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Fusion gene ID: 4561 |
FusionGeneSummary for BTG3_FHL1 |
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Fusion gene information | Fusion gene name: BTG3_FHL1 | Fusion gene ID: 4561 | Hgene | Tgene | Gene symbol | BTG3 | FHL1 | Gene ID | 10950 | 3075 |
Gene name | BTG anti-proliferation factor 3 | complement factor H | |
Synonyms | ANA|ANA/BTG3|APRO4|TOB5|TOB55|TOFA | AHUS1|AMBP1|ARMD4|ARMS1|CFHL3|FH|FHL1|HF|HF1|HF2|HUS | |
Cytomap | 21q21.1 | 1q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein BTG3B-cell translocation gene 3BTG family member 3abundant in neuroepithelium area proteinprotein Tob5 | complement factor HH factor 1 (complement)H factor 2 (complement)adrenomedullin binding proteinage-related maculopathy susceptibility 1beta-1-H-globulinbeta-1Hfactor Hfactor H-like 1 | |
Modification date | 20180527 | 20180520 | |
UniProtAcc | Q14201 | Q13642 | |
Ensembl transtripts involved in fusion gene | ENST00000339775, ENST00000348354, ENST00000464058, | ENST00000394155, ENST00000370690, ENST00000535737, ENST00000543669, ENST00000394153, ENST00000345434, ENST00000539015, ENST00000370683, ENST00000370676, ENST00000477080, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 1=9 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BTG3 [Title/Abstract] AND FHL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BTG3 | GO:0045930 | negative regulation of mitotic cell cycle | 9632145 |
Tgene | FHL1 | GO:0006956 | complement activation | 24835392 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF092514 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000339775 | ENST00000394155 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000339775 | ENST00000370690 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000339775 | ENST00000535737 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000339775 | ENST00000543669 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000339775 | ENST00000394153 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000339775 | ENST00000345434 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000339775 | ENST00000539015 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000339775 | ENST00000370683 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-intron | ENST00000339775 | ENST00000370676 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-intron | ENST00000339775 | ENST00000477080 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000348354 | ENST00000394155 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000348354 | ENST00000370690 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000348354 | ENST00000535737 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000348354 | ENST00000543669 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000348354 | ENST00000394153 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000348354 | ENST00000345434 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000348354 | ENST00000539015 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000348354 | ENST00000370683 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-intron | ENST00000348354 | ENST00000370676 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-intron | ENST00000348354 | ENST00000477080 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000464058 | ENST00000394155 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000464058 | ENST00000370690 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000464058 | ENST00000535737 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000464058 | ENST00000543669 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000464058 | ENST00000394153 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000464058 | ENST00000345434 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000464058 | ENST00000539015 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-3UTR | ENST00000464058 | ENST00000370683 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-intron | ENST00000464058 | ENST00000370676 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
intron-intron | ENST00000464058 | ENST00000477080 | BTG3 | chr21 | 18966569 | + | FHL1 | chrX | 135292681 | - |
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FusionProtFeatures for BTG3_FHL1 |
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Hgene | Tgene |
BTG3 | FHL1 |
Overexpression impairs serum-induced cell cycleprogression from the G0/G1 to S phase. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BTG3_FHL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BTG3_FHL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BTG3_FHL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BTG3_FHL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BTG3 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | BTG3 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | FHL1 | C2678055 | MYOPATHY, X-LINKED, WITH POSTURAL MUSCLE ATROPHY (disorder) | 3 | CTD_human;ORPHANET;UNIPROT |
Tgene | FHL1 | C4225159 | REDUCING BODY MYOPATHY, X-LINKED 1B, WITH LATE CHILDHOOD OR ADULT ONSET | 3 | UNIPROT |
Tgene | FHL1 | C2678061 | SCAPULOPERONEAL MYOPATHY, X-LINKED DOMINANT | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | FHL1 | C4225423 | REDUCING BODY MYOPATHY, X-LINKED 1A, SEVERE, WITH INFANTILE OR EARLY CHILDHOOD ONSET | 2 | UNIPROT |
Tgene | FHL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |