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Fusion gene ID: 43795 |
FusionGeneSummary for ZNF98_NDUFA7 |
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Fusion gene information | Fusion gene name: ZNF98_NDUFA7 | Fusion gene ID: 43795 | Hgene | Tgene | Gene symbol | ZNF98 | NDUFA7 | Gene ID | 148198 | 4701 |
Gene name | zinc finger protein 98 | NADH:ubiquinone oxidoreductase subunit A7 | |
Synonyms | F7175|ZNF739 | B14.5a|CI-B14.5a | |
Cytomap | 19p12 | 19p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 98zinc finger protein 739zinc finger protein F7175 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDaNADH-ubiquinone oxidoreductase subunit B14.5acomplex I B14.5a subunit | |
Modification date | 20180403 | 20180523 | |
UniProtAcc | A6NK75 | O95182 | |
Ensembl transtripts involved in fusion gene | ENST00000599879, ENST00000357774, ENST00000601553, | ENST00000598884, ENST00000301457, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ZNF98 [Title/Abstract] AND NDUFA7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A0BT-01A | ZNF98 | chr19 | 22715141 | - | NDUFA7 | chr19 | 8376479 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000599879 | ENST00000598884 | ZNF98 | chr19 | 22715141 | - | NDUFA7 | chr19 | 8376479 | - |
5UTR-3CDS | ENST00000599879 | ENST00000301457 | ZNF98 | chr19 | 22715141 | - | NDUFA7 | chr19 | 8376479 | - |
intron-3CDS | ENST00000357774 | ENST00000598884 | ZNF98 | chr19 | 22715141 | - | NDUFA7 | chr19 | 8376479 | - |
intron-3CDS | ENST00000357774 | ENST00000301457 | ZNF98 | chr19 | 22715141 | - | NDUFA7 | chr19 | 8376479 | - |
intron-3CDS | ENST00000601553 | ENST00000598884 | ZNF98 | chr19 | 22715141 | - | NDUFA7 | chr19 | 8376479 | - |
intron-3CDS | ENST00000601553 | ENST00000301457 | ZNF98 | chr19 | 22715141 | - | NDUFA7 | chr19 | 8376479 | - |
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FusionProtFeatures for ZNF98_NDUFA7 |
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Hgene | Tgene |
ZNF98 | NDUFA7 |
May be involved in transcriptional regulation. | Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF98_NDUFA7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF98_NDUFA7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF98 | NDUFA7 | PRKAB1, RPL38, TIMM44, RRBP1, PIN1, SBDS, RAB8A, PDLIM5, RBM27, MRRF, TAGLN, PIN4, RANGAP1, UBL4A, PDLIM7, TPX2, UBE2L3, SNX3, ECI2, HRSP12, RBMS1, SUGP1, QKI, PQBP1, KIAA0101, RPS10P5, TBL2, RFX5, STX7, MPLKIP, SNRPC, SCO2, NABP2, MRPS28, ZC3H11A, CDV3, MRPL14, OLA1, SRRM2, TOMM40, RPS28, UBE2I, GATAD2B, UBE4B, VDAC3, SCP2, ACAA1, NUP214, MDFI, UPF2, NDUFS3, TMX2, DNAJC30, GJA1, ENPP6, NDUFA8, VAPB, NDUFA12, NDUFS4, NDUFS5, NDUFA9, NDUFS6, RAB5C, RAB7A, VAPA, GOLT1B, MMGT1, NDUFA4, C15orf48, COX6B1, NDUFB11, NDUFS7, NDUFA13, SSMEM1, FUT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF98_NDUFA7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF98_NDUFA7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |