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Fusion gene ID: 43870 |
FusionGeneSummary for ZSWIM6_CWC27 |
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Fusion gene information | Fusion gene name: ZSWIM6_CWC27 | Fusion gene ID: 43870 | Hgene | Tgene | Gene symbol | ZSWIM6 | CWC27 | Gene ID | 57688 | 10283 |
Gene name | zinc finger SWIM-type containing 6 | CWC27 spliceosome associated protein homolog | |
Synonyms | AFND|NEDMAGA | NY-CO-10|RPSKA|SDCCAG-10|SDCCAG10 | |
Cytomap | 5q12.1 | 5q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger SWIM domain-containing protein 6zinc finger, SWIM domain containing 6 | peptidyl-prolyl cis-trans isomerase CWC27 homologPPIase CWC27PPIase SDCCAG10antigen NY-CO-10peptidyl-prolyl cis-trans isomerase SDCCAG10serologically defined colon cancer antigen 10 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9HCJ5 | Q6UX04 | |
Ensembl transtripts involved in fusion gene | ENST00000252744, | ENST00000381070, ENST00000508024, ENST00000545000, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 3 X 3=36 |
# samples | 4 | 4 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZSWIM6 [Title/Abstract] AND CWC27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-J9-A52D-01A | ZSWIM6 | chr5 | 60628775 | + | CWC27 | chr5 | 64267530 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000252744 | ENST00000381070 | ZSWIM6 | chr5 | 60628775 | + | CWC27 | chr5 | 64267530 | + |
5CDS-intron | ENST00000252744 | ENST00000508024 | ZSWIM6 | chr5 | 60628775 | + | CWC27 | chr5 | 64267530 | + |
5CDS-3UTR | ENST00000252744 | ENST00000545000 | ZSWIM6 | chr5 | 60628775 | + | CWC27 | chr5 | 64267530 | + |
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FusionProtFeatures for ZSWIM6_CWC27 |
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Hgene | Tgene |
ZSWIM6 | CWC27 |
As part of the spliceosome, plays a role in pre-mRNAsplicing (PubMed:29360106). Probable inactive PPIase with nopeptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).{ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ZSWIM6 | chr5:60628775 | chr5:64267530 | ENST00000252744 | + | 1 | 14 | 155_158 | 225 | 1216 | Compositional bias | Note=Poly-Ser |
Hgene | ZSWIM6 | chr5:60628775 | chr5:64267530 | ENST00000252744 | + | 1 | 14 | 160_197 | 225 | 1216 | Compositional bias | Note=Ala-rich |
Hgene | ZSWIM6 | chr5:60628775 | chr5:64267530 | ENST00000252744 | + | 1 | 14 | 19_154 | 225 | 1216 | Compositional bias | Note=Gly-rich |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ZSWIM6 | chr5:60628775 | chr5:64267530 | ENST00000252744 | + | 1 | 14 | 246_283 | 225 | 1216 | Zinc finger | SWIM-type |
Tgene | CWC27 | chr5:60628775 | chr5:64267530 | ENST00000381070 | + | 10 | 14 | 206_230 | 347 | 473 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | CWC27 | chr5:60628775 | chr5:64267530 | ENST00000381070 | + | 10 | 14 | 306_377 | 347 | 473 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | CWC27 | chr5:60628775 | chr5:64267530 | ENST00000381070 | + | 10 | 14 | 11_166 | 347 | 473 | Domain | PPIase cyclophilin-type |
