	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 43750

FusionGeneSummary for ZNF814_USF1

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF814_USF1
	Fusion gene ID: 43750
		Hgene	Tgene
	Gene symbol	ZNF814	USF1
	Gene ID	730051	7391
	Gene name	zinc finger protein 814	upstream transcription factor 1
	Synonyms	-	FCHL\|FCHL1\|HYPLIP1\|MLTF\|MLTFI\|UEF\|bHLHb11
	Cytomap	19q13.43	1q23.3
	Type of gene	protein-coding	protein-coding
	Description	putative uncharacterized zinc finger protein 814	upstream stimulatory factor 1class B basic helix-loop-helix protein 11major late transcription factor 1
	Modification date	20180403	20180522
	UniProtAcc	B7Z6K7	P22415
	Ensembl transtripts involved in fusion gene	ENST00000597652, ENST00000596604, ENST00000597342, ENST00000597832, ENST00000595295, ENST00000600634, ENST00000435989, ENST00000597807,	ENST00000368020, ENST00000368021, ENST00000435396, ENST00000368019,
Fusion gene scores	* DoF score	8 X 6 X 4=192	4 X 6 X 2=48
	# samples	8	6
	** MAII score	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ZNF814 [Title/Abstract] AND USF1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	USF1	GO:0006366	transcription by RNA polymerase II	2249772
Tgene	USF1	GO:0019086	late viral transcription	2249772
Tgene	USF1	GO:0032869	cellular response to insulin stimulus	19303849

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF932409	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000597652	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597652	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597652	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597652	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000596604	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000596604	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000596604	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000596604	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597342	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597342	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597342	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597342	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597832	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597832	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597832	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597832	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000595295	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000595295	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000595295	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000595295	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000600634	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000600634	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000600634	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000600634	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000435989	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000435989	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000435989	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000435989	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597807	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597807	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597807	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597807	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+

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FusionProtFeatures for ZNF814_USF1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF814 B7Z6K7	USF1 P22415
	Transcription factor that binds to a symmetrical DNAsequence (E-boxes) (5'-CACGTG-3') that is found in a variety ofviral and cellular promoters.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ZNF814_USF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF814_USF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ZNF814_USF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZNF814_USF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 43750

FusionGeneSummary for ZNF814_USF1

FusionProtFeatures for ZNF814_USF1

FusionGeneSequence for ZNF814_USF1

FusionGenePPI for ZNF814_USF1

RelatedDrugs for ZNF814_USF1

RelatedDiseases for ZNF814_USF1