	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 4486

FusionGeneSummary for BSDC1_PDLIM5

Fusion gene summary

Fusion gene information	Fusion gene name: BSDC1_PDLIM5
	Fusion gene ID: 4486
		Hgene	Tgene
	Gene symbol	BSDC1	PDLIM5
	Gene ID	55108	10611
	Gene name	BSD domain containing 1	PDZ and LIM domain 5
	Synonyms	-	ENH\|ENH1\|L9\|LIM
	Cytomap	1p35.1	4q22.3
	Type of gene	protein-coding	protein-coding
	Description	BSD domain-containing protein 1	PDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains protein
	Modification date	20180519	20180522
	UniProtAcc	Q9NW68	Q96HC4
	Ensembl transtripts involved in fusion gene	ENST00000455895, ENST00000413080, ENST00000341071, ENST00000526031, ENST00000419121, ENST00000446293, ENST00000463967, ENST00000449308,	ENST00000450793, ENST00000538141, ENST00000380180, ENST00000318007, ENST00000437932, ENST00000317968, ENST00000542407, ENST00000508216, ENST00000514743, ENST00000380176, ENST00000359265, ENST00000512274, ENST00000504489,
Fusion gene scores	* DoF score	5 X 5 X 4=100	9 X 12 X 5=540
	# samples	5	12
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/540*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BSDC1 [Title/Abstract] AND PDLIM5 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF991287	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000455895	ENST00000450793	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000538141	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000380180	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000318007	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000437932	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000317968	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000542407	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000508216	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000514743	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000380176	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000359265	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000512274	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000455895	ENST00000504489	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000450793	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000538141	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000380180	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000318007	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000437932	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000317968	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000542407	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000508216	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000514743	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000380176	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000359265	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000512274	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000413080	ENST00000504489	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000450793	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000538141	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000380180	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000318007	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000437932	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000317968	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000542407	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000508216	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000514743	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000380176	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000359265	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000512274	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000341071	ENST00000504489	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000450793	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000538141	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000380180	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000318007	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000437932	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000317968	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000542407	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000508216	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000514743	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000380176	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000359265	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000512274	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000526031	ENST00000504489	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000450793	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000538141	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000380180	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000318007	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000437932	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000317968	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000542407	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000508216	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000514743	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000380176	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000359265	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000512274	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000419121	ENST00000504489	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000450793	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000538141	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000380180	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000318007	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000437932	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000317968	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000542407	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000508216	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000514743	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000380176	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000359265	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000512274	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000446293	ENST00000504489	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000450793	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000538141	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000380180	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000318007	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000437932	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000317968	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000542407	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000508216	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000514743	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000380176	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000359265	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000512274	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000463967	ENST00000504489	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000450793	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000538141	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000380180	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000318007	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000437932	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000317968	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000542407	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000508216	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000514743	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000380176	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000359265	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000512274	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+
intron-intron	ENST00000449308	ENST00000504489	BSDC1	chr1	32838444	+	PDLIM5	chr4	95498510	+

Top

FusionProtFeatures for BSDC1_PDLIM5

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BSDC1 Q9NW68	PDLIM5 Q96HC4
	May play an important role in the heart development byscaffolding PKC to the Z-disk region. May play a role in theregulation of cardiomyocyte expansion. Overexpression promotes thedevelopment of heart hypertrophy. Contributes to the regulation ofdendritic spine morphogenesis in neurons. May restrainpostsynaptic growth of excitatory synapses (By similarity).{ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for BSDC1_PDLIM5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BSDC1_PDLIM5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for BSDC1_PDLIM5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for BSDC1_PDLIM5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PDLIM5	C0005586	Bipolar Disorder	5	PSYGENET
Tgene	PDLIM5	C0036341	Schizophrenia	4	PSYGENET
Tgene	PDLIM5	C0041696	Unipolar Depression	4	PSYGENET
Tgene	PDLIM5	C1269683	Major Depressive Disorder	4	PSYGENET
Tgene	PDLIM5	C0151744	Myocardial Ischemia	1	CTD_human
Tgene	PDLIM5	C0221765	Chronic schizophrenia	1	PSYGENET

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 4486

FusionGeneSummary for BSDC1_PDLIM5

FusionProtFeatures for BSDC1_PDLIM5

FusionGeneSequence for BSDC1_PDLIM5

FusionGenePPI for BSDC1_PDLIM5

RelatedDrugs for BSDC1_PDLIM5

RelatedDiseases for BSDC1_PDLIM5