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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43894

FusionGeneSummary for ZZZ3_RAD51B

check button Fusion gene summary
Fusion gene informationFusion gene name: ZZZ3_RAD51B
Fusion gene ID: 43894
HgeneTgene
Gene symbol

ZZZ3

RAD51B

Gene ID

26009

5890

Gene namezinc finger ZZ-type containing 3RAD51 paralog B
SynonymsATAC1R51H2|RAD51L1|REC2
Cytomap

1p31.1

14q24.1

Type of geneprotein-codingprotein-coding
DescriptionZZ-type zinc finger-containing protein 3ATAC component 1 homologzinc finger, ZZ domain containing 3DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
Modification date2018051920180523
UniProtAcc

Q8IYH5

O15315

Ensembl transtripts involved in fusion geneENST00000370801, ENST00000370798, 
ENST00000476275, 		ENST00000487861, 
ENST00000471583, ENST00000487270, 
ENST00000488612, ENST00000390683, 
ENST00000469165, 
Fusion gene scores* DoF score6 X 5 X 3=9025 X 15 X 8=3000
# samples 633
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/3000*10)=-3.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZZZ3 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA420457ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000370801ENST00000487861ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370801ENST00000471583ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370801ENST00000487270ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370801ENST00000488612ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370801ENST00000390683ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370801ENST00000469165ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370798ENST00000487861ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370798ENST00000471583ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370798ENST00000487270ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370798ENST00000488612ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370798ENST00000390683ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000370798ENST00000469165ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000476275ENST00000487861ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000476275ENST00000471583ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000476275ENST00000487270ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000476275ENST00000488612ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000476275ENST00000390683ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-
intron-intronENST00000476275ENST00000469165ZZZ3chr1

78106038

+RAD51Bchr14

68603002

-

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FusionProtFeatures for ZZZ3_RAD51B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZZZ3

Q8IYH5

RAD51B

O15315

Component of the ATAC complex, a complex with histoneacetyltransferase activity on histones H3 and H4.{ECO:0000269|PubMed:19103755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZZZ3_RAD51B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZZZ3_RAD51B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZZZ3_RAD51B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZZZ3_RAD51B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAD51BC0236969Substance-Related Disorders1CTD_human
TgeneRAD51BC0242788Breast Neoplasms, Male1CTD_human
TgeneRAD51BC1458155Mammary Neoplasms1CTD_human