![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 43793 |
FusionGeneSummary for ZNF98_ACTR5 |
![]() |
Fusion gene information | Fusion gene name: ZNF98_ACTR5 | Fusion gene ID: 43793 | Hgene | Tgene | Gene symbol | ZNF98 | ACTR5 | Gene ID | 148198 | 79913 |
Gene name | zinc finger protein 98 | ARP5 actin related protein 5 homolog | |
Synonyms | F7175|ZNF739 | Arp5|INO80M | |
Cytomap | 19p12 | 20q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 98zinc finger protein 739zinc finger protein F7175 | actin-related protein 5INO80 complex subunit MhARP5sarcoma antigen NY-SAR-16 | |
Modification date | 20180403 | 20180519 | |
UniProtAcc | A6NK75 | Q9H9F9 | |
Ensembl transtripts involved in fusion gene | ENST00000599879, ENST00000357774, ENST00000601553, | ENST00000243903, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 2 X 2=12 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF98 [Title/Abstract] AND ACTR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A1KX-01A | ZNF98 | chr19 | 22697166 | - | ACTR5 | chr20 | 37400202 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000599879 | ENST00000243903 | ZNF98 | chr19 | 22697166 | - | ACTR5 | chr20 | 37400202 | + |
intron-3CDS | ENST00000357774 | ENST00000243903 | ZNF98 | chr19 | 22697166 | - | ACTR5 | chr20 | 37400202 | + |
intron-3CDS | ENST00000601553 | ENST00000243903 | ZNF98 | chr19 | 22697166 | - | ACTR5 | chr20 | 37400202 | + |
Top |
FusionProtFeatures for ZNF98_ACTR5 |
![]() |
Hgene | Tgene |
ZNF98 | ACTR5 |
May be involved in transcriptional regulation. | Proposed core component of the chromatin remodelingINO80 complex which is involved in transcriptional regulation, DNAreplication and probably DNA repair. Involved in DNA double-strandbreak repair and UV-damage excision repair.{ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF98_ACTR5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF98_ACTR5 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF98 | ACTR5 | RUVBL2, INO80, YY1, INO80E, RUVBL1, ACTL6A, INO80C, NFRKB, TFPT, ACTR8, INO80B, UCHL5, INO80D, MCRS1, CSNK2B, DDB1, HECW2, WBP2NL, BLM, KLF5, FMNL1, EIF4G1, PPM1A, ZNF148, EXO1, KNTC1, TOMM20, HEXIM1, FAF2, DICER1, INTS7, NARF, PLXNA3, PDF, TBRG1, MICALL1, SPICE1, FBXW7, BCL7C |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF98_ACTR5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF98_ACTR5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |