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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43790

FusionGeneSummary for ZNF91_RNF38

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF91_RNF38
Fusion gene ID: 43790
HgeneTgene
Gene symbol

ZNF91

RNF38

Gene ID

7644

152006

Gene namezinc finger protein 91ring finger protein 38
SynonymsHPF7|HTF10-
Cytomap

19p12

9p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10E3 ubiquitin-protein ligase RNF38RING-type E3 ubiquitin transferase RNF38
Modification date2018051920180522
UniProtAcc

Q05481

Q9H0F5

Ensembl transtripts involved in fusion geneENST00000596528, ENST00000599743, 
ENST00000300619, ENST00000397082, 
ENST00000259605, ENST00000353739, 
ENST00000357058, ENST00000350199, 
ENST00000377885, ENST00000377877, 
ENST00000491349, 
Fusion gene scores* DoF score6 X 5 X 5=1504 X 4 X 4=64
# samples 84
** MAII scorelog2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF91 [Title/Abstract] AND RNF38 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF91

GO:0045892

negative regulation of transcription, DNA-templated

25274305

HgeneZNF91

GO:0070895

negative regulation of transposon integration

25274305

TgeneRNF38

GO:0016567

protein ubiquitination

23973461


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0YG-01AZNF91chr19

23556540

-RNF38chr9

36424676

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000596528ENST00000259605ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000596528ENST00000353739ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000596528ENST00000357058ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000596528ENST00000350199ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000596528ENST00000377885ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000596528ENST00000377877ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000596528ENST00000491349ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000599743ENST00000259605ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000599743ENST00000353739ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000599743ENST00000357058ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000599743ENST00000350199ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000599743ENST00000377885ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000599743ENST00000377877ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000599743ENST00000491349ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000300619ENST00000259605ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000300619ENST00000353739ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000300619ENST00000357058ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000300619ENST00000350199ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000300619ENST00000377885ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000300619ENST00000377877ZNF91chr19

23556540

-RNF38chr9

36424676

-
5CDS-intronENST00000300619ENST00000491349ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000397082ENST00000259605ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000397082ENST00000353739ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000397082ENST00000357058ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000397082ENST00000350199ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000397082ENST00000377885ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000397082ENST00000377877ZNF91chr19

23556540

-RNF38chr9

36424676

-
intron-intronENST00000397082ENST00000491349ZNF91chr19

23556540

-RNF38chr9

36424676

-

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FusionProtFeatures for ZNF91_RNF38


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF91

Q05481

RNF38

Q9H0F5

Transcription factor specifically required to repressSINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVAsequences and represses their expression by recruiting arepressive complex containing TRIM28/KAP1 (PubMed:25274305). Mayalso bind the promoter of the FCGR2B gene, leading to repress itsexpression; however, additional evidences are required to confirmthis result in vivo (PubMed:11470777).{ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:11470777}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF91_RNF38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF91_RNF38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF91NDEL1, ELAVL1, CHMP5, TRIM44RNF38TP53, TP63, TP73, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2H, ELAVL1, LDB1, RNF114, DZIP3, DTX3, RNF38, ZDHHC17, UBC, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF91_RNF38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF91_RNF38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource