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Fusion gene ID: 4471 |
FusionGeneSummary for BRWD1_KIF2A |
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Fusion gene information | Fusion gene name: BRWD1_KIF2A | Fusion gene ID: 4471 | Hgene | Tgene | Gene symbol | BRWD1 | KIF2A | Gene ID | 54014 | 3796 |
Gene name | bromodomain and WD repeat domain containing 1 | kinesin family member 2A | |
Synonyms | C21orf107|DCAF19|N143|WDR9|WRD9 | CDCBM3|HK2|KIF2 | |
Cytomap | 21q22.2 | 5q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | bromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143 | kinesin-like protein KIF2AKinesin, heavy chain, 2kinesin heavy chain member 2Akinesin-2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NSI6 | O00139 | |
Ensembl transtripts involved in fusion gene | ENST00000333229, ENST00000342449, ENST00000380800, ENST00000341322, ENST00000470108, | ENST00000401507, ENST00000509663, ENST00000381103, ENST00000407818, ENST00000506857, | |
Fusion gene scores | * DoF score | 14 X 13 X 8=1456 | 3 X 3 X 3=27 |
# samples | 15 | 3 | |
** MAII score | log2(15/1456*10)=-3.27897594970282 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BRWD1 [Title/Abstract] AND KIF2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KIF2A | GO:0007052 | mitotic spindle organization | 18411309 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | KIRP | TCGA-B9-A5W9-01A | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000333229 | ENST00000401507 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000333229 | ENST00000509663 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000333229 | ENST00000381103 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000333229 | ENST00000407818 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-5UTR | ENST00000333229 | ENST00000506857 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
Frame-shift | ENST00000342449 | ENST00000401507 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000342449 | ENST00000509663 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000342449 | ENST00000381103 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000342449 | ENST00000407818 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-5UTR | ENST00000342449 | ENST00000506857 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
Frame-shift | ENST00000380800 | ENST00000401507 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000380800 | ENST00000509663 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000380800 | ENST00000381103 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000380800 | ENST00000407818 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-5UTR | ENST00000380800 | ENST00000506857 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
Frame-shift | ENST00000341322 | ENST00000401507 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000341322 | ENST00000509663 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000341322 | ENST00000381103 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-intron | ENST00000341322 | ENST00000407818 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5CDS-5UTR | ENST00000341322 | ENST00000506857 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5UTR-3CDS | ENST00000470108 | ENST00000401507 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5UTR-intron | ENST00000470108 | ENST00000509663 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5UTR-intron | ENST00000470108 | ENST00000381103 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5UTR-intron | ENST00000470108 | ENST00000407818 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
5UTR-5UTR | ENST00000470108 | ENST00000506857 | BRWD1 | chr21 | 40684767 | - | KIF2A | chr5 | 61642957 | + |
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FusionProtFeatures for BRWD1_KIF2A |
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Hgene | Tgene |
BRWD1 | KIF2A |
Plus end-directed microtubule-dependent motor requiredfor normal brain development. May regulate microtubule dynamicsduring axonal growth. Required for normal progression throughmitosis. Required for normal congress of chromosomes at themetaphase plate. Required for normal spindle dynamics duringmitosis. Promotes spindle turnover. Implicated in formation ofbipolar mitotic spindles. Has microtubule depolymerizationactivity. {ECO:0000269|PubMed:15843429,ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BRWD1_KIF2A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BRWD1_KIF2A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BRWD1 | DDB1, CUL4A, SMARCA4, UBXN7, CALM1, COPS5, APP, CUL3, RDX, APPL1, STAT3, MYO5C, MMGT1 | KIF2A | HDGF, NOTCH1, HIST3H3, STK4, WWOX, KIF2A, LARP1B, MRPL53, FAM13C, OBSL1, TSNAX, RPS6KB2, CHM, WBSCR22, NTRK1, EWSR1, PLK4, RPGRIP1L, CEP170, SPICE1, DCTN1, ACADVL, ALDH7A1, CSNK1E, GNS, ILK, TTK, KIF2C, LTN1, SKA1, MTRR, NFKBIL1, PRKCA, ROBO2, TIAL1, BAG6, UBL4A, EIF3F, TRAP1, CELF1, TRIOBP, EXOC3, MTF2, KIAA0556, ATP5S, UBR5, GET4, CEP192, WDR35, TMPRSS3, ZMYM1, SLC35E1, C2orf44, FIP1L1, CD99L2, GADD45GIP1, CEP170B, PES1, TP53, TYW3, RHPN1, KBTBD7, FGB, PTPN14 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BRWD1_KIF2A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BRWD1_KIF2A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BRWD1 | C0028960 | Oligospermia | 1 | CTD_human |
Tgene | KIF2A | C0025958 | Microcephaly | 1 | CTD_human |
Tgene | KIF2A | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | KIF2A | C1955869 | Malformations of Cortical Development | 1 | CTD_human |
Tgene | KIF2A | C3809414 | CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 3 | 1 | UNIPROT |