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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4508

FusionGeneSummary for BTAF1_PTPRR

check button Fusion gene summary
Fusion gene informationFusion gene name: BTAF1_PTPRR
Fusion gene ID: 4508
HgeneTgene
Gene symbol

BTAF1

PTPRR

Gene ID

9044

5801

Gene nameB-TFIID TATA-box binding protein associated factor 1protein tyrosine phosphatase, receptor type R
SynonymsMOT1|TAF(II)170|TAF172|TAFII170EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ
Cytomap

10q23.32

12q15

Type of geneprotein-codingprotein-coding
DescriptionTATA-binding protein-associated factor 172ATP-dependent helicase BTAF1B-TFIID transcription factor-associated 170 kDa subunitBTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)Mot1 homologTBP-associareceptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1
Modification date2018051920180519
UniProtAcc

O14981

Q15256

Ensembl transtripts involved in fusion geneENST00000265990, ENST00000471217, 
ENST00000544642, 
ENST00000283228, 
ENST00000440835, ENST00000537619, 
ENST00000378778, ENST00000342084, 
ENST00000549308, 
Fusion gene scores* DoF score2 X 2 X 2=833 X 13 X 10=4290
# samples 231
** MAII scorelog2(2/8*10)=1.32192809488736log2(31/4290*10)=-3.79063752711267
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTAF1 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5510-01ABTAF1chr10

93726514

+PTPRRchr12

71095103

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000265990ENST00000283228BTAF1chr10

93726514

+PTPRRchr12

71095103

-
Frame-shitENST00000265990ENST00000440835BTAF1chr10

93726514

+PTPRRchr12

71095103

-
5CDS-intronENST00000265990ENST00000537619BTAF1chr10

93726514

+PTPRRchr12

71095103

-
5CDS-intronENST00000265990ENST00000378778BTAF1chr10

93726514

+PTPRRchr12

71095103

-
5CDS-intronENST00000265990ENST00000342084BTAF1chr10

93726514

+PTPRRchr12

71095103

-
5CDS-intronENST00000265990ENST00000549308BTAF1chr10

93726514

+PTPRRchr12

71095103

-
3UTR-3CDSENST00000471217ENST00000283228BTAF1chr10

93726514

+PTPRRchr12

71095103

-
3UTR-3CDSENST00000471217ENST00000440835BTAF1chr10

93726514

+PTPRRchr12

71095103

-
3UTR-intronENST00000471217ENST00000537619BTAF1chr10

93726514

+PTPRRchr12

71095103

-
3UTR-intronENST00000471217ENST00000378778BTAF1chr10

93726514

+PTPRRchr12

71095103

-
3UTR-intronENST00000471217ENST00000342084BTAF1chr10

93726514

+PTPRRchr12

71095103

-
3UTR-intronENST00000471217ENST00000549308BTAF1chr10

93726514

+PTPRRchr12

71095103

-
intron-3CDSENST00000544642ENST00000283228BTAF1chr10

93726514

+PTPRRchr12

71095103

-
intron-3CDSENST00000544642ENST00000440835BTAF1chr10

93726514

+PTPRRchr12

71095103

-
intron-intronENST00000544642ENST00000537619BTAF1chr10

93726514

+PTPRRchr12

71095103

-
intron-intronENST00000544642ENST00000378778BTAF1chr10

93726514

+PTPRRchr12

71095103

-
intron-intronENST00000544642ENST00000342084BTAF1chr10

93726514

+PTPRRchr12

71095103

-
intron-intronENST00000544642ENST00000549308BTAF1chr10

93726514

+PTPRRchr12

71095103

-

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FusionProtFeatures for BTAF1_PTPRR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTAF1

O14981

PTPRR

Q15256

Regulates transcription in association with TATA bindingprotein (TBP). Removes TBP from the TATA box in an ATP-dependentmanner. Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BTAF1_PTPRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BTAF1_PTPRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BTAF1MVD, TBP, GTF2H4, ELAVL1, TFAP4, PIAS4, PIH1D3, CCDC8, BSG, TNFSF13B, PNKD, LYPD3, TRRAP, NTRK1, TEAD2, FOXB1, FOXE1, FOXG1, FOXH1, FOXI2, FOXL1, FOXL2, FOXQ1, SNW1, CDC5L, NFATC2, EGFR, SIGLECL1, APLNR, C5AR2, LPAR4, HTR2C, SLC15A1, VIPR2, CD83, FZD10, MAS1, EDNRB, RHOT2, GRPR, EPHA1, NPY2R, TRIM25, UBE2A, UHRF2PTPRRMAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BTAF1_PTPRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BTAF1_PTPRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRRC0041696Unipolar Depression1PSYGENET
TgenePTPRRC1269683Major Depressive Disorder1PSYGENET