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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43817

FusionGeneSummary for ZNRF3_DCAF11

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNRF3_DCAF11
Fusion gene ID: 43817
HgeneTgene
Gene symbol

ZNRF3

DCAF11

Gene ID

84133

80344

Gene namezinc and ring finger 3DDB1 and CUL4 associated factor 11
SynonymsBK747E2.3|RNF203GL014|PRO2389|WDR23
Cytomap

22q12.1

14q12

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ZNRF3CTA-292E10.6RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3novel C3HC4 type Zinc finger (ring finger)zinc/RING finger protein 3DDB1- and CUL4-associated factor 11WD repeat domain 23WD repeat-containing protein 23
Modification date2018052320180523
UniProtAcc

Q9ULT6

Q8TEB1

Ensembl transtripts involved in fusion geneENST00000544604, ENST00000332811, 
ENST00000402174, ENST00000406323, 
ENST00000559115, ENST00000446197, 
ENST00000560171, ENST00000396941, 
ENST00000396936, 
Fusion gene scores* DoF score14 X 4 X 12=6721 X 1 X 1=1
# samples 171
** MAII scorelog2(17/672*10)=-1.98292648664106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ZNRF3 [Title/Abstract] AND DCAF11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNRF3

GO:0016567

protein ubiquitination

22575959


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-V1-A8WS-01AZNRF3chr22

29280054

+DCAF11chr14

24586475

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000544604ENST00000559115ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
Frame-shiftENST00000544604ENST00000446197ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
5CDS-intronENST00000544604ENST00000560171ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
5CDS-intronENST00000544604ENST00000396941ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
5CDS-intronENST00000544604ENST00000396936ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
5UTR-3CDSENST00000332811ENST00000559115ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
5UTR-3CDSENST00000332811ENST00000446197ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
5UTR-intronENST00000332811ENST00000560171ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
5UTR-intronENST00000332811ENST00000396941ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
5UTR-intronENST00000332811ENST00000396936ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-3CDSENST00000402174ENST00000559115ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-3CDSENST00000402174ENST00000446197ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-intronENST00000402174ENST00000560171ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-intronENST00000402174ENST00000396941ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-intronENST00000402174ENST00000396936ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-3CDSENST00000406323ENST00000559115ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-3CDSENST00000406323ENST00000446197ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-intronENST00000406323ENST00000560171ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-intronENST00000406323ENST00000396941ZNRF3chr22

29280054

+DCAF11chr14

24586475

+
intron-intronENST00000406323ENST00000396936ZNRF3chr22

29280054

+DCAF11chr14

24586475

+

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FusionProtFeatures for ZNRF3_DCAF11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNRF3

Q9ULT6

DCAF11

Q8TEB1

E3 ubiquitin-protein ligase that acts as a negativeregulator of the Wnt signaling pathway by mediating theubiquitination and subsequent degradation of Wnt receptor complexcomponents Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in theintestinal stem cell zone by inhibiting the Wnt signaling pathway,thereby resticting the size of the intestinal stem cell zone.{ECO:0000269|PubMed:22575959}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNRF3_DCAF11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNRF3_DCAF11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNRF3UBE2N, FZD4, RSPO1, LGR4, LRP6, GFI1B, DVL2, HSPB1, RSPO2, RSPO3, LGR5, FZD7DCAF11COPS5, COPS6, PARP11, DDB1, CUL4A, DDA1, CUL5, NEDD8, RFWD2, COPS3, COPS4, COPS7A, COPS2, ASPSCR1, DCAF8, LRBA, VCP, CUL4B, PNKD, CDRT15, TENC1, PTEN, SLBP, EYA2, COPS8, PPP2R5E, DBT, CCT2, TCP1, GNPAT, CCT4, CCT3, PLK1, CCT7, CCT6A, COPS7B, MICU2, CCT5, CCT6B, GPS1, MICU1, NFE2L2, SIRT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNRF3_DCAF11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNRF3_DCAF11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNRF3C0030297Pancreatic Neoplasm2CTD_human
HgeneZNRF3C0206686Adrenocortical carcinoma1CTD_human