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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4471

FusionGeneSummary for BRWD1_KIF2A

check button Fusion gene summary
Fusion gene informationFusion gene name: BRWD1_KIF2A
Fusion gene ID: 4471
HgeneTgene
Gene symbol

BRWD1

KIF2A

Gene ID

54014

3796

Gene namebromodomain and WD repeat domain containing 1kinesin family member 2A
SynonymsC21orf107|DCAF19|N143|WDR9|WRD9CDCBM3|HK2|KIF2
Cytomap

21q22.2

5q12.1

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143kinesin-like protein KIF2AKinesin, heavy chain, 2kinesin heavy chain member 2Akinesin-2
Modification date2018052320180523
UniProtAcc

Q9NSI6

O00139

Ensembl transtripts involved in fusion geneENST00000333229, ENST00000342449, 
ENST00000380800, ENST00000341322, 
ENST00000470108, 
ENST00000401507, 
ENST00000509663, ENST00000381103, 
ENST00000407818, ENST00000506857, 
Fusion gene scores* DoF score14 X 13 X 8=14563 X 3 X 3=27
# samples 153
** MAII scorelog2(15/1456*10)=-3.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BRWD1 [Title/Abstract] AND KIF2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKIF2A

GO:0007052

mitotic spindle organization

18411309


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRPTCGA-B9-A5W9-01ABRWD1chr21

40684767

-KIF2Achr5

61642957

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000333229ENST00000401507BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000333229ENST00000509663BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000333229ENST00000381103BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000333229ENST00000407818BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-5UTRENST00000333229ENST00000506857BRWD1chr21

40684767

-KIF2Achr5

61642957

+
Frame-shiftENST00000342449ENST00000401507BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000342449ENST00000509663BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000342449ENST00000381103BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000342449ENST00000407818BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-5UTRENST00000342449ENST00000506857BRWD1chr21

40684767

-KIF2Achr5

61642957

+
Frame-shiftENST00000380800ENST00000401507BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000380800ENST00000509663BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000380800ENST00000381103BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000380800ENST00000407818BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-5UTRENST00000380800ENST00000506857BRWD1chr21

40684767

-KIF2Achr5

61642957

+
Frame-shiftENST00000341322ENST00000401507BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000341322ENST00000509663BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000341322ENST00000381103BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-intronENST00000341322ENST00000407818BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5CDS-5UTRENST00000341322ENST00000506857BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5UTR-3CDSENST00000470108ENST00000401507BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5UTR-intronENST00000470108ENST00000509663BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5UTR-intronENST00000470108ENST00000381103BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5UTR-intronENST00000470108ENST00000407818BRWD1chr21

40684767

-KIF2Achr5

61642957

+
5UTR-5UTRENST00000470108ENST00000506857BRWD1chr21

40684767

-KIF2Achr5

61642957

+

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FusionProtFeatures for BRWD1_KIF2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRWD1

Q9NSI6

KIF2A

O00139

Plus end-directed microtubule-dependent motor requiredfor normal brain development. May regulate microtubule dynamicsduring axonal growth. Required for normal progression throughmitosis. Required for normal congress of chromosomes at themetaphase plate. Required for normal spindle dynamics duringmitosis. Promotes spindle turnover. Implicated in formation ofbipolar mitotic spindles. Has microtubule depolymerizationactivity. {ECO:0000269|PubMed:15843429,ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BRWD1_KIF2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRWD1_KIF2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRWD1DDB1, CUL4A, SMARCA4, UBXN7, CALM1, COPS5, APP, CUL3, RDX, APPL1, STAT3, MYO5C, MMGT1KIF2AHDGF, NOTCH1, HIST3H3, STK4, WWOX, KIF2A, LARP1B, MRPL53, FAM13C, OBSL1, TSNAX, RPS6KB2, CHM, WBSCR22, NTRK1, EWSR1, PLK4, RPGRIP1L, CEP170, SPICE1, DCTN1, ACADVL, ALDH7A1, CSNK1E, GNS, ILK, TTK, KIF2C, LTN1, SKA1, MTRR, NFKBIL1, PRKCA, ROBO2, TIAL1, BAG6, UBL4A, EIF3F, TRAP1, CELF1, TRIOBP, EXOC3, MTF2, KIAA0556, ATP5S, UBR5, GET4, CEP192, WDR35, TMPRSS3, ZMYM1, SLC35E1, C2orf44, FIP1L1, CD99L2, GADD45GIP1, CEP170B, PES1, TP53, TYW3, RHPN1, KBTBD7, FGB, PTPN14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRWD1_KIF2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BRWD1_KIF2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRWD1C0028960Oligospermia1CTD_human
TgeneKIF2AC0025958Microcephaly1CTD_human
TgeneKIF2AC0036341Schizophrenia1PSYGENET
TgeneKIF2AC1955869Malformations of Cortical Development1CTD_human
TgeneKIF2AC3809414CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 31UNIPROT