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Fusion gene ID: 43702 |
FusionGeneSummary for ZNF785_DCX |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF785_DCX | Fusion gene ID: 43702 | Hgene | Tgene | Gene symbol | ZNF785 | DCX | Gene ID | 146540 | 1641 |
| Gene name | zinc finger protein 785 | doublecortin | |
| Synonyms | - | DBCN|DC|LISX|SCLH|XLIS | |
| Cytomap | 16p11.2 | Xq23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 785 | neuronal migration protein doublecortindoublecortexdoublinlis-Xlissencephalin-X | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | A8K8V0 | O43602 | |
| Ensembl transtripts involved in fusion gene | ENST00000470110, ENST00000395216, | ENST00000371993, ENST00000356915, ENST00000338081, ENST00000356220, ENST00000488120, ENST00000496551, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ZNF785 [Title/Abstract] AND DCX [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DCX | GO:0001764 | neuron migration | 14741102 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM678941 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000470110 | ENST00000371993 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-3UTR | ENST00000470110 | ENST00000356915 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-3UTR | ENST00000470110 | ENST00000338081 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-intron | ENST00000470110 | ENST00000356220 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-intron | ENST00000470110 | ENST00000488120 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-intron | ENST00000470110 | ENST00000496551 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-3UTR | ENST00000395216 | ENST00000371993 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-3UTR | ENST00000395216 | ENST00000356915 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-3UTR | ENST00000395216 | ENST00000338081 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-intron | ENST00000395216 | ENST00000356220 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-intron | ENST00000395216 | ENST00000488120 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
| intron-intron | ENST00000395216 | ENST00000496551 | ZNF785 | chr16 | 30590845 | + | DCX | chrX | 110539882 | + |
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FusionProtFeatures for ZNF785_DCX |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF785 | DCX |
| May be involved in transcriptional regulation.{ECO:0000250}. | Microtubule-associated protein required for initialsteps of neuronal dispersion and cortex lamination during cerebralcortex development. May act by competing with the putativeneuronal protein kinase DCLK1 in binding to a target protein. Mayin that way participate in a signaling pathway that is crucial forneuronal interaction before and during migration, possibly as partof a calcium ion-dependent signal transduction pathway. May bepart with PAFAH1B1/LIS-1 of overlapping, but distinct, signalingpathways that promote neuronal migration.{ECO:0000269|PubMed:22359282}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF785_DCX |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF785_DCX |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF785_DCX |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF785_DCX |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DCX | C1848199 | X-Linked Lissencephaly | 11 | ORPHANET;UNIPROT |
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