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Fusion gene ID: 4430 |
FusionGeneSummary for BRE_PRKCE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BRE_PRKCE | Fusion gene ID: 4430 | Hgene | Tgene | Gene symbol | BRE | PRKCE | Gene ID | 5581 |
| Gene name | protein kinase C epsilon | ||
| Synonyms | PKCE|nPKC-epsilon | ||
| Cytomap | 2p21 | ||
| Type of gene | protein-coding | ||
| Description | protein kinase C epsilon type | ||
| Modification date | 20180523 | ||
| UniProtAcc | Q02156 | ||
| Ensembl transtripts involved in fusion gene | ENST00000344773, ENST00000379624, ENST00000342045, ENST00000379632, ENST00000361704, ENST00000603461, | ENST00000306156, ENST00000467135, ENST00000394874, | |
| Fusion gene scores | * DoF score | 7 X 7 X 6=294 | 8 X 9 X 4=288 |
| # samples | 9 | 10 | |
| ** MAII score | log2(9/294*10)=-1.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BRE [Title/Abstract] AND PRKCE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRKCE | GO:0006468 | protein phosphorylation | 18556656 |
| Tgene | PRKCE | GO:0018105 | peptidyl-serine phosphorylation | 15695813 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-C8-A134-01A | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344773 | ENST00000306156 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000344773 | ENST00000467135 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000344773 | ENST00000394874 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| In-frame | ENST00000379624 | ENST00000306156 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000379624 | ENST00000467135 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000379624 | ENST00000394874 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| In-frame | ENST00000342045 | ENST00000306156 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000342045 | ENST00000467135 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000342045 | ENST00000394874 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| In-frame | ENST00000379632 | ENST00000306156 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000379632 | ENST00000467135 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000379632 | ENST00000394874 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| In-frame | ENST00000361704 | ENST00000306156 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000361704 | ENST00000467135 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| 5CDS-intron | ENST00000361704 | ENST00000394874 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| intron-3CDS | ENST00000603461 | ENST00000306156 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| intron-intron | ENST00000603461 | ENST00000467135 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
| intron-intron | ENST00000603461 | ENST00000394874 | BRE | chr2 | 28268666 | + | PRKCE | chr2 | 46313347 | + |
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FusionProtFeatures for BRE_PRKCE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BRE | PRKCE |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Calcium-independent, phospholipid- and diacylglycerol(DAG)-dependent serine/threonine-protein kinase that playsessential roles in the regulation of multiple cellular processeslinked to cytoskeletal proteins, such as cell adhesion, motility,migration and cell cycle, functions in neuron growth and ionchannel regulation, and is involved in immune response, cancercell invasion and regulation of apoptosis. Mediates cell adhesionto the extracellular matrix via integrin-dependent signaling, bymediating angiotensin-2-induced activation of integrin beta-1(ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, whichphosphorylates and activates PTK2/FAK, leading to the spread ofcardiomyocytes. Involved in the control of the directionaltransport of ITGB1 in mesenchymal cells by phosphorylatingvimentin (VIM), an intermediate filament (IF) protein. Inepithelial cells, associates with and phosphorylates keratin-8(KRT8), which induces targeting of desmoplakin at desmosomes andregulates cell-cell contact. Phosphorylates IQGAP1, which binds toCDC42, mediating epithelial cell-cell detachment prior tomigration. In HeLa cells, contributes to hepatocyte growth factor(HGF)-induced cell migration, and in human corneal epithelialcells, plays a critical role in wound healing after activation byHGF. During cytokinesis, forms a complex with YWHAB, which iscrucial for daughter cell separation, and facilitates abscissionby a mechanism which may implicate the regulation of RHOA. Incardiac myocytes, regulates myofilament function and excitationcoupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-inducedcardiomyocyte hypertrophy, mediates activation of PTK2/FAK, whichis critical for cardiomyocyte survival and regulation of sarcomerelength. Plays a role in the pathogenesis of dilated cardiomyopathyvia persistent phosphorylation of troponin I (TNNI3). Involved innerve growth factor (NFG)-induced neurite outgrowth and neuronmorphological change independently of its kinase activity, byinhibition of RHOA pathway, activation of CDC42 and cytoskeletalrearrangement. May be involved in presynaptic facilitation bymediating phorbol ester-induced synaptic potentiation.Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2(GABRG2), which reduces the response of GABA receptors to ethanoland benzodiazepines and may mediate acute tolerance to theintoxicating effects of ethanol. Upon PMA treatment,phosphorylates the capsaicin- and heat-activated cation channelTRPV1, which is required for bradykinin-induced sensitization ofthe heat response in nociceptive neurons. Is able to form acomplex with PDLIM5 and N-type calcium channel, and may enhancechannel activities and potentiates fast synaptic transmission byphosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2).In prostate cancer cells, interacts with and phosphorylates STAT3,which increases DNA-binding and transcriptional activity of STAT3and seems to be essential for prostate cancer cell invasion.Downstream of TLR4, plays an important role in thelipopolysaccharide (LPS)-induced immune response byphosphorylating and activating TICAM2/TRAM, which in turnactivates the transcription factor IRF3 and subsequent cytokinesproduction. In differentiating erythroid progenitors, is regulatedby EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation ofthe insulin-induced phosphorylation and activation of AKT1.{ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067,ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566,ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639,ECO:0000269|PubMed:17875724}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BRE | chr2:28268666 | chr2:46313347 | ENST00000342045 | + | 7 | 13 | 30_147 | 190 | 384 | Region | Note=UEV-like 1 |
| Hgene | BRE | chr2:28268666 | chr2:46313347 | ENST00000344773 | + | 6 | 13 | 30_147 | 190 | 528 | Region | Note=UEV-like 1 |
| Hgene | BRE | chr2:28268666 | chr2:46313347 | ENST00000361704 | + | 6 | 13 | 30_147 | 190 | 511 | Region | Note=UEV-like 1 |
| Hgene | BRE | chr2:28268666 | chr2:46313347 | ENST00000379624 | + | 6 | 12 | 30_147 | 190 | 384 | Region | Note=UEV-like 1 |
| Hgene | BRE | chr2:28268666 | chr2:46313347 | ENST00000379632 | + | 7 | 14 | 30_147 | 190 | 511 | Region | Note=UEV-like 1 |
| Tgene | >PRKCE | chr2:28268666 | chr2:46313347 | ENST00000306156 | + | 9 | 15 | 669_737 | 479 | 738 | Domain | Note=AGC-kinase C-terminal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >BRE | chr2:28268666 | chr2:46313347 | ENST00000342045 | + | 7 | 13 | 275_364 | 190 | 384 | Region | Note=UEV-like 2 |
| Hgene | >BRE | chr2:28268666 | chr2:46313347 | ENST00000344773 | + | 6 | 13 | 275_364 | 190 | 528 | Region | Note=UEV-like 2 |
| Hgene | >BRE | chr2:28268666 | chr2:46313347 | ENST00000361704 | + | 6 | 13 | 275_364 | 190 | 511 | Region | Note=UEV-like 2 |
| Hgene | >BRE | chr2:28268666 | chr2:46313347 | ENST00000379624 | + | 6 | 12 | 275_364 | 190 | 384 | Region | Note=UEV-like 2 |
| Hgene | >BRE | chr2:28268666 | chr2:46313347 | ENST00000379632 | + | 7 | 14 | 275_364 | 190 | 511 | Region | Note=UEV-like 2 |
| Tgene | PRKCE | chr2:28268666 | chr2:46313347 | ENST00000306156 | + | 9 | 15 | 1_99 | 479 | 738 | Domain | C2 |
| Tgene | PRKCE | chr2:28268666 | chr2:46313347 | ENST00000306156 | + | 9 | 15 | 408_668 | 479 | 738 | Domain | Protein kinase |
| Tgene | PRKCE | chr2:28268666 | chr2:46313347 | ENST00000306156 | + | 9 | 15 | 414_422 | 479 | 738 | Nucleotide binding | ATP |
| Tgene | PRKCE | chr2:28268666 | chr2:46313347 | ENST00000306156 | + | 9 | 15 | 169_220 | 479 | 738 | Zinc finger | Phorbol-ester/DAG-type 1 |
| Tgene | PRKCE | chr2:28268666 | chr2:46313347 | ENST00000306156 | + | 9 | 15 | 242_292 | 479 | 738 | Zinc finger | Phorbol-ester/DAG-type 2 |
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FusionGeneSequence for BRE_PRKCE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BRE_ENST00000344773_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_449aa MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR >In-frame_BRE_ENST00000379624_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_449aa MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR >In-frame_BRE_ENST00000342045_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_449aa MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR >In-frame_BRE_ENST00000379632_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_449aa MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR >In-frame_BRE_ENST00000361704_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_449aa MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BRE_ENST00000344773_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_1347nt ATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGAT GCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATA CCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCAATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCT GAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCTCCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTT GTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGGAGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAG TATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACAACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGAT TTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCTTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAG CGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATC TACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAGAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTG AATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGAC TGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTGGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATC CTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGC CTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCAAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAG AAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTC >In-frame_BRE_ENST00000379624_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_1347nt ATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGAT GCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATA CCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCAATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCT GAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCTCCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTT GTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGGAGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAG TATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACAACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGAT TTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCTTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAG CGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATC TACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAGAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTG AATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGAC TGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTGGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATC CTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGC CTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCAAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAG AAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTC >In-frame_BRE_ENST00000342045_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_1347nt ATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGAT GCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATA CCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCAATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCT GAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCTCCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTT GTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGGAGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAG TATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACAACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGAT TTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCTTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAG CGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATC TACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAGAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTG AATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGAC TGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTGGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATC CTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGC CTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCAAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAG AAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTC >In-frame_BRE_ENST00000379632_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_1347nt ATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGAT GCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATA CCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCAATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCT GAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCTCCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTT GTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGGAGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAG TATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACAACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGAT TTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCTTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAG CGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATC TACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAGAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTG AATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGAC TGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTGGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATC CTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGC CTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCAAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAG AAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTC >In-frame_BRE_ENST00000361704_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_1347nt ATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGAT GCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATA CCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCAATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCT GAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCTCCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTT GTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGGAGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAG TATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACAACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGAT TTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCTTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAG CGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATC TACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAGAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTG AATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGAC TGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTGGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATC CTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGC CTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCAAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAG AAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BRE_ENST00000344773_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_4594nt GAGTGCGCACGCATCCTGCCCGCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCG GTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTC TCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGC ACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCAAT GCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCTCC TGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGGAG AGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACAAC TGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCTTT TTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCT GCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAGAA GGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTAC ATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTGGA CAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAG GCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCAAG CAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGA GACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAGCAATTGTAAAGCAGATCAACCAGGAG GAATTCAAAGGTTTCTCCTACTTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGACTTTGCCGATGCTGCAAGAAGGGGTGC AGAGAAGACTCCTGTGTTGGAGACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCCAGTCCCATGTCCACTGTCTATTTATT GCATTCCCTTGCCCCAGGCCACCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTTCTTGTCTCACCAGTAATGCAGACTCA TTGGGTCAGCAATTAGCTGTATACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCCTCAGGGGCTCCTGGCAGTGAAGCAAC TTCAGTTCTTTTACTGCAAAGAACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTGCTATCGGACACAGATCCTGATCCCTC TTGCTTCTTTTCCCTCCTGCACCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACTGGTGCTTCTCCGCACACACGAGGGAG GGCGCCCTTGAGGCATGCCCTCTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGTTGGTTTGCTCTGGAATGGCTAACTCT TGCCTGCTTTGGTTTTAGCTTTTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAAATCCTCTTTGTGGAAAAAGAAACAGG GTTTTGAACTCTGTTAACATTTGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGAGATGAGTTCCAGTCTGAATACAGGTA GATATTAAAGGGCTAATAAAAAATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGAGTGACACATGAGAGCTGTATGAATTG AGAGAAAAGGCAACAAGTAGCATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGACCCTGGGGTTCCAACAAAGCTCAGCTC CCAGATTCTCTTTCCAGTTTCATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAGTGTGTTATTTTTGCGCACTTATACAA AATGGTAGTACTACTGTGTTGTGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATCTGCTTTTGGAATAAGCAGAATGAGGC TAAACATGGGTTATACAAAGGGTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATGTCGCAAGATGTACTCAGTTTTGTTTC TGTGTGACATGCAATGGCAACTCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAGATATGCTAACAGTGTTATTCTTTCAT TTCCAAGGGTTCTCTGTGGCTTTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTACTGAACTGATTTAGCAGGGAATGGAAT CCATTCCAACTATTGCACGTGGATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAAAGTGGCACTAATGAAGCTTTTGCCTT TTGTACATTTGAGATTTTTGTATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCATATAGAGGTATCAACTGCTGCATGTTC AGGCATATTATAAAACTTTAGTCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCTGTAAGTCTATTGGTTCAAGTTACCGA GAGATAGGTGTGTTCCTTTATGGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATTTCATTTTGGTTTATTTTAAAAGATGT AAACATATATTAAGCTATATTAAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATAGAGATGGGGGAGAGAAAGGAATGTTT TTGATGGTGGTTTCAAAGCTCGGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATATTTGCATCTGGCTGGTCATAGCCTTT GTTACTAATGATGACATTCAGTTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATTATCTGTTCTTAAGATAATTGCAAATA TTAAATATTATGATATATCAATTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGATTAATTTAATTTATCTTCGGTAACTTG ACATTCTGGAGAGAGACTATCTTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCATCATCTCATTTTTTAGGAAGACATGA TAATACTGCCCATCATATTCATGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAAACTTTGGACAACCAAGCAAGCTCTAA CCGCAATGCCAGATGGCCTTGTCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTTCCTACAGGACAACTGGCAAGTTTGCT GGGAAGTCAAATAATACATTCCACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGGGCCCTTTTCAGCACCCAAAGCTGGGC TGGCTGGGATGCCTCTGGCTGGTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTATAGAAAAAGGCTTGCGTGTTCGTTGA GTAATCATTGTTTCATTTTCATTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTGCCAGTTTTTTCTGATCTTTCCAGCCC CACCCCCTTTCTCTTTCTCTCTCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAAGCCAAAAAATATATGAAGGATAGCTG TTCTTCTGTGTTCTCTCATTATGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGGTGAAAAAACAATGCATTCTTGCTTTA AAAAAAAAAAAGAAGGCTAAAAAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAACTGTAAAATGTATTCAATTTTAGGAT TTTTTTTTTTTGTATTGTGATGCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAATCTCTTGCCATTCATTAGTGTTATTTC ATTGTAAACGTTATTGTGCCAAATGTACTGTATTCAAAAGGATGTGAATGTGTATTGTTTCAGAACCTAATAAATACAATGACGTTAAGT >In-frame_BRE_ENST00000379624_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_4573nt GCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTC CAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTG GTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCC AACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCAATGCCCAATACCCAGAACTGCCT CCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCTCCTGGAATCCTTCAAATCCTGAA TGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGGAGAGCTCCCGCCTCATGTTTGAA TACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACAACTGGACTGGTGAATTTTCAGCT CGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCTTTTTCGTCATGGAATATGTAAAT GGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTC ATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAGAAGGTCACTGCAAGCTGGCTGAC TTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAG GAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTGGACAGCCTCCCTTTGAGGCCGAC AATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCT TTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCAAGCAGCACCCATTCTTCAAAGAG ATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAA GACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAGCAATTGTAAAGCAGATCAACCAGGAGGAATTCAAAGGTTTCTCCTAC TTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGACTTTGCCGATGCTGCAAGAAGGGGTGCAGAGAAGACTCCTGTGTTGGA GACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCCAGTCCCATGTCCACTGTCTATTTATTGCATTCCCTTGCCCCAGGCCA CCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTTCTTGTCTCACCAGTAATGCAGACTCATTGGGTCAGCAATTAGCTGTA TACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCCTCAGGGGCTCCTGGCAGTGAAGCAACTTCAGTTCTTTTACTGCAAAG AACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTGCTATCGGACACAGATCCTGATCCCTCTTGCTTCTTTTCCCTCCTGCA CCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACTGGTGCTTCTCCGCACACACGAGGGAGGGCGCCCTTGAGGCATGCCCT CTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGTTGGTTTGCTCTGGAATGGCTAACTCTTGCCTGCTTTGGTTTTAGCTT TTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAAATCCTCTTTGTGGAAAAAGAAACAGGGTTTTGAACTCTGTTAACATT TGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGAGATGAGTTCCAGTCTGAATACAGGTAGATATTAAAGGGCTAATAAAA AATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGAGTGACACATGAGAGCTGTATGAATTGAGAGAAAAGGCAACAAGTAGC ATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGACCCTGGGGTTCCAACAAAGCTCAGCTCCCAGATTCTCTTTCCAGTTTC ATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAGTGTGTTATTTTTGCGCACTTATACAAAATGGTAGTACTACTGTGTTG TGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATCTGCTTTTGGAATAAGCAGAATGAGGCTAAACATGGGTTATACAAAGG GTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATGTCGCAAGATGTACTCAGTTTTGTTTCTGTGTGACATGCAATGGCAAC TCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAGATATGCTAACAGTGTTATTCTTTCATTTCCAAGGGTTCTCTGTGGCT TTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTACTGAACTGATTTAGCAGGGAATGGAATCCATTCCAACTATTGCACGTG GATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAAAGTGGCACTAATGAAGCTTTTGCCTTTTGTACATTTGAGATTTTTGT ATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCATATAGAGGTATCAACTGCTGCATGTTCAGGCATATTATAAAACTTTAG TCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCTGTAAGTCTATTGGTTCAAGTTACCGAGAGATAGGTGTGTTCCTTTAT GGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATTTCATTTTGGTTTATTTTAAAAGATGTAAACATATATTAAGCTATATT AAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATAGAGATGGGGGAGAGAAAGGAATGTTTTTGATGGTGGTTTCAAAGCTC GGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATATTTGCATCTGGCTGGTCATAGCCTTTGTTACTAATGATGACATTCAG TTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATTATCTGTTCTTAAGATAATTGCAAATATTAAATATTATGATATATCAA TTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGATTAATTTAATTTATCTTCGGTAACTTGACATTCTGGAGAGAGACTATC TTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCATCATCTCATTTTTTAGGAAGACATGATAATACTGCCCATCATATTCA TGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAAACTTTGGACAACCAAGCAAGCTCTAACCGCAATGCCAGATGGCCTTG TCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTTCCTACAGGACAACTGGCAAGTTTGCTGGGAAGTCAAATAATACATTC CACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGGGCCCTTTTCAGCACCCAAAGCTGGGCTGGCTGGGATGCCTCTGGCTG GTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTATAGAAAAAGGCTTGCGTGTTCGTTGAGTAATCATTGTTTCATTTTCA TTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTGCCAGTTTTTTCTGATCTTTCCAGCCCCACCCCCTTTCTCTTTCTCTC TCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAAGCCAAAAAATATATGAAGGATAGCTGTTCTTCTGTGTTCTCTCATTA TGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGGTGAAAAAACAATGCATTCTTGCTTTAAAAAAAAAAAAGAAGGCTAAA AAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAACTGTAAAATGTATTCAATTTTAGGATTTTTTTTTTTTGTATTGTGAT GCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAATCTCTTGCCATTCATTAGTGTTATTTCATTGTAAACGTTATTGTGCCA >In-frame_BRE_ENST00000342045_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_4597nt GGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAA ACACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATG CTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGC TGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTC AATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCC TCCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGG GAGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAAC AACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTC TTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTAT GCTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCA GAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGAC TACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCT GGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAG GAGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATC AAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAA AGAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAGCAATTGTAAAGCAGATCAACCAG GAGGAATTCAAAGGTTTCTCCTACTTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGACTTTGCCGATGCTGCAAGAAGGGG TGCAGAGAAGACTCCTGTGTTGGAGACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCCAGTCCCATGTCCACTGTCTATTT ATTGCATTCCCTTGCCCCAGGCCACCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTTCTTGTCTCACCAGTAATGCAGAC TCATTGGGTCAGCAATTAGCTGTATACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCCTCAGGGGCTCCTGGCAGTGAAGC AACTTCAGTTCTTTTACTGCAAAGAACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTGCTATCGGACACAGATCCTGATCC CTCTTGCTTCTTTTCCCTCCTGCACCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACTGGTGCTTCTCCGCACACACGAGG GAGGGCGCCCTTGAGGCATGCCCTCTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGTTGGTTTGCTCTGGAATGGCTAAC TCTTGCCTGCTTTGGTTTTAGCTTTTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAAATCCTCTTTGTGGAAAAAGAAAC AGGGTTTTGAACTCTGTTAACATTTGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGAGATGAGTTCCAGTCTGAATACAG GTAGATATTAAAGGGCTAATAAAAAATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGAGTGACACATGAGAGCTGTATGAA TTGAGAGAAAAGGCAACAAGTAGCATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGACCCTGGGGTTCCAACAAAGCTCAG CTCCCAGATTCTCTTTCCAGTTTCATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAGTGTGTTATTTTTGCGCACTTATA CAAAATGGTAGTACTACTGTGTTGTGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATCTGCTTTTGGAATAAGCAGAATGA GGCTAAACATGGGTTATACAAAGGGTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATGTCGCAAGATGTACTCAGTTTTGT TTCTGTGTGACATGCAATGGCAACTCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAGATATGCTAACAGTGTTATTCTTT CATTTCCAAGGGTTCTCTGTGGCTTTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTACTGAACTGATTTAGCAGGGAATGG AATCCATTCCAACTATTGCACGTGGATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAAAGTGGCACTAATGAAGCTTTTGC CTTTTGTACATTTGAGATTTTTGTATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCATATAGAGGTATCAACTGCTGCATG TTCAGGCATATTATAAAACTTTAGTCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCTGTAAGTCTATTGGTTCAAGTTAC CGAGAGATAGGTGTGTTCCTTTATGGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATTTCATTTTGGTTTATTTTAAAAGA TGTAAACATATATTAAGCTATATTAAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATAGAGATGGGGGAGAGAAAGGAATG TTTTTGATGGTGGTTTCAAAGCTCGGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATATTTGCATCTGGCTGGTCATAGCC TTTGTTACTAATGATGACATTCAGTTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATTATCTGTTCTTAAGATAATTGCAA ATATTAAATATTATGATATATCAATTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGATTAATTTAATTTATCTTCGGTAAC TTGACATTCTGGAGAGAGACTATCTTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCATCATCTCATTTTTTAGGAAGACA TGATAATACTGCCCATCATATTCATGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAAACTTTGGACAACCAAGCAAGCTC TAACCGCAATGCCAGATGGCCTTGTCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTTCCTACAGGACAACTGGCAAGTTT GCTGGGAAGTCAAATAATACATTCCACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGGGCCCTTTTCAGCACCCAAAGCTG GGCTGGCTGGGATGCCTCTGGCTGGTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTATAGAAAAAGGCTTGCGTGTTCGT TGAGTAATCATTGTTTCATTTTCATTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTGCCAGTTTTTTCTGATCTTTCCAG CCCCACCCCCTTTCTCTTTCTCTCTCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAAGCCAAAAAATATATGAAGGATAG CTGTTCTTCTGTGTTCTCTCATTATGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGGTGAAAAAACAATGCATTCTTGCT TTAAAAAAAAAAAAGAAGGCTAAAAAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAACTGTAAAATGTATTCAATTTTAG GATTTTTTTTTTTTGTATTGTGATGCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAATCTCTTGCCATTCATTAGTGTTAT TTCATTGTAAACGTTATTGTGCCAAATGTACTGTATTCAAAAGGATGTGAATGTGTATTGTTTCAGAACCTAATAAATACAATGACGTTA >In-frame_BRE_ENST00000379632_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_4596nt GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAAA CACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGC TCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCT GCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCA ATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCT CCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGG AGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACA ACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCT TTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATG CTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAG AAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACT ACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTG GACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGG AGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCA AGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAA GAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAGCAATTGTAAAGCAGATCAACCAGG AGGAATTCAAAGGTTTCTCCTACTTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGACTTTGCCGATGCTGCAAGAAGGGGT GCAGAGAAGACTCCTGTGTTGGAGACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCCAGTCCCATGTCCACTGTCTATTTA TTGCATTCCCTTGCCCCAGGCCACCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTTCTTGTCTCACCAGTAATGCAGACT CATTGGGTCAGCAATTAGCTGTATACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCCTCAGGGGCTCCTGGCAGTGAAGCA ACTTCAGTTCTTTTACTGCAAAGAACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTGCTATCGGACACAGATCCTGATCCC TCTTGCTTCTTTTCCCTCCTGCACCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACTGGTGCTTCTCCGCACACACGAGGG AGGGCGCCCTTGAGGCATGCCCTCTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGTTGGTTTGCTCTGGAATGGCTAACT CTTGCCTGCTTTGGTTTTAGCTTTTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAAATCCTCTTTGTGGAAAAAGAAACA GGGTTTTGAACTCTGTTAACATTTGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGAGATGAGTTCCAGTCTGAATACAGG TAGATATTAAAGGGCTAATAAAAAATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGAGTGACACATGAGAGCTGTATGAAT TGAGAGAAAAGGCAACAAGTAGCATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGACCCTGGGGTTCCAACAAAGCTCAGC TCCCAGATTCTCTTTCCAGTTTCATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAGTGTGTTATTTTTGCGCACTTATAC AAAATGGTAGTACTACTGTGTTGTGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATCTGCTTTTGGAATAAGCAGAATGAG GCTAAACATGGGTTATACAAAGGGTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATGTCGCAAGATGTACTCAGTTTTGTT TCTGTGTGACATGCAATGGCAACTCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAGATATGCTAACAGTGTTATTCTTTC ATTTCCAAGGGTTCTCTGTGGCTTTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTACTGAACTGATTTAGCAGGGAATGGA ATCCATTCCAACTATTGCACGTGGATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAAAGTGGCACTAATGAAGCTTTTGCC TTTTGTACATTTGAGATTTTTGTATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCATATAGAGGTATCAACTGCTGCATGT TCAGGCATATTATAAAACTTTAGTCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCTGTAAGTCTATTGGTTCAAGTTACC GAGAGATAGGTGTGTTCCTTTATGGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATTTCATTTTGGTTTATTTTAAAAGAT GTAAACATATATTAAGCTATATTAAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATAGAGATGGGGGAGAGAAAGGAATGT TTTTGATGGTGGTTTCAAAGCTCGGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATATTTGCATCTGGCTGGTCATAGCCT TTGTTACTAATGATGACATTCAGTTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATTATCTGTTCTTAAGATAATTGCAAA TATTAAATATTATGATATATCAATTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGATTAATTTAATTTATCTTCGGTAACT TGACATTCTGGAGAGAGACTATCTTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCATCATCTCATTTTTTAGGAAGACAT GATAATACTGCCCATCATATTCATGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAAACTTTGGACAACCAAGCAAGCTCT AACCGCAATGCCAGATGGCCTTGTCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTTCCTACAGGACAACTGGCAAGTTTG CTGGGAAGTCAAATAATACATTCCACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGGGCCCTTTTCAGCACCCAAAGCTGG GCTGGCTGGGATGCCTCTGGCTGGTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTATAGAAAAAGGCTTGCGTGTTCGTT GAGTAATCATTGTTTCATTTTCATTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTGCCAGTTTTTTCTGATCTTTCCAGC CCCACCCCCTTTCTCTTTCTCTCTCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAAGCCAAAAAATATATGAAGGATAGC TGTTCTTCTGTGTTCTCTCATTATGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGGTGAAAAAACAATGCATTCTTGCTT TAAAAAAAAAAAAGAAGGCTAAAAAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAACTGTAAAATGTATTCAATTTTAGG ATTTTTTTTTTTTGTATTGTGATGCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAATCTCTTGCCATTCATTAGTGTTATT TCATTGTAAACGTTATTGTGCCAAATGTACTGTATTCAAAAGGATGTGAATGTGTATTGTTTCAGAACCTAATAAATACAATGACGTTAA >In-frame_BRE_ENST00000361704_chr2_28268666_+_PRKCE_ENST00000306156_chr2_46313347_+_4530nt GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGG CCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGA GGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGA CATTAAAGTGGGATATCATTTTCAATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACC CCTCAGCTTTGCAGAATCTTGCCTCCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACC AATTCCAATGTAGCCGCCTCCGGGAGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGG AAATTTATGCTGGGAAAAAAAACAACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCA CATACCTTCTCAAGGACCGCCTCTTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCG ACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAAC TGGACAACATCCTTCTGGATGCAGAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCA CCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGG TGCTGATGTACGAGATGATGGCTGGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGC TGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCAT CGCAGAATGGCGAGGACGCCATCAAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCT TCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAG CAATTGTAAAGCAGATCAACCAGGAGGAATTCAAAGGTTTCTCCTACTTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGAC TTTGCCGATGCTGCAAGAAGGGGTGCAGAGAAGACTCCTGTGTTGGAGACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCC AGTCCCATGTCCACTGTCTATTTATTGCATTCCCTTGCCCCAGGCCACCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTT CTTGTCTCACCAGTAATGCAGACTCATTGGGTCAGCAATTAGCTGTATACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCC TCAGGGGCTCCTGGCAGTGAAGCAACTTCAGTTCTTTTACTGCAAAGAACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTG CTATCGGACACAGATCCTGATCCCTCTTGCTTCTTTTCCCTCCTGCACCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACT GGTGCTTCTCCGCACACACGAGGGAGGGCGCCCTTGAGGCATGCCCTCTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGT TGGTTTGCTCTGGAATGGCTAACTCTTGCCTGCTTTGGTTTTAGCTTTTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAA ATCCTCTTTGTGGAAAAAGAAACAGGGTTTTGAACTCTGTTAACATTTGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGA GATGAGTTCCAGTCTGAATACAGGTAGATATTAAAGGGCTAATAAAAAATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGA GTGACACATGAGAGCTGTATGAATTGAGAGAAAAGGCAACAAGTAGCATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGAC CCTGGGGTTCCAACAAAGCTCAGCTCCCAGATTCTCTTTCCAGTTTCATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAG TGTGTTATTTTTGCGCACTTATACAAAATGGTAGTACTACTGTGTTGTGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATC TGCTTTTGGAATAAGCAGAATGAGGCTAAACATGGGTTATACAAAGGGTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATG TCGCAAGATGTACTCAGTTTTGTTTCTGTGTGACATGCAATGGCAACTCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAG ATATGCTAACAGTGTTATTCTTTCATTTCCAAGGGTTCTCTGTGGCTTTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTAC TGAACTGATTTAGCAGGGAATGGAATCCATTCCAACTATTGCACGTGGATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAA AGTGGCACTAATGAAGCTTTTGCCTTTTGTACATTTGAGATTTTTGTATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCAT ATAGAGGTATCAACTGCTGCATGTTCAGGCATATTATAAAACTTTAGTCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCT GTAAGTCTATTGGTTCAAGTTACCGAGAGATAGGTGTGTTCCTTTATGGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATT TCATTTTGGTTTATTTTAAAAGATGTAAACATATATTAAGCTATATTAAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATA GAGATGGGGGAGAGAAAGGAATGTTTTTGATGGTGGTTTCAAAGCTCGGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATA TTTGCATCTGGCTGGTCATAGCCTTTGTTACTAATGATGACATTCAGTTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATT ATCTGTTCTTAAGATAATTGCAAATATTAAATATTATGATATATCAATTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGAT TAATTTAATTTATCTTCGGTAACTTGACATTCTGGAGAGAGACTATCTTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCA TCATCTCATTTTTTAGGAAGACATGATAATACTGCCCATCATATTCATGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAA ACTTTGGACAACCAAGCAAGCTCTAACCGCAATGCCAGATGGCCTTGTCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTT CCTACAGGACAACTGGCAAGTTTGCTGGGAAGTCAAATAATACATTCCACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGG GCCCTTTTCAGCACCCAAAGCTGGGCTGGCTGGGATGCCTCTGGCTGGTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTA TAGAAAAAGGCTTGCGTGTTCGTTGAGTAATCATTGTTTCATTTTCATTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTG CCAGTTTTTTCTGATCTTTCCAGCCCCACCCCCTTTCTCTTTCTCTCTCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAA GCCAAAAAATATATGAAGGATAGCTGTTCTTCTGTGTTCTCTCATTATGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGG TGAAAAAACAATGCATTCTTGCTTTAAAAAAAAAAAAGAAGGCTAAAAAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAA CTGTAAAATGTATTCAATTTTAGGATTTTTTTTTTTTGTATTGTGATGCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAAT CTCTTGCCATTCATTAGTGTTATTTCATTGTAAACGTTATTGTGCCAAATGTACTGTATTCAAAAGGATGTGAATGTGTATTGTTTCAGA |
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FusionGenePPI for BRE_PRKCE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BRE | BABAM1, BRCC3, FAM175B, BARD1, BRCA1, BRCA2, RAD51, TP53, UBE2D1, UIMC1, PHB, RPN2, SHMT2, SSR3, USP7, LRPPRC, SLC25A13, ATG2A, TTC28, FKBP8, DHRS7B, TMX3, UGGT2, MMS19, FAM175A, TNFRSF1A, FAS, COPS5, NCOA3, UBC, SUMO2, GFI1B, GRB2, MDC1, PAXIP1, AKAP2, HNRNPA2B1, OPTN, TFG, DEF6, CHI3L1, HIST1H2BG, EGFR, WWP2, FAM189B, TENC1 | PRKCE | RASGRP3, GAD2, GAD1, ADAP1, VDAC1, SLC25A4, HK2, MAPK1, RAF1, GJA1, GNB2L1, CFTR, GNA12, GNA13, MYH9, COPB2, KRT1, ACTA1, YWHAZ, TIAM1, PDLIM5, PIK3CB, AFAP1, KRT8, KRT18, DSP, MAP4K4, STAT1, HSP90AB1, PRKCE, KAT5, HIST1H1A, IBTK, MARK2, PPP1R14A, IKBKB, IKBKG, ITGB2, ATF2, RPS6KB2, BRAF, HSP90AA1, ELAVL1, NUMB, KEAP1, IL32, ZBTB16, NANOG, EGFR, BAD, BCL6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BRE_PRKCE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BRE_PRKCE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PRKCE | C0020429 | Hyperalgesia | 3 | CTD_human |
| Tgene | PRKCE | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | PRKCE | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Tgene | PRKCE | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
| Tgene | PRKCE | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | PRKCE | C0027051 | Myocardial Infarction | 1 | CTD_human |
| Tgene | PRKCE | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| Tgene | PRKCE | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | PRKCE | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | PRKCE | C0242231 | Coronary Stenosis | 1 | CTD_human |
| Tgene | PRKCE | C0878544 | Cardiomyopathies | 1 | CTD_human |
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