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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43835

FusionGeneSummary for ZRANB2-AS1_DOK7

check button Fusion gene summary
Fusion gene informationFusion gene name: ZRANB2-AS1_DOK7
Fusion gene ID: 43835
HgeneTgene
Gene symbol

ZRANB2-AS1

DOK7

Gene ID

100132618

285489

Gene nameZRANB2 antisense RNA 1docking protein 7
Synonyms-C4orf25|CMS10|CMS1B
Cytomap

1p31.1

4p16.3

Type of genencRNAprotein-coding
DescriptionZRANB2 antisense RNA 1 (non-protein coding)protein Dok-7downstream of tyrosine kinase 7
Modification date2018032920180519
UniProtAcc

Q18PE1

Ensembl transtripts involved in fusion geneENST00000450461, ENST00000426999, 
ENST00000389653, ENST00000340083, 
ENST00000507039, ENST00000512714, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ZRANB2-AS1 [Title/Abstract] AND DOK7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDOK7

GO:0061098

positive regulation of protein tyrosine kinase activity

20603078


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1L34968ZRANB2-AS1chr1

71535019

+DOK7chr4

3493997

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000450461ENST00000389653ZRANB2-AS1chr1

71535019

+DOK7chr4

3493997

-
intron-intronENST00000450461ENST00000340083ZRANB2-AS1chr1

71535019

+DOK7chr4

3493997

-
intron-intronENST00000450461ENST00000507039ZRANB2-AS1chr1

71535019

+DOK7chr4

3493997

-
intron-intronENST00000450461ENST00000512714ZRANB2-AS1chr1

71535019

+DOK7chr4

3493997

-
intron-intronENST00000426999ENST00000389653ZRANB2-AS1chr1

71535019

+DOK7chr4

3493997

-
intron-intronENST00000426999ENST00000340083ZRANB2-AS1chr1

71535019

+DOK7chr4

3493997

-
intron-intronENST00000426999ENST00000507039ZRANB2-AS1chr1

71535019

+DOK7chr4

3493997

-
intron-intronENST00000426999ENST00000512714ZRANB2-AS1chr1

71535019

+DOK7chr4

3493997

-

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FusionProtFeatures for ZRANB2-AS1_DOK7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZRANB2-AS1

DOK7

Q18PE1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Probable muscle-intrinsic activator of MUSK that playsan essential role in neuromuscular synaptogenesis. Acts in aneuralactivation of MUSK and subsequent acetylcholine receptor (AchR)clustering in myotubes. Induces autophosphorylation of MUSK.{ECO:0000269|PubMed:20603078}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZRANB2-AS1_DOK7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZRANB2-AS1_DOK7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZRANB2-AS1_DOK7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZRANB2-AS1_DOK7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDOK7C1850792Congenital myasthenic syndrome ib3CTD_human;UNIPROT