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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 438

FusionGeneSummary for ACOX3_DLGAP4

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOX3_DLGAP4
Fusion gene ID: 438
HgeneTgene
Gene symbol

ACOX3

DLGAP4

Gene ID

8310

22839

Gene nameacyl-CoA oxidase 3, pristanoylDLG associated protein 4
Synonyms-DAP-4|DAP4|DLP4|SAPAP-4|SAPAP4
Cytomap

4p16.1

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal acyl-coenzyme A oxidase 3BRCACoxacyl-Coenzyme A oxidase 3, pristanoylbranched-chain acyl-CoA oxidasepristanoyl-CoA oxidasedisks large-associated protein 4PSD-95/SAP90-binding protein 4SAP90/PSD-95-associated protein 4discs large homolog associated protein 4
Modification date2018052320180519
UniProtAcc

O15254

Q9Y2H0

Ensembl transtripts involved in fusion geneENST00000356406, ENST00000413009, 
ENST00000503233, ENST00000515797, 
ENST00000373913, ENST00000401952, 
ENST00000373907, ENST00000339266, 
ENST00000475894, ENST00000340491, 
Fusion gene scores* DoF score7 X 7 X 3=14711 X 13 X 6=858
# samples 716
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/858*10)=-2.42290574261218
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACOX3 [Title/Abstract] AND DLGAP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI915466ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000356406ENST00000373913ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3CDSENST00000356406ENST00000401952ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3CDSENST00000356406ENST00000373907ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3CDSENST00000356406ENST00000339266ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3UTRENST00000356406ENST00000475894ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3UTRENST00000356406ENST00000340491ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3CDSENST00000413009ENST00000373913ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3CDSENST00000413009ENST00000401952ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3CDSENST00000413009ENST00000373907ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3CDSENST00000413009ENST00000339266ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3UTRENST00000413009ENST00000475894ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
5UTR-3UTRENST00000413009ENST00000340491ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3CDSENST00000503233ENST00000373913ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3CDSENST00000503233ENST00000401952ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3CDSENST00000503233ENST00000373907ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3CDSENST00000503233ENST00000339266ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3UTRENST00000503233ENST00000475894ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3UTRENST00000503233ENST00000340491ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3CDSENST00000515797ENST00000373913ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3CDSENST00000515797ENST00000401952ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3CDSENST00000515797ENST00000373907ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3CDSENST00000515797ENST00000339266ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3UTRENST00000515797ENST00000475894ACOX3chr4

8442373

-DLGAP4chr20

35125107

+
intron-3UTRENST00000515797ENST00000340491ACOX3chr4

8442373

-DLGAP4chr20

35125107

+

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FusionProtFeatures for ACOX3_DLGAP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACOX3

O15254

DLGAP4

Q9Y2H0

Oxidizes the CoA-esters of 2-methyl-branched fattyacids. {ECO:0000250, ECO:0000269|PubMed:9271077}. May play a role in the molecular organization ofsynapses and neuronal cell signaling. Could be an adapter proteinlinking ion channel to the subsynaptic cytoskeleton. May induceenrichment of PSD-95/SAP90 at the plasma membrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACOX3_DLGAP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACOX3_DLGAP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACOX3PEX5, SMURF2, TMEM150A, FKBP6, MICU2, YTHDF1, HERC3, CENPH, HAUS7DLGAP4PPP1R1B, UBC, DLG4, SHANK3, SHANK2, SORBS2, SH3GL2, BIN1, MOV10, NXF1, PARD6B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACOX3_DLGAP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACOX3_DLGAP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource