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Fusion gene ID: 4552 |
FusionGeneSummary for BTC_ZBTB7B |
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Fusion gene information | Fusion gene name: BTC_ZBTB7B | Fusion gene ID: 4552 | Hgene | Tgene | Gene symbol | BTC | ZBTB7B | Gene ID | 685 | 51043 |
Gene name | betacellulin | zinc finger and BTB domain containing 7B | |
Synonyms | - | CKROX|THPOK|ZBTB15|ZFP-67|ZFP67|ZNF857B|c-KROX|hcKROX | |
Cytomap | 4q13.3 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | probetacellulin | zinc finger and BTB domain-containing protein 7BT-helper-inducing POZ/Krueppel-like factorkrueppel-related zinc finger protein cKroxzinc finger and BTB domain containing 15zinc finger protein 67 homologzinc finger protein 857Bzinc finger protein Th- | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P35070 | O15156 | |
Ensembl transtripts involved in fusion gene | ENST00000395743, | ENST00000535420, ENST00000368426, ENST00000487542, ENST00000417934, ENST00000292176, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BTC [Title/Abstract] AND ZBTB7B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-3C-AAAU-01A | BTC | chr4 | 75719472 | - | ZBTB7B | chr1 | 154982734 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000395743 | ENST00000535420 | BTC | chr4 | 75719472 | - | ZBTB7B | chr1 | 154982734 | + |
5CDS-intron | ENST00000395743 | ENST00000368426 | BTC | chr4 | 75719472 | - | ZBTB7B | chr1 | 154982734 | + |
5CDS-intron | ENST00000395743 | ENST00000487542 | BTC | chr4 | 75719472 | - | ZBTB7B | chr1 | 154982734 | + |
5CDS-5UTR | ENST00000395743 | ENST00000417934 | BTC | chr4 | 75719472 | - | ZBTB7B | chr1 | 154982734 | + |
5CDS-intron | ENST00000395743 | ENST00000292176 | BTC | chr4 | 75719472 | - | ZBTB7B | chr1 | 154982734 | + |
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FusionProtFeatures for BTC_ZBTB7B |
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Hgene | Tgene |
BTC | ZBTB7B |
Growth factor that binds to EGFR, ERBB4 and other EGFreceptor family members. Potent mitogen for retinal pigmentepithelial cells and vascular smooth muscle cells.{ECO:0000269|PubMed:8570211}. | Transcription regulator that acts as a key regulator oflineage commitment of immature T-cell precursors. Exerts distinctbiological functions in the mammary epithelial cells and T cellsin a tissue-specific manner. Necessary and sufficient forcommitment of CD4 lineage, while its absence causes CD8commitment. Development of immature T-cell precursors (thymocytes)to either the CD4 helper or CD8 killer T-cell lineages correlatesprecisely with their T-cell receptor specificity for majorhistocompatibility complex class II or class I molecules,respectively. Cross-antagonism between ZBTB7B and CBF complexesare determinative to CD4 versus CD8 cell fate decision. SuppressesRUNX3 expression and imposes CD4+ lineage fate by inducing theSOCS suppressors of cytokine signaling. induces, as atranscriptional activator, SOCS genes expression which repressesRUNX3 expression and promotes the CD4+ lineage fate. During CD4lineage commitment, associates with multiple sites at the CD8locus, acting as a negative regulator of the CD8 promoter andenhancers by epigenetic silencing through the recruitment of classII histone deacetylases, such as HDAC4 and HDAC5, to these loci.Regulates the development of IL17-producing CD1d-restricted nauralkiller (NK) T cells. Also functions as an important metabolicregulator in the lactating mammary glands. Critical feed-forwardregulator of insulin signaling in mammary gland lactation,directly regulates expression of insulin receptor substrate-1(IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (Bysimilarity). Transcriptional repressor of the collagen COL1A1 andCOL1A2 genes. May also function as a repressor of fibronectin andpossibly other extracellular matrix genes (PubMed:9370309). Potentdriver of brown fat development, thermogenesis and cold-inducedbeige fat formation. Recruits the brown fat lncRNA 1(Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenicgene expression in brown and beige adipocytes (By similarity).{ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BTC_ZBTB7B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BTC_ZBTB7B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BTC | KRT31, GMPPA, ERBB2 | ZBTB7B | GRAP2, ZNF277, SP1, SP3, EP300, PRPF8, MYBBP1A, CEBPZ, HSPH1, ZBTB7B, RELA, TFAP4, HDAC4, HDAC5, HDAC3, HDAC10, KPNA2, KAT5, NDN, BCL6, GRB2, PIN1, RPL9, NCK2, MORF4L2, ZBTB5, SORBS3, SH3YL1, SH3KBP1, IMP4, SYTL4, RNF2, CDK2AP1, P4HA3, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BTC_ZBTB7B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BTC_ZBTB7B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BTC | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | BTC | C0162568 | Erythropoietic Protoporphyria | 1 | CTD_human |