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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43859

FusionGeneSummary for ZSWIM3_PTPRT

check button Fusion gene summary
Fusion gene informationFusion gene name: ZSWIM3_PTPRT
Fusion gene ID: 43859
HgeneTgene
Gene symbol

ZSWIM3

PTPRT

Gene ID

140831

11122

Gene namezinc finger SWIM-type containing 3protein tyrosine phosphatase, receptor type T
SynonymsC20orf164|PPP1R174RPTPrho
Cytomap

20q13.12

20q12-q13.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger SWIM domain-containing protein 3protein phosphatase 1, regulatory subunit 174zinc finger, SWIM domain containing 3receptor-type tyrosine-protein phosphatase TR-PTP-TRPTP-rhoreceptor protein tyrosine phosphatasereceptor-type tyrosine-protein phosphatase rho
Modification date2018051920180519
UniProtAcc

Q96MP5

O14522

Ensembl transtripts involved in fusion geneENST00000454862, ENST00000255152, 
ENST00000373184, ENST00000373187, 
ENST00000356100, ENST00000373190, 
ENST00000373193, ENST00000373198, 
ENST00000373201, ENST00000485499, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 8 X 6=480
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZSWIM3 [Title/Abstract] AND PTPRT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPRT

GO:0006470

protein dephosphorylation

16973135

TgenePTPRT

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

18644975


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-YG-AA3P-06AZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000454862ENST00000373184ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
5UTR-3CDSENST00000454862ENST00000373187ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
5UTR-3CDSENST00000454862ENST00000356100ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
5UTR-3CDSENST00000454862ENST00000373190ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
5UTR-3CDSENST00000454862ENST00000373193ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
5UTR-3CDSENST00000454862ENST00000373198ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
5UTR-3CDSENST00000454862ENST00000373201ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
5UTR-5UTRENST00000454862ENST00000485499ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
Frame-shiftENST00000255152ENST00000373184ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
Frame-shiftENST00000255152ENST00000373187ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
Frame-shiftENST00000255152ENST00000356100ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
Frame-shiftENST00000255152ENST00000373190ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
Frame-shiftENST00000255152ENST00000373193ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
Frame-shiftENST00000255152ENST00000373198ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
Frame-shiftENST00000255152ENST00000373201ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-
5CDS-5UTRENST00000255152ENST00000485499ZSWIM3chr20

44486619

+PTPRTchr20

41514572

-

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FusionProtFeatures for ZSWIM3_PTPRT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZSWIM3

Q96MP5

PTPRT

O14522


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZSWIM3_PTPRT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZSWIM3_PTPRT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZSWIM3PTPRTCUL3, EGFR, ERBB2, ERBB4, ATP2A2, PHKA1, PHKB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZSWIM3_PTPRT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZSWIM3_PTPRT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource