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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 440

FusionGeneSummary for ACOX3_STAT1

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOX3_STAT1
Fusion gene ID: 440
HgeneTgene
Gene symbol

ACOX3

STAT1

Gene ID

8310

6772

Gene nameacyl-CoA oxidase 3, pristanoylsignal transducer and activator of transcription 1
Synonyms-CANDF7|IMD31A|IMD31B|IMD31C|ISGF-3|STAT91
Cytomap

4p16.1

2q32.2

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal acyl-coenzyme A oxidase 3BRCACoxacyl-Coenzyme A oxidase 3, pristanoylbranched-chain acyl-CoA oxidasepristanoyl-CoA oxidasesignal transducer and activator of transcription 1-alpha/betasignal transducer and activator of transcription 1, 91kDsignal transducer and activator of transcription 1, 91kDatranscription factor ISGF-3 components p91/p84
Modification date2018052320180527
UniProtAcc

O15254

P42224

Ensembl transtripts involved in fusion geneENST00000356406, ENST00000413009, 
ENST00000503233, ENST00000515797, 
ENST00000361099, ENST00000409465, 
ENST00000540176, ENST00000392322, 
ENST00000392323, 
Fusion gene scores* DoF score7 X 7 X 3=1474 X 4 X 3=48
# samples 74
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACOX3 [Title/Abstract] AND STAT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTAT1

GO:0007259

JAK-STAT cascade

22002246

TgeneSTAT1

GO:0010742

macrophage derived foam cell differentiation

26504087

TgeneSTAT1

GO:0032727

positive regulation of interferon-alpha production

28753426

TgeneSTAT1

GO:0033209

tumor necrosis factor-mediated signaling pathway

10848577

TgeneSTAT1

GO:0045893

positive regulation of transcription, DNA-templated

10973496

TgeneSTAT1

GO:0051607

defense response to virus

28753426

TgeneSTAT1

GO:0060333

interferon-gamma-mediated signaling pathway

21268089

TgeneSTAT1

GO:0060337

type I interferon signaling pathway

23386060

TgeneSTAT1

GO:0071346

cellular response to interferon-gamma

23386060


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-TS-A7P8-01AACOX3chr4

8442375

-STAT1chr2

191863034

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000356406ENST00000361099ACOX3chr4

8442375

-STAT1chr2

191863034

-
5UTR-3CDSENST00000356406ENST00000409465ACOX3chr4

8442375

-STAT1chr2

191863034

-
5UTR-intronENST00000356406ENST00000540176ACOX3chr4

8442375

-STAT1chr2

191863034

-
5UTR-intronENST00000356406ENST00000392322ACOX3chr4

8442375

-STAT1chr2

191863034

-
5UTR-intronENST00000356406ENST00000392323ACOX3chr4

8442375

-STAT1chr2

191863034

-
5UTR-3CDSENST00000413009ENST00000361099ACOX3chr4

8442375

-STAT1chr2

191863034

-
5UTR-3CDSENST00000413009ENST00000409465ACOX3chr4

8442375

-STAT1chr2

191863034

-
5UTR-intronENST00000413009ENST00000540176ACOX3chr4

8442375

-STAT1chr2

191863034

-
5UTR-intronENST00000413009ENST00000392322ACOX3chr4

8442375

-STAT1chr2

191863034

-
5UTR-intronENST00000413009ENST00000392323ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-3CDSENST00000503233ENST00000361099ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-3CDSENST00000503233ENST00000409465ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-intronENST00000503233ENST00000540176ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-intronENST00000503233ENST00000392322ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-intronENST00000503233ENST00000392323ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-3CDSENST00000515797ENST00000361099ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-3CDSENST00000515797ENST00000409465ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-intronENST00000515797ENST00000540176ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-intronENST00000515797ENST00000392322ACOX3chr4

8442375

-STAT1chr2

191863034

-
intron-intronENST00000515797ENST00000392323ACOX3chr4

8442375

-STAT1chr2

191863034

-

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FusionProtFeatures for ACOX3_STAT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACOX3

O15254

STAT1

P42224

Oxidizes the CoA-esters of 2-methyl-branched fattyacids. {ECO:0000250, ECO:0000269|PubMed:9271077}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACOX3_STAT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACOX3_STAT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACOX3PEX5, SMURF2, TMEM150A, FKBP6, MICU2, YTHDF1, HERC3, CENPH, HAUS7STAT1PIAS1, LMO2, EIF1AD, BPIFB3, FANCC, GNB2L1, TYK2, IL27RA, CREBBP, EP300, STAT3, EIF2AK2, IL2RB, STAT2, STAT1, KIT, PTK2, IFNAR2, MCM5, EGFR, SRC, VDR, HSF1, TNFRSF1A, TRADD, MTOR, PRKCD, ELP2, IRF1, IRF9, JUN, NMI, GTF2I, BRCA1, KPNA1, RNF11, PTPN2, MBD1, ACTN4, DCTN1, GFAP, HSP90AB1, SPTAN1, SPTBN1, SHANK1, LZTR1, BCL3, SMARCA4, TRIM28, CTNNBL1, JAK2, PRKCE, IFNGR1, ATF3, SMARCA2, MAVS, DOT1L, SMURF1, ARRB2, PSMC3, HIST2H3C, HDAC4, ISG15, UBE2I, IRAK1, PRMT1, PRMT3, NMD3, NSF, PHGDH, VCP, PIK3CA, ERBB2, JAK1, NFKBIA, HDAC1, HDAC3, XPO1, IGBP1, MLST8, PPP2R4, RPS6KB1, DDB1, RXRA, HLA-B, HADH, ND4L, POR, NOMO1, NOMO2, CASP3, CASP7, E2F1, USP13, APEH, CAND1, CTTN, GSPT2, HIRIP3, HSPA4L, IDE, JMJD6, KARS, NAA10, SARS, SHMT2, SNX2, SNX6, ATG7, ATP6V1C1, NAA15, PAWR, RTF1, SHMT1, SNX1, TSNAX, VPS29, YAP1, TBCD, VPS26A, DTX3L, GNB2, HUWE1, OTUD4, CCDC8, HLA-DRB5, SPACA1, TEX264, AARS, AHSA1, CIAPIN1, PAK2, NTRK1, SPTB, FOS, RELA, STAT5A, PDGFRA, FOXA3, PML, PARP9, HIST1H2BJ, PPARA, PPARD, PPARG, FANCE, U2AF2, ITGAV, HSP90B1, CDH1, DOCK4, STAT4, G3BP1, PTPN11, TNK2, USP2, NR1H3, NR1H2, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACOX3_STAT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACOX3_STAT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSTAT1C3279990CANDIDIASIS, FAMILIAL, 75ORPHANET;UNIPROT
TgeneSTAT1C3151088IMMUNODEFICIENCY 31B3ORPHANET;UNIPROT
TgeneSTAT1C4013950IMMUNODEFICIENCY 31A3ORPHANET;UNIPROT
TgeneSTAT1C0003873Rheumatoid Arthritis1CTD_human
TgeneSTAT1C0006845Candidiasis, Chronic Mucocutaneous1CTD_human;HPO
TgeneSTAT1C0010823Cytomegalovirus Infections1CTD_human
TgeneSTAT1C0021400Influenza1CTD_human
TgeneSTAT1C0023890Liver Cirrhosis1CTD_human
TgeneSTAT1C0026918Mycobacterium Infections1CTD_human
TgeneSTAT1C0993582Arthritis, Experimental1CTD_human
TgeneSTAT1C1384666hearing impairment1CTD_human
TgeneSTAT1C2239176Liver carcinoma1CTD_human