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Fusion gene ID: 43787 |
FusionGeneSummary for ZNF91_NANOS3 |
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Fusion gene information | Fusion gene name: ZNF91_NANOS3 | Fusion gene ID: 43787 | Hgene | Tgene | Gene symbol | ZNF91 | NANOS3 | Gene ID | 7644 | 342977 |
Gene name | zinc finger protein 91 | nanos C2HC-type zinc finger 3 | |
Synonyms | HPF7|HTF10 | NANOS1L|NOS3|ZC2HC12C | |
Cytomap | 19p12 | 19p13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10 | nanos homolog 3 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q05481 | P60323 | |
Ensembl transtripts involved in fusion gene | ENST00000596528, ENST00000599743, ENST00000300619, ENST00000397082, | ENST00000591727, ENST00000339133, ENST00000397555, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 1 X 4=16 |
# samples | 8 | 4 | |
** MAII score | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF91 [Title/Abstract] AND NANOS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZNF91 | GO:0045892 | negative regulation of transcription, DNA-templated | 25274305 |
Hgene | ZNF91 | GO:0070895 | negative regulation of transposon integration | 25274305 |
Tgene | NANOS3 | GO:0017148 | negative regulation of translation | 24736845 |
Tgene | NANOS3 | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 24736845 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-S9-A7IZ-01A | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000596528 | ENST00000591727 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
intron-3UTR | ENST00000596528 | ENST00000339133 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
intron-3UTR | ENST00000596528 | ENST00000397555 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
5CDS-3UTR | ENST00000599743 | ENST00000591727 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
5CDS-3UTR | ENST00000599743 | ENST00000339133 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
5CDS-3UTR | ENST00000599743 | ENST00000397555 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
5CDS-3UTR | ENST00000300619 | ENST00000591727 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
5CDS-3UTR | ENST00000300619 | ENST00000339133 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
5CDS-3UTR | ENST00000300619 | ENST00000397555 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
5CDS-3UTR | ENST00000397082 | ENST00000591727 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
5CDS-3UTR | ENST00000397082 | ENST00000339133 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
5CDS-3UTR | ENST00000397082 | ENST00000397555 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
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FusionProtFeatures for ZNF91_NANOS3 |
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Hgene | Tgene |
ZNF91 | NANOS3 |
Transcription factor specifically required to repressSINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVAsequences and represses their expression by recruiting arepressive complex containing TRIM28/KAP1 (PubMed:25274305). Mayalso bind the promoter of the FCGR2B gene, leading to repress itsexpression; however, additional evidences are required to confirmthis result in vivo (PubMed:11470777).{ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:11470777}. | Plays a role in the maintenance of the undifferentiatedstate of germ cells regulating the spermatogonia cell cycle andinducing a prolonged transit in G1 phase. Affects cellproliferation probably by repressing translation of specificmRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in theearly stage embryo to protect the migrating primordial germ cells(PGCs) from apoptosis. {ECO:0000269|PubMed:21421998}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF91_NANOS3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF91_NANOS3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF91 | NDEL1, ELAVL1, CHMP5, TRIM44 | NANOS3 | PUM2, CNOT1, CNOT3, DMRT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF91_NANOS3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF91_NANOS3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |