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Fusion gene ID: 4503 |
FusionGeneSummary for BSPRY_NPM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BSPRY_NPM1 | Fusion gene ID: 4503 | Hgene | Tgene | Gene symbol | BSPRY | NPM1 | Gene ID | 54836 | 4869 |
| Gene name | B-box and SPRY domain containing | nucleophosmin 1 | |
| Synonyms | - | B23|NPM | |
| Cytomap | 9q32 | 5q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | B box and SPRY domain-containing proteinB-box and SPRY-domain containing proteinzetin 1 | nucleophosminnucleolar protein NO38nucleophosmin (nucleolar phosphoprotein B23, numatrin)nucleophosmin/nucleoplasmin family, member 1testicular tissue protein Li 128 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q5W0U4 | P06748 | |
| Ensembl transtripts involved in fusion gene | ENST00000374183, ENST00000462085, | ENST00000517671, ENST00000296930, ENST00000351986, ENST00000393820, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 2=32 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BSPRY [Title/Abstract] AND NPM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NPM1 | GO:0006281 | DNA repair | 19188445 |
| Tgene | NPM1 | GO:0006334 | nucleosome assembly | 11602260 |
| Tgene | NPM1 | GO:0006913 | nucleocytoplasmic transport | 16041368 |
| Tgene | NPM1 | GO:0008104 | protein localization | 18420587 |
| Tgene | NPM1 | GO:0008284 | positive regulation of cell proliferation | 22528486 |
| Tgene | NPM1 | GO:0032071 | regulation of endodeoxyribonuclease activity | 19188445 |
| Tgene | NPM1 | GO:0034644 | cellular response to UV | 19160485 |
| Tgene | NPM1 | GO:0043066 | negative regulation of apoptotic process | 12882984 |
| Tgene | NPM1 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | 12882984 |
| Tgene | NPM1 | GO:0045727 | positive regulation of translation | 12882984 |
| Tgene | NPM1 | GO:0045893 | positive regulation of transcription, DNA-templated | 22528486 |
| Tgene | NPM1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19160485 |
| Tgene | NPM1 | GO:0051259 | protein complex oligomerization | 18809582 |
| Tgene | NPM1 | GO:0060699 | regulation of endoribonuclease activity | 19188445 |
| Tgene | NPM1 | GO:0060735 | regulation of eIF2 alpha phosphorylation by dsRNA | 12882984 |
| Tgene | NPM1 | GO:1902751 | positive regulation of cell cycle G2/M phase transition | 22528486 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-LL-A5YO-01A | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000374183 | ENST00000517671 | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
| Frame-shift | ENST00000374183 | ENST00000296930 | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
| Frame-shift | ENST00000374183 | ENST00000351986 | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
| 5CDS-intron | ENST00000374183 | ENST00000393820 | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
| 3UTR-3CDS | ENST00000462085 | ENST00000517671 | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
| 3UTR-3CDS | ENST00000462085 | ENST00000296930 | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
| 3UTR-3CDS | ENST00000462085 | ENST00000351986 | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
| 3UTR-intron | ENST00000462085 | ENST00000393820 | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
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FusionProtFeatures for BSPRY_NPM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BSPRY | NPM1 |
