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Fusion gene ID: 43887 |
FusionGeneSummary for ZZEF1_SMG6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZZEF1_SMG6 | Fusion gene ID: 43887 | Hgene | Tgene | Gene symbol | ZZEF1 | SMG6 | Gene ID | 23140 | 23293 |
| Gene name | zinc finger ZZ-type and EF-hand domain containing 1 | SMG6, nonsense mediated mRNA decay factor | |
| Synonyms | ZZZ4 | C17orf31|EST1A|SMG-6|hSMG5/7a | |
| Cytomap | 17p13.2 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger ZZ-type and EF-hand domain-containing protein 1zinc finger, ZZ-type with EF hand domain 1 | telomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1A | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O43149 | Q86US8 | |
| Ensembl transtripts involved in fusion gene | ENST00000381638, ENST00000574474, | ENST00000544865, ENST00000263073, ENST00000354901, ENST00000536871, ENST00000573166, | |
| Fusion gene scores | * DoF score | 5 X 7 X 3=105 | 8 X 6 X 5=240 |
| # samples | 9 | 8 | |
| ** MAII score | log2(9/105*10)=-0.222392421336448 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZZEF1 [Title/Abstract] AND SMG6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SMG6 | GO:1904354 | negative regulation of telomere capping | 12676087 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-LL-A7SZ-01A | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000381638 | ENST00000544865 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| In-frame | ENST00000381638 | ENST00000263073 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| In-frame | ENST00000381638 | ENST00000354901 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| In-frame | ENST00000381638 | ENST00000536871 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| 5CDS-5UTR | ENST00000381638 | ENST00000573166 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| 5UTR-3CDS | ENST00000574474 | ENST00000544865 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| 5UTR-3CDS | ENST00000574474 | ENST00000263073 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| 5UTR-3CDS | ENST00000574474 | ENST00000354901 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| 5UTR-3CDS | ENST00000574474 | ENST00000536871 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
| 5UTR-5UTR | ENST00000574474 | ENST00000573166 | ZZEF1 | chr17 | 3991972 | - | SMG6 | chr17 | 1989195 | - |
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FusionProtFeatures for ZZEF1_SMG6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZZEF1 | SMG6 |
| Component of the telomerase ribonucleoprotein (RNP)complex that is essential for the replication of chromosometermini. May have a general role in telomere regulation. Promotesin vitro the ability of TERT to elongate telomeres. Overexpressioninduces telomere uncapping, chromosomal end-to-end fusions(telomeric DNA persists at the fusion points) and did not perturbTRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNAtemplate component (TER). Plays a role in nonsense-mediated mRNA decay. Is thoughtto provide a link to the mRNA degradation machinery as it hasendonuclease activity required to initiate NMD, and to serve as anadapter for UPF1 to protein phosphatase 2A (PP2A), therebytriggering UPF1 dephosphorylation. Degrades single-stranded RNA(ssRNA), but not ssDNA or dsRNA. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ZZEF1 | chr17:3991972 | chr17:1989195 | ENST00000381638 | - | 13 | 55 | 111_146 | 747 | 2962 | Domain | EF-hand |
| Hgene | ZZEF1 | chr17:3991972 | chr17:1989195 | ENST00000381638 | - | 13 | 55 | 226_405 | 747 | 2962 | Domain | DOC |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000263073 | - | 12 | 19 | 1197_1239 | 1119 | 1420 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000354901 | - | 5 | 12 | 1197_1239 | 211 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000354901 | - | 5 | 12 | 567_625 | 211 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000536871 | - | 4 | 11 | 1197_1239 | 211 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000536871 | - | 4 | 11 | 567_625 | 211 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000544865 | - | 12 | 19 | 1197_1239 | 1088 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000263073 | - | 12 | 19 | 1246_1397 | 1119 | 1420 | Domain | Note=PINc |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000354901 | - | 5 | 12 | 1246_1397 | 211 | 512 | Domain | Note=PINc |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000536871 | - | 4 | 11 | 1246_1397 | 211 | 512 | Domain | Note=PINc |
| Tgene | >SMG6 | chr17:3991972 | chr17:1989195 | ENST00000544865 | - | 12 | 19 | 1246_1397 | 1088 | 1389 | Domain | Note=PINc |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZZEF1 | chr17:3991972 | chr17:1989195 | ENST00000381638 | - | 13 | 55 | 1777_1825 | 747 | 2962 | Zinc finger | ZZ-type 1 |
| Hgene | >ZZEF1 | chr17:3991972 | chr17:1989195 | ENST00000381638 | - | 13 | 55 | 1826_1872 | 747 | 2962 | Zinc finger | ZZ-type 2 |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000263073 | - | 12 | 19 | 163_193 | 1119 | 1420 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000263073 | - | 12 | 19 | 567_625 | 1119 | 1420 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000354901 | - | 5 | 12 | 163_193 | 211 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000536871 | - | 4 | 11 | 163_193 | 211 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000544865 | - | 12 | 19 | 163_193 | 1088 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000544865 | - | 12 | 19 | 567_625 | 1088 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for ZZEF1_SMG6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000544865_chr17_1989195_-_1048aa MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPALPPAAALLEPARLREAAAALLPTPPCESLVSRHRGALFRWLEERLGR GEESVTLEQFRELLEARGAGCSSEQFEEAFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQACSLVPGFTDIFSESKEGLD IHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRSPEMDKLKSVAKCYAYIETSSNSADIDKMTN GETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQIN IKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALRHMPPLSLSPGSTDFSTFLSP NVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKYGKPLQLTLQACDVKGK EDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYNSSSDKFCAEEHFKRFEKYDKWKLQE LRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCR KDTEESVCGATLLLRTLQFIQQLAHDLVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDV VIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYI LVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLH >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000263073_chr17_1989195_-_1048aa MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPALPPAAALLEPARLREAAAALLPTPPCESLVSRHRGALFRWLEERLGR GEESVTLEQFRELLEARGAGCSSEQFEEAFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQACSLVPGFTDIFSESKEGLD IHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRSPEMDKLKSVAKCYAYIETSSNSADIDKMTN GETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQIN IKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALRHMPPLSLSPGSTDFSTFLSP NVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKYGKPLQLTLQACDVKGK EDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYNSSSDKFCAEEHFKRFEKYDKWKLQE LRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCR KDTEESVCGATLLLRTLQFIQQLAHDLVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDV VIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYI LVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLH >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000354901_chr17_1989195_-_1048aa MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPALPPAAALLEPARLREAAAALLPTPPCESLVSRHRGALFRWLEERLGR GEESVTLEQFRELLEARGAGCSSEQFEEAFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQACSLVPGFTDIFSESKEGLD IHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRSPEMDKLKSVAKCYAYIETSSNSADIDKMTN GETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQIN IKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALRHMPPLSLSPGSTDFSTFLSP NVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKYGKPLQLTLQACDVKGK EDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYNSSSDKFCAEEHFKRFEKYDKWKLQE LRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCR KDTEESVCGATLLLRTLQFIQQLAHDLVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDV VIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYI LVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLH >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000536871_chr17_1989195_-_1048aa MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPALPPAAALLEPARLREAAAALLPTPPCESLVSRHRGALFRWLEERLGR GEESVTLEQFRELLEARGAGCSSEQFEEAFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQACSLVPGFTDIFSESKEGLD IHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRSPEMDKLKSVAKCYAYIETSSNSADIDKMTN GETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQIN IKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALRHMPPLSLSPGSTDFSTFLSP NVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKYGKPLQLTLQACDVKGK EDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYNSSSDKFCAEEHFKRFEKYDKWKLQE LRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCR KDTEESVCGATLLLRTLQFIQQLAHDLVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDV VIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYI LVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000544865_chr17_1989195_-_3144nt ATGGGGAACGCTCCGAGTCACAGCAGTGAAGACGAAGCGGCAGCTGCCGGTGGCGAGGGCTGGGGCCCACACCAGGACTGGGCCGCGGTC TCGGGCACGACCCCCGGCCCGGGCGTCGCGGCTCCAGCGCTACCACCCGCCGCGGCGCTGCTGGAGCCGGCCAGGCTGCGAGAGGCTGCT GCAGCGTTGCTGCCCACACCCCCCTGCGAGTCGCTGGTGTCGAGGCATCGCGGCGCGTTGTTTCGCTGGCTGGAAGAGCGGCTGGGCCGC GGCGAAGAGTCTGTCACTCTGGAGCAGTTCCGGGAGCTGCTGGAGGCTCGCGGCGCCGGCTGCTCTAGCGAGCAGTTCGAGGAGGCCTTT GCCCAGTTTGATGCTGAGGGTGATGGGACAGTTGATGCCGAGAACATGTTGGAGGCCCTCAAGAATTCCAGTGGAGCTAATCTTCAGGGG GAGCTGAGCCACATCATCAGACAACTACAGGCCTGCTCTCTGGTTCCAGGTTTCACAGACATATTTTCAGAGTCGAAGGAGGGCCTTGAT ATTCACTCGTCAATGATACTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGGTGATGCCCTACCCGATGCTGGAGCACTGCAATAAC ATGTGCACCATGCGGTCTTCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAAAGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGT CCAGAGATGGATAAACTCAAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACATCCTCCAACTCGGCAGACATTGACAAGATGACAAAT GGAGAAACCTCATCCTACTGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTCGTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCAC CTGTCCATTGCAGTGGCTGCCACTGACCAGAGCTACATGCCACAGCAGGTGACAGTAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAA GTCCGAGATGTGCACATCCCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAAATGCCAACGTCAGTCAGCTCTATGTCCAGATTAAC ATAAAGCGTTGTCTTAGCGATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTGTTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCA GTCTCAGATGCTTCTGCAATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGGCTTCTATGGAGACAAATCCCGCCTTTGTCCAGACA GTGCTGCACAATACTCAGAAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCACCAGGATCTACAGATTTCTCAACTTTCCTCTCCCCT AATGTGCTGGAAGAAGTGGACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTACCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCT CTCGCAAGAGGAAGTGTTGCCAAAGTCATGAGCTCTCTATGCACCATCACTGACCATCTGGACACGCAGTATGATGCCTCATCCCTCATC TTGTCCATGGCGTCAGTCAGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCCAGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAA GAAGATAAGTCTGGACCCGAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTTTTCTTACGGAAACTGGAAAAACCAGAGCCAGCACT ATTTTTTCTACCGGAACTGAATCTGCCTTCCAAGTTACACAGATAAGAATTATGGTTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTG GTGTTTGCCTATAACTCATCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAAGGTTTGAAAAATATGACAAATGGAAGCTTCAGGAG CTCAGGCAATTTGTAAAAAGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGGATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAA TGGGATGAAGCAGATGTGAAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGGTGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAG CGCTTGGGAGTGCAAGGCTTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAGAAGCAGAACAGAGCGTCACCTGTGCACACTGCAGA AAGGACACAGAGGAGAGTGTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGTTTATCCAGCAGCTCGCCCATGACCTGGTTATTGCA GCTGACTGCAAAAGGGTCACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGACAAGAAGAGCCTCTGCTGGCATTCAAGGGTGGAAAG TATGTGTCAGTGGCACCCGTCCCAGACACCATGGGAAAGGAAATGGGAAGCCAAGAGGGAACACGACTGGAAGATGAGGAGGAGGATGTG GTGATTGAAGACTTTGAGGAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGATGACATCAGGGAGCTTCGGGCCAAGAAGCTGGCTCTG GCCAGGAAGATAGCTGAGCAGCAGCGTCGCCAGGAAAAGATCCAGGCTGTCCTGGAGGACCACAGTCAGATGAGGCAGATGGAGCTCGAA ATCAGACCTTTGTTCCTCGTACCAGACACCAACGGCTTCATTGACCACCTGGCCAGTCTGGCGCGGCTGCTGGAGAGCAGGAAGTACATC CTGGTGGTGCCCCTCATCGTGATCAATGAGCTGGACGGCCTGGCCAAGGGGCAGGAGACAGACCACCGGGCTGGGGGCTACGCCCGTGTG GTACAAGAGAAGGCCCGCAAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGTCGGGACTCTTGCCTGCGAGCCCTGACCAGCCGTGGC AATGAACTCGAATCCATCGCCTTCCGCAGTGAGGACATCACTGGCCAGCTGGGTAACAACGATGATCTCATCCTGTCCTGCTGCCTCCAC TACTGCAAAGACAAGGCTAAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGAC >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000263073_chr17_1989195_-_3144nt ATGGGGAACGCTCCGAGTCACAGCAGTGAAGACGAAGCGGCAGCTGCCGGTGGCGAGGGCTGGGGCCCACACCAGGACTGGGCCGCGGTC TCGGGCACGACCCCCGGCCCGGGCGTCGCGGCTCCAGCGCTACCACCCGCCGCGGCGCTGCTGGAGCCGGCCAGGCTGCGAGAGGCTGCT GCAGCGTTGCTGCCCACACCCCCCTGCGAGTCGCTGGTGTCGAGGCATCGCGGCGCGTTGTTTCGCTGGCTGGAAGAGCGGCTGGGCCGC GGCGAAGAGTCTGTCACTCTGGAGCAGTTCCGGGAGCTGCTGGAGGCTCGCGGCGCCGGCTGCTCTAGCGAGCAGTTCGAGGAGGCCTTT GCCCAGTTTGATGCTGAGGGTGATGGGACAGTTGATGCCGAGAACATGTTGGAGGCCCTCAAGAATTCCAGTGGAGCTAATCTTCAGGGG GAGCTGAGCCACATCATCAGACAACTACAGGCCTGCTCTCTGGTTCCAGGTTTCACAGACATATTTTCAGAGTCGAAGGAGGGCCTTGAT ATTCACTCGTCAATGATACTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGGTGATGCCCTACCCGATGCTGGAGCACTGCAATAAC ATGTGCACCATGCGGTCTTCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAAAGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGT CCAGAGATGGATAAACTCAAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACATCCTCCAACTCGGCAGACATTGACAAGATGACAAAT GGAGAAACCTCATCCTACTGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTCGTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCAC CTGTCCATTGCAGTGGCTGCCACTGACCAGAGCTACATGCCACAGCAGGTGACAGTAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAA GTCCGAGATGTGCACATCCCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAAATGCCAACGTCAGTCAGCTCTATGTCCAGATTAAC ATAAAGCGTTGTCTTAGCGATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTGTTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCA GTCTCAGATGCTTCTGCAATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGGCTTCTATGGAGACAAATCCCGCCTTTGTCCAGACA GTGCTGCACAATACTCAGAAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCACCAGGATCTACAGATTTCTCAACTTTCCTCTCCCCT AATGTGCTGGAAGAAGTGGACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTACCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCT CTCGCAAGAGGAAGTGTTGCCAAAGTCATGAGCTCTCTATGCACCATCACTGACCATCTGGACACGCAGTATGATGCCTCATCCCTCATC TTGTCCATGGCGTCAGTCAGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCCAGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAA GAAGATAAGTCTGGACCCGAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTTTTCTTACGGAAACTGGAAAAACCAGAGCCAGCACT ATTTTTTCTACCGGAACTGAATCTGCCTTCCAAGTTACACAGATAAGAATTATGGTTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTG GTGTTTGCCTATAACTCATCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAAGGTTTGAAAAATATGACAAATGGAAGCTTCAGGAG CTCAGGCAATTTGTAAAAAGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGGATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAA TGGGATGAAGCAGATGTGAAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGGTGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAG CGCTTGGGAGTGCAAGGCTTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAGAAGCAGAACAGAGCGTCACCTGTGCACACTGCAGA AAGGACACAGAGGAGAGTGTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGTTTATCCAGCAGCTCGCCCATGACCTGGTTATTGCA GCTGACTGCAAAAGGGTCACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGACAAGAAGAGCCTCTGCTGGCATTCAAGGGTGGAAAG TATGTGTCAGTGGCACCCGTCCCAGACACCATGGGAAAGGAAATGGGAAGCCAAGAGGGAACACGACTGGAAGATGAGGAGGAGGATGTG GTGATTGAAGACTTTGAGGAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGATGACATCAGGGAGCTTCGGGCCAAGAAGCTGGCTCTG GCCAGGAAGATAGCTGAGCAGCAGCGTCGCCAGGAAAAGATCCAGGCTGTCCTGGAGGACCACAGTCAGATGAGGCAGATGGAGCTCGAA ATCAGACCTTTGTTCCTCGTACCAGACACCAACGGCTTCATTGACCACCTGGCCAGTCTGGCGCGGCTGCTGGAGAGCAGGAAGTACATC CTGGTGGTGCCCCTCATCGTGATCAATGAGCTGGACGGCCTGGCCAAGGGGCAGGAGACAGACCACCGGGCTGGGGGCTACGCCCGTGTG GTACAAGAGAAGGCCCGCAAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGTCGGGACTCTTGCCTGCGAGCCCTGACCAGCCGTGGC AATGAACTCGAATCCATCGCCTTCCGCAGTGAGGACATCACTGGCCAGCTGGGTAACAACGATGATCTCATCCTGTCCTGCTGCCTCCAC TACTGCAAAGACAAGGCTAAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGAC >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000354901_chr17_1989195_-_3144nt ATGGGGAACGCTCCGAGTCACAGCAGTGAAGACGAAGCGGCAGCTGCCGGTGGCGAGGGCTGGGGCCCACACCAGGACTGGGCCGCGGTC TCGGGCACGACCCCCGGCCCGGGCGTCGCGGCTCCAGCGCTACCACCCGCCGCGGCGCTGCTGGAGCCGGCCAGGCTGCGAGAGGCTGCT GCAGCGTTGCTGCCCACACCCCCCTGCGAGTCGCTGGTGTCGAGGCATCGCGGCGCGTTGTTTCGCTGGCTGGAAGAGCGGCTGGGCCGC GGCGAAGAGTCTGTCACTCTGGAGCAGTTCCGGGAGCTGCTGGAGGCTCGCGGCGCCGGCTGCTCTAGCGAGCAGTTCGAGGAGGCCTTT GCCCAGTTTGATGCTGAGGGTGATGGGACAGTTGATGCCGAGAACATGTTGGAGGCCCTCAAGAATTCCAGTGGAGCTAATCTTCAGGGG GAGCTGAGCCACATCATCAGACAACTACAGGCCTGCTCTCTGGTTCCAGGTTTCACAGACATATTTTCAGAGTCGAAGGAGGGCCTTGAT ATTCACTCGTCAATGATACTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGGTGATGCCCTACCCGATGCTGGAGCACTGCAATAAC ATGTGCACCATGCGGTCTTCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAAAGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGT CCAGAGATGGATAAACTCAAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACATCCTCCAACTCGGCAGACATTGACAAGATGACAAAT GGAGAAACCTCATCCTACTGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTCGTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCAC CTGTCCATTGCAGTGGCTGCCACTGACCAGAGCTACATGCCACAGCAGGTGACAGTAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAA GTCCGAGATGTGCACATCCCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAAATGCCAACGTCAGTCAGCTCTATGTCCAGATTAAC ATAAAGCGTTGTCTTAGCGATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTGTTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCA GTCTCAGATGCTTCTGCAATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGGCTTCTATGGAGACAAATCCCGCCTTTGTCCAGACA GTGCTGCACAATACTCAGAAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCACCAGGATCTACAGATTTCTCAACTTTCCTCTCCCCT AATGTGCTGGAAGAAGTGGACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTACCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCT CTCGCAAGAGGAAGTGTTGCCAAAGTCATGAGCTCTCTATGCACCATCACTGACCATCTGGACACGCAGTATGATGCCTCATCCCTCATC TTGTCCATGGCGTCAGTCAGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCCAGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAA GAAGATAAGTCTGGACCCGAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTTTTCTTACGGAAACTGGAAAAACCAGAGCCAGCACT ATTTTTTCTACCGGAACTGAATCTGCCTTCCAAGTTACACAGATAAGAATTATGGTTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTG GTGTTTGCCTATAACTCATCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAAGGTTTGAAAAATATGACAAATGGAAGCTTCAGGAG CTCAGGCAATTTGTAAAAAGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGGATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAA TGGGATGAAGCAGATGTGAAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGGTGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAG CGCTTGGGAGTGCAAGGCTTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAGAAGCAGAACAGAGCGTCACCTGTGCACACTGCAGA AAGGACACAGAGGAGAGTGTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGTTTATCCAGCAGCTCGCCCATGACCTGGTTATTGCA GCTGACTGCAAAAGGGTCACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGACAAGAAGAGCCTCTGCTGGCATTCAAGGGTGGAAAG TATGTGTCAGTGGCACCCGTCCCAGACACCATGGGAAAGGAAATGGGAAGCCAAGAGGGAACACGACTGGAAGATGAGGAGGAGGATGTG GTGATTGAAGACTTTGAGGAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGATGACATCAGGGAGCTTCGGGCCAAGAAGCTGGCTCTG GCCAGGAAGATAGCTGAGCAGCAGCGTCGCCAGGAAAAGATCCAGGCTGTCCTGGAGGACCACAGTCAGATGAGGCAGATGGAGCTCGAA ATCAGACCTTTGTTCCTCGTACCAGACACCAACGGCTTCATTGACCACCTGGCCAGTCTGGCGCGGCTGCTGGAGAGCAGGAAGTACATC CTGGTGGTGCCCCTCATCGTGATCAATGAGCTGGACGGCCTGGCCAAGGGGCAGGAGACAGACCACCGGGCTGGGGGCTACGCCCGTGTG GTACAAGAGAAGGCCCGCAAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGTCGGGACTCTTGCCTGCGAGCCCTGACCAGCCGTGGC AATGAACTCGAATCCATCGCCTTCCGCAGTGAGGACATCACTGGCCAGCTGGGTAACAACGATGATCTCATCCTGTCCTGCTGCCTCCAC TACTGCAAAGACAAGGCTAAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGAC >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000536871_chr17_1989195_-_3144nt ATGGGGAACGCTCCGAGTCACAGCAGTGAAGACGAAGCGGCAGCTGCCGGTGGCGAGGGCTGGGGCCCACACCAGGACTGGGCCGCGGTC TCGGGCACGACCCCCGGCCCGGGCGTCGCGGCTCCAGCGCTACCACCCGCCGCGGCGCTGCTGGAGCCGGCCAGGCTGCGAGAGGCTGCT GCAGCGTTGCTGCCCACACCCCCCTGCGAGTCGCTGGTGTCGAGGCATCGCGGCGCGTTGTTTCGCTGGCTGGAAGAGCGGCTGGGCCGC GGCGAAGAGTCTGTCACTCTGGAGCAGTTCCGGGAGCTGCTGGAGGCTCGCGGCGCCGGCTGCTCTAGCGAGCAGTTCGAGGAGGCCTTT GCCCAGTTTGATGCTGAGGGTGATGGGACAGTTGATGCCGAGAACATGTTGGAGGCCCTCAAGAATTCCAGTGGAGCTAATCTTCAGGGG GAGCTGAGCCACATCATCAGACAACTACAGGCCTGCTCTCTGGTTCCAGGTTTCACAGACATATTTTCAGAGTCGAAGGAGGGCCTTGAT ATTCACTCGTCAATGATACTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGGTGATGCCCTACCCGATGCTGGAGCACTGCAATAAC ATGTGCACCATGCGGTCTTCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAAAGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGT CCAGAGATGGATAAACTCAAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACATCCTCCAACTCGGCAGACATTGACAAGATGACAAAT GGAGAAACCTCATCCTACTGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTCGTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCAC CTGTCCATTGCAGTGGCTGCCACTGACCAGAGCTACATGCCACAGCAGGTGACAGTAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAA GTCCGAGATGTGCACATCCCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAAATGCCAACGTCAGTCAGCTCTATGTCCAGATTAAC ATAAAGCGTTGTCTTAGCGATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTGTTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCA GTCTCAGATGCTTCTGCAATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGGCTTCTATGGAGACAAATCCCGCCTTTGTCCAGACA GTGCTGCACAATACTCAGAAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCACCAGGATCTACAGATTTCTCAACTTTCCTCTCCCCT AATGTGCTGGAAGAAGTGGACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTACCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCT CTCGCAAGAGGAAGTGTTGCCAAAGTCATGAGCTCTCTATGCACCATCACTGACCATCTGGACACGCAGTATGATGCCTCATCCCTCATC TTGTCCATGGCGTCAGTCAGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCCAGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAA GAAGATAAGTCTGGACCCGAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTTTTCTTACGGAAACTGGAAAAACCAGAGCCAGCACT ATTTTTTCTACCGGAACTGAATCTGCCTTCCAAGTTACACAGATAAGAATTATGGTTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTG GTGTTTGCCTATAACTCATCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAAGGTTTGAAAAATATGACAAATGGAAGCTTCAGGAG CTCAGGCAATTTGTAAAAAGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGGATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAA TGGGATGAAGCAGATGTGAAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGGTGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAG CGCTTGGGAGTGCAAGGCTTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAGAAGCAGAACAGAGCGTCACCTGTGCACACTGCAGA AAGGACACAGAGGAGAGTGTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGTTTATCCAGCAGCTCGCCCATGACCTGGTTATTGCA GCTGACTGCAAAAGGGTCACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGACAAGAAGAGCCTCTGCTGGCATTCAAGGGTGGAAAG TATGTGTCAGTGGCACCCGTCCCAGACACCATGGGAAAGGAAATGGGAAGCCAAGAGGGAACACGACTGGAAGATGAGGAGGAGGATGTG GTGATTGAAGACTTTGAGGAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGATGACATCAGGGAGCTTCGGGCCAAGAAGCTGGCTCTG GCCAGGAAGATAGCTGAGCAGCAGCGTCGCCAGGAAAAGATCCAGGCTGTCCTGGAGGACCACAGTCAGATGAGGCAGATGGAGCTCGAA ATCAGACCTTTGTTCCTCGTACCAGACACCAACGGCTTCATTGACCACCTGGCCAGTCTGGCGCGGCTGCTGGAGAGCAGGAAGTACATC CTGGTGGTGCCCCTCATCGTGATCAATGAGCTGGACGGCCTGGCCAAGGGGCAGGAGACAGACCACCGGGCTGGGGGCTACGCCCGTGTG GTACAAGAGAAGGCCCGCAAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGTCGGGACTCTTGCCTGCGAGCCCTGACCAGCCGTGGC AATGAACTCGAATCCATCGCCTTCCGCAGTGAGGACATCACTGGCCAGCTGGGTAACAACGATGATCTCATCCTGTCCTGCTGCCTCCAC TACTGCAAAGACAAGGCTAAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000544865_chr17_1989195_-_4922nt AAGCCGCAGGGGCCGCCGTCGTCTCCTCCGCGTCCCCGCCCGCCAGCTGCTGTCGGAGGTTGACAGGTCGAGGCGGGGAGGCGGCGGCGG CGGCTGCAGAGCCAGGCGCCCAAGACGGAGACCCCATGGGGAACGCTCCGAGTCACAGCAGTGAAGACGAAGCGGCAGCTGCCGGTGGCG AGGGCTGGGGCCCACACCAGGACTGGGCCGCGGTCTCGGGCACGACCCCCGGCCCGGGCGTCGCGGCTCCAGCGCTACCACCCGCCGCGG CGCTGCTGGAGCCGGCCAGGCTGCGAGAGGCTGCTGCAGCGTTGCTGCCCACACCCCCCTGCGAGTCGCTGGTGTCGAGGCATCGCGGCG CGTTGTTTCGCTGGCTGGAAGAGCGGCTGGGCCGCGGCGAAGAGTCTGTCACTCTGGAGCAGTTCCGGGAGCTGCTGGAGGCTCGCGGCG CCGGCTGCTCTAGCGAGCAGTTCGAGGAGGCCTTTGCCCAGTTTGATGCTGAGGGTGATGGGACAGTTGATGCCGAGAACATGTTGGAGG CCCTCAAGAATTCCAGTGGAGCTAATCTTCAGGGGGAGCTGAGCCACATCATCAGACAACTACAGGCCTGCTCTCTGGTTCCAGGTTTCA CAGACATATTTTCAGAGTCGAAGGAGGGCCTTGATATTCACTCGTCAATGATACTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGG TGATGCCCTACCCGATGCTGGAGCACTGCAATAACATGTGCACCATGCGGTCTTCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAA AGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGTCCAGAGATGGATAAACTCAAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACAT CCTCCAACTCGGCAGACATTGACAAGATGACAAATGGAGAAACCTCATCCTACTGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTC GTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCACCTGTCCATTGCAGTGGCTGCCACTGACCAGAGCTACATGCCACAGCAGGTGACAG TAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAAGTCCGAGATGTGCACATCCCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAA ATGCCAACGTCAGTCAGCTCTATGTCCAGATTAACATAAAGCGTTGTCTTAGCGATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTG TTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCAGTCTCAGATGCTTCTGCAATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGG CTTCTATGGAGACAAATCCCGCCTTTGTCCAGACAGTGCTGCACAATACTCAGAAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCAC CAGGATCTACAGATTTCTCAACTTTCCTCTCCCCTAATGTGCTGGAAGAAGTGGACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTA CCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCTCTCGCAAGAGGAAGTGTTGCCAAAGTCATGAGCTCTCTATGCACCATCACTGACC ATCTGGACACGCAGTATGATGCCTCATCCCTCATCTTGTCCATGGCGTCAGTCAGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCC AGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAAGAAGATAAGTCTGGACCCGAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTT TTCTTACGGAAACTGGAAAAACCAGAGCCAGCACTATTTTTTCTACCGGAACTGAATCTGCCTTCCAAGTTACACAGATAAGAATTATGG TTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTGGTGTTTGCCTATAACTCATCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAA GGTTTGAAAAATATGACAAATGGAAGCTTCAGGAGCTCAGGCAATTTGTAAAAAGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGG ATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAATGGGATGAAGCAGATGTGAAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGG TGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAGCGCTTGGGAGTGCAAGGCTTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAG AAGCAGAACAGAGCGTCACCTGTGCACACTGCAGAAAGGACACAGAGGAGAGTGTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGT TTATCCAGCAGCTCGCCCATGACCTGGTTATTGCAGCTGACTGCAAAAGGGTCACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGAC AAGAAGAGCCTCTGCTGGCATTCAAGGGTGGAAAGTATGTGTCAGTGGCACCCGTCCCAGACACCATGGGAAAGGAAATGGGAAGCCAAG AGGGAACACGACTGGAAGATGAGGAGGAGGATGTGGTGATTGAAGACTTTGAGGAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGATG ACATCAGGGAGCTTCGGGCCAAGAAGCTGGCTCTGGCCAGGAAGATAGCTGAGCAGCAGCGTCGCCAGGAAAAGATCCAGGCTGTCCTGG AGGACCACAGTCAGATGAGGCAGATGGAGCTCGAAATCAGACCTTTGTTCCTCGTACCAGACACCAACGGCTTCATTGACCACCTGGCCA GTCTGGCGCGGCTGCTGGAGAGCAGGAAGTACATCCTGGTGGTGCCCCTCATCGTGATCAATGAGCTGGACGGCCTGGCCAAGGGGCAGG AGACAGACCACCGGGCTGGGGGCTACGCCCGTGTGGTACAAGAGAAGGCCCGCAAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGTC GGGACTCTTGCCTGCGAGCCCTGACCAGCCGTGGCAATGAACTCGAATCCATCGCCTTCCGCAGTGAGGACATCACTGGCCAGCTGGGTA ACAACGATGATCTCATCCTGTCCTGCTGCCTCCACTACTGCAAAGACAAGGCTAAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATCC GGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAG CCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAG TGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGCCACGGCCATGCTGTG GGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGC TGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGA GGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGCAGTGAAATCACAGTT CCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCT CCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCCCACCTCTTCTACCAT CCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCG TGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGC CTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCA GAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCGGTTCCTCGTCATAGG GGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGT GCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCT CACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCTTCCTTACCAAGAATG AGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAATCTTAATGGGACCAGT GGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGC CAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGA GTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTT >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000263073_chr17_1989195_-_4918nt AAGCCGCAGGGGCCGCCGTCGTCTCCTCCGCGTCCCCGCCCGCCAGCTGCTGTCGGAGGTTGACAGGTCGAGGCGGGGAGGCGGCGGCGG CGGCTGCAGAGCCAGGCGCCCAAGACGGAGACCCCATGGGGAACGCTCCGAGTCACAGCAGTGAAGACGAAGCGGCAGCTGCCGGTGGCG AGGGCTGGGGCCCACACCAGGACTGGGCCGCGGTCTCGGGCACGACCCCCGGCCCGGGCGTCGCGGCTCCAGCGCTACCACCCGCCGCGG CGCTGCTGGAGCCGGCCAGGCTGCGAGAGGCTGCTGCAGCGTTGCTGCCCACACCCCCCTGCGAGTCGCTGGTGTCGAGGCATCGCGGCG CGTTGTTTCGCTGGCTGGAAGAGCGGCTGGGCCGCGGCGAAGAGTCTGTCACTCTGGAGCAGTTCCGGGAGCTGCTGGAGGCTCGCGGCG CCGGCTGCTCTAGCGAGCAGTTCGAGGAGGCCTTTGCCCAGTTTGATGCTGAGGGTGATGGGACAGTTGATGCCGAGAACATGTTGGAGG CCCTCAAGAATTCCAGTGGAGCTAATCTTCAGGGGGAGCTGAGCCACATCATCAGACAACTACAGGCCTGCTCTCTGGTTCCAGGTTTCA CAGACATATTTTCAGAGTCGAAGGAGGGCCTTGATATTCACTCGTCAATGATACTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGG TGATGCCCTACCCGATGCTGGAGCACTGCAATAACATGTGCACCATGCGGTCTTCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAA AGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGTCCAGAGATGGATAAACTCAAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACAT CCTCCAACTCGGCAGACATTGACAAGATGACAAATGGAGAAACCTCATCCTACTGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTC GTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCACCTGTCCATTGCAGTGGCTGCCACTGACCAGAGCTACATGCCACAGCAGGTGACAG TAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAAGTCCGAGATGTGCACATCCCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAA ATGCCAACGTCAGTCAGCTCTATGTCCAGATTAACATAAAGCGTTGTCTTAGCGATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTG TTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCAGTCTCAGATGCTTCTGCAATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGG CTTCTATGGAGACAAATCCCGCCTTTGTCCAGACAGTGCTGCACAATACTCAGAAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCAC CAGGATCTACAGATTTCTCAACTTTCCTCTCCCCTAATGTGCTGGAAGAAGTGGACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTA CCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCTCTCGCAAGAGGAAGTGTTGCCAAAGTCATGAGCTCTCTATGCACCATCACTGACC ATCTGGACACGCAGTATGATGCCTCATCCCTCATCTTGTCCATGGCGTCAGTCAGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCC AGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAAGAAGATAAGTCTGGACCCGAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTT TTCTTACGGAAACTGGAAAAACCAGAGCCAGCACTATTTTTTCTACCGGAACTGAATCTGCCTTCCAAGTTACACAGATAAGAATTATGG TTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTGGTGTTTGCCTATAACTCATCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAA GGTTTGAAAAATATGACAAATGGAAGCTTCAGGAGCTCAGGCAATTTGTAAAAAGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGG ATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAATGGGATGAAGCAGATGTGAAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGG TGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAGCGCTTGGGAGTGCAAGGCTTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAG AAGCAGAACAGAGCGTCACCTGTGCACACTGCAGAAAGGACACAGAGGAGAGTGTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGT TTATCCAGCAGCTCGCCCATGACCTGGTTATTGCAGCTGACTGCAAAAGGGTCACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGAC AAGAAGAGCCTCTGCTGGCATTCAAGGGTGGAAAGTATGTGTCAGTGGCACCCGTCCCAGACACCATGGGAAAGGAAATGGGAAGCCAAG AGGGAACACGACTGGAAGATGAGGAGGAGGATGTGGTGATTGAAGACTTTGAGGAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGATG ACATCAGGGAGCTTCGGGCCAAGAAGCTGGCTCTGGCCAGGAAGATAGCTGAGCAGCAGCGTCGCCAGGAAAAGATCCAGGCTGTCCTGG AGGACCACAGTCAGATGAGGCAGATGGAGCTCGAAATCAGACCTTTGTTCCTCGTACCAGACACCAACGGCTTCATTGACCACCTGGCCA GTCTGGCGCGGCTGCTGGAGAGCAGGAAGTACATCCTGGTGGTGCCCCTCATCGTGATCAATGAGCTGGACGGCCTGGCCAAGGGGCAGG AGACAGACCACCGGGCTGGGGGCTACGCCCGTGTGGTACAAGAGAAGGCCCGCAAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGTC GGGACTCTTGCCTGCGAGCCCTGACCAGCCGTGGCAATGAACTCGAATCCATCGCCTTCCGCAGTGAGGACATCACTGGCCAGCTGGGTA ACAACGATGATCTCATCCTGTCCTGCTGCCTCCACTACTGCAAAGACAAGGCTAAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATCC GGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAG CCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAG TGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGCCACGGCCATGCTGTG GGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGC TGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGA GGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGCAGTGAAATCACAGTT CCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCT CCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCCCACCTCTTCTACCAT CCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCG TGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGC CTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCA GAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCGGTTCCTCGTCATAGG GGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGT GCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCT CACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCTTCCTTACCAAGAATG AGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAATCTTAATGGGACCAGT GGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGC CAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGA GTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTT >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000354901_chr17_1989195_-_4911nt AAGCCGCAGGGGCCGCCGTCGTCTCCTCCGCGTCCCCGCCCGCCAGCTGCTGTCGGAGGTTGACAGGTCGAGGCGGGGAGGCGGCGGCGG CGGCTGCAGAGCCAGGCGCCCAAGACGGAGACCCCATGGGGAACGCTCCGAGTCACAGCAGTGAAGACGAAGCGGCAGCTGCCGGTGGCG AGGGCTGGGGCCCACACCAGGACTGGGCCGCGGTCTCGGGCACGACCCCCGGCCCGGGCGTCGCGGCTCCAGCGCTACCACCCGCCGCGG CGCTGCTGGAGCCGGCCAGGCTGCGAGAGGCTGCTGCAGCGTTGCTGCCCACACCCCCCTGCGAGTCGCTGGTGTCGAGGCATCGCGGCG CGTTGTTTCGCTGGCTGGAAGAGCGGCTGGGCCGCGGCGAAGAGTCTGTCACTCTGGAGCAGTTCCGGGAGCTGCTGGAGGCTCGCGGCG CCGGCTGCTCTAGCGAGCAGTTCGAGGAGGCCTTTGCCCAGTTTGATGCTGAGGGTGATGGGACAGTTGATGCCGAGAACATGTTGGAGG CCCTCAAGAATTCCAGTGGAGCTAATCTTCAGGGGGAGCTGAGCCACATCATCAGACAACTACAGGCCTGCTCTCTGGTTCCAGGTTTCA CAGACATATTTTCAGAGTCGAAGGAGGGCCTTGATATTCACTCGTCAATGATACTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGG TGATGCCCTACCCGATGCTGGAGCACTGCAATAACATGTGCACCATGCGGTCTTCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAA AGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGTCCAGAGATGGATAAACTCAAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACAT CCTCCAACTCGGCAGACATTGACAAGATGACAAATGGAGAAACCTCATCCTACTGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTC GTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCACCTGTCCATTGCAGTGGCTGCCACTGACCAGAGCTACATGCCACAGCAGGTGACAG TAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAAGTCCGAGATGTGCACATCCCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAA ATGCCAACGTCAGTCAGCTCTATGTCCAGATTAACATAAAGCGTTGTCTTAGCGATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTG TTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCAGTCTCAGATGCTTCTGCAATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGG CTTCTATGGAGACAAATCCCGCCTTTGTCCAGACAGTGCTGCACAATACTCAGAAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCAC CAGGATCTACAGATTTCTCAACTTTCCTCTCCCCTAATGTGCTGGAAGAAGTGGACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTA CCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCTCTCGCAAGAGGAAGTGTTGCCAAAGTCATGAGCTCTCTATGCACCATCACTGACC ATCTGGACACGCAGTATGATGCCTCATCCCTCATCTTGTCCATGGCGTCAGTCAGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCC AGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAAGAAGATAAGTCTGGACCCGAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTT TTCTTACGGAAACTGGAAAAACCAGAGCCAGCACTATTTTTTCTACCGGAACTGAATCTGCCTTCCAAGTTACACAGATAAGAATTATGG TTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTGGTGTTTGCCTATAACTCATCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAA GGTTTGAAAAATATGACAAATGGAAGCTTCAGGAGCTCAGGCAATTTGTAAAAAGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGG ATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAATGGGATGAAGCAGATGTGAAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGG TGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAGCGCTTGGGAGTGCAAGGCTTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAG AAGCAGAACAGAGCGTCACCTGTGCACACTGCAGAAAGGACACAGAGGAGAGTGTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGT TTATCCAGCAGCTCGCCCATGACCTGGTTATTGCAGCTGACTGCAAAAGGGTCACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGAC AAGAAGAGCCTCTGCTGGCATTCAAGGGTGGAAAGTATGTGTCAGTGGCACCCGTCCCAGACACCATGGGAAAGGAAATGGGAAGCCAAG AGGGAACACGACTGGAAGATGAGGAGGAGGATGTGGTGATTGAAGACTTTGAGGAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGATG ACATCAGGGAGCTTCGGGCCAAGAAGCTGGCTCTGGCCAGGAAGATAGCTGAGCAGCAGCGTCGCCAGGAAAAGATCCAGGCTGTCCTGG AGGACCACAGTCAGATGAGGCAGATGGAGCTCGAAATCAGACCTTTGTTCCTCGTACCAGACACCAACGGCTTCATTGACCACCTGGCCA GTCTGGCGCGGCTGCTGGAGAGCAGGAAGTACATCCTGGTGGTGCCCCTCATCGTGATCAATGAGCTGGACGGCCTGGCCAAGGGGCAGG AGACAGACCACCGGGCTGGGGGCTACGCCCGTGTGGTACAAGAGAAGGCCCGCAAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGTC GGGACTCTTGCCTGCGAGCCCTGACCAGCCGTGGCAATGAACTCGAATCCATCGCCTTCCGCAGTGAGGACATCACTGGCCAGCTGGGTA ACAACGATGATCTCATCCTGTCCTGCTGCCTCCACTACTGCAAAGACAAGGCTAAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATCC GGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAG CCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAG TGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGCCACGGCCATGCTGTG GGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGC TGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGA GGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGCAGTGAAATCACAGTT CCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCT CCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCCCACCTCTTCTACCAT CCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCG TGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGC CTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCA GAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCGGTTCCTCGTCATAGG GGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGT GCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCT CACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCTTCCTTACCAAGAATG AGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAATCTTAATGGGACCAGT GGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGC CAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGA GTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTT >In-frame_ZZEF1_ENST00000381638_chr17_3991972_-_SMG6_ENST00000536871_chr17_1989195_-_3356nt AAGCCGCAGGGGCCGCCGTCGTCTCCTCCGCGTCCCCGCCCGCCAGCTGCTGTCGGAGGTTGACAGGTCGAGGCGGGGAGGCGGCGGCGG CGGCTGCAGAGCCAGGCGCCCAAGACGGAGACCCCATGGGGAACGCTCCGAGTCACAGCAGTGAAGACGAAGCGGCAGCTGCCGGTGGCG AGGGCTGGGGCCCACACCAGGACTGGGCCGCGGTCTCGGGCACGACCCCCGGCCCGGGCGTCGCGGCTCCAGCGCTACCACCCGCCGCGG CGCTGCTGGAGCCGGCCAGGCTGCGAGAGGCTGCTGCAGCGTTGCTGCCCACACCCCCCTGCGAGTCGCTGGTGTCGAGGCATCGCGGCG CGTTGTTTCGCTGGCTGGAAGAGCGGCTGGGCCGCGGCGAAGAGTCTGTCACTCTGGAGCAGTTCCGGGAGCTGCTGGAGGCTCGCGGCG CCGGCTGCTCTAGCGAGCAGTTCGAGGAGGCCTTTGCCCAGTTTGATGCTGAGGGTGATGGGACAGTTGATGCCGAGAACATGTTGGAGG CCCTCAAGAATTCCAGTGGAGCTAATCTTCAGGGGGAGCTGAGCCACATCATCAGACAACTACAGGCCTGCTCTCTGGTTCCAGGTTTCA CAGACATATTTTCAGAGTCGAAGGAGGGCCTTGATATTCACTCGTCAATGATACTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGG TGATGCCCTACCCGATGCTGGAGCACTGCAATAACATGTGCACCATGCGGTCTTCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAA AGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGTCCAGAGATGGATAAACTCAAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACAT CCTCCAACTCGGCAGACATTGACAAGATGACAAATGGAGAAACCTCATCCTACTGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTC GTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCACCTGTCCATTGCAGTGGCTGCCACTGACCAGAGCTACATGCCACAGCAGGTGACAG TAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAAGTCCGAGATGTGCACATCCCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAA ATGCCAACGTCAGTCAGCTCTATGTCCAGATTAACATAAAGCGTTGTCTTAGCGATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTG TTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCAGTCTCAGATGCTTCTGCAATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGG CTTCTATGGAGACAAATCCCGCCTTTGTCCAGACAGTGCTGCACAATACTCAGAAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCAC CAGGATCTACAGATTTCTCAACTTTCCTCTCCCCTAATGTGCTGGAAGAAGTGGACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTA CCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCTCTCGCAAGAGGAAGTGTTGCCAAAGTCATGAGCTCTCTATGCACCATCACTGACC ATCTGGACACGCAGTATGATGCCTCATCCCTCATCTTGTCCATGGCGTCAGTCAGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCC AGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAAGAAGATAAGTCTGGACCCGAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTT TTCTTACGGAAACTGGAAAAACCAGAGCCAGCACTATTTTTTCTACCGGAACTGAATCTGCCTTCCAAGTTACACAGATAAGAATTATGG TTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTGGTGTTTGCCTATAACTCATCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAA GGTTTGAAAAATATGACAAATGGAAGCTTCAGGAGCTCAGGCAATTTGTAAAAAGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGG ATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAATGGGATGAAGCAGATGTGAAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGG TGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAGCGCTTGGGAGTGCAAGGCTTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAG AAGCAGAACAGAGCGTCACCTGTGCACACTGCAGAAAGGACACAGAGGAGAGTGTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGT TTATCCAGCAGCTCGCCCATGACCTGGTTATTGCAGCTGACTGCAAAAGGGTCACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGAC AAGAAGAGCCTCTGCTGGCATTCAAGGGTGGAAAGTATGTGTCAGTGGCACCCGTCCCAGACACCATGGGAAAGGAAATGGGAAGCCAAG AGGGAACACGACTGGAAGATGAGGAGGAGGATGTGGTGATTGAAGACTTTGAGGAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGATG ACATCAGGGAGCTTCGGGCCAAGAAGCTGGCTCTGGCCAGGAAGATAGCTGAGCAGCAGCGTCGCCAGGAAAAGATCCAGGCTGTCCTGG AGGACCACAGTCAGATGAGGCAGATGGAGCTCGAAATCAGACCTTTGTTCCTCGTACCAGACACCAACGGCTTCATTGACCACCTGGCCA GTCTGGCGCGGCTGCTGGAGAGCAGGAAGTACATCCTGGTGGTGCCCCTCATCGTGATCAATGAGCTGGACGGCCTGGCCAAGGGGCAGG AGACAGACCACCGGGCTGGGGGCTACGCCCGTGTGGTACAAGAGAAGGCCCGCAAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGTC GGGACTCTTGCCTGCGAGCCCTGACCAGCCGTGGCAATGAACTCGAATCCATCGCCTTCCGCAGTGAGGACATCACTGGCCAGCTGGGTA ACAACGATGATCTCATCCTGTCCTGCTGCCTCCACTACTGCAAAGACAAGGCTAAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATCC GGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAG CCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAG |
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FusionGenePPI for ZZEF1_SMG6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZZEF1 | PHYHIP, PTPN4, HSPB3, SKIL, HECTD3, MYCBP, S100A4, EPS15L1, LMNB1, MAD1L1, NCAPH, GLIPR1L2, GAS2L1, RPS4X, RSPO1, DHRS4L2, MRM1, PARD6B, FOSL2, DLK1, POGLUT1, CCDC130, SCCPDH, TRMT10C, WNT9B, CCNG1, PDGFRB, XRCC5, THOC1, TGS1, GAN, EGFL6, ANGPT2, CHRDL1, RBFA, GAST, CPA6, WFDC10A, PTRF, MRPS24, LYZL1, CLEC3A, SERPINA5, MRPS34, NKAP, FGFRL1, COPS7B, ZBBX, ACSBG2, TTC25, MRPL10, DCAF12, PRSS33, GPR156, LYZL2, CDK5RAP1, GMNN | SMG6 | TERT, HDAC8, UPF1, HBB, PPP1CC, SOX2, RBM8A, MAGOH, PABPC1, SMG6, UPF3B, SMG5, SMG7, PSG1, C2orf68, FAM221B, SPATA1, HAO2, LPIN3, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000263073 | - | 12 | 19 | 114_503 | 1119 | 1420 | telomeric DNA |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000354901 | - | 5 | 12 | 114_503 | 211 | 512 | telomeric DNA |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000536871 | - | 4 | 11 | 114_503 | 211 | 512 | telomeric DNA |
| Tgene | SMG6 | chr17:3991972 | chr17:1989195 | ENST00000544865 | - | 12 | 19 | 114_503 | 1088 | 1389 | telomeric DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZZEF1_SMG6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZZEF1_SMG6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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