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Fusion gene ID: 43790 |
FusionGeneSummary for ZNF91_RNF38 |
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Fusion gene information | Fusion gene name: ZNF91_RNF38 | Fusion gene ID: 43790 | Hgene | Tgene | Gene symbol | ZNF91 | RNF38 | Gene ID | 7644 | 152006 |
Gene name | zinc finger protein 91 | ring finger protein 38 | |
Synonyms | HPF7|HTF10 | - | |
Cytomap | 19p12 | 9p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10 | E3 ubiquitin-protein ligase RNF38RING-type E3 ubiquitin transferase RNF38 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q05481 | Q9H0F5 | |
Ensembl transtripts involved in fusion gene | ENST00000596528, ENST00000599743, ENST00000300619, ENST00000397082, | ENST00000259605, ENST00000353739, ENST00000357058, ENST00000350199, ENST00000377885, ENST00000377877, ENST00000491349, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 4 X 4=64 |
# samples | 8 | 4 | |
** MAII score | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF91 [Title/Abstract] AND RNF38 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZNF91 | GO:0045892 | negative regulation of transcription, DNA-templated | 25274305 |
Hgene | ZNF91 | GO:0070895 | negative regulation of transposon integration | 25274305 |
Tgene | RNF38 | GO:0016567 | protein ubiquitination | 23973461 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A2-A0YG-01A | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000596528 | ENST00000259605 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000596528 | ENST00000353739 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000596528 | ENST00000357058 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000596528 | ENST00000350199 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000596528 | ENST00000377885 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000596528 | ENST00000377877 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000596528 | ENST00000491349 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000599743 | ENST00000259605 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000599743 | ENST00000353739 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000599743 | ENST00000357058 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000599743 | ENST00000350199 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000599743 | ENST00000377885 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000599743 | ENST00000377877 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000599743 | ENST00000491349 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000300619 | ENST00000259605 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000300619 | ENST00000353739 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000300619 | ENST00000357058 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000300619 | ENST00000350199 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000300619 | ENST00000377885 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000300619 | ENST00000377877 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
5CDS-intron | ENST00000300619 | ENST00000491349 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000397082 | ENST00000259605 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000397082 | ENST00000353739 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000397082 | ENST00000357058 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000397082 | ENST00000350199 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000397082 | ENST00000377885 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000397082 | ENST00000377877 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
intron-intron | ENST00000397082 | ENST00000491349 | ZNF91 | chr19 | 23556540 | - | RNF38 | chr9 | 36424676 | - |
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FusionProtFeatures for ZNF91_RNF38 |
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Hgene | Tgene |
ZNF91 | RNF38 |
Transcription factor specifically required to repressSINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVAsequences and represses their expression by recruiting arepressive complex containing TRIM28/KAP1 (PubMed:25274305). Mayalso bind the promoter of the FCGR2B gene, leading to repress itsexpression; however, additional evidences are required to confirmthis result in vivo (PubMed:11470777).{ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:11470777}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF91_RNF38 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF91_RNF38 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF91 | NDEL1, ELAVL1, CHMP5, TRIM44 | RNF38 | TP53, TP63, TP73, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2H, ELAVL1, LDB1, RNF114, DZIP3, DTX3, RNF38, ZDHHC17, UBC, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF91_RNF38 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF91_RNF38 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |