FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 43795

FusionGeneSummary for ZNF98_NDUFA7

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF98_NDUFA7
Fusion gene ID: 43795
HgeneTgene
Gene symbol

ZNF98

NDUFA7

Gene ID

148198

4701

Gene namezinc finger protein 98NADH:ubiquinone oxidoreductase subunit A7
SynonymsF7175|ZNF739B14.5a|CI-B14.5a
Cytomap

19p12

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 98zinc finger protein 739zinc finger protein F7175NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDaNADH-ubiquinone oxidoreductase subunit B14.5acomplex I B14.5a subunit
Modification date2018040320180523
UniProtAcc

A6NK75

O95182

Ensembl transtripts involved in fusion geneENST00000599879, ENST00000357774, 
ENST00000601553, 
ENST00000598884, 
ENST00000301457, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: ZNF98 [Title/Abstract] AND NDUFA7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0BT-01AZNF98chr19

22715141

-NDUFA7chr19

8376479

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000599879ENST00000598884ZNF98chr19

22715141

-NDUFA7chr19

8376479

-
5UTR-3CDSENST00000599879ENST00000301457ZNF98chr19

22715141

-NDUFA7chr19

8376479

-
intron-3CDSENST00000357774ENST00000598884ZNF98chr19

22715141

-NDUFA7chr19

8376479

-
intron-3CDSENST00000357774ENST00000301457ZNF98chr19

22715141

-NDUFA7chr19

8376479

-
intron-3CDSENST00000601553ENST00000598884ZNF98chr19

22715141

-NDUFA7chr19

8376479

-
intron-3CDSENST00000601553ENST00000301457ZNF98chr19

22715141

-NDUFA7chr19

8376479

-

Top

FusionProtFeatures for ZNF98_NDUFA7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF98

A6NK75

NDUFA7

O95182

May be involved in transcriptional regulation. Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZNF98_NDUFA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZNF98_NDUFA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF98NDUFA7PRKAB1, RPL38, TIMM44, RRBP1, PIN1, SBDS, RAB8A, PDLIM5, RBM27, MRRF, TAGLN, PIN4, RANGAP1, UBL4A, PDLIM7, TPX2, UBE2L3, SNX3, ECI2, HRSP12, RBMS1, SUGP1, QKI, PQBP1, KIAA0101, RPS10P5, TBL2, RFX5, STX7, MPLKIP, SNRPC, SCO2, NABP2, MRPS28, ZC3H11A, CDV3, MRPL14, OLA1, SRRM2, TOMM40, RPS28, UBE2I, GATAD2B, UBE4B, VDAC3, SCP2, ACAA1, NUP214, MDFI, UPF2, NDUFS3, TMX2, DNAJC30, GJA1, ENPP6, NDUFA8, VAPB, NDUFA12, NDUFS4, NDUFS5, NDUFA9, NDUFS6, RAB5C, RAB7A, VAPA, GOLT1B, MMGT1, NDUFA4, C15orf48, COX6B1, NDUFB11, NDUFS7, NDUFA13, SSMEM1, FUT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZNF98_NDUFA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZNF98_NDUFA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource