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Fusion gene ID: 43779 |
FusionGeneSummary for ZNF850_WTIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF850_WTIP | Fusion gene ID: 43779 | Hgene | Tgene | Gene symbol | ZNF850 | WTIP | Gene ID | 342892 | 126374 |
| Gene name | zinc finger protein 850 | WT1 interacting protein | |
| Synonyms | ZNF850P | - | |
| Cytomap | 19q13.12 | 19q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 850putative zinc finger protein ENSP00000330994 | Wilms tumor protein 1-interacting proteinWilms tumor 1 interacting protein | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | A8MQ14 | A6NIX2 | |
| Ensembl transtripts involved in fusion gene | ENST00000589390, ENST00000591344, | ENST00000590071, ENST00000270288, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF850 [Title/Abstract] AND WTIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | WTIP | GO:0001666 | response to hypoxia | 22286099 |
| Tgene | WTIP | GO:0035331 | negative regulation of hippo signaling | 20303269 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-XC-AA0X-01A | ZNF850 | chr19 | 37253207 | - | WTIP | chr19 | 34981281 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000589390 | ENST00000590071 | ZNF850 | chr19 | 37253207 | - | WTIP | chr19 | 34981281 | + |
| Frame-shift | ENST00000589390 | ENST00000270288 | ZNF850 | chr19 | 37253207 | - | WTIP | chr19 | 34981281 | + |
| Frame-shift | ENST00000591344 | ENST00000590071 | ZNF850 | chr19 | 37253207 | - | WTIP | chr19 | 34981281 | + |
| Frame-shift | ENST00000591344 | ENST00000270288 | ZNF850 | chr19 | 37253207 | - | WTIP | chr19 | 34981281 | + |
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FusionProtFeatures for ZNF850_WTIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF850 | WTIP |
| May be involved in transcriptional regulation.{ECO:0000250}. | Adapter or scaffold protein which participates in theassembly of numerous protein complexes and is involved in severalcellular processes such as cell fate determination, cytoskeletalorganization, repression of gene transcription, cell-celladhesion, cell differentiation, proliferation and migration.Positively regulates microRNA (miRNA)-mediated gene silencing.Negatively regulates Hippo signaling pathway and antagonizesphosphorylation of YAP1. Acts as a transcriptional corepressor forSNAI1 and SNAI2/SLUG-dependent repression of E-cadherintranscription. Acts as a hypoxic regulator by bridging anassociation between the prolyl hydroxylases and VHL enablingefficient degradation of HIF1A. In podocytes, may play a role inthe regulation of actin dynamics and/or foot processcytoarchitecture (By similarity). In the course of podocyteinjury, shuttles into the nucleus and acts as a transcriptionregulator that represses WT1-dependent transcription regulation,thereby translating changes in slit diaphragm structure intoaltered gene expression and a less differentiated phenotype.Involved in the organization of the basal body (By similarity).Involved in cilia growth and positioning (By similarity).{ECO:0000250, ECO:0000250|UniProtKB:A9LS46,ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046,ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF850_WTIP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF850_WTIP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF850 | WTIP | RARA, EGLN2, EGLN3, VHL, TRIP6, LATS1, LATS2, SAV1, PPP2R3A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF850_WTIP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF850_WTIP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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