![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 43762 |
FusionGeneSummary for ZNF827_EEF2 |
![]() |
Fusion gene information | Fusion gene name: ZNF827_EEF2 | Fusion gene ID: 43762 | Hgene | Tgene | Gene symbol | ZNF827 | EEF2 | Gene ID | 152485 | 1938 |
Gene name | zinc finger protein 827 | eukaryotic translation elongation factor 2 | |
Synonyms | - | EEF-2|EF-2|EF2|SCA26 | |
Cytomap | 4q31.21-q31.22 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 827 | elongation factor 2polypeptidyl-tRNA translocase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q17R98 | P13639 | |
Ensembl transtripts involved in fusion gene | ENST00000508784, ENST00000513320, ENST00000379448, ENST00000511534, | ENST00000309311, ENST00000600720, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 7 X 13 X 3=273 |
# samples | 2 | 17 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(17/273*10)=-0.683366204782151 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF827 [Title/Abstract] AND EEF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-5511-01A | ZNF827 | chr4 | 146682281 | - | EEF2 | chr19 | 3985461 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000508784 | ENST00000309311 | ZNF827 | chr4 | 146682281 | - | EEF2 | chr19 | 3985461 | - |
intron-intron | ENST00000508784 | ENST00000600720 | ZNF827 | chr4 | 146682281 | - | EEF2 | chr19 | 3985461 | - |
intron-3CDS | ENST00000513320 | ENST00000309311 | ZNF827 | chr4 | 146682281 | - | EEF2 | chr19 | 3985461 | - |
intron-intron | ENST00000513320 | ENST00000600720 | ZNF827 | chr4 | 146682281 | - | EEF2 | chr19 | 3985461 | - |
intron-3CDS | ENST00000379448 | ENST00000309311 | ZNF827 | chr4 | 146682281 | - | EEF2 | chr19 | 3985461 | - |
intron-intron | ENST00000379448 | ENST00000600720 | ZNF827 | chr4 | 146682281 | - | EEF2 | chr19 | 3985461 | - |
intron-3CDS | ENST00000511534 | ENST00000309311 | ZNF827 | chr4 | 146682281 | - | EEF2 | chr19 | 3985461 | - |
intron-intron | ENST00000511534 | ENST00000600720 | ZNF827 | chr4 | 146682281 | - | EEF2 | chr19 | 3985461 | - |
Top |
FusionProtFeatures for ZNF827_EEF2 |
![]() |
Hgene | Tgene |
ZNF827 | EEF2 |
May be involved in transcriptional regulation.{ECO:0000250}. | Catalyzes the GTP-dependent ribosomal translocation stepduring translation elongation. During this step, the ribosomechanges from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-boundpeptidyl-tRNA and P-site-bound deacylated tRNA move to the P and Esites, respectively. Catalyzes the coordinated movement of the twotRNA molecules, the mRNA and conformational changes in theribosome. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF827_EEF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF827_EEF2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF827 | PPP1CA, UBE2E1, ATP6V1E1, CHERP, VPS45, UNC80, HDAC1, GATAD2A, GATAD2B, RBBP7, RBBP4, CHD3, CHD4, MTA1, MTA2, MTA3, HDAC2, MCPH1, BRCA1 | EEF2 | TP53, MLLT3, POU5F1, UCHL5, PPP2R1A, PPP2R1B, NOP56, DISC1, PSMA3, NDRG1, HDGF, ARRB2, ISG15, FBXO25, EEF2K, CUL3, CUL4B, CUL5, CDK2, CUL1, COPS5, COPS6, CAND1, GRK5, RAD23A, RPL5, RPS6, RPS3A, RPL7, RPS4X, RPL7A, EEF1A1, RPS16, RPS23, RPL31, RPS24, RPL12, RPL4, RPS15A, RPL10A, RPL14, RPL6, RPL18, RPS7, RPL21, RPL11, RPL23, RPS2, RPS5, RPS19, TARS, MRPS5, HSPD1, HSPA8, EIF4A1, PABPC1, FARSA, RPLP0P6, XRCC6, RPL10L, FLOT2, RRM1, HNRNPA0, EPHA2, ERLIN2, RBM4, HNRNPH1, RHOT2, HNRNPDL, HNRNPL, DDX5, ATP6V1H, NUP62, HNRNPA3, UPF1, SMURF1, CCT2, HSP90AA1, HSP90AB1, FN1, VCAM1, ATF2, MLH1, EEF2KMT, UBL4A, ITGA4, NPM1, SMG1, ADRB2, HNRNPD, MAPK14, HIPK4, CDK18, CDK20, TARDBP, CDKN2A, BZW1, CASP7, CKB, CAPN1, FTO, GSR, PGD, TYMP, EIF4H, GINS2, MAT2A, PAK2, PFAS, RPS6KA1, XPO1, YWHAQ, SHFM1, LGR4, HUWE1, FUS, MDM2, RNF2, SIRT6, ARAF, BLK, BUB1B, CASK, CDK13, DAPK1, IRAK1, LIMK2, WEE1, ESR1, HNRNPA1, UNK, EP300, CALR, ABCC3, ABCD3, AHNAK, ARPC2, ATIC, ATP1B3, AURKA, CASP3, CSE1L, DPH1, DPH2, EEF1A2, ENO1, GSPT1, HSD17B10, NDUFV1, NOTCH2, PGK1, TAGLN, TAGLN2, TOMM40, TXN, HCFC1, HSD17B4, IPO4, ISYNA1, OPA1, RDX, TUBB, NTRK1, PTEN, PPME1, GAN, CRY1, CRY2, MCM2, SENP3, U2AF2, NFATC2, CDC73, WWP2, ZNF746, CDH1, FBXO9, DEFA1, SLC25A48, CYLD, DLD, DLST, DNM1L, PARK7, SDHA, SOAT1, SOD1, VDAC1, TRIM25, BRCA1, HDAC6 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF827_EEF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF827_EEF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | EEF2 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | EEF2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | EEF2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | EEF2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | EEF2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | EEF2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | EEF2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | EEF2 | C1836395 | SPINOCEREBELLAR ATAXIA 26 | 1 | ORPHANET;UNIPROT |