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Fusion gene ID: 43868 |
FusionGeneSummary for ZSWIM4_UBQLN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZSWIM4_UBQLN4 | Fusion gene ID: 43868 | Hgene | Tgene | Gene symbol | ZSWIM4 | UBQLN4 | Gene ID | 65249 | 56893 |
| Gene name | zinc finger SWIM-type containing 4 | ubiquilin 4 | |
| Synonyms | - | A1U|A1Up|C1orf6|CIP75|UBIN | |
| Cytomap | 19p13.13-p13.12 | 1q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger SWIM domain-containing protein 4zinc finger, SWIM domain containing 4 | ubiquilin-4ataxin-1 interacting ubiquitin-like proteinataxin-1 ubiquitin-like interacting proteinataxin-1 ubiquitin-like-interacting protein A1Uconnexin43-interacting protein of 75 kDa | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H7M6 | Q9NRR5 | |
| Ensembl transtripts involved in fusion gene | ENST00000254323, ENST00000440752, | ENST00000368309, ENST00000472638, | |
| Fusion gene scores | * DoF score | 10 X 11 X 7=770 | 5 X 4 X 4=80 |
| # samples | 11 | 5 | |
| ** MAII score | log2(11/770*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZSWIM4 [Title/Abstract] AND UBQLN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-26-5139-01A | ZSWIM4 | chr19 | 13920034 | + | UBQLN4 | chr1 | 156012704 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000254323 | ENST00000368309 | ZSWIM4 | chr19 | 13920034 | + | UBQLN4 | chr1 | 156012704 | - |
| 5CDS-intron | ENST00000254323 | ENST00000472638 | ZSWIM4 | chr19 | 13920034 | + | UBQLN4 | chr1 | 156012704 | - |
| In-frame | ENST00000440752 | ENST00000368309 | ZSWIM4 | chr19 | 13920034 | + | UBQLN4 | chr1 | 156012704 | - |
| 5CDS-intron | ENST00000440752 | ENST00000472638 | ZSWIM4 | chr19 | 13920034 | + | UBQLN4 | chr1 | 156012704 | - |
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FusionProtFeatures for ZSWIM4_UBQLN4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZSWIM4 | UBQLN4 |
