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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43804

FusionGeneSummary for ZNHIT6_ISG20

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNHIT6_ISG20
Fusion gene ID: 43804
HgeneTgene
Gene symbol

ZNHIT6

ISG20

Gene ID

54680

3669

Gene namezinc finger HIT-type containing 6interferon stimulated exonuclease gene 20
SynonymsBCD1|C1orf181|NY-BR-75CD25|HEM45
Cytomap

1p22.3

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionbox C/D snoRNA protein 1box C/D snoRNA essential 1 homologserologically defined breast cancer antigen NY-BR-75zinc finger HIT domain-containing protein 6zinc finger, HIT type 6interferon-stimulated gene 20 kDa proteinestrogen-regulated transcript 45 proteininterferon stimulated exonuclease gene 20kDapromyelocytic leukemia nuclear body-associated protein ISG20
Modification date2018051920180519
UniProtAcc

Q9NWK9

Q96AZ6

Ensembl transtripts involved in fusion geneENST00000431532, ENST00000370574, 
ENST00000560741, ENST00000306072, 
ENST00000379224, ENST00000560746, 
Fusion gene scores* DoF score3 X 3 X 1=92 X 2 X 2=8
# samples 32
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: ZNHIT6 [Title/Abstract] AND ISG20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneISG20

GO:0000738

DNA catabolic process, exonucleolytic

11401564

TgeneISG20

GO:0006401

RNA catabolic process

11401564

TgeneISG20

GO:0009615

response to virus

12594219


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC094819ZNHIT6chr1

86173608

-ISG20chr15

89182206

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000431532ENST00000560741ZNHIT6chr1

86173608

-ISG20chr15

89182206

+
intron-5UTRENST00000431532ENST00000306072ZNHIT6chr1

86173608

-ISG20chr15

89182206

+
intron-5UTRENST00000431532ENST00000379224ZNHIT6chr1

86173608

-ISG20chr15

89182206

+
intron-intronENST00000431532ENST00000560746ZNHIT6chr1

86173608

-ISG20chr15

89182206

+
intron-intronENST00000370574ENST00000560741ZNHIT6chr1

86173608

-ISG20chr15

89182206

+
intron-5UTRENST00000370574ENST00000306072ZNHIT6chr1

86173608

-ISG20chr15

89182206

+
intron-5UTRENST00000370574ENST00000379224ZNHIT6chr1

86173608

-ISG20chr15

89182206

+
intron-intronENST00000370574ENST00000560746ZNHIT6chr1

86173608

-ISG20chr15

89182206

+

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FusionProtFeatures for ZNHIT6_ISG20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNHIT6

Q9NWK9

ISG20

Q96AZ6

Required for box C/D snoRNAs accumulation involved insnoRNA processing, snoRNA transport to the nucleolus and ribosomebiogenesis. {ECO:0000269|PubMed:17636026}. Interferon-induced antiviral exoribonuclease that actson single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA virusesincluding hepatitis C virus (HCV), hepatitis A virus (HAV) andyellow fever virus (YFV) in an exonuclease-dependent manner. Mayalso play additional roles in the maturation of snRNAs and rRNAs,and in ribosome biogenesis. {ECO:0000269|PubMed:11401564,ECO:0000269|PubMed:12594219, ECO:0000269|PubMed:16033969,ECO:0000269|PubMed:21036379}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNHIT6_ISG20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNHIT6_ISG20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNHIT6_ISG20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNHIT6_ISG20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneISG20C0023893Liver Cirrhosis, Experimental1CTD_human