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Fusion gene ID: 441 |
FusionGeneSummary for ACOX3_VAMP7 |
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Fusion gene information | Fusion gene name: ACOX3_VAMP7 | Fusion gene ID: 441 | Hgene | Tgene | Gene symbol | ACOX3 | VAMP7 | Gene ID | 8310 | 6845 |
Gene name | acyl-CoA oxidase 3, pristanoyl | vesicle associated membrane protein 7 | |
Synonyms | - | SYBL1|TI-VAMP|TIVAMP|VAMP-7 | |
Cytomap | 4p16.1 | Xq28 and Yq12 | |
Type of gene | protein-coding | protein-coding | |
Description | peroxisomal acyl-coenzyme A oxidase 3BRCACoxacyl-Coenzyme A oxidase 3, pristanoylbranched-chain acyl-CoA oxidasepristanoyl-CoA oxidase | vesicle-associated membrane protein 7synaptobrevin-like 1synaptobrevin-like protein 1tetanus neurotoxin-insensitive VAMPtetanus-insensitive VAMP | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O15254 | P51809 | |
Ensembl transtripts involved in fusion gene | ENST00000356406, ENST00000413009, ENST00000503233, ENST00000515797, | ENST00000286448, ENST00000479687, ENST00000262640, ENST00000460621, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 4 X 3 X 3=36 |
# samples | 7 | 4 | |
** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ACOX3 [Title/Abstract] AND VAMP7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | VAMP7 | GO:0006906 | vesicle fusion | 10888671 |
Tgene | VAMP7 | GO:0008333 | endosome to lysosome transport | 10888671 |
Tgene | VAMP7 | GO:0016192 | vesicle-mediated transport | 10888671 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-DK-A3IS-01A | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000356406 | ENST00000286448 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3UTR | ENST00000356406 | ENST00000479687 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3UTR | ENST00000356406 | ENST00000262640 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3UTR | ENST00000356406 | ENST00000460621 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3CDS | ENST00000413009 | ENST00000286448 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3UTR | ENST00000413009 | ENST00000479687 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3UTR | ENST00000413009 | ENST00000262640 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3UTR | ENST00000413009 | ENST00000460621 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
5UTR-3CDS | ENST00000503233 | ENST00000286448 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
5UTR-3UTR | ENST00000503233 | ENST00000479687 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
5UTR-3UTR | ENST00000503233 | ENST00000262640 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
5UTR-3UTR | ENST00000503233 | ENST00000460621 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3CDS | ENST00000515797 | ENST00000286448 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3UTR | ENST00000515797 | ENST00000479687 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3UTR | ENST00000515797 | ENST00000262640 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
intron-3UTR | ENST00000515797 | ENST00000460621 | ACOX3 | chr4 | 8430078 | - | VAMP7 | chrY | 59272371 | + |
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FusionProtFeatures for ACOX3_VAMP7 |
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Hgene | Tgene |
ACOX3 | VAMP7 |
Oxidizes the CoA-esters of 2-methyl-branched fattyacids. {ECO:0000250, ECO:0000269|PubMed:9271077}. | Involved in the targeting and/or fusion of transportvesicles to their target membrane during transport of proteinsfrom the early endosome to the lysosome. Required for heterotypicfusion of late endosomes with lysosomes and homotypic lysosomalfusion. Required for calcium regulated lysosomal exocytosis.Involved in the export of chylomicrons from the endoplasmicreticulum to the cis Golgi. Required for exocytosis of mediatorsduring eosinophil and neutrophil degranulation, and target cellkilling by natural killer cells. Required for focal exocytosis oflate endocytic vesicles during phagosome formation.{ECO:0000269|PubMed:10888671, ECO:0000269|PubMed:16677249,ECO:0000269|PubMed:18042464}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACOX3_VAMP7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACOX3_VAMP7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACOX3 | PEX5, SMURF2, TMEM150A, FKBP6, MICU2, YTHDF1, HERC3, CENPH, HAUS7 | VAMP7 | AP3D1, SNAP29, AP3M1, SNAP25, STX1A, SNAP23, STX4, ANKRD27, ATP6V1B1, STX6, STX7, STX8, STX12, GINM1, SIRT2, TMEM17, STX3, RAB11A, PPP2R1A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACOX3_VAMP7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACOX3_VAMP7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | VAMP7 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | VAMP7 | C0950124 | Papillomavirus Infections | 1 | CTD_human |
Tgene | VAMP7 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |