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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4552

FusionGeneSummary for BTC_ZBTB7B

check button Fusion gene summary
Fusion gene informationFusion gene name: BTC_ZBTB7B
Fusion gene ID: 4552
HgeneTgene
Gene symbol

BTC

ZBTB7B

Gene ID

685

51043

Gene namebetacellulinzinc finger and BTB domain containing 7B
Synonyms-CKROX|THPOK|ZBTB15|ZFP-67|ZFP67|ZNF857B|c-KROX|hcKROX
Cytomap

4q13.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionprobetacellulinzinc finger and BTB domain-containing protein 7BT-helper-inducing POZ/Krueppel-like factorkrueppel-related zinc finger protein cKroxzinc finger and BTB domain containing 15zinc finger protein 67 homologzinc finger protein 857Bzinc finger protein Th-
Modification date2018052320180523
UniProtAcc

P35070

O15156

Ensembl transtripts involved in fusion geneENST00000395743, ENST00000535420, 
ENST00000368426, ENST00000487542, 
ENST00000417934, ENST00000292176, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 2 X 3=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BTC [Title/Abstract] AND ZBTB7B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-3C-AAAU-01ABTCchr4

75719472

-ZBTB7Bchr1

154982734

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000395743ENST00000535420BTCchr4

75719472

-ZBTB7Bchr1

154982734

+
5CDS-intronENST00000395743ENST00000368426BTCchr4

75719472

-ZBTB7Bchr1

154982734

+
5CDS-intronENST00000395743ENST00000487542BTCchr4

75719472

-ZBTB7Bchr1

154982734

+
5CDS-5UTRENST00000395743ENST00000417934BTCchr4

75719472

-ZBTB7Bchr1

154982734

+
5CDS-intronENST00000395743ENST00000292176BTCchr4

75719472

-ZBTB7Bchr1

154982734

+

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FusionProtFeatures for BTC_ZBTB7B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTC

P35070

ZBTB7B

O15156

Growth factor that binds to EGFR, ERBB4 and other EGFreceptor family members. Potent mitogen for retinal pigmentepithelial cells and vascular smooth muscle cells.{ECO:0000269|PubMed:8570211}. Transcription regulator that acts as a key regulator oflineage commitment of immature T-cell precursors. Exerts distinctbiological functions in the mammary epithelial cells and T cellsin a tissue-specific manner. Necessary and sufficient forcommitment of CD4 lineage, while its absence causes CD8commitment. Development of immature T-cell precursors (thymocytes)to either the CD4 helper or CD8 killer T-cell lineages correlatesprecisely with their T-cell receptor specificity for majorhistocompatibility complex class II or class I molecules,respectively. Cross-antagonism between ZBTB7B and CBF complexesare determinative to CD4 versus CD8 cell fate decision. SuppressesRUNX3 expression and imposes CD4+ lineage fate by inducing theSOCS suppressors of cytokine signaling. induces, as atranscriptional activator, SOCS genes expression which repressesRUNX3 expression and promotes the CD4+ lineage fate. During CD4lineage commitment, associates with multiple sites at the CD8locus, acting as a negative regulator of the CD8 promoter andenhancers by epigenetic silencing through the recruitment of classII histone deacetylases, such as HDAC4 and HDAC5, to these loci.Regulates the development of IL17-producing CD1d-restricted nauralkiller (NK) T cells. Also functions as an important metabolicregulator in the lactating mammary glands. Critical feed-forwardregulator of insulin signaling in mammary gland lactation,directly regulates expression of insulin receptor substrate-1(IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (Bysimilarity). Transcriptional repressor of the collagen COL1A1 andCOL1A2 genes. May also function as a repressor of fibronectin andpossibly other extracellular matrix genes (PubMed:9370309). Potentdriver of brown fat development, thermogenesis and cold-inducedbeige fat formation. Recruits the brown fat lncRNA 1(Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenicgene expression in brown and beige adipocytes (By similarity).{ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BTC_ZBTB7B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BTC_ZBTB7B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BTCKRT31, GMPPA, ERBB2ZBTB7BGRAP2, ZNF277, SP1, SP3, EP300, PRPF8, MYBBP1A, CEBPZ, HSPH1, ZBTB7B, RELA, TFAP4, HDAC4, HDAC5, HDAC3, HDAC10, KPNA2, KAT5, NDN, BCL6, GRB2, PIN1, RPL9, NCK2, MORF4L2, ZBTB5, SORBS3, SH3YL1, SH3KBP1, IMP4, SYTL4, RNF2, CDK2AP1, P4HA3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BTC_ZBTB7B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BTC_ZBTB7B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBTCC0036341Schizophrenia1PSYGENET
HgeneBTCC0162568Erythropoietic Protoporphyria1CTD_human