|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 4504 |
FusionGeneSummary for BST1_SLTM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BST1_SLTM | Fusion gene ID: 4504 | Hgene | Tgene | Gene symbol | BST1 | SLTM | Gene ID | 683 | 79811 |
| Gene name | bone marrow stromal cell antigen 1 | SAFB like transcription modulator | |
| Synonyms | CD157 | Met | |
| Cytomap | 4p15.32 | 15q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2ADP-ribosyl cyclase 2NAD(+) nucleosidasebone marrow stromal antigen 1cADPr hydrolase 2cyclic ADP-ribose hydrolase 2 | SAFB-like transcription modulatormodulator of estrogen-induced transcription | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q10588 | Q9NWH9 | |
| Ensembl transtripts involved in fusion gene | ENST00000265016, ENST00000382346, | ENST00000380516, ENST00000536328, ENST00000557950, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 9 X 2=144 |
| # samples | 1 | 9 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BST1 [Title/Abstract] AND SLTM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BST1 | GO:0001952 | regulation of cell-matrix adhesion | 15328157 |
| Hgene | BST1 | GO:0008284 | positive regulation of cell proliferation | 8202488 |
| Hgene | BST1 | GO:0032956 | regulation of actin cytoskeleton organization | 15328157 |
| Hgene | BST1 | GO:0050727 | regulation of inflammatory response | 15328157 |
| Hgene | BST1 | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 8941363 |
| Hgene | BST1 | GO:0090022 | regulation of neutrophil chemotaxis | 15328157 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE856481 | BST1 | chr4 | 15733447 | - | SLTM | chr15 | 59192845 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000265016 | ENST00000380516 | BST1 | chr4 | 15733447 | - | SLTM | chr15 | 59192845 | + |
| 5CDS-intron | ENST00000265016 | ENST00000536328 | BST1 | chr4 | 15733447 | - | SLTM | chr15 | 59192845 | + |
| 5CDS-5UTR | ENST00000265016 | ENST00000557950 | BST1 | chr4 | 15733447 | - | SLTM | chr15 | 59192845 | + |
| 5CDS-intron | ENST00000382346 | ENST00000380516 | BST1 | chr4 | 15733447 | - | SLTM | chr15 | 59192845 | + |
| 5CDS-intron | ENST00000382346 | ENST00000536328 | BST1 | chr4 | 15733447 | - | SLTM | chr15 | 59192845 | + |
| 5CDS-5UTR | ENST00000382346 | ENST00000557950 | BST1 | chr4 | 15733447 | - | SLTM | chr15 | 59192845 | + |
Top |
FusionProtFeatures for BST1_SLTM |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BST1 | SLTM |
| Synthesizes the second messagers cyclic ADP-ribose andnicotinate-adenine dinucleotide phosphate, the former a secondmessenger that elicits calcium release from intracellular stores.May be involved in pre-B-cell growth.{ECO:0000269|PubMed:11866528}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for BST1_SLTM |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for BST1_SLTM |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for BST1_SLTM |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | BST1 | Q10588 | DB02701 | Nicotinamide | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | small molecule | approved|investigational |
Top |
RelatedDiseases for BST1_SLTM |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BST1 | C0024115 | Lung diseases | 1 | CTD_human |
| Hgene | BST1 | C0030567 | Parkinson Disease | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|