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Fusion gene ID: 43817 |
FusionGeneSummary for ZNRF3_DCAF11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNRF3_DCAF11 | Fusion gene ID: 43817 | Hgene | Tgene | Gene symbol | ZNRF3 | DCAF11 | Gene ID | 84133 | 80344 |
| Gene name | zinc and ring finger 3 | DDB1 and CUL4 associated factor 11 | |
| Synonyms | BK747E2.3|RNF203 | GL014|PRO2389|WDR23 | |
| Cytomap | 22q12.1 | 14q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase ZNRF3CTA-292E10.6RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3novel C3HC4 type Zinc finger (ring finger)zinc/RING finger protein 3 | DDB1- and CUL4-associated factor 11WD repeat domain 23WD repeat-containing protein 23 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9ULT6 | Q8TEB1 | |
| Ensembl transtripts involved in fusion gene | ENST00000544604, ENST00000332811, ENST00000402174, ENST00000406323, | ENST00000559115, ENST00000446197, ENST00000560171, ENST00000396941, ENST00000396936, | |
| Fusion gene scores | * DoF score | 14 X 4 X 12=672 | 1 X 1 X 1=1 |
| # samples | 17 | 1 | |
| ** MAII score | log2(17/672*10)=-1.98292648664106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZNRF3 [Title/Abstract] AND DCAF11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNRF3 | GO:0016567 | protein ubiquitination | 22575959 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-V1-A8WS-01A | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000544604 | ENST00000559115 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| Frame-shift | ENST00000544604 | ENST00000446197 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| 5CDS-intron | ENST00000544604 | ENST00000560171 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| 5CDS-intron | ENST00000544604 | ENST00000396941 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| 5CDS-intron | ENST00000544604 | ENST00000396936 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| 5UTR-3CDS | ENST00000332811 | ENST00000559115 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| 5UTR-3CDS | ENST00000332811 | ENST00000446197 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| 5UTR-intron | ENST00000332811 | ENST00000560171 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| 5UTR-intron | ENST00000332811 | ENST00000396941 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| 5UTR-intron | ENST00000332811 | ENST00000396936 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-3CDS | ENST00000402174 | ENST00000559115 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-3CDS | ENST00000402174 | ENST00000446197 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-intron | ENST00000402174 | ENST00000560171 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-intron | ENST00000402174 | ENST00000396941 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-intron | ENST00000402174 | ENST00000396936 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-3CDS | ENST00000406323 | ENST00000559115 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-3CDS | ENST00000406323 | ENST00000446197 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-intron | ENST00000406323 | ENST00000560171 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-intron | ENST00000406323 | ENST00000396941 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
| intron-intron | ENST00000406323 | ENST00000396936 | ZNRF3 | chr22 | 29280054 | + | DCAF11 | chr14 | 24586475 | + |
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FusionProtFeatures for ZNRF3_DCAF11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNRF3 | DCAF11 |
| E3 ubiquitin-protein ligase that acts as a negativeregulator of the Wnt signaling pathway by mediating theubiquitination and subsequent degradation of Wnt receptor complexcomponents Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in theintestinal stem cell zone by inhibiting the Wnt signaling pathway,thereby resticting the size of the intestinal stem cell zone.{ECO:0000269|PubMed:22575959}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNRF3_DCAF11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNRF3_DCAF11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNRF3 | UBE2N, FZD4, RSPO1, LGR4, LRP6, GFI1B, DVL2, HSPB1, RSPO2, RSPO3, LGR5, FZD7 | DCAF11 | COPS5, COPS6, PARP11, DDB1, CUL4A, DDA1, CUL5, NEDD8, RFWD2, COPS3, COPS4, COPS7A, COPS2, ASPSCR1, DCAF8, LRBA, VCP, CUL4B, PNKD, CDRT15, TENC1, PTEN, SLBP, EYA2, COPS8, PPP2R5E, DBT, CCT2, TCP1, GNPAT, CCT4, CCT3, PLK1, CCT7, CCT6A, COPS7B, MICU2, CCT5, CCT6B, GPS1, MICU1, NFE2L2, SIRT7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNRF3_DCAF11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNRF3_DCAF11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZNRF3 | C0030297 | Pancreatic Neoplasm | 2 | CTD_human |
| Hgene | ZNRF3 | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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