![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 43871 |
FusionGeneSummary for ZSWIM6_ERP29 |
![]() |
Fusion gene information | Fusion gene name: ZSWIM6_ERP29 | Fusion gene ID: 43871 | Hgene | Tgene | Gene symbol | ZSWIM6 | ERP29 | Gene ID | 57688 | 10961 |
Gene name | zinc finger SWIM-type containing 6 | endoplasmic reticulum protein 29 | |
Synonyms | AFND|NEDMAGA | C12orf8|ERp28|ERp31|HEL-S-107|PDI-DB|PDIA9 | |
Cytomap | 5q12.1 | 12q24.13 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger SWIM domain-containing protein 6zinc finger, SWIM domain containing 6 | endoplasmic reticulum resident protein 29endoplasmic reticulum lumenal protein ERp28endoplasmic reticulum resident protein 28endoplasmic reticulum resident protein 31epididymis secretory protein Li 107protein disulfide isomerase family A, member 9 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9HCJ5 | P30040 | |
Ensembl transtripts involved in fusion gene | ENST00000252744, | ENST00000261735, ENST00000455836, ENST00000546477, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 3 X 3 X 2=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZSWIM6 [Title/Abstract] AND ERP29 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ERP29 | GO:0000187 | activation of MAPK activity | 22064321 |
Tgene | ERP29 | GO:0001934 | positive regulation of protein phosphorylation | 22064321 |
Tgene | ERP29 | GO:0010628 | positive regulation of gene expression | 22064321 |
Tgene | ERP29 | GO:0010629 | negative regulation of gene expression | 22064321 |
Tgene | ERP29 | GO:0050709 | negative regulation of protein secretion | 22064321 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DN998968 | ZSWIM6 | chr5 | 60840893 | + | ERP29 | chr12 | 112451264 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000252744 | ENST00000261735 | ZSWIM6 | chr5 | 60840893 | + | ERP29 | chr12 | 112451264 | + |
3UTR-5UTR | ENST00000252744 | ENST00000455836 | ZSWIM6 | chr5 | 60840893 | + | ERP29 | chr12 | 112451264 | + |
3UTR-intron | ENST00000252744 | ENST00000546477 | ZSWIM6 | chr5 | 60840893 | + | ERP29 | chr12 | 112451264 | + |
Top |
FusionProtFeatures for ZSWIM6_ERP29 |
![]() |
Hgene | Tgene |
ZSWIM6 | ERP29 |
Does not seem to be a disulfide isomerase. Plays animportant role in the processing of secretory proteins within theendoplasmic reticulum (ER), possibly by participating in thefolding of proteins in the ER. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZSWIM6_ERP29 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZSWIM6_ERP29 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZSWIM6_ERP29 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZSWIM6_ERP29 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZSWIM6 | C1863616 | ACROMELIC FRONTONASAL DYSOSTOSIS | 1 | UNIPROT |
Tgene | ERP29 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ERP29 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ERP29 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | ERP29 | C2239176 | Liver carcinoma | 1 | CTD_human |