| May regulate epithelial calcium transport by inhibitingTRPV5 activity. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BSPRY | chr9:116123017 | chr5:170837531 | ENST00000374183 | + | 3 | 6 | 17_65 | 177 | 403 | Zinc finger | Note=B box-type |
| Tgene | >NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | + | 0 | 10 | 120_132 | -33 | 260 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Tgene | >NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | + | 0 | 10 | 161_188 | -33 | 260 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Tgene | >NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | + | 0 | 10 | 1_9 | -33 | 260 | Compositional bias | Note=Met-rich |
| Tgene | >NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | + | 0 | 10 | 152_157 | -33 | 260 | Motif | Nuclear localization signal |
| Tgene | >NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | + | 0 | 10 | 191_197 | -33 | 260 | Motif | Nuclear localization signal |
| Tgene | >NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | + | 0 | 10 | 243_294 | -33 | 260 | Region | Note=Required for nucleolar localization |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >BSPRY | chr9:116123017 | chr5:170837531 | ENST00000374183 | + | 3 | 6 | 212_402 | 177 | 403 | Domain | B30.2/SPRY |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | + | 9 | 11 | 120_132 | 282 | 295 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | + | 9 | 11 | 161_188 | 282 | 295 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | + | 9 | 11 | 1_9 | 282 | 295 | Compositional bias | Note=Met-rich |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | + | 8 | 10 | 120_132 | 253 | 266 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | + | 8 | 10 | 161_188 | 253 | 266 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | + | 8 | 10 | 1_9 | 253 | 266 | Compositional bias | Note=Met-rich |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | + | 10 | 12 | 120_132 | 282 | 295 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | + | 10 | 12 | 161_188 | 282 | 295 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | + | 10 | 12 | 1_9 | 282 | 295 | Compositional bias | Note=Met-rich |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | + | 9 | 11 | 152_157 | 282 | 295 | Motif | Nuclear localization signal |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | + | 9 | 11 | 191_197 | 282 | 295 | Motif | Nuclear localization signal |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | + | 8 | 10 | 152_157 | 253 | 266 | Motif | Nuclear localization signal |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | + | 8 | 10 | 191_197 | 253 | 266 | Motif | Nuclear localization signal |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | + | 10 | 12 | 152_157 | 282 | 295 | Motif | Nuclear localization signal |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | + | 10 | 12 | 191_197 | 282 | 295 | Motif | Nuclear localization signal |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | + | 9 | 11 | 243_294 | 282 | 295 | Region | Note=Required for nucleolar localization |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | + | 8 | 10 | 243_294 | 253 | 266 | Region | Note=Required for nucleolar localization |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | + | 10 | 12 | 243_294 | 282 | 295 | Region | Note=Required for nucleolar localization |