| Plays a role in the regulation of protein degradationvia the ubiquitin-proteasome system (UPS). Mediates theproteasomal targeting of misfolded or accumulated proteins fordegradation by binding (via UBA domain) to their polyubiquitinchains and by interacting (via ubiquitin-like domain) with thesubunits of the proteasome (Ref. 6). Plays a role in theregulation of the proteasomal degradation of non-ubiquitinatedGJA1 (By similarity). Acts as an adapter protein that recruitsUBQLN1 to the autophagy machinery. Mediates the association ofUBQLN1 with autophagosomes and the autophagy-related protein LC3(MAP1LC3A/B/C) and may assist in the maturation of autophagosomesto autolysosomes by mediating autophagosome-lysosome fusion(PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8,ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ZSWIM4 | chr19:13920034 | chr1:156012704 | ENST00000254323 | + | 5 | 13 | 139_176 | 337 | 990 | Zinc finger | SWIM-type |
| Tgene | >UBQLN4 | chr19:13920034 | chr1:156012704 | ENST00000368309 | - | 5 | 11 | 393_440 | 375 | 602 | Domain | STI1 3 |
| Tgene | >UBQLN4 | chr19:13920034 | chr1:156012704 | ENST00000368309 | - | 5 | 11 | 444_476 | 375 | 602 | Domain | STI1 4 |
| Tgene | >UBQLN4 | chr19:13920034 | chr1:156012704 | ENST00000368309 | - | 5 | 11 | 553_598 | 375 | 602 | Domain | UBA |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | UBQLN4 | chr19:13920034 | chr1:156012704 | ENST00000368309 | - | 5 | 11 | 13_87 | 375 | 602 | Domain | Ubiquitin-like |
| Tgene | UBQLN4 | chr19:13920034 | chr1:156012704 | ENST00000368309 | - | 5 | 11 | 192_229 | 375 | 602 | Domain | STI1 1 |
| Tgene | UBQLN4 | chr19:13920034 | chr1:156012704 | ENST00000368309 | - | 5 | 11 | 230_261 | 375 | 602 | Domain | STI1 2 |
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FusionGeneSequence for ZSWIM4_UBQLN4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZSWIM4_ENST00000254323_chr19_13920034_+_UBQLN4_ENST00000368309_chr1_156012704_-_564aa MEPPAAKRSRGCPAGPEERDAGAGAARGRGRPEALLDLSAKRVAESWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYPPP EGEHDARVPFTRGLHLLQSGAVDRVLQVGFHLSGNIREPGSPGEPERLYHVSISFDRCKITSVSCGCDNRDLFYCAHVVALSLYRIRHAH QVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPTAQRLADEILLLGSEINLVNGAPDPTAGAGIEDANCWHLDEEQIQEQVKQLLS NGGYYGASQQLRSMFSKVREMLRMRDSNGARMLILMTEQFLQDTRLALWRQQGAGMTDKCRQLWDELGMFNSPEMQALLQQISENPQLMQ NVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVP SLGSFGISRTPAPSAGSNAGSTPEAPTSSPATPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMGFINREANL >In-frame_ZSWIM4_ENST00000440752_chr19_13920034_+_UBQLN4_ENST00000368309_chr1_156012704_-_281aa MFSKVREMLRMRDSNGARMLILMTEQFLQDTRLALWRQQGAGMTDKCRQLWDELGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQ TLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAP SAGSNAGSTPEAPTSSPATPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMGFINREANLQALIATGGDINAA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZSWIM4_ENST00000254323_chr19_13920034_+_UBQLN4_ENST00000368309_chr1_156012704_-_1692nt ATGGAACCCCCCGCGGCCAAGCGGAGCCGGGGCTGCCCCGCGGGACCCGAGGAGCGCGATGCCGGGGCCGGGGCCGCGCGTGGCCGGGGC CGGCCCGAGGCGCTGCTGGACCTCAGCGCCAAGCGGGTAGCCGAGAGCTGGGCCTTCGAGCAGGTGGAGGAGCGGTTCTCCCGGGTGCCT GAGCCCGTCCAGAAGCGCATCGTGTTTTGGTCGTTTCCACGCAGTGAACGGGAAATATGTATGTACTCGTCGCTGGGTTACCCGCCCCCA GAGGGCGAGCACGATGCCCGGGTGCCCTTTACCCGCGGGCTGCACCTGCTCCAGAGCGGGGCCGTGGACCGCGTGTTGCAAGTGGGATTC CACCTGAGCGGAAACATCCGCGAGCCAGGGAGTCCTGGAGAGCCCGAGCGCCTCTACCATGTCTCCATCAGCTTTGATCGCTGCAAGATC ACGTCCGTGAGCTGCGGCTGTGACAACCGCGACCTCTTCTACTGTGCCCACGTGGTGGCCCTGTCCCTGTACCGCATTCGGCACGCCCAC CAGGTGGAGCTGCGGCTGCCCATCTCCGAGACGCTCTCCCAGATGAACCGGGACCAGCTGCAGAAGTTCGTGCAGTACCTCATCAGCGCC CATCACACTGAGGTGCTGCCCACTGCTCAGCGCTTGGCTGATGAGATCCTCCTGCTGGGCTCCGAGATCAACTTGGTGAATGGTGCCCCA GACCCCACCGCCGGCGCAGGAATCGAGGACGCCAACTGCTGGCACCTGGACGAGGAGCAGATCCAGGAGCAGGTGAAGCAGCTACTGTCC AATGGCGGCTACTACGGGGCCAGCCAGCAGCTGCGCTCCATGTTCAGCAAGGTGCGGGAGATGCTGCGAATGCGGGACTCCAACGGGGCG CGCATGCTGATTCTCATGACCGAGCAGTTCCTGCAGGACACGCGCCTGGCCCTGTGGCGGCAGCAGGGCGCGGGCATGACGGACAAGTGC CGGCAGCTCTGGGATGAGCTGGGGATGTTCAATAGCCCAGAAATGCAAGCCCTCCTCCAGCAGATCTCTGAGAACCCCCAGCTGATGCAG AATGTGATCTCAGCACCCTACATGCGCAGCATGATGCAGACGCTTGCCCAGAACCCCGACTTTGCTGCTCAGATGATGGTGAATGTGCCG CTCTTCGCGGGGAACCCCCAACTGCAGGAGCAGCTCCGCCTGCAGCTCCCAGTCTTCCTGCAGCAGATGCAGAACCCAGAGTCACTCTCC ATCCTTACCAATCCCCGAGCCATGCAGGCATTGCTGCAGATCCAGCAGGGACTACAGACCTTGCAGACCGAGGCCCCTGGGCTGGTACCC AGCCTTGGCTCCTTTGGGATATCCCGGACCCCAGCACCCTCAGCAGGCAGCAACGCAGGGTCTACGCCCGAGGCCCCCACTTCCTCACCA GCCACGCCAGCCACATCTTCTCCAACAGGGGCTTCCAGCGCCCAGCAGCAACTCATGCAGCAGATGATCCAGCTTTTGGCTGGAAGTGGA AACTCACAGGTGCAGACGCCAGAAGTGAGATTTCAGCAGCAGCTGGAGCAGCTCAACTCCATGGGCTTCATCAATCGTGAGGCTAACCTG >In-frame_ZSWIM4_ENST00000440752_chr19_13920034_+_UBQLN4_ENST00000368309_chr1_156012704_-_843nt ATGTTCAGCAAGGTGCGGGAGATGCTGCGAATGCGGGACTCCAACGGGGCGCGCATGCTGATTCTCATGACCGAGCAGTTCCTGCAGGAC ACGCGCCTGGCCCTGTGGCGGCAGCAGGGCGCGGGCATGACGGACAAGTGCCGGCAGCTCTGGGATGAGCTGGGGATGTTCAATAGCCCA GAAATGCAAGCCCTCCTCCAGCAGATCTCTGAGAACCCCCAGCTGATGCAGAATGTGATCTCAGCACCCTACATGCGCAGCATGATGCAG ACGCTTGCCCAGAACCCCGACTTTGCTGCTCAGATGATGGTGAATGTGCCGCTCTTCGCGGGGAACCCCCAACTGCAGGAGCAGCTCCGC CTGCAGCTCCCAGTCTTCCTGCAGCAGATGCAGAACCCAGAGTCACTCTCCATCCTTACCAATCCCCGAGCCATGCAGGCATTGCTGCAG ATCCAGCAGGGACTACAGACCTTGCAGACCGAGGCCCCTGGGCTGGTACCCAGCCTTGGCTCCTTTGGGATATCCCGGACCCCAGCACCC TCAGCAGGCAGCAACGCAGGGTCTACGCCCGAGGCCCCCACTTCCTCACCAGCCACGCCAGCCACATCTTCTCCAACAGGGGCTTCCAGC GCCCAGCAGCAACTCATGCAGCAGATGATCCAGCTTTTGGCTGGAAGTGGAAACTCACAGGTGCAGACGCCAGAAGTGAGATTTCAGCAG CAGCTGGAGCAGCTCAACTCCATGGGCTTCATCAATCGTGAGGCTAACCTGCAGGCCCTGATTGCCACAGGAGGGGACATCAACGCAGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZSWIM4_ENST00000254323_chr19_13920034_+_UBQLN4_ENST00000368309_chr1_156012704_-_3558nt TAAAGGGGCCGCATCACCCTGCCGGCCCGGCGCGGGTCGGGGGTGGGTGCGGTAGGGGTCCCGGGGCGGCCGAGCGCAGAGGACGGACGG GAAGGAGGGCAGGGGGCGCGGGAGCCGGCGAAGCGGAGCGGGCATCGGACCGAGCCCCCCAAAGAGGCCCCGCCCCGGCCCTGGCCCCGG CCGGGCCGGATGGAACCCCCCGCGGCCAAGCGGAGCCGGGGCTGCCCCGCGGGACCCGAGGAGCGCGATGCCGGGGCCGGGGCCGCGCGT GGCCGGGGCCGGCCCGAGGCGCTGCTGGACCTCAGCGCCAAGCGGGTAGCCGAGAGCTGGGCCTTCGAGCAGGTGGAGGAGCGGTTCTCC CGGGTGCCTGAGCCCGTCCAGAAGCGCATCGTGTTTTGGTCGTTTCCACGCAGTGAACGGGAAATATGTATGTACTCGTCGCTGGGTTAC CCGCCCCCAGAGGGCGAGCACGATGCCCGGGTGCCCTTTACCCGCGGGCTGCACCTGCTCCAGAGCGGGGCCGTGGACCGCGTGTTGCAA GTGGGATTCCACCTGAGCGGAAACATCCGCGAGCCAGGGAGTCCTGGAGAGCCCGAGCGCCTCTACCATGTCTCCATCAGCTTTGATCGC TGCAAGATCACGTCCGTGAGCTGCGGCTGTGACAACCGCGACCTCTTCTACTGTGCCCACGTGGTGGCCCTGTCCCTGTACCGCATTCGG CACGCCCACCAGGTGGAGCTGCGGCTGCCCATCTCCGAGACGCTCTCCCAGATGAACCGGGACCAGCTGCAGAAGTTCGTGCAGTACCTC ATCAGCGCCCATCACACTGAGGTGCTGCCCACTGCTCAGCGCTTGGCTGATGAGATCCTCCTGCTGGGCTCCGAGATCAACTTGGTGAAT GGTGCCCCAGACCCCACCGCCGGCGCAGGAATCGAGGACGCCAACTGCTGGCACCTGGACGAGGAGCAGATCCAGGAGCAGGTGAAGCAG CTACTGTCCAATGGCGGCTACTACGGGGCCAGCCAGCAGCTGCGCTCCATGTTCAGCAAGGTGCGGGAGATGCTGCGAATGCGGGACTCC AACGGGGCGCGCATGCTGATTCTCATGACCGAGCAGTTCCTGCAGGACACGCGCCTGGCCCTGTGGCGGCAGCAGGGCGCGGGCATGACG GACAAGTGCCGGCAGCTCTGGGATGAGCTGGGGATGTTCAATAGCCCAGAAATGCAAGCCCTCCTCCAGCAGATCTCTGAGAACCCCCAG CTGATGCAGAATGTGATCTCAGCACCCTACATGCGCAGCATGATGCAGACGCTTGCCCAGAACCCCGACTTTGCTGCTCAGATGATGGTG AATGTGCCGCTCTTCGCGGGGAACCCCCAACTGCAGGAGCAGCTCCGCCTGCAGCTCCCAGTCTTCCTGCAGCAGATGCAGAACCCAGAG TCACTCTCCATCCTTACCAATCCCCGAGCCATGCAGGCATTGCTGCAGATCCAGCAGGGACTACAGACCTTGCAGACCGAGGCCCCTGGG CTGGTACCCAGCCTTGGCTCCTTTGGGATATCCCGGACCCCAGCACCCTCAGCAGGCAGCAACGCAGGGTCTACGCCCGAGGCCCCCACT TCCTCACCAGCCACGCCAGCCACATCTTCTCCAACAGGGGCTTCCAGCGCCCAGCAGCAACTCATGCAGCAGATGATCCAGCTTTTGGCT GGAAGTGGAAACTCACAGGTGCAGACGCCAGAAGTGAGATTTCAGCAGCAGCTGGAGCAGCTCAACTCCATGGGCTTCATCAATCGTGAG GCTAACCTGCAGGCCCTGATTGCCACAGGAGGGGACATCAACGCAGCTATCGAGAGACTGCTGGGCTCCCAGCTCTCCTAATCCCTCGGC CCATGCCTCCTGCCTCTCCCCTCCCTCGATGTCAGCATTCGGTTCTTCTGTCAATCCTTACCCTCTGCAGCTTGTCCTCCCTTCCGTCTT CTCCCTCATCCTTTCCAAACAGCAGGGTGACTTTAGAGGCATGGGCTCCAACCCCTTAGCTCTGTCTGAGAATTATGGTTTTACTGCTAC GTCTCTAACAGACTCTTCTCTCCTGGTCTCCTTGAGCAGTGCTACTTAAACAGTTTTCACAGTTTCATTGATTGACTCTACCTCCTTGCC CCACACCACTTTTGCAATCTTTAAACTTTCAGTGGCTGTGCAGAGTCGAGGGAGGAACCAGCTCTCTGGTTTACTGGAACATAGTCTTCC ATCTATACCACTAGGGTTTTGTCTTATGTTTACTTTTGGTAACTCTCTTCCTTCTTTTTCTCCCTACCCCCCAACCCCTAGCCCAACCAA TGCTAGAATTTCTTGCTCTGAAGGAGGAGCAGGTGAAACAGGTGGTAATTTTCCTTCTCGGCCCCTATTCTGGTTCATTCAGCACTTTTT GGTGGGAACTGTTGGAAATTCCAGGGTAAGGAGGAAGATGCCTGTTCTCCCTGTCTGAAGAGGGAGATGAGACAGCTCTCTGGACAGGAA TTAACAAACGCTGGAGCAGCCCAGAGGAAATTCGTGTGAAAGAGGAGGGAATGAGATTATTCGGAGGAAGGGAATGGGGGAGACAGCCTG AGTAAAAGGCTTGGAAGTTGGAATTAACAGTGGGGAGCAGAAGCACTCATAGCTCTTTTAGGCAGAAGAATCCAGGCCCGAGCTGGCAGA AGAGACTTAGAGATGCTAATGGAATTTAAACTGAAAAAAGGAGCCCAATGAAGCTAAGCGCCACGCCCCACAAGGGGTCATATTGGCTTT AGTTCCTCAAGCATATGTGCTTATATGCACACACACACACATTTCCATGGACCCAGGTCTTGCTTGTGTCCCCAGGCACCAGTAGTTTGA GCCCCCCTCAAAAGACATGAAGGGGGTTGGGGTCTGTGTGAGTAGTGGGGAGGTGCATGTGTATCCACATGTGTGCATACACTCTTAAGT TGGGTGGGAAGTGGATTCCTTGTTGGTTTCTGGTTCAGAGTGCTCTCCCACCACCAGAGACAAGTGGGTAAAAAGGTCAGTCCATTGCAG GAATATATATCCGGGAGAGCTAGGTCCCTTGGGGCTCTGGATGCTGGGTAACCCAGAGGTAATGTGGGTACCCTTTCTGAAGCTGTCAGG GCTGTGACTAGCACCCTTATCACCCCTCACTGCCTTGTGGGAATAGTAGAGGGTTTTTTTCCTCCAGAGCCCCTGGCCTTTCAGTTCTTA ACTATTTCCCTCCAGGCCAGAAAGTTTTCTTTGAGGAAGGAGAGGAGAGGGTGGCAATGATGCCTTTGATCTGGAATTGGACATTTCTCT GTCAGAGCACAGAGGAGGCTCATATCACCTCTTCCCTCTCCTACTTGGCCCAGCTGCTTGGAGGACCGACCCCATGGCTGAGAATATGAC GGCAAGAGGAACAGAGTTTGCTCCAAGTGGGAAAGGGTCCCAAGCAGTCCAGAGAAGATGTCTGTGTGGCTTTCCCTCCCTGCCTCCCCC >In-frame_ZSWIM4_ENST00000440752_chr19_13920034_+_UBQLN4_ENST00000368309_chr1_156012704_-_2745nt