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Fusion gene ID: 43872 |
FusionGeneSummary for ZSWIM6_GATAD2B |
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Fusion gene information | Fusion gene name: ZSWIM6_GATAD2B | Fusion gene ID: 43872 | Hgene | Tgene | Gene symbol | ZSWIM6 | GATAD2B | Gene ID | 57688 | 57459 |
Gene name | zinc finger SWIM-type containing 6 | GATA zinc finger domain containing 2B | |
Synonyms | AFND|NEDMAGA | MRD18|P66beta|p68 | |
Cytomap | 5q12.1 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger SWIM domain-containing protein 6zinc finger, SWIM domain containing 6 | transcriptional repressor p66-betaGATA zinc finger domain-containing protein 2Btranscription repressor p66 beta component of the MeCP1 complex | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9HCJ5 | Q8WXI9 | |
Ensembl transtripts involved in fusion gene | ENST00000252744, | ENST00000368655, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 7 X 6 X 3=126 |
# samples | 4 | 7 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZSWIM6 [Title/Abstract] AND GATAD2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI392738 | ZSWIM6 | chr5 | 60729594 | - | GATAD2B | chr1 | 153848756 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000252744 | ENST00000368655 | ZSWIM6 | chr5 | 60729594 | - | GATAD2B | chr1 | 153848756 | + |
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FusionProtFeatures for ZSWIM6_GATAD2B |
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Hgene | Tgene |
ZSWIM6 | GATAD2B |
Transcriptional repressor. Enhances MBD2-mediatedrepression. Efficient repression requires the presence of GATAD2A.Targets MBD3 to discrete loci in the nucleus. May play a role insynapse development. {ECO:0000269|PubMed:12183469,ECO:0000269|PubMed:16415179}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZSWIM6_GATAD2B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZSWIM6_GATAD2B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZSWIM6_GATAD2B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZSWIM6_GATAD2B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZSWIM6 | C1863616 | ACROMELIC FRONTONASAL DYSOSTOSIS | 1 | UNIPROT |