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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43743

FusionGeneSummary for ZNF808_PIGX

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF808_PIGX
Fusion gene ID: 43743
HgeneTgene
Gene symbol

ZNF808

PIGX

Gene ID

388558

54965

Gene namezinc finger protein 808phosphatidylinositol glycan anchor biosynthesis class X
Synonyms-PIG-X
Cytomap

19q13.41

3q29

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 808phosphatidylinositol-glycan biosynthesis class X proteinGPI-mannosyltransferase subunit
Modification date2018052420180522
UniProtAcc

Q8N4W9

Q8TBF5

Ensembl transtripts involved in fusion geneENST00000359798, ENST00000314118, 
ENST00000421265, ENST00000541663, 
ENST00000495440, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 3 X 4=48
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF808 [Title/Abstract] AND PIGX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-IC-A6RF-01AZNF808chr19

53046600

+PIGXchr3

196454794

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000359798ENST00000314118ZNF808chr19

53046600

+PIGXchr3

196454794

+
In-frameENST00000359798ENST00000421265ZNF808chr19

53046600

+PIGXchr3

196454794

+
5CDS-5UTRENST00000359798ENST00000541663ZNF808chr19

53046600

+PIGXchr3

196454794

+
5CDS-intronENST00000359798ENST00000495440ZNF808chr19

53046600

+PIGXchr3

196454794

+

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FusionProtFeatures for ZNF808_PIGX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF808

Q8N4W9

PIGX

Q8TBF5

May be involved in transcriptional regulation. Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannosesin the GPI-anchor precursors during GPI-anchor biosynthesis.Probably acts by stabilizing the mannosyltransferase PIGM (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+3524_9821904DomainKRAB
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35231_25321904Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35259_28121904Zinc fingerC2H2-type 2
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35287_30921904Zinc fingerC2H2-type 3
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35315_33721904Zinc fingerC2H2-type 4
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35343_36521904Zinc fingerC2H2-type 5
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35371_39321904Zinc fingerC2H2-type 6
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35399_42121904Zinc fingerC2H2-type 7
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35427_44921904Zinc fingerC2H2-type 8
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35455_47721904Zinc fingerC2H2-type 9
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35483_50521904Zinc fingerC2H2-type 10
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35511_53321904Zinc fingerC2H2-type 11
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35539_56121904Zinc fingerC2H2-type 12
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35567_58921904Zinc fingerC2H2-type 13
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35595_61721904Zinc fingerC2H2-type 14
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35623_64521904Zinc fingerC2H2-type 15
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35651_67321904Zinc fingerC2H2-type 16
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35679_70121904Zinc fingerC2H2-type 17
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35707_72921904Zinc fingerC2H2-type 18
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35735_75721904Zinc fingerC2H2-type 19
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35763_78521904Zinc fingerC2H2-type 20
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35791_81321904Zinc fingerC2H2-type 21
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35819_84121904Zinc fingerC2H2-type 22
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35847_86921904Zinc fingerC2H2-type 23
HgeneZNF808chr19:53046600chr3:196454794ENST00000359798+35875_89721904Zinc fingerC2H2-type 24


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FusionGeneSequence for ZNF808_PIGX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF808_ENST00000359798_chr19_53046600_+_PIGX_ENST00000314118_chr3_196454794_+_174aa
MLREEAAQKRKGKESGMALPQAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFC

>In-frame_ZNF808_ENST00000359798_chr19_53046600_+_PIGX_ENST00000421265_chr3_196454794_+_107aa
MLREEAAQKRKGKESGMALPQAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFC


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF808_ENST00000359798_chr19_53046600_+_PIGX_ENST00000314118_chr3_196454794_+_522nt
ATGTTACGTGAGGAAGCAGCTCAGAAGAGGAAAGGAAAGGAGTCAGGCATGGCTCTTCCTCAGGCAGTGATGGTTTCAGAAAATTTTGAT
ATAGAGGCCCCTAACTATTTGTCCAAGGAGTCTGAAGTTCTCATTTATGCCAGACGAGATTCACAGTGCATTGACTGTTTTCAAGCCTTT
TTGCCTGTGCACTGCCGCTATCATCGGCCGCACAGTGAAGATGGAGAAGCCTCGATTGTGGTCAATAACCCAGATTTGTTGATGTTTTGT
GACCAAGAGTTCCCGATTTTGAAATGCTGGGCTCACTCAGAAGTGGCAGCCCCTTGTGCTTTGGAGAATGAGGATATCTGCCAATGGAAC
AAGATGAAGTATAAATCAGTATATAAGAATGTGATTCTACAAGTTCCAGTGGGACTGACTGTACATACCTCTCTAGTATGTTCTGTGACT

