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Fusion gene ID: 440 |
FusionGeneSummary for ACOX3_STAT1 |
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Fusion gene information | Fusion gene name: ACOX3_STAT1 | Fusion gene ID: 440 | Hgene | Tgene | Gene symbol | ACOX3 | STAT1 | Gene ID | 8310 | 6772 |
Gene name | acyl-CoA oxidase 3, pristanoyl | signal transducer and activator of transcription 1 | |
Synonyms | - | CANDF7|IMD31A|IMD31B|IMD31C|ISGF-3|STAT91 | |
Cytomap | 4p16.1 | 2q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | peroxisomal acyl-coenzyme A oxidase 3BRCACoxacyl-Coenzyme A oxidase 3, pristanoylbranched-chain acyl-CoA oxidasepristanoyl-CoA oxidase | signal transducer and activator of transcription 1-alpha/betasignal transducer and activator of transcription 1, 91kDsignal transducer and activator of transcription 1, 91kDatranscription factor ISGF-3 components p91/p84 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | O15254 | P42224 | |
Ensembl transtripts involved in fusion gene | ENST00000356406, ENST00000413009, ENST00000503233, ENST00000515797, | ENST00000361099, ENST00000409465, ENST00000540176, ENST00000392322, ENST00000392323, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 4 X 4 X 3=48 |
# samples | 7 | 4 | |
** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACOX3 [Title/Abstract] AND STAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | STAT1 | GO:0007259 | JAK-STAT cascade | 22002246 |
Tgene | STAT1 | GO:0010742 | macrophage derived foam cell differentiation | 26504087 |
Tgene | STAT1 | GO:0032727 | positive regulation of interferon-alpha production | 28753426 |
Tgene | STAT1 | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 10848577 |
Tgene | STAT1 | GO:0045893 | positive regulation of transcription, DNA-templated | 10973496 |
Tgene | STAT1 | GO:0051607 | defense response to virus | 28753426 |
Tgene | STAT1 | GO:0060333 | interferon-gamma-mediated signaling pathway | 21268089 |
Tgene | STAT1 | GO:0060337 | type I interferon signaling pathway | 23386060 |
Tgene | STAT1 | GO:0071346 | cellular response to interferon-gamma | 23386060 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | MESO | TCGA-TS-A7P8-01A | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000356406 | ENST00000361099 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
5UTR-3CDS | ENST00000356406 | ENST00000409465 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
5UTR-intron | ENST00000356406 | ENST00000540176 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
5UTR-intron | ENST00000356406 | ENST00000392322 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
5UTR-intron | ENST00000356406 | ENST00000392323 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
5UTR-3CDS | ENST00000413009 | ENST00000361099 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
5UTR-3CDS | ENST00000413009 | ENST00000409465 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
5UTR-intron | ENST00000413009 | ENST00000540176 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
5UTR-intron | ENST00000413009 | ENST00000392322 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
5UTR-intron | ENST00000413009 | ENST00000392323 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-3CDS | ENST00000503233 | ENST00000361099 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-3CDS | ENST00000503233 | ENST00000409465 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-intron | ENST00000503233 | ENST00000540176 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-intron | ENST00000503233 | ENST00000392322 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-intron | ENST00000503233 | ENST00000392323 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-3CDS | ENST00000515797 | ENST00000361099 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-3CDS | ENST00000515797 | ENST00000409465 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-intron | ENST00000515797 | ENST00000540176 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-intron | ENST00000515797 | ENST00000392322 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
intron-intron | ENST00000515797 | ENST00000392323 | ACOX3 | chr4 | 8442375 | - | STAT1 | chr2 | 191863034 | - |
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FusionProtFeatures for ACOX3_STAT1 |
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Hgene | Tgene |
ACOX3 | STAT1 |
Oxidizes the CoA-esters of 2-methyl-branched fattyacids. {ECO:0000250, ECO:0000269|PubMed:9271077}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACOX3_STAT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACOX3_STAT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACOX3 | PEX5, SMURF2, TMEM150A, FKBP6, MICU2, YTHDF1, HERC3, CENPH, HAUS7 | STAT1 | PIAS1, LMO2, EIF1AD, BPIFB3, FANCC, GNB2L1, TYK2, IL27RA, CREBBP, EP300, STAT3, EIF2AK2, IL2RB, STAT2, STAT1, KIT, PTK2, IFNAR2, MCM5, EGFR, SRC, VDR, HSF1, TNFRSF1A, TRADD, MTOR, PRKCD, ELP2, IRF1, IRF9, JUN, NMI, GTF2I, BRCA1, KPNA1, RNF11, PTPN2, MBD1, ACTN4, DCTN1, GFAP, HSP90AB1, SPTAN1, SPTBN1, SHANK1, LZTR1, BCL3, SMARCA4, TRIM28, CTNNBL1, JAK2, PRKCE, IFNGR1, ATF3, SMARCA2, MAVS, DOT1L, SMURF1, ARRB2, PSMC3, HIST2H3C, HDAC4, ISG15, UBE2I, IRAK1, PRMT1, PRMT3, NMD3, NSF, PHGDH, VCP, PIK3CA, ERBB2, JAK1, NFKBIA, HDAC1, HDAC3, XPO1, IGBP1, MLST8, PPP2R4, RPS6KB1, DDB1, RXRA, HLA-B, HADH, ND4L, POR, NOMO1, NOMO2, CASP3, CASP7, E2F1, USP13, APEH, CAND1, CTTN, GSPT2, HIRIP3, HSPA4L, IDE, JMJD6, KARS, NAA10, SARS, SHMT2, SNX2, SNX6, ATG7, ATP6V1C1, NAA15, PAWR, RTF1, SHMT1, SNX1, TSNAX, VPS29, YAP1, TBCD, VPS26A, DTX3L, GNB2, HUWE1, OTUD4, CCDC8, HLA-DRB5, SPACA1, TEX264, AARS, AHSA1, CIAPIN1, PAK2, NTRK1, SPTB, FOS, RELA, STAT5A, PDGFRA, FOXA3, PML, PARP9, HIST1H2BJ, PPARA, PPARD, PPARG, FANCE, U2AF2, ITGAV, HSP90B1, CDH1, DOCK4, STAT4, G3BP1, PTPN11, TNK2, USP2, NR1H3, NR1H2, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACOX3_STAT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACOX3_STAT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | STAT1 | C3279990 | CANDIDIASIS, FAMILIAL, 7 | 5 | ORPHANET;UNIPROT |
Tgene | STAT1 | C3151088 | IMMUNODEFICIENCY 31B | 3 | ORPHANET;UNIPROT |
Tgene | STAT1 | C4013950 | IMMUNODEFICIENCY 31A | 3 | ORPHANET;UNIPROT |
Tgene | STAT1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | STAT1 | C0006845 | Candidiasis, Chronic Mucocutaneous | 1 | CTD_human;HPO |
Tgene | STAT1 | C0010823 | Cytomegalovirus Infections | 1 | CTD_human |
Tgene | STAT1 | C0021400 | Influenza | 1 | CTD_human |
Tgene | STAT1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Tgene | STAT1 | C0026918 | Mycobacterium Infections | 1 | CTD_human |
Tgene | STAT1 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Tgene | STAT1 | C1384666 | hearing impairment | 1 | CTD_human |
Tgene | STAT1 | C2239176 | Liver carcinoma | 1 | CTD_human |