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FusionGeneSequence for BSPRY_NPM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BSPRY_ENST00000374183_chr9_116123017_+_NPM1_ENST00000517671_chr5_170837531_+_190aa MSAEGAEPGPGSGSGPGPGPLCPEHGQALSWFCGSERRPVCAACAGLGGRCRGHRIRRAEERAEELRNKIVDQCERLQLQSAAITKYVAD VLPGKNQRAVSMASAARELVIQRLSLVRSLCESEEQRLLEQVHGEEERAHQSILTQRVHWAEALQKLDTIRTGLVGMLTHLDDLQLIAIQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BSPRY_ENST00000374183_chr9_116123017_+_NPM1_ENST00000517671_chr5_170837531_+_570nt ATGTCCGCCGAGGGCGCGGAGCCGGGGCCGGGGTCCGGGTCCGGGCCCGGGCCGGGGCCACTCTGCCCCGAACACGGCCAGGCTCTGAGC TGGTTCTGCGGCTCCGAGCGACGGCCCGTGTGCGCCGCCTGCGCGGGGTTGGGCGGTCGCTGCCGGGGGCACCGCATCCGCCGGGCGGAG GAGCGCGCCGAGGAGCTGCGGAACAAGATTGTGGACCAGTGTGAGAGGCTGCAGTTACAGAGTGCTGCCATCACCAAGTATGTGGCGGAC GTCCTGCCGGGGAAGAATCAAAGAGCAGTGAGCATGGCCAGTGCAGCGAGGGAACTGGTTATCCAGCGGTTGAGTCTGGTGAGGAGTCTT TGCGAGAGCGAGGAGCAGCGGTTACTGGAACAGGTGCATGGCGAAGAGGAGCGGGCCCACCAGAGCATCCTGACACAGCGGGTGCACTGG GCCGAGGCGCTGCAGAAACTTGACACCATCCGCACTGGCCTGGTGGGCATGCTTACTCACCTGGATGACCTCCAGCTGATTGCTATTCAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BSPRY_ENST00000374183_chr9_116123017_+_NPM1_ENST00000517671_chr5_170837531_+_927nt ACCTGCGACAGGTGGAGCGCACGGGGCGGGCGCACGGCCATGTCCGCCGAGGGCGCGGAGCCGGGGCCGGGGTCCGGGTCCGGGCCCGGG CCGGGGCCACTCTGCCCCGAACACGGCCAGGCTCTGAGCTGGTTCTGCGGCTCCGAGCGACGGCCCGTGTGCGCCGCCTGCGCGGGGTTG GGCGGTCGCTGCCGGGGGCACCGCATCCGCCGGGCGGAGGAGCGCGCCGAGGAGCTGCGGAACAAGATTGTGGACCAGTGTGAGAGGCTG CAGTTACAGAGTGCTGCCATCACCAAGTATGTGGCGGACGTCCTGCCGGGGAAGAATCAAAGAGCAGTGAGCATGGCCAGTGCAGCGAGG GAACTGGTTATCCAGCGGTTGAGTCTGGTGAGGAGTCTTTGCGAGAGCGAGGAGCAGCGGTTACTGGAACAGGTGCATGGCGAAGAGGAG CGGGCCCACCAGAGCATCCTGACACAGCGGGTGCACTGGGCCGAGGCGCTGCAGAAACTTGACACCATCCGCACTGGCCTGGTGGGCATG CTTACTCACCTGGATGACCTCCAGCTGATTGCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTTAAGAAAATAGTTTAAACAATTTG TTAAAAAATTTTCCGTCTTATTTCATTTCTGTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCAGAGTGAGAACTTTCCCTACCGTG TTTGATAAATGTTGTCCAGGTTCTATTGCCAAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAAAGATGGAACTCCACCCTTTGCTT GGTTTTAAGTATGTATGGAATGTTATGATAGGACATAGTAGTAGCGGTGGTCAGACATGGAAATGGTGGGGAGACAAAAATATACATGTG |
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FusionGenePPI for BSPRY_NPM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BSPRY | CEP162, NCS1, CEP55, DEAF1, RNF135, TMF1, HAUS4, MBLAC2, HAUS1, USP4, HSBP1, FEM1B, OSBPL1A, SEMG2, RAB11B, BTBD9, RUNX1T1, C17orf49, KLHL23, SEMG1, CENPH | NPM1 | TCERG1, LYAR, USF2, HIST3H3, SWAP70, HAND2, NCL, OTUB1, AKT1, CDT1, RRP1B, GRB2, CENPF, CASKIN1, CDC14A, PIK3R1, NUP98, PPID, GRB7, NCAPG, NUMA1, NSUN2, PADI4, TP53, BARD1, BRCA1, H2AFX, CDKN2A, HMGA2, HMGA1, YY1, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, EP300, PML, RARA, CTNNBL1, FANCA, FANCC, TFAP2A, HDAC1, HDAC2, SMARCA4, DOT1L, ACACA, HNRNPM, HNRNPU, DDX21, HIST1H1C, SIRT1, YBX1, PC, YBX3, H1FX, HIST1H1A, ESR1, CDK5RAP3, ZNF668, UBC, RYK, SMN1, CD4, YWHAQ, USP36, CTCF, HDAC5, CDKN1A, NOP56, CENPA, AFF1, DYRK2, TOP1, CDK2, SREK1, SENP3, RB1, PARP1, HJURP, ARRB1, ARRB2, SIRT7, NPM3, NPM1, FBXO25, IRF1, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, MDM2, PA2G4, PPP2R1A, MID1, GZF1, APEX1, COPS2, PLCG1, FBXO6, GAPDH, SIAH1, PTBP1, SRSF1, APP, RPL14, RPS6, RPL24, RPL6, NAP1L1, HNRNPR, RPS4X, PRPF6, LAMP2, SURF4, RPL10L, NAP1L4, ZYX, NUP62, NUP50, RPL5, YWHAE, FMNL1, CPSF6, HNRNPH1, PAPOLG, JUNB, MC4R, HIVEP2, CPSF1, CPSF2, CPSF4, CPSF3, FN1, VCAM1, CSNK2A1, NOS2, UBL4A, ITGA4, CBX2, CBX4, CBX8, PHB, EIF2AK2, XPO1, GZMM, PAN2, CD81, IGSF8, ICAM1, PRKCZ, KIF11, SQSTM1, FLNA, LLGL1, HSP90AA1, TRIM21, TUBA1C, HSP90AB1, PARD6B, CDC37, TUBB3, MRPL46, KCTD2, CLTC, MRPL50, VCP, KCTD5, MRPL12, HSPA5, PTRF, MRPL52, EEF1A1, KCTD17, TAB1, BAG2, ANXA2, EIF5A, PPIL4, MRPL38, STK38, FLNB, LGALS1, C1QBP, COPB1, MRPL37, MRPL49, KEAP1, PRDX4, WDR26, PSMC4, SDPR, SLC25A3, RPS12, EEF1B2, NIPSNAP1, EEF1G, MRPL39, DDX3X, RNH1, OSBPL1A, EIF3H, MRPL54, ENO1, MYCBP, MRPL18, MAP1B, PSMD1, EEF1D, DNAJC13, HSPB1, CFL1, FLNC, PPP1CC, RPLP1, CEP152, SNRPD1, ATP5A1, ARHGAP5, PRKAR1A, MRPL53, GID8, YWHAZ, CCT2, EIF3E, LAMB2, DICER1, CHCHD4, MRPL19, SNRPD2, GRWD1, TPR, PSMD4, PSMC5, PPP2CA, UNC5C, SLC25A5, PTPN14, RPS5, TTC27, BOLA2, EIF4A1, TUFM, S100A10, IMPG1, NUDT21, UTRN, MRPL44, EIF3M, MRPL43, PKM, IMPDH2, TRRAP, CHCHD6, RANBP6, EIF3I, TAB2, MRPL24, DZIP1, IPO5, AGR2, MRPS30, ICT1, PRDX6, TCP1, RCOR1, GRN, TXN, RPLP0, PCBP1, MRPL28, MRPL10, TAF3, EPAS1, CHCHD3, TXNDC12, ELMO2, SRRT, MRPL11, EIF2S1, SNRPF, KTN1, FGD6, UQCRH, RBBP4, DNAJA1, CTTN, USP15, NUDCD1, RPS28, JAK1, PROS1, PYGB, KDR, EEF2, FASN, AKAP11, CSNK2B, DNAJA2, EIF3G, DHX15, MRPS26, HNRNPA0, DOCK4, PRKCI, VASP, COPE, SAMM50, TEX15, PSME3, PPM1G, COPG1, CALU, S100A11, HSPA4, PSMD12, POLR2E, TRIM28, SLAIN2, RPL10, GOLGA2, GOLGA3, PRKCA, IPO9, PARK7, SPIN1, PPA1, BANP, DSTN, GNAI2, HOXA7, ABCC1, RELA, ACY1, TARDBP, PARK2, KPNA1, ARMCX3, LIMCH1, OSBP, TRMT61A, RPA1, RPA2, RPA3, ERG, LGR4, STAU1, ELF4, AURKA, HUWE1, FUS, COX8A, NPM2, MOV10, NXF1, PHF6, CUL7, OBSL1, CCDC8, SIRT6, EBNA1BP2, NOL12, RPL10A, POP4, ZNF22, NSA2, TAF1D, NIFK, RPL26L1, NIP7, RPL4, RPF1, CCDC137, KNOP1, RBM28, RPL7A, POP1, DDX24, FTSJ3, RRS1, RPL3, ZFP62, ZNF512, DDX56, DDX27, GLYR1, MAK16, CEBPZ, RSL1D1, HP1BP3, REXO4, DDX31, MYBBP1A, NOP16, C3orf17, RRP8, GNL2, PAPD5, RSL24D1, SURF6, GTPBP4, KIAA0020, NOP2, NVL, GLTSCR2, URB1, RPL23A, GPATCH4, TEX10, RPS8, NOC3L, BRIX1, DDX54, PWP1, RBM34, NMNAT1, CENPC, SENP5, RPL36AL, PAK1IP1, ZNF800, RPL7L1, RPL37A, RPF2, PELP1, NOC2L, RPP40, RBMX2, CENPV, PPAN-P2RY11, SDAD1, RPP38, RPP25, SPTY2D1, RPP25L, POP7, RPS6KB2, UTP15, NTRK1, EWSR1, CLK1, HIST1H3E, BYSL, CHD1, DDX1, DECR1, EIF1AX, EIF4G2, FBL, FAU, HIST1H1D, HIST1H1B, RPSA, MKI67, MPG, EXOSC10, RPL7, RPL8, RPL9, RPL11, RPL13, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL27, RPL27A, RPL29, RPL32, RPL37, RPL38, RPS2, RPS3, RPS3A, RPS9, RPS10, RPS11, RPS13, RPS14, RPS15, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS27, RPS29, SKIV2L, SRP72, XPC, IFRD2, HIST1H2BC, SMARCA5, CGGBP1, EIF3A, EIF3C, PABPC4, USP10, TTC37, JADE3, ABCF2, G3BP1, GNB2L1, EMG1, IGF2BP3, PSIP1, SUPT16H, RPL35, PDCD11, LARP4B, RRP12, LARP1, RPL13A, RPL36, MTHFD1L, AHCTF1, FAM98A, SERBP1, GNL3, SND1, NOB1, RPS27L, DDX47, EIF3L, RTCB, TRMT112, DHX29, MTPAP, NAT10, TSR1, NKRF, MEPCE, BCCIP, PNO1, MRPS22, WDR18, SCAF1, NOL6, DDX50, CCDC86, MUS81, ZNF622, DHX57, H2AFV, LARP4, WBSCR22, GAN, HEMGN, TMUB1, CRY1, DNAJB4, MCM2, GLI1, SP1, U2AF2, RC3H1, EIF2S2, EGFR, WWP2, CD24, ZNF746, DDX51, CYLD, INO80B, LMNA, YAP1, MTF1, BRD1, HDAC6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BSPRY_NPM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NPM1 | P06748 | DB11638 | Artenimol | Nucleophosmin | small molecule | approved|investigational |
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RelatedDiseases for BSPRY_NPM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NPM1 | C0023467 | Leukemia, Myelocytic, Acute | 3 | CTD_human |
| Tgene | NPM1 | C0023487 | Acute Promyelocytic Leukemia | 2 | CTD_human;ORPHANET |
| Tgene | NPM1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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