|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 43831 |
FusionGeneSummary for ZRANB1_HSPA9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZRANB1_HSPA9 | Fusion gene ID: 43831 | Hgene | Tgene | Gene symbol | ZRANB1 | HSPA9 | Gene ID | 54764 | 3313 |
| Gene name | zinc finger RANBP2-type containing 1 | heat shock protein family A (Hsp70) member 9 | |
| Synonyms | TRABID | CRP40|CSA|EVPLS|GRP-75|GRP75|HEL-S-124m|HSPA9B|MOT|MOT2|MTHSP75|PBP74|SAAN|SIDBA4 | |
| Cytomap | 10q26.13 | 5q31.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin thioesterase ZRANB1TRAF-binding domain-containing proteinTRAF-binding protein domainhTrabidzinc finger Ran-binding domain-containing protein 1zinc finger, RAN-binding domain containing 1 | stress-70 protein, mitochondrial75 kDa glucose-regulated proteincatecholamine-regulated protein 40epididymis secretory sperm binding protein Li 124mheat shock 70kD protein 9Bheat shock 70kDa protein 9 (mortalin)mortalin, perinuclearmortalin-2morta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UGI0 | P38646 | |
| Ensembl transtripts involved in fusion gene | ENST00000359653, ENST00000471421, | ENST00000297185, ENST00000501917, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 6 X 5 X 3=90 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZRANB1 [Title/Abstract] AND HSPA9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZRANB1 | GO:0035523 | protein K29-linked deubiquitination | 23827681 |
| Hgene | ZRANB1 | GO:0070536 | protein K63-linked deubiquitination | 23827681 |
| Hgene | ZRANB1 | GO:1990168 | protein K33-linked deubiquitination | 23827681|24768539 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG993754 | ZRANB1 | chr10 | 126656269 | + | HSPA9 | chr5 | 137899629 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000359653 | ENST00000297185 | ZRANB1 | chr10 | 126656269 | + | HSPA9 | chr5 | 137899629 | - |
| intron-intron | ENST00000359653 | ENST00000501917 | ZRANB1 | chr10 | 126656269 | + | HSPA9 | chr5 | 137899629 | - |
| intron-intron | ENST00000471421 | ENST00000297185 | ZRANB1 | chr10 | 126656269 | + | HSPA9 | chr5 | 137899629 | - |
| intron-intron | ENST00000471421 | ENST00000501917 | ZRANB1 | chr10 | 126656269 | + | HSPA9 | chr5 | 137899629 | - |
Top |
FusionProtFeatures for ZRANB1_HSPA9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZRANB1 | HSPA9 |
| Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with40-fold less efficiency compared to 'Lys-29'-linked ones. Positiveregulator of the Wnt signaling pathway that deubiquitinates APCprotein, a negative regulator of Wnt-mediated transcription. Playsa role in the regulation of cell morphology and cytoskeletalorganization. Required in the stress fiber dynamics and cellmigration. May also modulate TNF-alpha signaling.{ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987,ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZRANB1_HSPA9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZRANB1_HSPA9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZRANB1_HSPA9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZRANB1_HSPA9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | HSPA9 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
| Tgene | HSPA9 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | HSPA9 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | HSPA9 | C0030567 | Parkinson Disease | 1 | CTD_human |
| Tgene | HSPA9 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | HSPA9 | C0042164 | Uveitis | 1 | CTD_human |
| Tgene | HSPA9 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | HSPA9 | C0221765 | Chronic schizophrenia | 1 | PSYGENET |
| Tgene | HSPA9 | C0376618 | Endotoxemia | 1 | CTD_human |
| Tgene | HSPA9 | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human |
| Tgene | HSPA9 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | HSPA9 | C4225180 | EVEN-PLUS SYNDROME | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|