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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 443

FusionGeneSummary for ACOXL_KLHL23

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOXL_KLHL23
Fusion gene ID: 443
HgeneTgene
Gene symbol

ACOXL

KLHL23

Gene ID

55289

151230

Gene nameacyl-CoA oxidase likekelch like family member 23
Synonyms-DITHP
Cytomap

2q13

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionacyl-coenzyme A oxidase-like proteinacyl-CoA oxidase-like proteinkelch-like protein 23kelch-like 23
Modification date2018052320180523
UniProtAcc

Q9NUZ1

Q8NBE8

Ensembl transtripts involved in fusion geneENST00000389811, ENST00000439055, 
ENST00000340561, ENST00000496981, 
ENST00000272797, ENST00000602521, 
ENST00000392647, 
Fusion gene scores* DoF score4 X 4 X 2=321 X 1 X 1=1
# samples 31
** MAII scorelog2(3/32*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ACOXL [Title/Abstract] AND KLHL23 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-G2-AA3F-01AACOXLchr2

111526041

+KLHL23chr2

170597895

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000389811ENST00000272797ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000389811ENST00000602521ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000389811ENST00000392647ACOXLchr2

111526041

+KLHL23chr2

170597895

+
Frame-shiftENST00000439055ENST00000272797ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000439055ENST00000602521ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000439055ENST00000392647ACOXLchr2

111526041

+KLHL23chr2

170597895

+
Frame-shiftENST00000340561ENST00000272797ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000340561ENST00000602521ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000340561ENST00000392647ACOXLchr2

111526041

+KLHL23chr2

170597895

+
intron-3CDSENST00000496981ENST00000272797ACOXLchr2

111526041

+KLHL23chr2

170597895

+
intron-5UTRENST00000496981ENST00000602521ACOXLchr2

111526041

+KLHL23chr2

170597895

+
intron-5UTRENST00000496981ENST00000392647ACOXLchr2

111526041

+KLHL23chr2

170597895

+

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FusionProtFeatures for ACOXL_KLHL23


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACOXL

Q9NUZ1

KLHL23

Q8NBE8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACOXL_KLHL23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACOXL_KLHL23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACOXLCUL1KLHL23USP22, BNIP3L, TK1, ANXA1, CDKN1A, ANXA7, CUL3, COPS5, DCUN1D1, HSP90AA1, ACOT8, AMDHD1, HNRNPK, PLS3, PES1, BCL7A, CTGF, C19orf45, TCP10L, RGS3, OSBPL5, BSPRY, LMO2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACOXL_KLHL23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACOXL_KLHL23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACOXLC0023434Chronic Lymphocytic Leukemia1CTD_human