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FusionGeneSequence for ZSWIM6_CWC27 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ZSWIM6_ENST00000252744_chr5_60628775_+_CWC27_ENST00000381070_chr5_64267530_+_351aa MAERGQQPPPAKRLCCRPGGGGGGGGSSGGGGGAGGGYSSACRPGPRAGGAAAAAACGGGAALGLLPPGKTQSPESLLDIAARRVAEKWP FQRVEERFERIPEPVQRRIVYWSFPRSEREICMYSSFNTGGGAAGGPGDDSGGGGGAGGGGGGGSSSSPAATSAAATSAAAAAAAAAAAA AAAAGAGAPSVGAAGAADGGDETRLPFRRGIALLESGCVDNVLQVEEEAPPDGAVAEYRREKQKYEALRKQQSKKGTSREDQTLALLNQF |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ZSWIM6_ENST00000252744_chr5_60628775_+_CWC27_ENST00000381070_chr5_64267530_+_1053nt ATGGCGGAGCGCGGACAGCAGCCTCCTCCCGCGAAACGGCTTTGCTGCCGGCCGGGCGGCGGCGGCGGCGGCGGGGGCAGCAGCGGCGGC GGCGGCGGCGCGGGTGGCGGCTACAGCTCTGCCTGTCGGCCAGGCCCGCGGGCGGGTGGCGCGGCGGCGGCGGCGGCGTGCGGGGGCGGC GCGGCGCTGGGGTTGCTGCCGCCGGGCAAGACCCAGAGCCCCGAGTCGCTGCTGGACATCGCGGCGCGCAGGGTGGCGGAGAAGTGGCCG TTCCAGCGCGTGGAGGAGCGCTTTGAGCGCATCCCGGAGCCGGTGCAGCGCCGCATAGTCTATTGGTCCTTCCCCCGCAGCGAGCGGGAG ATCTGCATGTACTCGTCCTTCAACACCGGCGGCGGCGCCGCGGGCGGCCCCGGCGACGACAGCGGTGGCGGCGGCGGCGCGGGCGGCGGC GGCGGCGGCGGCTCCTCGTCTTCCCCGGCCGCAACCTCGGCGGCCGCAACCTCGGCCGCCGCCGCCGCTGCCGCCGCCGCCGCCGCCGCC GCCGCCGCCGCGGGGGCCGGGGCCCCGTCGGTGGGGGCTGCCGGGGCGGCGGACGGCGGCGACGAGACGCGGCTGCCTTTCCGCCGGGGC ATCGCGCTGTTGGAAAGCGGCTGCGTAGACAACGTCCTGCAAGTCGAGGAAGAAGCCCCTCCAGATGGTGCTGTTGCCGAATACAGAAGA GAAAAGCAAAAGTATGAAGCTTTGAGGAAGCAACAGTCAAAGAAGGGAACTTCCCGGGAAGATCAGACCCTTGCACTGCTGAACCAGTTT AAATCTAAACTCACTCAAGCAATTGCTGAAACGCCTGAAAATGACATTCCTGAAACAGAAGTAGAAGATGATGAAGGATGGATGTCACAT GTACTTCAGTTTGAGGATAAAAGCAGAAAAGTGAAAGATGCAAGCATGCAAGACTCAGATACATTTGAAATCTATGATCCTCGGAATCCA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ZSWIM6_ENST00000252744_chr5_60628775_+_CWC27_ENST00000381070_chr5_64267530_+_1495nt ATGGCGGAGCGCGGACAGCAGCCTCCTCCCGCGAAACGGCTTTGCTGCCGGCCGGGCGGCGGCGGCGGCGGCGGGGGCAGCAGCGGCGGC GGCGGCGGCGCGGGTGGCGGCTACAGCTCTGCCTGTCGGCCAGGCCCGCGGGCGGGTGGCGCGGCGGCGGCGGCGGCGTGCGGGGGCGGC GCGGCGCTGGGGTTGCTGCCGCCGGGCAAGACCCAGAGCCCCGAGTCGCTGCTGGACATCGCGGCGCGCAGGGTGGCGGAGAAGTGGCCG TTCCAGCGCGTGGAGGAGCGCTTTGAGCGCATCCCGGAGCCGGTGCAGCGCCGCATAGTCTATTGGTCCTTCCCCCGCAGCGAGCGGGAG ATCTGCATGTACTCGTCCTTCAACACCGGCGGCGGCGCCGCGGGCGGCCCCGGCGACGACAGCGGTGGCGGCGGCGGCGCGGGCGGCGGC GGCGGCGGCGGCTCCTCGTCTTCCCCGGCCGCAACCTCGGCGGCCGCAACCTCGGCCGCCGCCGCCGCTGCCGCCGCCGCCGCCGCCGCC GCCGCCGCCGCGGGGGCCGGGGCCCCGTCGGTGGGGGCTGCCGGGGCGGCGGACGGCGGCGACGAGACGCGGCTGCCTTTCCGCCGGGGC ATCGCGCTGTTGGAAAGCGGCTGCGTAGACAACGTCCTGCAAGTCGAGGAAGAAGCCCCTCCAGATGGTGCTGTTGCCGAATACAGAAGA GAAAAGCAAAAGTATGAAGCTTTGAGGAAGCAACAGTCAAAGAAGGGAACTTCCCGGGAAGATCAGACCCTTGCACTGCTGAACCAGTTT AAATCTAAACTCACTCAAGCAATTGCTGAAACGCCTGAAAATGACATTCCTGAAACAGAAGTAGAAGATGATGAAGGATGGATGTCACAT GTACTTCAGTTTGAGGATAAAAGCAGAAAAGTGAAAGATGCAAGCATGCAAGACTCAGATACATTTGAAATCTATGATCCTCGGAATCCA GTGAATAAAAGAAGGAGGGAAGAAAGCAAAAAGCTGATGAGAGAGAAAAAAGAAAGAAGATAAAATGAGAATAATGATAACCAGAACTTG CTGGAAATGTGCCTACAATGGCCTTGTAACAGCCATTGTTCCCAACAGCATCACTTAGGGGTGTGAAAAGAAGTATTTTTGAACCTGTTG TCTGGTTTTGAAAAACAATTATCTTGTTTTGCAAATTGTGGAATGATGTAAGCAAATGCTTTTGGTTACTGGTACATGTGTTTTTTCCTA GCTGACCTTTTATATTGCTAAATCTGAAATAAAATAACTTTCCTTCCACATTACATGTTAACCATTGCAGACTGCAAGCCTGTTTGTGTC CTTTTACCCTAAAATATATGAAGGCTTCCTTTTCAAGATTTTTTTATAAGAAGTTCCTACAGAAAGAATATTTGTGGGAAACCTCCCTTT |
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FusionGenePPI for ZSWIM6_CWC27 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZSWIM6 | HECW2, GLMN | CWC27 | SNW1, SKIV2L2, DHX38, PRKDC, XRCC4, SCYL1, HOXC10, SIPA1L1, FRA10AC1, HMGA1, VTI1B, EDA, EPB41L3, LSM2, LSM6, CLK1, YWHAZ, IGSF6, EPB41L5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZSWIM6_CWC27 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZSWIM6_CWC27 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZSWIM6 | C1863616 | ACROMELIC FRONTONASAL DYSOSTOSIS | 1 | UNIPROT |