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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43792

FusionGeneSummary for ZNF93_CYP4F22

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF93_CYP4F22
Fusion gene ID: 43792
HgeneTgene
Gene symbol

ZNF93

CYP4F22

Gene ID

81931

126410

Gene namezinc finger protein 93cytochrome P450 family 4 subfamily F member 22
SynonymsHPF34|HTF34|TF34|ZNF505ARCI5|INLNE|LI3
Cytomap

19p12

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 93zinc finger protein 505zinc finger protein HTF34cytochrome P450 4F22cytochrome P450, family 2, subfamily E, polypeptide 2 homologcytochrome P450, family 4, subfamily F, polypeptide 22
Modification date2018052220180329
UniProtAcc

P35789

Q6NT55

Ensembl transtripts involved in fusion geneENST00000592613, ENST00000591366, 
ENST00000592160, ENST00000343769, 
ENST00000269703, ENST00000601005, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 3 X 3=45
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF93 [Title/Abstract] AND CYP4F22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF93

GO:0045892

negative regulation of transcription, DNA-templated

25274305

HgeneZNF93

GO:0070895

negative regulation of transposon integration

25274305


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1474-01AZNF93chr19

20011900

+CYP4F22chr19

15634504

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000592613ENST00000269703ZNF93chr19

20011900

+CYP4F22chr19

15634504

+
3UTR-intronENST00000592613ENST00000601005ZNF93chr19

20011900

+CYP4F22chr19

15634504

+
5CDS-5UTRENST00000591366ENST00000269703ZNF93chr19

20011900

+CYP4F22chr19

15634504

+
5CDS-intronENST00000591366ENST00000601005ZNF93chr19

20011900

+CYP4F22chr19

15634504

+
5CDS-5UTRENST00000592160ENST00000269703ZNF93chr19

20011900

+CYP4F22chr19

15634504

+
5CDS-intronENST00000592160ENST00000601005ZNF93chr19

20011900

+CYP4F22chr19

15634504

+
5CDS-5UTRENST00000343769ENST00000269703ZNF93chr19

20011900

+CYP4F22chr19

15634504

+
5CDS-intronENST00000343769ENST00000601005ZNF93chr19

20011900

+CYP4F22chr19

15634504

+

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FusionProtFeatures for ZNF93_CYP4F22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF93

P35789

CYP4F22

Q6NT55

Transcription factor specifically required to represslong interspersed nuclear element 1 (L1) retrotransposons:recognizes and binds L1 sequences and repress their expression byrecruiting a repressive complex containing TRIM28/KAP1(PubMed:25274305). Not able to repress expression of all subtypesof L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or oldersubtypes nor at the most recently evolved L1PA2 and L1Hs. 50% ofL1PA3 elements have lost the ZNF93-binding site, explaining whyZNF93 is not able to repress their expression (PubMed:25274305).{ECO:0000269|PubMed:25274305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF93_CYP4F22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF93_CYP4F22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF93FBLCYP4F22


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF93_CYP4F22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF93_CYP4F22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCYP4F22C1858133Ichthyosis, Nonlamellar and Nonerythrodermic, Congenital, Autosomal Recessive1UNIPROT