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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4478

FusionGeneSummary for BRWD3_LRCH2

check button Fusion gene summary
Fusion gene informationFusion gene name: BRWD3_LRCH2
Fusion gene ID: 4478
HgeneTgene
Gene symbol

BRWD3

LRCH2

Gene ID

254065

57631

Gene namebromodomain and WD repeat domain containing 3leucine rich repeats and calponin homology domain containing 2
SynonymsBRODL|MRX93dA204F4.4
Cytomap

Xq21.1

Xq23

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 3bromo domain-containing protein disrupted in leukemianovel WD repeat domain proteinleucine-rich repeat and calponin homology domain-containing protein 2leucine-rich repeats and calponin homology (CH) domain containing 2
Modification date2018052320180523
UniProtAcc

Q6RI45

Q5VUJ6

Ensembl transtripts involved in fusion geneENST00000373275, ENST00000473691, 
ENST00000317135, ENST00000538422, 
Fusion gene scores* DoF score3 X 2 X 3=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: BRWD3 [Title/Abstract] AND LRCH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-ZJ-AAX4-01ABRWD3chrX

80064038

-LRCH2chrX

114391230

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000373275ENST00000317135BRWD3chrX

80064038

-LRCH2chrX

114391230

-
Frame-shitENST00000373275ENST00000538422BRWD3chrX

80064038

-LRCH2chrX

114391230

-
intron-3CDSENST00000473691ENST00000317135BRWD3chrX

80064038

-LRCH2chrX

114391230

-
intron-3CDSENST00000473691ENST00000538422BRWD3chrX

80064038

-LRCH2chrX

114391230

-

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FusionProtFeatures for BRWD3_LRCH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRWD3

Q6RI45

LRCH2

Q5VUJ6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BRWD3_LRCH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRWD3_LRCH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRWD3UBXN7, CSNK2A1, TERF1, CUL4B, LLGL2LRCH2RPAP2, RPAP3, COPS5, CRLF3, DOCK7, DOCK8, LRCH3, MOB1A, MOB1B, CEP250, ARPC3, RASSF10, FBXW11, SKP2, C6orf141, NPRL2, BPNT1, DOCK5, CARD8, CBY1, DCAF7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRWD3_LRCH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BRWD3_LRCH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRWD3C1970841MENTAL RETARDATION, X-LINKED 93 (disorder)1CTD_human;UNIPROT