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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4461

FusionGeneSummary for BRSK1_HSPBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: BRSK1_HSPBP1
Fusion gene ID: 4461
HgeneTgene
Gene symbol

BRSK1

HSPBP1

Gene ID

84446

23640

Gene nameBR serine/threonine kinase 1HSPA (Hsp70) binding protein 1
SynonymshSAD1FES1
Cytomap

19q13.42

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase BRSK1BR serine/threonine-protein kinase 1SAD1 homologSAD1 kinaseSadB kinase short isoformbrain-selective kinase 1brain-specific serine/threonine-protein kinase 1protein kinase SAD1Aserine/threonine-protein kinase SAhsp70-binding protein 1HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1heat shock protein-binding protein 1hsp70 interacting protein
Modification date2018052320180527
UniProtAcc

Q8TDC3

Q9NZL4

Ensembl transtripts involved in fusion geneENST00000590333, ENST00000309383, 
ENST00000585418, ENST00000326848, 
ENST00000588584, 		ENST00000255631, 
ENST00000433386, ENST00000376343, 
ENST00000587922, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 2=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BRSK1 [Title/Abstract] AND HSPBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRSK1

GO:0006468

protein phosphorylation

15150265

HgeneBRSK1

GO:0006974

cellular response to DNA damage stimulus

15150265

HgeneBRSK1

GO:0007095

mitotic G2 DNA damage checkpoint

15150265

HgeneBRSK1

GO:0009411

response to UV

15150265

HgeneBRSK1

GO:0010212

response to ionizing radiation

15150265

TgeneHSPBP1

GO:0031398

positive regulation of protein ubiquitination

16831871

TgeneHSPBP1

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

16831871


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A03V-01ABRSK1chr19

55795946

+HSPBP1chr19

55777654

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000590333ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000590333ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000590333ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000590333ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000309383ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000309383ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000309383ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000309383ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000585418ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
In-frameENST00000585418ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000585418ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
5CDS-intronENST00000585418ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-3CDSENST00000326848ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-3CDSENST00000326848ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-intronENST00000326848ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-intronENST00000326848ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-3CDSENST00000588584ENST00000255631BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-3CDSENST00000588584ENST00000433386BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-intronENST00000588584ENST00000376343BRSK1chr19

55795946

+HSPBP1chr19

55777654

-
intron-intronENST00000588584ENST00000587922BRSK1chr19

55795946

+HSPBP1chr19

55777654

-

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FusionProtFeatures for BRSK1_HSPBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRSK1

Q8TDC3

HSPBP1

Q9NZL4

Serine/threonine-protein kinase that plays a key role inpolarization of neurons and centrosome duplication. PhosphorylatesCDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Followingphosphorylation and activation by STK11/LKB1, acts as a keyregulator of polarization of cortical neurons, probably bymediating phosphorylation of microtubule-associated proteins suchas MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuronpolarization by mediating phosphorylation of WEE1 at 'Ser-642' inpost-mitotic neurons, leading to down-regulate WEE1 activity inpolarized neurons. In neurons, localizes to synaptic vesicles andplays a role in neurotransmitter release, possibly byphosphorylating RIMS1. Also acts as a positive regulator ofcentrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocationof gamma-tubulin and its associated proteins to the centrosome.Involved in the UV-induced DNA damage checkpoint response,probably by inhibiting CDK1 activity through phosphorylation andactivation of WEE1, and inhibition of CDC25B and CDC25C.{ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265,ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}. Inhibits HSPA1A chaperone activity by changing theconformation of the ATP-binding domain of HSPA1A and interferingwith ATP binding. Interferes with ubiquitination mediated by STUB1and inhibits chaperone-assisted degradation of immature CFTR.{ECO:0000269|PubMed:10786638, ECO:0000269|PubMed:12651857,ECO:0000269|PubMed:15215316, ECO:0000269|PubMed:9830037}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRSK1chr19:55795946chr19:55777654ENST00000309383+11940_4845779Nucleotide bindingATP
HgeneBRSK1chr19:55795946chr19:55777654ENST00000585418+11040_4845344Nucleotide bindingATP
HgeneBRSK1chr19:55795946chr19:55777654ENST00000590333+32140_4861795Nucleotide bindingATP
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000255631-49223_262213360RepeatNote=ARM 3
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000255631-49265_304213360RepeatNote=ARM 4
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000433386-38223_262213360RepeatNote=ARM 3
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000433386-38265_304213360RepeatNote=ARM 4
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000587922-27223_262213360RepeatNote=ARM 3
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000587922-27265_304213360RepeatNote=ARM 4

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRSK1chr19:55795946chr19:55777654ENST00000309383+119492_54045779Compositional biasNote=Pro-rich
HgeneBRSK1chr19:55795946chr19:55777654ENST00000585418+110492_54045344Compositional biasNote=Pro-rich
HgeneBRSK1chr19:55795946chr19:55777654ENST00000590333+321492_54061795Compositional biasNote=Pro-rich
HgeneBRSK1chr19:55795946chr19:55777654ENST00000309383+119314_35645779DomainUBA
HgeneBRSK1chr19:55795946chr19:55777654ENST00000309383+11934_28545779DomainProtein kinase
HgeneBRSK1chr19:55795946chr19:55777654ENST00000585418+110314_35645344DomainUBA
HgeneBRSK1chr19:55795946chr19:55777654ENST00000585418+11034_28545344DomainProtein kinase
HgeneBRSK1chr19:55795946chr19:55777654ENST00000590333+321314_35661795DomainUBA
HgeneBRSK1chr19:55795946chr19:55777654ENST00000590333+32134_28561795DomainProtein kinase
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000255631-4921_40213360Compositional biasNote=Gly-rich
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000433386-3821_40213360Compositional biasNote=Gly-rich
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000587922-2721_40213360Compositional biasNote=Gly-rich
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000255631-49135_177213360RepeatNote=ARM 1
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000255631-49180_220213360RepeatNote=ARM 2
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000433386-38135_177213360RepeatNote=ARM 1
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000433386-38180_220213360RepeatNote=ARM 2
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000587922-27135_177213360RepeatNote=ARM 1
TgeneHSPBP1chr19:55795946chr19:55777654ENST00000587922-27180_220213360RepeatNote=ARM 2


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FusionGeneSequence for BRSK1_HSPBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRSK1_HSPBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRSK1PRKAA1, HSD17B7, BRCA1, PAK1HSPBP1HSPA2, HSPA8, HSPA4, LRIF1, STUB1, HSPA1B, CRK, PGLYRP1, APP, HSPA9, HSPA5, METTL21A, ACTR2, AGFG1, ALAD, C14orf142, DBNL, DRAP1, ERO1L, FKBP10, GPN1, P3H1, LPP, LRSAM1, PPME1, PPP1R7, SURF2, TPRKB, OGT, SH3GLB1, TOM1L1, WDR4, ZPR1, FKBP8, HSF1, NOTCH2NL, HSPA6, EDRF1, NT5C2, ELF2, ASNS, CSTF1, FASN, GARS, HNRNPL, NUP50, NMD3, NTRK1, MED4, CLK1, EVC2, UBXN2B, CDC25C, FAN1, ELF1, ARMC1, C6orf106, ABL2, CCDC117, CLTCL1, HSF2, ZNF703, GAK, C21orf59, GMNN, TACC3, FLYWCH2, UBAP2, DNAJC13, HGS, FOXC1, SF1, MAP3K7, TAB1, DGCR14, DPH2, QSER1, RUFY1, ARFIP1, QRICH1, NEDD1, ZNF503, HMCES, SF3A3, MKLN1, EDEM3, FBXL13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRSK1_HSPBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BRSK1_HSPBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource