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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 445

FusionGeneSummary for ACOXL_UNC5D

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOXL_UNC5D
Fusion gene ID: 445
HgeneTgene
Gene symbol

ACOXL

UNC5D

Gene ID

55289

137970

Gene nameacyl-CoA oxidase likeunc-5 netrin receptor D
Synonyms-PRO34692|Unc5h4
Cytomap

2q13

8p12

Type of geneprotein-codingprotein-coding
Descriptionacyl-coenzyme A oxidase-like proteinacyl-CoA oxidase-like proteinnetrin receptor UNC5Dnetrin receptor Unc5h4protein unc-5 homolog 4protein unc-5 homolog Dunc-5 homolog 4unc-5 homolog D
Modification date2018052320180329
UniProtAcc

Q9NUZ1

Q6UXZ4

Ensembl transtripts involved in fusion geneENST00000389811, ENST00000439055, 
ENST00000340561, ENST00000496981, 
ENST00000287272, ENST00000453357, 
ENST00000404895, ENST00000420357, 
ENST00000416672, ENST00000449677, 
Fusion gene scores* DoF score4 X 4 X 2=3213 X 7 X 6=546
# samples 314
** MAII scorelog2(3/32*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/546*10)=-1.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACOXL [Title/Abstract] AND UNC5D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUNC5D

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

26235030


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A3SJ-01AACOXLchr2

111850543

+UNC5Dchr8

35406810

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000389811ENST00000287272ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
Frame-shiftENST00000389811ENST00000453357ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
Frame-shiftENST00000389811ENST00000404895ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
Frame-shiftENST00000389811ENST00000420357ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
Frame-shiftENST00000389811ENST00000416672ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
5CDS-intronENST00000389811ENST00000449677ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
Frame-shiftENST00000439055ENST00000287272ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
Frame-shiftENST00000439055ENST00000453357ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
Frame-shiftENST00000439055ENST00000404895ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
Frame-shiftENST00000439055ENST00000420357ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
Frame-shiftENST00000439055ENST00000416672ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
5CDS-intronENST00000439055ENST00000449677ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000340561ENST00000287272ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000340561ENST00000453357ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000340561ENST00000404895ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000340561ENST00000420357ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000340561ENST00000416672ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-intronENST00000340561ENST00000449677ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000496981ENST00000287272ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000496981ENST00000453357ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000496981ENST00000404895ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000496981ENST00000420357ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-3CDSENST00000496981ENST00000416672ACOXLchr2

111850543

+UNC5Dchr8

35406810

+
intron-intronENST00000496981ENST00000449677ACOXLchr2

111850543

+UNC5Dchr8

35406810

+

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FusionProtFeatures for ACOXL_UNC5D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACOXL

Q9NUZ1

UNC5D

Q6UXZ4

Receptor for the netrin NTN4 that promotes neuronal cellsurvival (By similarity). Plays a role in cell-cell adhesion andcell guidance. Receptor for netrin involved in cell migration.Plays a role in axon guidance by mediating axon repulsion ofneuronal growth cones in the developing nervous system upon ligandbinding (By similarity). May play a role in apoptosis in responseto DNA damage (PubMed:24691657). It also acts as a dependencereceptor required for apoptosis induction when not associated withnetrin ligand (PubMed:24519068). Mediates cell-cell adhesion viaits interaction with FLRT3 on an adjacent cell (By similarity).{ECO:0000250|UniProtKB:Q8K1S2, ECO:0000305|PubMed:24519068,ECO:0000305|PubMed:24691657}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACOXL_UNC5D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACOXL_UNC5D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACOXLCUL1UNC5D


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACOXL_UNC5D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACOXL_UNC5D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACOXLC0023434Chronic Lymphocytic Leukemia1CTD_human