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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 441

FusionGeneSummary for ACOX3_VAMP7

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOX3_VAMP7
Fusion gene ID: 441
HgeneTgene
Gene symbol

ACOX3

VAMP7

Gene ID

8310

6845

Gene nameacyl-CoA oxidase 3, pristanoylvesicle associated membrane protein 7
Synonyms-SYBL1|TI-VAMP|TIVAMP|VAMP-7
Cytomap

4p16.1

Xq28 and Yq12

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal acyl-coenzyme A oxidase 3BRCACoxacyl-Coenzyme A oxidase 3, pristanoylbranched-chain acyl-CoA oxidasepristanoyl-CoA oxidasevesicle-associated membrane protein 7synaptobrevin-like 1synaptobrevin-like protein 1tetanus neurotoxin-insensitive VAMPtetanus-insensitive VAMP
Modification date2018052320180523
UniProtAcc

O15254

P51809

Ensembl transtripts involved in fusion geneENST00000356406, ENST00000413009, 
ENST00000503233, ENST00000515797, 
ENST00000286448, ENST00000479687, 
ENST00000262640, ENST00000460621, 
Fusion gene scores* DoF score7 X 7 X 3=1474 X 3 X 3=36
# samples 74
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ACOX3 [Title/Abstract] AND VAMP7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneVAMP7

GO:0006906

vesicle fusion

10888671

TgeneVAMP7

GO:0008333

endosome to lysosome transport

10888671

TgeneVAMP7

GO:0016192

vesicle-mediated transport

10888671


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A3IS-01AACOX3chr4

8430078

-VAMP7chrY

59272371

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000356406ENST00000286448ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3UTRENST00000356406ENST00000479687ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3UTRENST00000356406ENST00000262640ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3UTRENST00000356406ENST00000460621ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3CDSENST00000413009ENST00000286448ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3UTRENST00000413009ENST00000479687ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3UTRENST00000413009ENST00000262640ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3UTRENST00000413009ENST00000460621ACOX3chr4

8430078

-VAMP7chrY

59272371

+
5UTR-3CDSENST00000503233ENST00000286448ACOX3chr4

8430078

-VAMP7chrY

59272371

+
5UTR-3UTRENST00000503233ENST00000479687ACOX3chr4

8430078

-VAMP7chrY

59272371

+
5UTR-3UTRENST00000503233ENST00000262640ACOX3chr4

8430078

-VAMP7chrY

59272371

+
5UTR-3UTRENST00000503233ENST00000460621ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3CDSENST00000515797ENST00000286448ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3UTRENST00000515797ENST00000479687ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3UTRENST00000515797ENST00000262640ACOX3chr4

8430078

-VAMP7chrY

59272371

+
intron-3UTRENST00000515797ENST00000460621ACOX3chr4

8430078

-VAMP7chrY

59272371

+

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FusionProtFeatures for ACOX3_VAMP7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACOX3

O15254

VAMP7

P51809

Oxidizes the CoA-esters of 2-methyl-branched fattyacids. {ECO:0000250, ECO:0000269|PubMed:9271077}. Involved in the targeting and/or fusion of transportvesicles to their target membrane during transport of proteinsfrom the early endosome to the lysosome. Required for heterotypicfusion of late endosomes with lysosomes and homotypic lysosomalfusion. Required for calcium regulated lysosomal exocytosis.Involved in the export of chylomicrons from the endoplasmicreticulum to the cis Golgi. Required for exocytosis of mediatorsduring eosinophil and neutrophil degranulation, and target cellkilling by natural killer cells. Required for focal exocytosis oflate endocytic vesicles during phagosome formation.{ECO:0000269|PubMed:10888671, ECO:0000269|PubMed:16677249,ECO:0000269|PubMed:18042464}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACOX3_VAMP7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACOX3_VAMP7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACOX3PEX5, SMURF2, TMEM150A, FKBP6, MICU2, YTHDF1, HERC3, CENPH, HAUS7VAMP7AP3D1, SNAP29, AP3M1, SNAP25, STX1A, SNAP23, STX4, ANKRD27, ATP6V1B1, STX6, STX7, STX8, STX12, GINM1, SIRT2, TMEM17, STX3, RAB11A, PPP2R1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACOX3_VAMP7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACOX3_VAMP7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneVAMP7C0036341Schizophrenia1PSYGENET
TgeneVAMP7C0950124Papillomavirus Infections1CTD_human
TgeneVAMP7C1168401Squamous cell carcinoma of the head and neck1CTD_human