATTGGGCAGTGTGGTGGCCCTGTGTCTCCTCACCTCTGCTCCTGTCTTCATCACCTTCTCTCTGGAAGGGAAGAGGAGT TGGAAGGTCTCTGGTTTTCTTTTCTTTTTTTTTTTTTTTGCCAAAGGTTTACTTCCAGCATCTGAGCTCTGGCTCTCACCCCTGAAGCTC AGTTATAGTGCACTGATGAACTGAGAGGATGCGTGTGGATGTGTGTGCATGCCTGAGTGCGTTTTTTGGGGAGGGGTGTTTATTTTTAGT ACCCCATTCTGGGGTTCTCTGATGCAGTGTGGATGTGAAGATATGGTACCTTCTCAAGTGTAGCTCTTTCAAATATAGTCAATGCTGGGA AATGTGATTGCAGTGATCTCTATCTCTCCACTTCTTTTGGGAAAGAGGAGCACAGGAGCGGAGGAAAAACTTGGCCACAGTCACACTTGG AAAGATAGTAGATTATTTTCGTTCTCCTCAGCAGGTCTGCTGTATTCCTCGCTCAGCGCTCAAAGATGTGGGTGATGTGTCAAGGAGGCA TGCACTCAGCTGGTCCTTGCTGAGTTATTTGCTGACACAGGTCTCACTAAGGTGGCTGAGGGGTGGGAGGGAGAAGGCTAATCTTGGAAC CTTCACAGGATTGGCCTTGATCCTTGGGTAACACAAGAGTGATTCCTGATTTTTAGACACCTAATATGTGCCTAGTGCTTTTCTCTTTGT TCCTCACTATCCTGCAAGGTAGGTATTCTCACTTACAGATGAATAAATGGGCTCAGAGAGATTAGGTGATTAGTGACAATCAGTTGTAAC TTAGCACTGTTAGGCTGCAAACCCCTTGCTCCTTCCTTTCCACCAAACTATGTTGATTTTCCTTCCTTACCTCCCTCCTTGTACCACAGG TTCTGTCCTCAAGATATCACCCCACTGGGCAGTATCTGAAGGCAGACCCAGCCCAAGATGGTGCAGAATATACAGCTCAGGGTGAAAGTT CTTCTGGGCTCCTGCTAACAAAGTCTTGGAAAAACTGCCTGGGAAGCCATATTATGAATTAGTGCTAGAAGAAGCTGTGGGGGGAACTGA GTTCTGTGTCTAATTGCATTACTTATGTGTCCTTGAATAGGACCCATAACTCCTCCCGGCATGCTTTTGCATCTATAGAACTGAAGCTGT AGTTCTAGATGGCACTAAGGGTCTTGGTTCATATTCAGCTGCTGCTTCCCCCCAAGGAAAAGATGAGGTTTTTCCCCTTCGATTACCTTT TGAGGGATGTTTAGGCTCAAATTCTGCTTGCCACAGAGGAAACATTTCTGCTGTAGTTGTTTACCTCCATCCTAGCTGGCAGTGTGGGAC ACACACATACAGCAAGTGAAGGTGGGGGTTTGGGCCTGTATAGAGGTCAGCTACGCTGCAGGCTCATCTATTCACACCAGCAGGTACAGA GAAAACTAGTGTTTTGTAAAGTCAAATATTTGTTGGGGGTTGGAGTTCTGGGGTTGGAGGAGGGGCTGTTCTGGGCATCAGTTGAGCAGA TGCCCAGGATGCCTGGGGGAGACCAGCTTCCCCTACAAATCAGAGCTCTAAATTACAAGGTTTTTACCAACGTGAACAGTTGGGGGAAGT CGTCTGCTCTCATTTGCGTAATGGTTTCTGTCACTGGTGATTAGACACAGGATGAAGGAAAAGAAATTTGACAATTAGGAATGAGCGATC ATTAATCTGAATCTGTTAGGAGACAGAGAGGGGAAGGATCCTTATCAGTGGGCCAGCCCAGTATGGGGAGACACTCCCTCCCTCTGCCCC CAGAGACTCCTGGGCTACATCCTCTTTCAGTATTGCCACAAGTGGGCAGAGCTTGTATTTCTTAACAAAGATTAGGGACCCAGTTGCCAG CCTGAGATGGATATAGGAACAGACATCTTTGGGCATGAGCCAACAAAGATAGAAATAGATGAGTGTCAGGTACAAGCTATAAGGCAAAGA ATAACAGTGGAAAAGTTTTGACATGTGTTTGCCATTTGTGGAAAATGTTTTTGTAATAGTCAACACCCCTCATAGCCCACCTGTGACAAG TACTTGTTACATTCCAGCACTGTAGGGCGTGAGGAAAATCTGGTCCTTATCAAATCCCAGGAGCTTCTGCTTAGTTGGGGAAGAAATTAC ATGAAGCAACCAGAGGTTATAAGGCCACACTTGTATATCGTGCACCCTGTGTGGACAAGATTAGGGACTGTTGAGAGAGGAGGAAACCAG TAGAGAGCAAAGCTCTACCCAGGCTCCTTGTAAGCCTCTGGGCTCCCCCGAGAGGGCCTCGCTACTCTACGCTTCCTAGCAACGTTGATG TCCCCACAACCCCACATCAGTGCAGCTGTGGCTGTGTGGAGGGGCTCTGAGGCCTCTGAGGCCAGATGTGTAAACAGTGCTGAGGTTCAG TAATAGGATGAGTCTTCAGGTGTGGAGCAGCCCACCTTGGCTCTTCCCATGTCTCTGTGTTACTTCTCATATTCTGCTGTCCTTTCAAAC TTCAAGGACAGTATTAATTTATACTAGTATTTCTTCCTCAGTTTTGTGACTTGAATGCAGTGAGTGCCTTAGAGGATCCAAGGATGAAGG AATGCGGGTTGGTGGTTCTCTCTTTCAGAATGGGAACTTCCCAAAAATGGGGCTGCGTCTCGCCTCTCAGTAGGTTCCCTACCTCTGGGT CTTCCACCCTTCAAAATCTGGTACAGAATTTAGCAGGGGCTGCAGGGAATGACCCTCAGGGACCAGTTTCACCCAGATGGGGTAGATGAT GAGGTATACCTAGAAGTAGCTCAGGGCTCCAGAGTCTGGCCTTTCAGCTGGTGTCTTACTCCCCTTTGAGACCTTCAGCTGCTTGTCTTC CACTGCCTGCATACTTCTCTGATGTCTTCTCAAACTGTTGGCTCTAAAGGGATGTTCCAGCCTCCCTCTCCAGAGCTGCCTGCAGTTTCC CTTATTCAGCTGTCTCCTGCCTAGTCTCTCCAGCGGCCTCCTTACCAAGACCCTTTTTCCTAAACAGTTGTCCTTCCCTCAGAAACTCCA TGGCTGCAAGTGTGAATAGACTTGTCTTTAGGATCCCTCTCTCTGGTCATCCCTGATCATCTTAGGGCCGTCTCCCTTTTCTGATTTTTG ACAGCTCTGTTTATTTTGCCCATGGCTAGTCCTCTTGTTTTGTGTCTGCTGTGTGTTCTTGCCCTTCCATTGTCAGTTCTGTACATCCTG GTTCAGCTTGTCTCACTGTGGTAGCCCCTTCTGCTTGTCTTCAGCCATCTTGGTTTAATCCTCATAGGTCATGGATGAATGGAGCCTTGC TGAGCACTTTGAGGGCATTTCTGTTGGGCACAACCTCAGAAACGGGAAGTCTTGAGGCCTGGGGGCGTGTGGTCAGTGAGGCCTCCAGAG GTGGGTTAGGGGTGGGCACCTACAAGGGCCAGTTGAGGGGAGAGGTGCAGGGATTGCTGAGGAGACTTTGTGAGAATGATGTCAGGCCCG GGAAGCTGGTGTGGAAGAACTGAGCTGTCAGAAGGAGATACCAATATCCCCTTTGCAGGGTGGTGATGGGCATCAAACATGACGTGGAAC ATGTCCCCTTCATGGAGGGTTTCCATCTAAATGCATCTGTGTGCCTTAGGGATCAGTAGTTCAGGGGTGGTGGACTTTTTTGAGTGTCTC CTAATTTCTCTGAGGTGTCTTTGGCTCTGTGTCACCAAATGTGCCTGACCTCTGCATCCCAGTGGTTGCTGAAAGGGAAACAGTATATTG CGTAGTCAGATGTCAGGAGTAGAGATCTTAATGAGAAAGGCCCTGGCAGCTGGAGAGATGAGAGGACCTAGTGGTCAGCTTATACCCAGA CTATCTCTCCACTCCTCCAAGAGTTTGAGTCCCATAGCTGATGAAAGAATTTACATATGGGCTCCCCCCTGCTTTCCCACTGAAAATCTA TTCTCATATTTTGGGAAGGAGCATATGTCCTTTAACTTTCAATGGTAAACAATCTAGGATAGTGTTTAAAGGCATGGATTTTGGAGTCAC