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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43762

FusionGeneSummary for ZNF827_EEF2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF827_EEF2
Fusion gene ID: 43762
HgeneTgene
Gene symbol

ZNF827

EEF2

Gene ID

152485

1938

Gene namezinc finger protein 827eukaryotic translation elongation factor 2
Synonyms-EEF-2|EF-2|EF2|SCA26
Cytomap

4q31.21-q31.22

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 827elongation factor 2polypeptidyl-tRNA translocase
Modification date2018052320180523
UniProtAcc

Q17R98

P13639

Ensembl transtripts involved in fusion geneENST00000508784, ENST00000513320, 
ENST00000379448, ENST00000511534, 
ENST00000309311, ENST00000600720, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 13 X 3=273
# samples 217
** MAII scorelog2(2/4*10)=2.32192809488736log2(17/273*10)=-0.683366204782151
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF827 [Title/Abstract] AND EEF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5511-01AZNF827chr4

146682281

-EEF2chr19

3985461

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000508784ENST00000309311ZNF827chr4

146682281

-EEF2chr19

3985461

-
intron-intronENST00000508784ENST00000600720ZNF827chr4

146682281

-EEF2chr19

3985461

-
intron-3CDSENST00000513320ENST00000309311ZNF827chr4

146682281

-EEF2chr19

3985461

-
intron-intronENST00000513320ENST00000600720ZNF827chr4

146682281

-EEF2chr19

3985461

-
intron-3CDSENST00000379448ENST00000309311ZNF827chr4

146682281

-EEF2chr19

3985461

-
intron-intronENST00000379448ENST00000600720ZNF827chr4

146682281

-EEF2chr19

3985461

-
intron-3CDSENST00000511534ENST00000309311ZNF827chr4

146682281

-EEF2chr19

3985461

-
intron-intronENST00000511534ENST00000600720ZNF827chr4

146682281

-EEF2chr19

3985461

-

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FusionProtFeatures for ZNF827_EEF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF827

Q17R98

EEF2

P13639

May be involved in transcriptional regulation.{ECO:0000250}. Catalyzes the GTP-dependent ribosomal translocation stepduring translation elongation. During this step, the ribosomechanges from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-boundpeptidyl-tRNA and P-site-bound deacylated tRNA move to the P and Esites, respectively. Catalyzes the coordinated movement of the twotRNA molecules, the mRNA and conformational changes in theribosome.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF827_EEF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF827_EEF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF827PPP1CA, UBE2E1, ATP6V1E1, CHERP, VPS45, UNC80, HDAC1, GATAD2A, GATAD2B, RBBP7, RBBP4, CHD3, CHD4, MTA1, MTA2, MTA3, HDAC2, MCPH1, BRCA1EEF2TP53, MLLT3, POU5F1, UCHL5, PPP2R1A, PPP2R1B, NOP56, DISC1, PSMA3, NDRG1, HDGF, ARRB2, ISG15, FBXO25, EEF2K, CUL3, CUL4B, CUL5, CDK2, CUL1, COPS5, COPS6, CAND1, GRK5, RAD23A, RPL5, RPS6, RPS3A, RPL7, RPS4X, RPL7A, EEF1A1, RPS16, RPS23, RPL31, RPS24, RPL12, RPL4, RPS15A, RPL10A, RPL14, RPL6, RPL18, RPS7, RPL21, RPL11, RPL23, RPS2, RPS5, RPS19, TARS, MRPS5, HSPD1, HSPA8, EIF4A1, PABPC1, FARSA, RPLP0P6, XRCC6, RPL10L, FLOT2, RRM1, HNRNPA0, EPHA2, ERLIN2, RBM4, HNRNPH1, RHOT2, HNRNPDL, HNRNPL, DDX5, ATP6V1H, NUP62, HNRNPA3, UPF1, SMURF1, CCT2, HSP90AA1, HSP90AB1, FN1, VCAM1, ATF2, MLH1, EEF2KMT, UBL4A, ITGA4, NPM1, SMG1, ADRB2, HNRNPD, MAPK14, HIPK4, CDK18, CDK20, TARDBP, CDKN2A, BZW1, CASP7, CKB, CAPN1, FTO, GSR, PGD, TYMP, EIF4H, GINS2, MAT2A, PAK2, PFAS, RPS6KA1, XPO1, YWHAQ, SHFM1, LGR4, HUWE1, FUS, MDM2, RNF2, SIRT6, ARAF, BLK, BUB1B, CASK, CDK13, DAPK1, IRAK1, LIMK2, WEE1, ESR1, HNRNPA1, UNK, EP300, CALR, ABCC3, ABCD3, AHNAK, ARPC2, ATIC, ATP1B3, AURKA, CASP3, CSE1L, DPH1, DPH2, EEF1A2, ENO1, GSPT1, HSD17B10, NDUFV1, NOTCH2, PGK1, TAGLN, TAGLN2, TOMM40, TXN, HCFC1, HSD17B4, IPO4, ISYNA1, OPA1, RDX, TUBB, NTRK1, PTEN, PPME1, GAN, CRY1, CRY2, MCM2, SENP3, U2AF2, NFATC2, CDC73, WWP2, ZNF746, CDH1, FBXO9, DEFA1, SLC25A48, CYLD, DLD, DLST, DNM1L, PARK7, SDHA, SOAT1, SOD1, VDAC1, TRIM25, BRCA1, HDAC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF827_EEF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF827_EEF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEEF2C0001418Adenocarcinoma1CTD_human
TgeneEEF2C0007134Renal Cell Carcinoma1CTD_human
TgeneEEF2C0024121Lung Neoplasms1CTD_human
TgeneEEF2C0027626Neoplasm Invasiveness1CTD_human
TgeneEEF2C0027627Neoplasm Metastasis1CTD_human
TgeneEEF2C0029408Degenerative polyarthritis1CTD_human
TgeneEEF2C1458155Mammary Neoplasms1CTD_human
TgeneEEF2C1836395SPINOCEREBELLAR ATAXIA 261ORPHANET;UNIPROT