FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 43788

FusionGeneSummary for ZNF91_NR1H2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF91_NR1H2
Fusion gene ID: 43788
HgeneTgene
Gene symbol

ZNF91

NR1H2

Gene ID

7644

7376

Gene namezinc finger protein 91nuclear receptor subfamily 1 group H member 2
SynonymsHPF7|HTF10LXR-b|LXRB|NER|NER-I|RIP15|UNR
Cytomap

19p12

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10oxysterols receptor LXR-betaLX receptor betaliver X nuclear receptor betanuclear orphan receptor LXR-betanuclear receptor NERsteroid hormone-nuclear receptor NERubiquitously-expressed nuclear receptor
Modification date2018051920180523
UniProtAcc

Q05481

P55055

Ensembl transtripts involved in fusion geneENST00000596528, ENST00000599743, 
ENST00000300619, ENST00000397082, 
ENST00000542413, ENST00000600978, 
ENST00000598168, ENST00000411902, 
ENST00000253727, ENST00000599105, 
ENST00000593926, 
Fusion gene scores* DoF score6 X 5 X 5=1505 X 5 X 3=75
# samples 85
** MAII scorelog2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF91 [Title/Abstract] AND NR1H2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF91

GO:0045892

negative regulation of transcription, DNA-templated

25274305

HgeneZNF91

GO:0070895

negative regulation of transposon integration

25274305

TgeneNR1H2

GO:0032376

positive regulation of cholesterol transport

16141411

TgeneNR1H2

GO:0045892

negative regulation of transcription, DNA-templated

12393874

TgeneNR1H2

GO:0045893

positive regulation of transcription, DNA-templated

25661920

TgeneNR1H2

GO:0045944

positive regulation of transcription by RNA polymerase II

9013544|16141411|20219900


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-69-7978-01AZNF91chr19

23541232

-NR1H2chr19

50855748

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000596528ENST00000542413ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000596528ENST00000600978ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000596528ENST00000598168ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000596528ENST00000411902ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000596528ENST00000253727ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000596528ENST00000599105ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000596528ENST00000593926ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-5UTRENST00000599743ENST00000542413ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000599743ENST00000600978ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000599743ENST00000598168ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000599743ENST00000411902ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000599743ENST00000253727ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000599743ENST00000599105ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000599743ENST00000593926ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-5UTRENST00000300619ENST00000542413ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000300619ENST00000600978ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000300619ENST00000598168ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000300619ENST00000411902ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000300619ENST00000253727ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000300619ENST00000599105ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000300619ENST00000593926ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-5UTRENST00000397082ENST00000542413ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000397082ENST00000600978ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000397082ENST00000598168ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000397082ENST00000411902ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000397082ENST00000253727ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000397082ENST00000599105ZNF91chr19

23541232

-NR1H2chr19

50855748

+
intron-intronENST00000397082ENST00000593926ZNF91chr19

23541232

-NR1H2chr19

50855748

+

Top

FusionProtFeatures for ZNF91_NR1H2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF91

Q05481

NR1H2

P55055

Transcription factor specifically required to repressSINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVAsequences and represses their expression by recruiting arepressive complex containing TRIM28/KAP1 (PubMed:25274305). Mayalso bind the promoter of the FCGR2B gene, leading to repress itsexpression; however, additional evidences are required to confirmthis result in vivo (PubMed:11470777).{ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:11470777}. Nuclear receptor that exhibits a ligand-dependenttranscriptional activation activity (PubMed:25661920). Bindspreferentially to double-stranded oligonucleotide direct repeatshaving the consensus half-site sequence 5'-AGGTCA-3' and 4-ntspacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8.Interplays functionally with RORA for the regulation of genesinvolved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response byacting as a corepressor: inhibits the hepatic acute phase responseby preventing dissociation of the N-Cor corepressor complex(PubMed:20159957). {ECO:0000250|UniProtKB:Q60644,ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:25661920}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZNF91_NR1H2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZNF91_NR1H2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF91NDEL1, ELAVL1, CHMP5, TRIM44NR1H2MDFI, NCOA6, RXRB, NR0B2, RXRA, SIRT1, HDAC4, NCOR1, SMARCA4, ZXDC, NRIP1, MED1, NCOR2, NCOA3, RARA, NPY, FOXO3, SCG5, UBE2I, RXRG, TMEM161A, ING3, PCDH17, VDR, DUSP12, SPRY2, C14orf1, ROBO2, CHD3, MPP1, SMPD1, CSAD, VIM, COL4A5, SORBS2, BAG6, UBE2D1, RMI1, HMGXB4, FAF1, CORO2A, SENP3, PRKCA, PIAS1, PPARGC1B, USP7, PDCD4, KDM1A, ACVRL1, LAMC3, CDKN1A, YY1, SUV39H1, ABCA1, NCOA1, RHOU, DNMT3L, STAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZNF91_NR1H2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNR1H2P55055DB11994DiacereinOxysterols receptor LXR-betasmall moleculeapproved|investigational

Top

RelatedDiseases for ZNF91_NR1H2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNR1H2C0008370Cholestasis1CTD_human
TgeneNR1H2C2239176Liver carcinoma1CTD_human