![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 4461 |
FusionGeneSummary for BRSK1_HSPBP1 |
![]() |
Fusion gene information | Fusion gene name: BRSK1_HSPBP1 | Fusion gene ID: 4461 | Hgene | Tgene | Gene symbol | BRSK1 | HSPBP1 | Gene ID | 84446 | 23640 |
Gene name | BR serine/threonine kinase 1 | HSPA (Hsp70) binding protein 1 | |
Synonyms | hSAD1 | FES1 | |
Cytomap | 19q13.42 | 19q13.42 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase BRSK1BR serine/threonine-protein kinase 1SAD1 homologSAD1 kinaseSadB kinase short isoformbrain-selective kinase 1brain-specific serine/threonine-protein kinase 1protein kinase SAD1Aserine/threonine-protein kinase SA | hsp70-binding protein 1HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1heat shock protein-binding protein 1hsp70 interacting protein | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q8TDC3 | Q9NZL4 | |
Ensembl transtripts involved in fusion gene | ENST00000590333, ENST00000309383, ENST00000585418, ENST00000326848, ENST00000588584, | ENST00000255631, ENST00000433386, ENST00000376343, ENST00000587922, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 2=18 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BRSK1 [Title/Abstract] AND HSPBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BRSK1 | GO:0006468 | protein phosphorylation | 15150265 |
Hgene | BRSK1 | GO:0006974 | cellular response to DNA damage stimulus | 15150265 |
Hgene | BRSK1 | GO:0007095 | mitotic G2 DNA damage checkpoint | 15150265 |
Hgene | BRSK1 | GO:0009411 | response to UV | 15150265 |
Hgene | BRSK1 | GO:0010212 | response to ionizing radiation | 15150265 |
Tgene | HSPBP1 | GO:0031398 | positive regulation of protein ubiquitination | 16831871 |
Tgene | HSPBP1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 16831871 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AO-A03V-01A | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000590333 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000590333 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000590333 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000590333 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000309383 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000309383 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000309383 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000309383 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000585418 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000585418 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000585418 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000585418 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-3CDS | ENST00000326848 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-3CDS | ENST00000326848 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-intron | ENST00000326848 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-intron | ENST00000326848 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-3CDS | ENST00000588584 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-3CDS | ENST00000588584 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-intron | ENST00000588584 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-intron | ENST00000588584 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
Top |
FusionProtFeatures for BRSK1_HSPBP1 |
![]() |
Hgene | Tgene |
BRSK1 | HSPBP1 |
Serine/threonine-protein kinase that plays a key role inpolarization of neurons and centrosome duplication. PhosphorylatesCDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Followingphosphorylation and activation by STK11/LKB1, acts as a keyregulator of polarization of cortical neurons, probably bymediating phosphorylation of microtubule-associated proteins suchas MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuronpolarization by mediating phosphorylation of WEE1 at 'Ser-642' inpost-mitotic neurons, leading to down-regulate WEE1 activity inpolarized neurons. In neurons, localizes to synaptic vesicles andplays a role in neurotransmitter release, possibly byphosphorylating RIMS1. Also acts as a positive regulator ofcentrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocationof gamma-tubulin and its associated proteins to the centrosome.Involved in the UV-induced DNA damage checkpoint response,probably by inhibiting CDK1 activity through phosphorylation andactivation of WEE1, and inhibition of CDC25B and CDC25C.{ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265,ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}. | Inhibits HSPA1A chaperone activity by changing theconformation of the ATP-binding domain of HSPA1A and interferingwith ATP binding. Interferes with ubiquitination mediated by STUB1and inhibits chaperone-assisted degradation of immature CFTR.{ECO:0000269|PubMed:10786638, ECO:0000269|PubMed:12651857,ECO:0000269|PubMed:15215316, ECO:0000269|PubMed:9830037}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000309383 | + | 1 | 19 | 40_48 | 45 | 779 | Nucleotide binding | ATP |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000585418 | + | 1 | 10 | 40_48 | 45 | 344 | Nucleotide binding | ATP |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000590333 | + | 3 | 21 | 40_48 | 61 | 795 | Nucleotide binding | ATP |
Tgene | >HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | - | 4 | 9 | 223_262 | 213 | 360 | Repeat | Note=ARM 3 |
Tgene | >HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | - | 4 | 9 | 265_304 | 213 | 360 | Repeat | Note=ARM 4 |
Tgene | >HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | - | 3 | 8 | 223_262 | 213 | 360 | Repeat | Note=ARM 3 |
Tgene | >HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | - | 3 | 8 | 265_304 | 213 | 360 | Repeat | Note=ARM 4 |
Tgene | >HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | - | 2 | 7 | 223_262 | 213 | 360 | Repeat | Note=ARM 3 |
Tgene | >HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | - | 2 | 7 | 265_304 | 213 | 360 | Repeat | Note=ARM 4 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000309383 | + | 1 | 19 | 492_540 | 45 | 779 | Compositional bias | Note=Pro-rich |
Hgene | >BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000585418 | + | 1 | 10 | 492_540 | 45 | 344 | Compositional bias | Note=Pro-rich |
Hgene | >BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000590333 | + | 3 | 21 | 492_540 | 61 | 795 | Compositional bias | Note=Pro-rich |
Hgene | >BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000309383 | + | 1 | 19 | 314_356 | 45 | 779 | Domain | UBA |
Hgene | >BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000309383 | + | 1 | 19 | 34_285 | 45 | 779 | Domain | Protein kinase |
Hgene | >BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000585418 | + | 1 | 10 | 314_356 | 45 | 344 | Domain | UBA |
Hgene | >BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000585418 | + | 1 | 10 | 34_285 | 45 | 344 | Domain | Protein kinase |
Hgene | >BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000590333 | + | 3 | 21 | 314_356 | 61 | 795 | Domain | UBA |
Hgene | >BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000590333 | + | 3 | 21 | 34_285 | 61 | 795 | Domain | Protein kinase |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | - | 4 | 9 | 21_40 | 213 | 360 | Compositional bias | Note=Gly-rich |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | - | 3 | 8 | 21_40 | 213 | 360 | Compositional bias | Note=Gly-rich |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | - | 2 | 7 | 21_40 | 213 | 360 | Compositional bias | Note=Gly-rich |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | - | 4 | 9 | 135_177 | 213 | 360 | Repeat | Note=ARM 1 |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | - | 4 | 9 | 180_220 | 213 | 360 | Repeat | Note=ARM 2 |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | - | 3 | 8 | 135_177 | 213 | 360 | Repeat | Note=ARM 1 |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | - | 3 | 8 | 180_220 | 213 | 360 | Repeat | Note=ARM 2 |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | - | 2 | 7 | 135_177 | 213 | 360 | Repeat | Note=ARM 1 |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | - | 2 | 7 | 180_220 | 213 | 360 | Repeat | Note=ARM 2 |
Top |
FusionGeneSequence for BRSK1_HSPBP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for BRSK1_HSPBP1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BRSK1 | PRKAA1, HSD17B7, BRCA1, PAK1 | HSPBP1 | HSPA2, HSPA8, HSPA4, LRIF1, STUB1, HSPA1B, CRK, PGLYRP1, APP, HSPA9, HSPA5, METTL21A, ACTR2, AGFG1, ALAD, C14orf142, DBNL, DRAP1, ERO1L, FKBP10, GPN1, P3H1, LPP, LRSAM1, PPME1, PPP1R7, SURF2, TPRKB, OGT, SH3GLB1, TOM1L1, WDR4, ZPR1, FKBP8, HSF1, NOTCH2NL, HSPA6, EDRF1, NT5C2, ELF2, ASNS, CSTF1, FASN, GARS, HNRNPL, NUP50, NMD3, NTRK1, MED4, CLK1, EVC2, UBXN2B, CDC25C, FAN1, ELF1, ARMC1, C6orf106, ABL2, CCDC117, CLTCL1, HSF2, ZNF703, GAK, C21orf59, GMNN, TACC3, FLYWCH2, UBAP2, DNAJC13, HGS, FOXC1, SF1, MAP3K7, TAB1, DGCR14, DPH2, QSER1, RUFY1, ARFIP1, QRICH1, NEDD1, ZNF503, HMCES, SF3A3, MKLN1, EDEM3, FBXL13 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for BRSK1_HSPBP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for BRSK1_HSPBP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |