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Fusion gene ID: 444 |
FusionGeneSummary for ACOXL_SSB |
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Fusion gene information | Fusion gene name: ACOXL_SSB | Fusion gene ID: 444 | Hgene | Tgene | Gene symbol | ACOXL | SSB | Gene ID | 55289 | 6741 |
Gene name | acyl-CoA oxidase like | Sjogren syndrome antigen B | |
Synonyms | - | LARP3|La|La/SSB | |
Cytomap | 2q13 | 2q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | acyl-coenzyme A oxidase-like proteinacyl-CoA oxidase-like protein | lupus La proteinLa ribonucleoprotein domain family, member 3SS-BSS-B/La proteinautoantigen Lala autoantigenlupus La antigensjoegren syndrome type B antigen | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9NUZ1 | P05455 | |
Ensembl transtripts involved in fusion gene | ENST00000389811, ENST00000439055, ENST00000340561, ENST00000496981, | ENST00000260956, ENST00000409333, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 4 X 5=80 |
# samples | 3 | 5 | |
** MAII score | log2(3/32*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACOXL [Title/Abstract] AND SSB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SSB | GO:0075522 | IRES-dependent viral translational initiation | 12384597 |
Tgene | SSB | GO:1903608 | protein localization to cytoplasmic stress granule | 24965446 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-G2-AA3F-01A | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000389811 | ENST00000260956 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
5UTR-5UTR | ENST00000389811 | ENST00000409333 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
5UTR-5UTR | ENST00000439055 | ENST00000260956 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
5UTR-5UTR | ENST00000439055 | ENST00000409333 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
5UTR-5UTR | ENST00000340561 | ENST00000260956 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
5UTR-5UTR | ENST00000340561 | ENST00000409333 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
intron-5UTR | ENST00000496981 | ENST00000260956 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
intron-5UTR | ENST00000496981 | ENST00000409333 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
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FusionProtFeatures for ACOXL_SSB |
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Hgene | Tgene |
ACOXL | SSB |
Binds to the 3' poly(U) terminus of nascent RNApolymerase III transcripts, protecting them from exonucleasedigestion and facilitating their folding and maturation(PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3infection, binds to the viral internal ribosome entry site (IRES)and stimulates the IRES-mediated translation (PubMed:12384597).{ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590,ECO:0000269|PubMed:3192525}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACOXL_SSB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACOXL_SSB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACOXL | CUL1 | SSB | PUF60, PMVK, NCL, H2AFX, EMD, TADA2A, UBC, EIF2AK2, HDGF, ELAVL1, SIRT7, SPP1, CUL3, CUL4B, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, TROVE2, XIAP, APP, BARD1, PAXIP1, SMURF1, FN1, CSNK2A1, IFIT3, IL7R, CBX6, GZMH, CSNK2B, ARFGEF1, SOX2, HMGA1, SPIB, TARDBP, CTTN, KARS, PPP2CA, ANP32A, DNM1L, NPLOC4, RABGGTA, UBA2, VBP1, LIN28A, HUWE1, SUZ12, RNF2, BMI1, SURF2, HNRNPA1, ANKMY2, EEF1A1, LARP7, NAT10, NIFK, POLE, POLR1C, RBM34, SMC3, ABI1, CDC37, DDX27, DDX54, EXOSC10, MYH9, NOP56, PUS7, RPL31, RPS3, SAFB2, SNRPA1, SNRPB2, TPM2, TRMT6, WDR74, ZNF593, NTRK1, EWSR1, CCNA2, PRKCI, SNCA, TBC1D9, TRIM33, MRPL1, ARMC6, ATOH1, EGFR, FAN1, PTP4A1, TRMT2A, HIST1H1E, PRPF31, CYLD, SOD1, VDAC1, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACOXL_SSB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACOXL_SSB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACOXL | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |