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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43877

FusionGeneSummary for ZXDC_UROC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZXDC_UROC1
Fusion gene ID: 43877
HgeneTgene
Gene symbol

ZXDC

UROC1

Gene ID

79364

131669

Gene nameZXD family zinc finger Curocanate hydratase 1
SynonymsZXDLHMFN0320|UROCD
Cytomap

3q21.3

3q21.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein ZXDCSERH2790ZXD-like zinc finger proteinurocanate hydrataseimidazolonepropionate hydrolaseurocanase 1urocanase domain containing 1
Modification date2018051920180329
UniProtAcc

Q2QGD7

Q96N76

Ensembl transtripts involved in fusion geneENST00000389709, ENST00000336332, 
ENST00000290868, ENST00000383579, 
Fusion gene scores* DoF score2 X 4 X 2=161 X 1 X 1=1
# samples 41
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: ZXDC [Title/Abstract] AND UROC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZXDC

GO:0045893

positive regulation of transcription, DNA-templated

17696781


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDACCTCGA-OR-A5LD-01AZXDCchr3

126184998

-UROC1chr3

126201328

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389709ENST00000290868ZXDCchr3

126184998

-UROC1chr3

126201328

-
Frame-shiftENST00000389709ENST00000383579ZXDCchr3

126184998

-UROC1chr3

126201328

-
In-frameENST00000336332ENST00000290868ZXDCchr3

126184998

-UROC1chr3

126201328

-
Frame-shiftENST00000336332ENST00000383579ZXDCchr3

126184998

-UROC1chr3

126201328

-

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FusionProtFeatures for ZXDC_UROC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZXDC

Q2QGD7

UROC1

Q96N76

Cooperates with CIITA to promote transcription of MHCclass I and MHC class II genes. {ECO:0000269|PubMed:16600381,ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:17696781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56175_199480711Zinc fingerC2H2-type 1
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56208_232480711Zinc fingerC2H2-type 2
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56238_262480711Zinc fingerC2H2-type 3
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56268_290480711Zinc fingerC2H2-type 4
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56297_321480711Zinc fingerC2H2-type 5
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56328_352480711Zinc fingerC2H2-type 6
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56358_382480711Zinc fingerC2H2-type 7
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56388_412480711Zinc fingerC2H2-type 8
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56418_442480711Zinc fingerC2H2-type 9
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56451_476480711Zinc fingerC2H2-type 10
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510175_199480859Zinc fingerC2H2-type 1
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510208_232480859Zinc fingerC2H2-type 2
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510238_262480859Zinc fingerC2H2-type 3
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510268_290480859Zinc fingerC2H2-type 4
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510297_321480859Zinc fingerC2H2-type 5
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510328_352480859Zinc fingerC2H2-type 6
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510358_382480859Zinc fingerC2H2-type 7
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510388_412480859Zinc fingerC2H2-type 8
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510418_442480859Zinc fingerC2H2-type 9
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510451_476480859Zinc fingerC2H2-type 10

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56579_688480711RegionNote=Required for transcriptional activation
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510579_688480859RegionNote=Required for transcriptional activation
TgeneUROC1chr3:126184998chr3:126201328ENST00000290868-1820126_127630677Nucleotide bindingNAD
TgeneUROC1chr3:126184998chr3:126201328ENST00000290868-1820251_253630677Nucleotide bindingNAD
TgeneUROC1chr3:126184998chr3:126201328ENST00000290868-1820317_318630677Nucleotide bindingNAD
TgeneUROC1chr3:126184998chr3:126201328ENST00000290868-1820343_347630677Nucleotide bindingNAD
TgeneUROC1chr3:126184998chr3:126201328ENST00000290868-1820354_355630677Nucleotide bindingNAD
TgeneUROC1chr3:126184998chr3:126201328ENST00000383579-1921126_127690737Nucleotide bindingNAD
TgeneUROC1chr3:126184998chr3:126201328ENST00000383579-1921251_253690737Nucleotide bindingNAD
TgeneUROC1chr3:126184998chr3:126201328ENST00000383579-1921317_318690737Nucleotide bindingNAD
TgeneUROC1chr3:126184998chr3:126201328ENST00000383579-1921343_347690737Nucleotide bindingNAD
TgeneUROC1chr3:126184998chr3:126201328ENST00000383579-1921354_355690737Nucleotide bindingNAD


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FusionGeneSequence for ZXDC_UROC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZXDC_UROC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZXDCNR1H3, NR1H2, RORA, SH3GL2, TK1, JTB, SMN1, APP, ATXN1, WDR5, POGZ, NXF1UROC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZXDCchr3:126184998chr3:126201328ENST00000336332-56781_858480711CIITA
HgeneZXDCchr3:126184998chr3:126201328ENST00000389709-510781_858480859CIITA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZXDC_UROC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZXDC_UROC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUROC1C0004134Ataxia1CTD_human
TgeneUROC1C0268514Urocanase deficiency1CTD_human;ORPHANET;UNIPROT
TgeneUROC1C3714756Intellectual Disability1CTD_human