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Fusion gene ID: 4478 |
FusionGeneSummary for BRWD3_LRCH2 |
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Fusion gene information | Fusion gene name: BRWD3_LRCH2 | Fusion gene ID: 4478 | Hgene | Tgene | Gene symbol | BRWD3 | LRCH2 | Gene ID | 254065 | 57631 |
Gene name | bromodomain and WD repeat domain containing 3 | leucine rich repeats and calponin homology domain containing 2 | |
Synonyms | BRODL|MRX93 | dA204F4.4 | |
Cytomap | Xq21.1 | Xq23 | |
Type of gene | protein-coding | protein-coding | |
Description | bromodomain and WD repeat-containing protein 3bromo domain-containing protein disrupted in leukemianovel WD repeat domain protein | leucine-rich repeat and calponin homology domain-containing protein 2leucine-rich repeats and calponin homology (CH) domain containing 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q6RI45 | Q5VUJ6 | |
Ensembl transtripts involved in fusion gene | ENST00000373275, ENST00000473691, | ENST00000317135, ENST00000538422, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: BRWD3 [Title/Abstract] AND LRCH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CESC | TCGA-ZJ-AAX4-01A | BRWD3 | chrX | 80064038 | - | LRCH2 | chrX | 114391230 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000373275 | ENST00000317135 | BRWD3 | chrX | 80064038 | - | LRCH2 | chrX | 114391230 | - |
Frame-shift | ENST00000373275 | ENST00000538422 | BRWD3 | chrX | 80064038 | - | LRCH2 | chrX | 114391230 | - |
intron-3CDS | ENST00000473691 | ENST00000317135 | BRWD3 | chrX | 80064038 | - | LRCH2 | chrX | 114391230 | - |
intron-3CDS | ENST00000473691 | ENST00000538422 | BRWD3 | chrX | 80064038 | - | LRCH2 | chrX | 114391230 | - |
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FusionProtFeatures for BRWD3_LRCH2 |
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Hgene | Tgene |
BRWD3 | LRCH2 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BRWD3_LRCH2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BRWD3_LRCH2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BRWD3 | UBXN7, CSNK2A1, TERF1, CUL4B, LLGL2 | LRCH2 | RPAP2, RPAP3, COPS5, CRLF3, DOCK7, DOCK8, LRCH3, MOB1A, MOB1B, CEP250, ARPC3, RASSF10, FBXW11, SKP2, C6orf141, NPRL2, BPNT1, DOCK5, CARD8, CBY1, DCAF7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BRWD3_LRCH2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BRWD3_LRCH2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BRWD3 | C1970841 | MENTAL RETARDATION, X-LINKED 93 (disorder) | 1 | CTD_human;UNIPROT |