>In-frame_ZNF808_ENST00000359798_chr19_53046600_+_PIGX_ENST00000421265_chr3_196454794_+_321nt
ATGTTACGTGAGGAAGCAGCTCAGAAGAGGAAAGGAAAGGAGTCAGGCATGGCTCTTCCTCAGGCAGTGATGGTTTCAGAAAATTTTGAT
ATAGAGGCCCCTAACTATTTGTCCAAGGAGTCTGAAGTTCTCATTTATGCCAGACGAGATTCACAGTGCATTGACTGTTTTCAAGCCTTT
TTGCCTGTGCACTGCCGCTATCATCGGCCGCACAGTGAAGATGGAGAAGCCTCGATTGTGGTCAATAACCCAGATTTGTTGATGTTTTGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF808_ENST00000359798_chr19_53046600_+_PIGX_ENST00000314118_chr3_196454794_+_2784nt
CGCGGAGATTAACGCAAACCCGGAAGCGGATCGGGTGGAGTGAAGGTCACGTCGCCATGATATCTCTTCCAAATGCTTGATGAAAAAGGT
GGAAGGGTCACTTGACCCAGGGAGTTGAAGGCTGCAGTGAGCCCTGTTTTTGCCACCACACTCCAGCCTGGGATTGATTTCTAAAGACTC
ATGTTACGTGAGGAAGCAGCTCAGAAGAGGAAAGGAAAGGAGTCAGGCATGGCTCTTCCTCAGGCAGTGATGGTTTCAGAAAATTTTGAT
ATAGAGGCCCCTAACTATTTGTCCAAGGAGTCTGAAGTTCTCATTTATGCCAGACGAGATTCACAGTGCATTGACTGTTTTCAAGCCTTT
TTGCCTGTGCACTGCCGCTATCATCGGCCGCACAGTGAAGATGGAGAAGCCTCGATTGTGGTCAATAACCCAGATTTGTTGATGTTTTGT
GACCAAGAGTTCCCGATTTTGAAATGCTGGGCTCACTCAGAAGTGGCAGCCCCTTGTGCTTTGGAGAATGAGGATATCTGCCAATGGAAC
AAGATGAAGTATAAATCAGTATATAAGAATGTGATTCTACAAGTTCCAGTGGGACTGACTGTACATACCTCTCTAGTATGTTCTGTGACT
CTGCTCATTACAATCCTGTGCTCTACATTGATCCTTGTAGCAGTTTTCAAATATGGCCATTTTTCCCTATAAGTTTTATGTAGTTAAATG
CTTCCTAGAAACCTAAATAAGATCTATTAATTTCTGACGAGAGGTGTTCTTCTAGAATTAATTACTTTTATCTTTTGTCTTCATTTGTGG
CCAAAATTATGTTTACTAGAGGAAATTTGGGATCATTCTCAGCTAATTCCAAAATGTAGTGCTCTATTGCATGGATCCTTGGTAATCCTC
AAGCATCAGATGCCATAAGGGGAAACTTAATTCTGCTAAATTAATGTTTATTTTGTGAGAAGTGACTTTATCTTCATTTGGGGTAGAAAA
ATTATTTCTTTATGTAGTAGAGACAAATTATTCTCATTTTGCAAGTACTTTCAATTTAAGCTACAAATTGAGAAAACCGTTATAAATAAG
AATAAAATAGGCCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACCAGAGGTCAAGAGTTTG
AGACCAGCTTGGTGAAACCCTGTCTCTACTAAAAATACAAAAGTTAGCTGGGGCTGGTGGTGGGCATCTGTAGTCCCAGCTAATTGGAAG
GGTGAGGCGGGAGGATCGCTTGAACCTGGGAGGCGGAGGTTCCAGAGAGCCAAGATCGCACCACTGCACTACAGCCTGGGCGACAGAACG
AGACCCTGTCTCCAAAGGAAAAACAAAAAAGAAGAATAAAATAATTTGGATGAAAATCATGTTTATTTAAATAGTAATGTCATGAGACTA
TTAAAGATGTGCCAGAGTTTCAATGAAAATCATTAAAGTAGGACAGCTAAGAAATTAATATTAATATCAAAATTATTGATAATCTTAAAT
TATTGATTATTCCTTAACGCACTCCATTCTCCTTTTACATTTTATCATGTTTCTTTTGAATATATGAATTGGCAAAGGACTTGATGAAAC
TGAGTACTAAGATTTGGTACAGAGTATGTCAGGAAGACAACTCAGATTGCCATTTTAAATAAAGTTGTACATGAACAATAATTGGAATCA
TCAGGTAATTTTTTTAAACAAAGGTTCTTCATTTACTGTTATGATTGGAAAAAAATTAGAAAATAAAGTAAGTGCCATAGGCTAATTAAA
AAATAAAACCTTGGCCGGGCGCGGTGGCTTACGCCTATAATCCCAGCACTTTGGGAGGCCGAGACGGGCAGATCACGAGGTCAGGAGATT
GAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAAAAAAATGAGCCGGGTATGGTGGTGCATACCTGTAGTCCCA
GCTACTCGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGAAGGCAGAGCTTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTG
GGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTAAATAAAACCTTAGGGCAAGCATGTTCCAAAACA
GAAGACATCAAACCAGGGTGTGTTGGCATTATTTATTTTATGTAGAGTATTGAGATGTGATAAACCTTTGTATATGCCATCACTGCTCCA
TTTCCTAAAGTATTTTGGTGTTTTCATGGGACTACATCTTGTATAATTTGACATGTATGACCTGACTAGTCCTAACAGTTCTTTTTAAAC
GTGTATTTGAGACTTAAATATTGGAAAAGGTAACCCAGTGCCATAAAGCAGAAACAGTGACCTTTAAAATGACTAAAATTTCAACCCAGT
ATAGTTTCATACCTATTTCATGCTTTCTCGTAAGAAAGAATTTCATGTTTTAGAAACATTTCTTTCACTATGGGATTAATAATATGACAC
TGAAATGGAATTATATATGTCAGCTACAATTCAGGCATTGTTTTGGGATATGGTTAGATTGACAGGCAACGTTTTGGAATATGGTTAGAC
GGGGAGGGAACACGGTACTGTTTAACATCTTAAGAGTATGTGGGGGTATGTGTATACAGAATGTTTTTGTTTTTGCTCATCACAACCAGG

>In-frame_ZNF808_ENST00000359798_chr19_53046600_+_PIGX_ENST00000421265_chr3_196454794_+_672nt
CGCGGAGATTAACGCAAACCCGGAAGCGGATCGGGTGGAGTGAAGGTCACGTCGCCATGATATCTCTTCCAAATGCTTGATGAAAAAGGT
GGAAGGGTCACTTGACCCAGGGAGTTGAAGGCTGCAGTGAGCCCTGTTTTTGCCACCACACTCCAGCCTGGGATTGATTTCTAAAGACTC
ATGTTACGTGAGGAAGCAGCTCAGAAGAGGAAAGGAAAGGAGTCAGGCATGGCTCTTCCTCAGGCAGTGATGGTTTCAGAAAATTTTGAT
ATAGAGGCCCCTAACTATTTGTCCAAGGAGTCTGAAGTTCTCATTTATGCCAGACGAGATTCACAGTGCATTGACTGTTTTCAAGCCTTT
TTGCCTGTGCACTGCCGCTATCATCGGCCGCACAGTGAAGATGGAGAAGCCTCGATTGTGGTCAATAACCCAGATTTGTTGATGTTTTGT
GACCAAGGTGAGGGCTGCAAGTGTTTTCTAAGGGTTGAAACATCAGAATAAAGGTATGGTGGCAAGTCCTCCTTCTGCTAGGCTGGCTGG
CAAGGCCCTATGTCTTGACCTAGGTGGTAGTTACAAGGGTATTTATTTGCCTTATAATAATTCACTAAACTATGTATTTGAGTAGATTTT


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FusionGenePPI for ZNF808_PIGX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF808ZNF22PIGXFBXW11, CHRM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF808_PIGX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF808_PIGX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource