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Fusion gene ID: 43789 |
FusionGeneSummary for ZNF91_RBM3 |
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Fusion gene information | Fusion gene name: ZNF91_RBM3 | Fusion gene ID: 43789 | Hgene | Tgene | Gene symbol | ZNF91 | RBM3 | Gene ID | 7644 | 5935 |
Gene name | zinc finger protein 91 | RNA binding motif protein 3 | |
Synonyms | HPF7|HTF10 | IS1-RNPL|RNPL | |
Cytomap | 19p12 | Xp11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10 | RNA-binding protein 3RNA binding motif (RNP1, RRM) protein 3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q05481 | P98179 | |
Ensembl transtripts involved in fusion gene | ENST00000596528, ENST00000599743, ENST00000300619, ENST00000397082, | ENST00000466764, ENST00000376759, ENST00000430348, ENST00000376755, ENST00000354480, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 4 X 1=16 |
# samples | 8 | 5 | |
** MAII score | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF91 [Title/Abstract] AND RBM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZNF91 | GO:0045892 | negative regulation of transcription, DNA-templated | 25274305 |
Hgene | ZNF91 | GO:0070895 | negative regulation of transposon integration | 25274305 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU689713 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - | ||
ChiTaRS3.1 | BU678763 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000596528 | ENST00000466764 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000596528 | ENST00000376759 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000596528 | ENST00000430348 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-intron | ENST00000596528 | ENST00000376755 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000596528 | ENST00000354480 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000599743 | ENST00000466764 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000599743 | ENST00000376759 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000599743 | ENST00000430348 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-intron | ENST00000599743 | ENST00000376755 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000599743 | ENST00000354480 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000300619 | ENST00000466764 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000300619 | ENST00000376759 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000300619 | ENST00000430348 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-intron | ENST00000300619 | ENST00000376755 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000300619 | ENST00000354480 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000397082 | ENST00000466764 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000397082 | ENST00000376759 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000397082 | ENST00000430348 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-intron | ENST00000397082 | ENST00000376755 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
intron-3UTR | ENST00000397082 | ENST00000354480 | ZNF91 | chr19 | 23521758 | + | RBM3 | chrX | 48436351 | - |
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FusionProtFeatures for ZNF91_RBM3 |
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Hgene | Tgene |
ZNF91 | RBM3 |
Transcription factor specifically required to repressSINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVAsequences and represses their expression by recruiting arepressive complex containing TRIM28/KAP1 (PubMed:25274305). Mayalso bind the promoter of the FCGR2B gene, leading to repress itsexpression; however, additional evidences are required to confirmthis result in vivo (PubMed:11470777).{ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:11470777}. | Cold-inducible mRNA binding protein that enhances globalprotein synthesis at both physiological and mild hypothermictemperatures. Reduces the relative abundance of microRNAs, whenoverexpressed. Enhances phosphorylation of translation initiationfactors and active polysome formation (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF91_RBM3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF91_RBM3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF91_RBM3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF91_RBM3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RBM3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | RBM3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |