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Fusion gene ID: 43865 |
FusionGeneSummary for ZSWIM4_MSMO1 |
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Fusion gene information | Fusion gene name: ZSWIM4_MSMO1 | Fusion gene ID: 43865 | Hgene | Tgene | Gene symbol | ZSWIM4 | MSMO1 | Gene ID | 65249 | 6307 |
Gene name | zinc finger SWIM-type containing 4 | methylsterol monooxygenase 1 | |
Synonyms | - | DESP4|ERG25|MCCPD|SC4MOL | |
Cytomap | 19p13.13-p13.12 | 4q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger SWIM domain-containing protein 4zinc finger, SWIM domain containing 4 | methylsterol monooxygenase 1C-4 methylsterol oxidase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H7M6 | Q15800 | |
Ensembl transtripts involved in fusion gene | ENST00000254323, ENST00000440752, | ENST00000261507, ENST00000393766, ENST00000504317, | |
Fusion gene scores | * DoF score | 10 X 11 X 7=770 | 2 X 2 X 1=4 |
# samples | 11 | 2 | |
** MAII score | log2(11/770*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: ZSWIM4 [Title/Abstract] AND MSMO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG979123 | ZSWIM4 | chr19 | 13942671 | + | MSMO1 | chr4 | 166249256 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000254323 | ENST00000261507 | ZSWIM4 | chr19 | 13942671 | + | MSMO1 | chr4 | 166249256 | - |
3UTR-intron | ENST00000254323 | ENST00000393766 | ZSWIM4 | chr19 | 13942671 | + | MSMO1 | chr4 | 166249256 | - |
3UTR-intron | ENST00000254323 | ENST00000504317 | ZSWIM4 | chr19 | 13942671 | + | MSMO1 | chr4 | 166249256 | - |
intron-intron | ENST00000440752 | ENST00000261507 | ZSWIM4 | chr19 | 13942671 | + | MSMO1 | chr4 | 166249256 | - |
intron-intron | ENST00000440752 | ENST00000393766 | ZSWIM4 | chr19 | 13942671 | + | MSMO1 | chr4 | 166249256 | - |
intron-intron | ENST00000440752 | ENST00000504317 | ZSWIM4 | chr19 | 13942671 | + | MSMO1 | chr4 | 166249256 | - |
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FusionProtFeatures for ZSWIM4_MSMO1 |
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Hgene | Tgene |
ZSWIM4 | MSMO1 |
Catalyzes the first step in the removal of the two C-4methyl groups of 4,4-dimethylzymosterol.{ECO:0000250|UniProtKB:P53045}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZSWIM4_MSMO1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZSWIM4_MSMO1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZSWIM4_MSMO1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZSWIM4_MSMO1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MSMO1 | C4225189 | MICROCEPHALY, CONGENITAL CATARACT, AND PSORIASIFORM DERMATITIS | 1 | UNIPROT |