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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43737

FusionGeneSummary for ZNF804A_IRF2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF804A_IRF2
Fusion gene ID: 43737
HgeneTgene
Gene symbol

ZNF804A

IRF2

Gene ID

91752

3660

Gene namezinc finger protein 804Ainterferon regulatory factor 2
SynonymsC2orf10IRF-2
Cytomap

2q32.1

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 804Ainterferon regulatory factor 2
Modification date2018051920180519
UniProtAcc

Q7Z570

P14316

Ensembl transtripts involved in fusion geneENST00000302277, ENST00000393593, 
ENST00000512020, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 1 X 2=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: ZNF804A [Title/Abstract] AND IRF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIRF2

GO:0051607

defense response to virus

21478870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-HT-7477-01BZNF804Achr2

185463797

+IRF2chr4

185350224

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000302277ENST00000393593ZNF804Achr2

185463797

+IRF2chr4

185350224

-
5CDS-5UTRENST00000302277ENST00000512020ZNF804Achr2

185463797

+IRF2chr4

185350224

-

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FusionProtFeatures for ZNF804A_IRF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF804A

Q7Z570

IRF2

P14316

Specifically binds to the upstream regulatory region oftype I IFN and IFN-inducible MHC class I genes (the interferonconsensus sequence (ICS)) and represses those genes. Also acts asan activator for several genes including H4 and IL7.Constitutively binds to the ISRE promoter to activate IL7.Involved in cell cycle regulation through binding the site II(HiNF-M) promoter region of H4 and activating transcription duringcell growth. Antagonizes IRF1 transcriptional activation.{ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432,ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF804A_IRF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF804A_IRF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF804ASPP1, ATXN1IRF2CSNK2A1, PRKACA, KAT2B, EP300, KAT2A, BRD7, NFKB1, RELA, IRF8, ATG7, IRF2BPL, FOXK1, FOXK2, HCFC1, HCFC2, IRF2BP1, IRF2BP2, AP5Z1, PPP3CA, PPP3CB, MDM2, APP, HSP90AA1, FKBP7, PRDM1, IRF1, NCL, FAM208B, CTSS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF804A_IRF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF804A_IRF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF804AC0005586Bipolar Disorder5PSYGENET
HgeneZNF804AC0525045Mood Disorders2PSYGENET
HgeneZNF804AC0007134Renal Cell Carcinoma1CTD_human
HgeneZNF804AC0036341Schizophrenia1CTD_human
HgeneZNF804AC0236969Substance-Related Disorders1CTD_human
TgeneIRF2C2239176Liver carcinoma1CTD_human