ATATAGTTGGTTTGAATTTCTAGCTTCACTACTTACCAGCTGGGTTTGACCTTGGTTGATTTACTTAACCTCTCTGAGCCTCAGTTTCCT CAACTATAATAACATGGGTGGAGGGAGGCATGTTGAAAATATCTACCTCAGGGTTGTTGGAATAACTGAAACAATGTTTGTAAAGCTTTA GCACAGTGCCTGGCAAGCACTTAATAAATGGCTGTGGTGGTGGTGGTTATATTTATTATGTGATTTATTCAGAAACTTGGTTTCAGTGAT CTCTAAACAGATTTCCAGTGGTTCTTTCTCTCTCAAGAAAAGCATAGGGAAAAACGAGAAACACCTTAGATAAACCATATTGAGTTGAGG GTAGACAGAAGAGTCTAGTACCTAAACTCACCCTAGAGGAAGAGAAACAGGAAGTGTCTTATGCCTCTTCTGCCTGGGCAGCCAGACTTT ACTGCTGTACTACCAGCCCAGGGCCTTGGGTGAGAAGGTTTCAGGTCTGAGCTCCCCTTGCACTGTGTGAGAGGCCGTGGAGCCGAATGA GTCCTTATTATACCTGGAGAAGCTGTTGTCTCCTCACACCATGAAATGTAATAGCAGTCAAATCAGGCCCCTCTTGATTCAATTTTAGTC CATGCCTTTCCATGTATTTAAATTATATAAGTGTTGGCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTCGGGAGGCTGAGGCAG GAGGATCACTTGAGCCCAGGAGTTCGAACCAACCTTGGGCAGCATAGTGAGACCCCTTCTCTTAATAATTTTTTTTGAAAATAATTTTTT AAAAATTACAAATATGGACCAGACACCTGGGAGGATTACCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCT GAGGTCAGGAGTTTGAGACTATCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGATGTGGTGGTGGGTA CCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGTCATTG CACTCCAGCCTGGGTGACTACAGTGAGACTCCCTCTCAAAAAAAAAAAAAAAAAATTATGAGTATGTTAAGATTGTTCTAGGGGAGAAGG GCAATCAAAATTCAGAAAAATATGAGTGGGATGTTAATAGCTACCATTTGTTGAACACTTCTGTTCCAGGCACTGTATTAGTTCGTCCCC ATGTGGTGCTCTCAGATCAGTAGGGGAGACAGGCAGGCAGTTAGAATTATGGTGTATAGAGGAGAAGCATTGCACTATGTCCAGTTTTTT ATGGTAGGCTTCCTGCAGAAAGTGATAAGTCCAAGCTGATATGTGGAAGATGAATAATTAACCAGAGGTTGGGGGATTTCCCCCTTAGCT TCTCTTTCTTCCAGTCCAGCAGTCCAAAACAAACACTGCTTCCCAATGCCTAAGGGTTTTGTCGTACCTTACTCCAGGGAATGGGTGAGA CAGTAGATCCCAAGAAGAAAACCCTTTGGTTAGTCACAGAAATCTGAAAGTCTTGGTTGCTGGCTCAGATTTGTCCTGGAGTGGACGTAG ATTGGACTTGCTTATTTGTAGCCCTCCACCGTTCTCATTTGTGTTCTGGCCTCTGGAGCCACCCTGCCAGACCCTACTTGGAAGAAATGT TGAATCAAGCTACTCAGACTTCAGCCTGAGATGTATTATGGCTGGCTGGAATTCTCAGCCCTTTCCACATCATGATCCCATTAATCTCTT GGGTCTATCCCCACGCCCAGCCACCTCTCCTCCTCACTATAAGCCAAGTCTCCCTGCAGTTCTCTATAAATACTCAGATCCTCTTGCCTC AGACCCTGGTCCCTAGCTTTGTGGGTGAAGAAGATACCTCTTTAGCTTGTGCCAACCCATCCCTCTGGGCTACAGGCCATTCTGTAGTCA CCTTGCAGTCACGTCTTTCCTTCTAGATAACTGGCTCTGGGCCTTGGAAACCTTCTCTTTGGCTCTAGCTAATTTTGCTGTTTTATTCCG TTTACTTAAAACCTATTCACTTGGTCATTGAGGTCAGAACTATCAGGAAAGCTGTGCTCCTTAACCCATCATCTAAGCTAAGCTTGGGCC AGGTTTTTATTACCTCTTGAATATATATAGTGCAATATAGTGTAGTGGTTGAGAGTGGAGTCTGCATACCTGGATCTGCCATTCTGCATG ACTTTGGGCAAATGGACAAACTGCCCGAAACTTGACTTGTTTATATGTATGGGGAAGACATCATTTACATTGTCAGGGTAAGGCTTAGCA GAATGACCGGTCCATAGCAAGGGCTCAGTCTTTCTGTGTCTCTCAGTCTTTACCTCTCTTCCCCATCTAGCTTTCTGTCTAAGTTCCTGT TTCTAGTCTCAGGGCATATCTAGTTGTCAGCTCCTGAGCAGAGCAGAGGTATAAGTGTCAACTCATGCTTGTGTTACCAGTTCCTACCCC TGTCAGTAACCTCTGATGCTTACAAGGATACTATCACCTATGCCATCAGTGGGGAATGACCTTCCAAAAATATTTTTAACAATACTAAAA ATACCTGAAACATACTGGGTGAAAATAAGACATTGGAGCTGCTGCTCCCCAAGGAGATAAAAGGACAGTTCCTAAAGAGGCATTGAAGGT TTGTATGAGCCAGCAGCACAGTCAGAAGGCAAGAAGGAGACCCTGGGATGTGCACAAGGATGCAGGAGACGAGATTGTCACAGAGGCTGT CATGCTAGTAAGAGTCAGAGGTTACTGATGGGTAGAGATTGTCAGAGTCTGCCTTGCTAGTCTAGAGGTAGGACCATGGATTTAAGAACG TTGCCTCCAAGTTTTTGAATTGTGAATTTTTGATCATATTTGAACAAAACCCCACCTACAGTCTGCATGGTCATTGTTCTCACAAGGGTT TGTGTGATGCACTGACAAGAACAGAGGCTTTGGAGGTGACTCCTGGGTTTGAATCACCATTTGCCACTAGCTAATTCTAACCTTAGGTAA GTCAGTGTCTCTGGGTCTCAACCTCTTCCTCTGTGAGGGGTAGGAAATAGCACATAACTTGTAGCATTGTTATAAGGGCTCGTGATAATG TTTTTAAAACACCTGGCTCAAGCACTCAGGAAAATGTTTTATTATGAAGACCAAGTGTCTCTGAAAAGTGTTTCCTTAGTGTCTGGAGAG ACTACAGCAGCAAGGCTTTTCTGATCCTACTCTGACTCTCAAGATAATGGTGCTTGAAGTGAAATCACAGAAGAGATGACTGGGGCAGGA AAAGCAAGATGGAAAAGATAAAGTTGTGGAAGGGACTGAAAGTCCATGAAGTGCTGGGCTGGGGACAGAAAGGGTTTAATAGGGCAGGGT CTTGAGGAACAGGAACAGAGACCTTGGTTCTGGGTTGCCATCTGATTCCCAGAAGAGTAAAGGAAATGGGGCAGGAGGATGTCTGTGGAG GACACAGTGTGGCTGAGTGGAGAGAACACAAGCTTCTGGCCAGTGAACCTAAGTGAGAATGTCAGTGGACTTTGCACAGGCTGGGTGCCT TTGGGGGTGTTCATCTCGCTATGCTTCGGTCCCCTCATTTAAAAAAATTGGTTAATAATATGATGACCTGCCAATGTGTGTGGAAATACT ATGTAAACTGAGCACTATATAAATGCTGGTTGTTGAGATATTGGGAGTGGGGGTTTCGGGAGATTTTGTTTGTTTGTTTTTTTGAGATGG AGTTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCTCCAGGTTCAAGCAATTCTGC CTCAGCCTCCCGAGTAGCTGGGACTCAGGCGTGCGCCACCATGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTG GTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGCGAGCTACCACACCT GGCCCTGGATTTCTTAATAGGTCCTCTTATGTGGCTATTGAGAATGAATGAGACAACTCATTAACTAACTAAGTTAATTCAGAACTTAGT GCCTAGTAAGTGCTCAGTAAATGTTAGTTTCTTTTCCTCCATTTCTTCTTAGGAAGCATCGTTTACCCAGCATAAACAGGAGGACTCAAC TGTGCATGTCTTAGTGTGAACAAGTAACATCAGATTTCCCTTTTCTGAGGAGAGATCAGTTCTGTAAGAGGGAGCATGAGTGTGAATGGG GAAGAATCATGGAGAAGGGAGCAGGACTCCACAGTACTGGAGATGGAGTAGGGACCTCTGGGAATCGTTGGCATGGGGGTGTGGTGCAGA AAGGGTGATGCTAAGAGGTGAGAGTCTCAAGAAAGAAGATGGGTGTTCTAGAGGGGAAAGCTAAACGATGATAGGCAATGAGGAGCGGAG GACAAGACCCTGAACTAAGGGTGAGGAGGCCAGCATTCTGTCAGGAGAACCTTAGGAATTGTGACCAGAAGTCAAAGTTGTTACAGCAAT CCTGCATTCAACCAGGTTTCATCTGAAAAACTTAAGAGTTGCTAGGCACAGTCGTGCACACTTGTAATCCCAACACTTTGGGAGGCTTGA GTCAGGAGGAAGCTTGAGGCCAGGAGTTTGAGATCAGCCTAGGCAGCATAGTGACACCCCATCTCTTGAAAAAACAAACACTCTTAAGAG CAGTGGTTCACCTAGAAATAAAAAGCAGAAATCATCAAGATGAGAAGACATTTTGTGTTTTGACAGCCAAGGAAATTTGCCACTGAGACA AGGTATCTGACAGCCTAGATGGGATTCTAGACTTCTGTGAGAAAGTGCAGTTAGGCCCTGAATAGCGTCAAACTCAGGGATGTGAGCTGA CTGACTGCCTTTTTATGTAATGGAGGCCATGTGATAGGGCTTTATGAGGCCACAAATAGCACTTTCTGGGTCCTTTCACAGTCTAGTCAG TGGCCCAACCAACATATCTGGTTGTTCTGCAATCTCAGTCATCTGAGAAGATAACCTCCAAAATACATGCAGTGGCATCAGGTGTTTCCT TGGTAGGTGTGCATCTTTTAATGATGGAGGACTTAGGATGAAGAACAGGTGTGTTTAAAAACATCAAACCCCCACATCATTACTATTTGC TGTAAGGATCTATGCAGTTTGTATTTTAAGTCCTTGACATATGGAAGAGCATTTGTGAGAGTAACAGGTTTGCTTTGTAATGCCAACTAA AAAGTGTGTATTTATACTCGAATTTTAAGTTGAAATTTTGCTAAGTTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAG GCTGGAGTACAGTGGTACAATCATTGCTAAGTCTTTCTGTAGTTTTAGAACATTTAGAACAACTTAAGATTTCCTGTATTTATAAACTTA ATTTATTGGAAATATAAGTACTTGATCAGGTTTTGTCTTGGTCAGATAAATTAAGTACTTAAGGAAATCAAATACATTAATCATATAAAT GCCATTTAAGTGTTTAAAGGAGTTTAGTTAAATGTAAGTTGGATCAAACATTAAACTTTTTTGTTTTATAAGCAAAATAATAAGATTTGT TAGCAGAACTTAAAAGCTTAGAAAAGAGAGGATTTTGGATATGTAACTTTGAAGAGGTGAATAGTTTGCTCTTTTCTGAGACAGGGCATT GCTTTTCGACGCAGGCTGGAGTGCAGTGGGGCAAGCATGGCTCACTGCAGCCTCAACCTCCTGGACTCAAGTGATCCTCCTGCCTCAGCC TCCCATGTAGCTGGGATCACAGGCACATGCCACCACACCTGGCTAATTTTTTATTTTTTGTAGAGACAGGGGCCTCACTTCATTGCCCAG GCGGATCTCGAACACCTGGGCTCAAGCAGTCCTGCCTCAGCCTCCCAAAGTTCTGGGATTACAGGCATAAGCCACTGTGCCTGGCCTTGA ATATATTTTTTAACCAAAGTAATTTATGAATATAAATTGTTTCTATATAACCCAAAGTCACTCTCATTGACATTAAGAAACTCAGAGAGT GGGTTCTAAATGTAATATTACCACACACCCAAGTCACTTAGCCTCTACAAGTACCACGTAACTAGCAGCCGTTAAAAGATGGCCACCGCT AGTCCAGTCGGCCACAGACATGGTTTTGTTTGGCCAATACAAGTTTTTGAAAGTTTTAAAAAATTGACAACATTAAAGATCAGAAACTTG |
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FusionGenePPI for BTRC_HIF1AN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BTRC | TRIM9, TBK1, SMAD4, SMAD3, DLG1, CUL1, SKP1, IKBKB, NFKB1, NFKBIB, BTRC, FBXW11, NFKBIA, UBE2R2, CDC34, RELA, JUP, NFKB2, UBE2D2, HIPK2, PTTG1, BORA, PDCD4, TP63, EPOR, PHLPP1, AMER1, GHR, APC, CDC25A, HIVEP1, HIVEP2, IGHM, NRD1, PRKACA, SERPINB4, OGT, KEAP1, TUBGCP3, NUDC, TUBGCP2, CLPX, SUN2, COPS4, USP47, GPRASP2, KRT79, CLSPN, CTNNB1, EP300, ATF4, PER1, SNAI1, FBXO5, GLI3, WEE1, TNF, SNRNP70, AXIN1, GSK3B, HEY2, CASP3, MYC, RASA1, CDC25B, CLU, UBC, YAP1, TP53, IKBKG, IFNAR1, BST2, DEPTOR, SP1, PSMD4, UBE2D1, BMI1, MDM2, FBXW8, HNRNPU, MAPK14, CSNK2B, DBN1, RASSF1, ZC3H12A, ICE1, PCDH8, KDR, NEDD8, HRAS, CTTN, FAF1, IL10RA, TAZ, PRLR, EEF2K, RNF7, RBX1, BCL2L11, FGD1, AGO2, DDB1, CUL4A, IGF2BP1, FOXO3, WWTR1, ELF3, REST, CDC20, HSF1, CCNE1, BCL10, RCAN1, CCND1, IRAK1, MCL1, PLK4, CHUK, USP37, BTG1, BTG2, FGD3, SKP2, ELAVL1, UHRF1, DDIT4, HSP90AA1, SMURF1, AURKA, CCDC22, TERF1, CRY1, CRY2, PER2, TRIB2, NCOR2, CHPF, HNRNPK, CP, HNRNPC, PRDX1, PSMA3, FZR1, VCP, MAP2K1, MTSS1, UFD1L, NPLOC4, EZH2, SUZ12, OIP5, TFAP4, NEDD4, KRAS, SMURF2, NUAK1, NUAK2, ASF1A, UBE2D3, TIAM1, CDK1, CCNB1, RASSF5, BHLHE40, RAP1GAP, RAPGEF2, TBC1D4, SKP1P2, NFE2, TACC1, ENO1, MOV10, NXF1, E2F1, NFKBIE, AATF, ARIH1, CAND1, CPVL, DAP3, DOCK1, EGFLAM, ELMO2, GPATCH8, HNRNPA3, HNRNPAB, HNRNPD, HNRNPUL2, MRPL12, MRPL15, MRPL21, MRPL24, MRPL37, MRPL38, MRPL4, MRPL40, MRPL41, MRPL44, MRPL47, MRPL48, MRPL49, MRPS18A, MRPS22, MRPS27, MRPS31, MRPS34, MRPS35, YWHAB, YWHAE, YWHAG, YWHAZ, CSNK1A1, CTNNA1, GBF1, HCFC1, HSPB1, NFE2L1, PPP1R15B, PRKAR1A, RBMXL2, REL, STK3, STK4, DLD, TSC22D4, WBP1, SPANXN3, FAM219A, ZBTB46, NFE2L2, UBE4B, ZNF395, ZNF704, PRRC2A, AEBP2, GGNBP2, ALDH2, CEP44, DACT1, FNIP1, RIPK4, RASSF3, CEP68, WWC1, GLI1, SOX9, ALDH1A2, C11orf49, C1orf226, CCDC138, CEP55, DCP1A, DCP1B, DPCD, DVL1, EMG1, LRRC49, NEDD1, NOL10, NOS1AP, NSFL1C, OFD1, PCM1, PDLIM5, PFDN1, PFDN4, PFDN5, PFDN6, PPM1G, RAB5A, RPS10, RPS18, SMG5, SSX2IP, TCP11L2, TJP1, TPGS1, TXNL1, WWOX, ABCD3, ACBD5, BOP1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, COL10A1, KANK2, LRRC47, MDN1, PFDN2, SIRT2, SMG7, TNRC6A, TWISTNB, USMG5, VBP1, VCPIP1, WDR12, AFG3L2, AKAP2, ALDH3A2, ALMS1, BAG2, BUB1B, CNOT11, CCDC50, CKAP5, CLTCL1, CNOT1, CNOT10, CREBRF, DLG5, ERBB2IP, FAM21A, FLCN, GOPC, MAGED1, MAP1S, MAST2, MAST3, MTR, NME7, RGAG1, RQCD1, SPATA5, TCHP, TNRC6B, USP54, YTHDF3, STIL, COPS6, HINT1, CREB3L3, FOXN2, GADD45A, TWIST1, PAQR3, FANCM, LPCAT1, MAP3K2, USP15, FBXW2, LPIN1, ALPP, MTDH, PRKRA, CTNND1, DYRK1A, COPS7A, COPS7B, CHD1, MLPH, KHDRBS2, MYO10, MPRIP, DHX38, EML5, LSP1, PLEKHG5, SH3BP5L, ACOT7, GPR161, IL17RD, BTG3, TUBGCP5, SPATA20, KIF20A, EED, PRICKLE3, FOXN3, RAI14, APBA2, TUBGCP6, RALGAPB, TUBGCP4, CACHD1, MXI1, TNKS1BP1, CNOT2, INTU, CUL5, TRIM25, CENPW | HIF1AN | ASB9, FBF1, ASB13, INVS, HIF1A, VHL, HDAC1, HDAC2, HDAC3, SIAH1, ASB4, OTUD7B, ELAVL1, UBE3A, HIF1AN, NFKB1, FEM1B, UACA, ASB5, ASB6, ASB7, ASB8, ASB16, ANKRD44, CLDN20, KLHL20, CCDC94, NFKBIA, ANKRD12, ANKRD55, NFKBIB, ANKDD1A, XPO1, OTUB1, APBA3, CASKIN1, ANKRD49, TNKS2, ANKRD27, FYCO1, NOTCH3, ANKRD52, RNASEL, ANKS1A, TNKS, USP24, RIPK4, RPRD2, TXLNG, PIP4K2B, REL, ANK3, OSBPL1A, PIP4K2C, C2orf44, ANKFY1, GMDS, TXLNA, MLLT4, NFKB2, EIF4ENIF1, ANK2, ASB10, ZFP36L2, KIAA1804, OSBPL3, ASB3, TBK1, HECTD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | HIF1AN | chr10:103190209 | chr10:102296168 | ENST00000299163 | + | 0 | 8 | 2_125 | 59 | 350 | VHL |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BTRC_HIF1AN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BTRC_HIF1AN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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