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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4561

FusionGeneSummary for BTG3_FHL1

check button Fusion gene summary
Fusion gene informationFusion gene name: BTG3_FHL1
Fusion gene ID: 4561
HgeneTgene
Gene symbol

BTG3

FHL1

Gene ID

10950

3075

Gene nameBTG anti-proliferation factor 3complement factor H
SynonymsANA|ANA/BTG3|APRO4|TOB5|TOB55|TOFAAHUS1|AMBP1|ARMD4|ARMS1|CFHL3|FH|FHL1|HF|HF1|HF2|HUS
Cytomap

21q21.1

1q31.3

Type of geneprotein-codingprotein-coding
Descriptionprotein BTG3B-cell translocation gene 3BTG family member 3abundant in neuroepithelium area proteinprotein Tob5complement factor HH factor 1 (complement)H factor 2 (complement)adrenomedullin binding proteinage-related maculopathy susceptibility 1beta-1-H-globulinbeta-1Hfactor Hfactor H-like 1
Modification date2018052720180520
UniProtAcc

Q14201

Q13642

Ensembl transtripts involved in fusion geneENST00000339775, ENST00000348354, 
ENST00000464058, 
ENST00000394155, 
ENST00000370690, ENST00000535737, 
ENST00000543669, ENST00000394153, 
ENST00000345434, ENST00000539015, 
ENST00000370683, ENST00000370676, 
ENST00000477080, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 1=9
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BTG3 [Title/Abstract] AND FHL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBTG3

GO:0045930

negative regulation of mitotic cell cycle

9632145

TgeneFHL1

GO:0006956

complement activation

24835392


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF092514BTG3chr21

18966569

+FHL1chrX

135292681

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000339775ENST00000394155BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000339775ENST00000370690BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000339775ENST00000535737BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000339775ENST00000543669BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000339775ENST00000394153BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000339775ENST00000345434BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000339775ENST00000539015BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000339775ENST00000370683BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-intronENST00000339775ENST00000370676BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-intronENST00000339775ENST00000477080BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000348354ENST00000394155BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000348354ENST00000370690BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000348354ENST00000535737BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000348354ENST00000543669BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000348354ENST00000394153BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000348354ENST00000345434BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000348354ENST00000539015BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000348354ENST00000370683BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-intronENST00000348354ENST00000370676BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-intronENST00000348354ENST00000477080BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000464058ENST00000394155BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000464058ENST00000370690BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000464058ENST00000535737BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000464058ENST00000543669BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000464058ENST00000394153BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000464058ENST00000345434BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000464058ENST00000539015BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-3UTRENST00000464058ENST00000370683BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-intronENST00000464058ENST00000370676BTG3chr21

18966569

+FHL1chrX

135292681

-
intron-intronENST00000464058ENST00000477080BTG3chr21

18966569

+FHL1chrX

135292681

-

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FusionProtFeatures for BTG3_FHL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTG3

Q14201

FHL1

Q13642

Overexpression impairs serum-induced cell cycleprogression from the G0/G1 to S phase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BTG3_FHL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BTG3_FHL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BTG3_FHL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BTG3_FHL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBTG3C0007134Renal Cell Carcinoma1CTD_human
HgeneBTG3C3495559Juvenile arthritis1CTD_human
TgeneFHL1C2678055MYOPATHY, X-LINKED, WITH POSTURAL MUSCLE ATROPHY (disorder)3CTD_human;ORPHANET;UNIPROT
TgeneFHL1C4225159REDUCING BODY MYOPATHY, X-LINKED 1B, WITH LATE CHILDHOOD OR ADULT ONSET3UNIPROT
TgeneFHL1C2678061SCAPULOPERONEAL MYOPATHY, X-LINKED DOMINANT2CTD_human;ORPHANET;UNIPROT
TgeneFHL1C4225423REDUCING BODY MYOPATHY, X-LINKED 1A, SEVERE, WITH INFANTILE OR EARLY CHILDHOOD ONSET2UNIPROT
TgeneFHL1C0023893Liver Cirrhosis, Experimental1CTD_human