AGCGCCCATCACACTGAGGTGCTGCCCACTGCTCAGCGCTTGGCTGATGAGATCCTCCTGCTGGGCTCCGAGATCAACTTGGTGAATGGT GCCCCAGACCCCACCGCCGGCGCAGGAATCGAGGACGCCAACTGCTGGCACCTGGACGAGGAGCAGATCCAGGAGCAGGTGAAGCAGCTA CTGTCCAATGGCGGCTACTACGGGGCCAGCCAGCAGCTGCGCTCCATGTTCAGCAAGGTGCGGGAGATGCTGCGAATGCGGGACTCCAAC GGGGCGCGCATGCTGATTCTCATGACCGAGCAGTTCCTGCAGGACACGCGCCTGGCCCTGTGGCGGCAGCAGGGCGCGGGCATGACGGAC AAGTGCCGGCAGCTCTGGGATGAGCTGGGGATGTTCAATAGCCCAGAAATGCAAGCCCTCCTCCAGCAGATCTCTGAGAACCCCCAGCTG ATGCAGAATGTGATCTCAGCACCCTACATGCGCAGCATGATGCAGACGCTTGCCCAGAACCCCGACTTTGCTGCTCAGATGATGGTGAAT GTGCCGCTCTTCGCGGGGAACCCCCAACTGCAGGAGCAGCTCCGCCTGCAGCTCCCAGTCTTCCTGCAGCAGATGCAGAACCCAGAGTCA CTCTCCATCCTTACCAATCCCCGAGCCATGCAGGCATTGCTGCAGATCCAGCAGGGACTACAGACCTTGCAGACCGAGGCCCCTGGGCTG GTACCCAGCCTTGGCTCCTTTGGGATATCCCGGACCCCAGCACCCTCAGCAGGCAGCAACGCAGGGTCTACGCCCGAGGCCCCCACTTCC TCACCAGCCACGCCAGCCACATCTTCTCCAACAGGGGCTTCCAGCGCCCAGCAGCAACTCATGCAGCAGATGATCCAGCTTTTGGCTGGA AGTGGAAACTCACAGGTGCAGACGCCAGAAGTGAGATTTCAGCAGCAGCTGGAGCAGCTCAACTCCATGGGCTTCATCAATCGTGAGGCT AACCTGCAGGCCCTGATTGCCACAGGAGGGGACATCAACGCAGCTATCGAGAGACTGCTGGGCTCCCAGCTCTCCTAATCCCTCGGCCCA TGCCTCCTGCCTCTCCCCTCCCTCGATGTCAGCATTCGGTTCTTCTGTCAATCCTTACCCTCTGCAGCTTGTCCTCCCTTCCGTCTTCTC CCTCATCCTTTCCAAACAGCAGGGTGACTTTAGAGGCATGGGCTCCAACCCCTTAGCTCTGTCTGAGAATTATGGTTTTACTGCTACGTC TCTAACAGACTCTTCTCTCCTGGTCTCCTTGAGCAGTGCTACTTAAACAGTTTTCACAGTTTCATTGATTGACTCTACCTCCTTGCCCCA CACCACTTTTGCAATCTTTAAACTTTCAGTGGCTGTGCAGAGTCGAGGGAGGAACCAGCTCTCTGGTTTACTGGAACATAGTCTTCCATC TATACCACTAGGGTTTTGTCTTATGTTTACTTTTGGTAACTCTCTTCCTTCTTTTTCTCCCTACCCCCCAACCCCTAGCCCAACCAATGC TAGAATTTCTTGCTCTGAAGGAGGAGCAGGTGAAACAGGTGGTAATTTTCCTTCTCGGCCCCTATTCTGGTTCATTCAGCACTTTTTGGT GGGAACTGTTGGAAATTCCAGGGTAAGGAGGAAGATGCCTGTTCTCCCTGTCTGAAGAGGGAGATGAGACAGCTCTCTGGACAGGAATTA ACAAACGCTGGAGCAGCCCAGAGGAAATTCGTGTGAAAGAGGAGGGAATGAGATTATTCGGAGGAAGGGAATGGGGGAGACAGCCTGAGT AAAAGGCTTGGAAGTTGGAATTAACAGTGGGGAGCAGAAGCACTCATAGCTCTTTTAGGCAGAAGAATCCAGGCCCGAGCTGGCAGAAGA GACTTAGAGATGCTAATGGAATTTAAACTGAAAAAAGGAGCCCAATGAAGCTAAGCGCCACGCCCCACAAGGGGTCATATTGGCTTTAGT TCCTCAAGCATATGTGCTTATATGCACACACACACACATTTCCATGGACCCAGGTCTTGCTTGTGTCCCCAGGCACCAGTAGTTTGAGCC CCCCTCAAAAGACATGAAGGGGGTTGGGGTCTGTGTGAGTAGTGGGGAGGTGCATGTGTATCCACATGTGTGCATACACTCTTAAGTTGG GTGGGAAGTGGATTCCTTGTTGGTTTCTGGTTCAGAGTGCTCTCCCACCACCAGAGACAAGTGGGTAAAAAGGTCAGTCCATTGCAGGAA TATATATCCGGGAGAGCTAGGTCCCTTGGGGCTCTGGATGCTGGGTAACCCAGAGGTAATGTGGGTACCCTTTCTGAAGCTGTCAGGGCT GTGACTAGCACCCTTATCACCCCTCACTGCCTTGTGGGAATAGTAGAGGGTTTTTTTCCTCCAGAGCCCCTGGCCTTTCAGTTCTTAACT ATTTCCCTCCAGGCCAGAAAGTTTTCTTTGAGGAAGGAGAGGAGAGGGTGGCAATGATGCCTTTGATCTGGAATTGGACATTTCTCTGTC AGAGCACAGAGGAGGCTCATATCACCTCTTCCCTCTCCTACTTGGCCCAGCTGCTTGGAGGACCGACCCCATGGCTGAGAATATGACGGC AAGAGGAACAGAGTTTGCTCCAAGTGGGAAAGGGTCCCAAGCAGTCCAGAGAAGATGTCTGTGTGGCTTTCCCTCCCTGCCTCCCCCAGC |
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FusionGenePPI for ZSWIM4_UBQLN4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZSWIM4 | UBQLN4 | SERPINH1, ATXN1, NAE1, SCG5, ZBTB22, SMARCB1, RXRA, EEF1A1, UNC119, PTN, HSPA5, PRL, FKBP7, CTSB, SPP1, HERPUD1, PSMD4, RNF185, GJA1, DNAJB11, TNFRSF14, PSMD2, ADPGK, AGR2, AREG, BAG6, IGLC1, EAPP, UBR7, C19orf10, C1QTNF1, RUNX1T1, CCL21, CD99, CDSN, COL8A1, CPSF6, CSTF2, CSTF2T, DAZAP2, DKK3, DTX2, EDN1, EFEMP2, ELF5, FGFBP1, FKBP2, RSRC2, KLHL26, CCDC134, ERP27, CCDC33, FZD7, GABRD, GKAP1, GPX7, HAVCR1, HK2, PLA2G16, IGFBP6, IGHM, KLHL42, ITPRIPL1, ZG16B, MDK, C1orf94, MLLT6, NME3, NPHP1, NPPA, CYB5R1, NXF1, PDIA5, PDLIM7, PELI2, PIN1, PIP4K2B, BPIFA1, PPIB, PPIC, SRGN, QSOX1, RAI2, RIC8A, RNPS1, RPN1, SCMH1, SEMG1, SERPINE1, SERPINI2, MIEF2, SPAG8, SPINT1, STAM2, HSPA13, TFF1, PMEPA1, TRIM32, UBQLN1, USMG5, VIP, LAT2, ZG16, ZNF205, UBQLN4, MIF4GD, ADAM33, ARL4C, ATPIF1, CEND1, ERP29, CACNA1G, CCDC14, COPB1, CRIPT, DMPK, EPDR1, FA2H, SUPT20H, PRPF40A, GDI1, HGS, IMMT, ANKRD13D, CCDC107, C11orf49, MOAP1, CCDC136, NOMO1, NOMO3, NOTCH2NL, OAT, PBXIP1, PCDH17, PCDH8, PNMA1, PICK1, PTPRN, PTPRN2, RBM10, ROBO2, SCG2, SRSF2, SCAF1, STMN1, TGFB1I1, TNRC6B, TRAF2, TRIB2, UBQLN2, UROS, WAC, YWHAQ, ZDHHC3, ZFPM2, RAD23A, IMPDH2, ZFYVE19, ZPR1, UBE2B, AHCYL1, UBXN1, UBE2A, VPS4B, USP34, TYMS, STAM, TXN, PRDX3, VPS26A, UBE2C, TTC9C, CD2BP2, MAP1LC3A, SMAD9, RNF11, SMAD3, ORC5, SHFM1, UBC, ASNS, RAD23B, GJA5, GJC1, GJB1, KDELR1, SLC17A2, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZSWIM4_UBQLN4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZSWIM4_UBQLN4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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