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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4457

FusionGeneSummary for BRPF3_N4BP2L2

check button Fusion gene summary
Fusion gene informationFusion gene name: BRPF3_N4BP2L2
Fusion gene ID: 4457
HgeneTgene
Gene symbol

BRPF3

N4BP2L2

Gene ID

27154

10443

Gene namebromodomain and PHD finger containing 3NEDD4 binding protein 2 like 2
Synonyms-92M18.3|CG005|CG016|PFAAP5
Cytomap

6p21.31

13q13.1

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and PHD finger-containing protein 3NEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region
Modification date2018051920180519
UniProtAcc

Q9ULD4

Q92802

Ensembl transtripts involved in fusion geneENST00000357641, ENST00000339717, 
ENST00000534694, ENST00000543502, 
ENST00000443324, ENST00000534400, 
ENST00000380121, ENST00000504114, 
ENST00000357505, ENST00000399396, 
ENST00000446957, ENST00000267068, 
Fusion gene scores* DoF score4 X 4 X 4=645 X 6 X 1=30
# samples 418
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/30*10)=2.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BRPF3 [Title/Abstract] AND N4BP2L2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRPF3

GO:0043966

histone H3 acetylation

16387653


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE930492BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000357641ENST00000380121BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000357641ENST00000504114BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000357641ENST00000357505BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000357641ENST00000399396BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000357641ENST00000446957BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000357641ENST00000267068BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
Frame-shiftENST00000339717ENST00000380121BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000339717ENST00000504114BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000339717ENST00000357505BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000339717ENST00000399396BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000339717ENST00000446957BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000339717ENST00000267068BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
Frame-shiftENST00000534694ENST00000380121BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534694ENST00000504114BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534694ENST00000357505BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534694ENST00000399396BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534694ENST00000446957BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534694ENST00000267068BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
Frame-shiftENST00000543502ENST00000380121BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000543502ENST00000504114BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000543502ENST00000357505BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000543502ENST00000399396BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000543502ENST00000446957BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000543502ENST00000267068BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
Frame-shiftENST00000443324ENST00000380121BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000443324ENST00000504114BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000443324ENST00000357505BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000443324ENST00000399396BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000443324ENST00000446957BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000443324ENST00000267068BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
Frame-shiftENST00000534400ENST00000380121BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534400ENST00000504114BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534400ENST00000357505BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534400ENST00000399396BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534400ENST00000446957BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-
5CDS-intronENST00000534400ENST00000267068BRPF3chr6

36168351

-N4BP2L2chr13

33054769

-

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FusionProtFeatures for BRPF3_N4BP2L2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRPF3

Q9ULD4

N4BP2L2

Q92802

Component of the MOZ/MORF complex which has a histone H3acetyltransferase activity. {ECO:0000269|PubMed:16387653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BRPF3_N4BP2L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRPF3_N4BP2L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRPF3_N4BP2L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BRPF3_N4BP2L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneN4BP2L2C0037274Dermatologic disorders1CTD_human
TgeneN4BP2L2C0311375Arsenic Poisoning1CTD_human