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Fusion gene ID: 437 |
FusionGeneSummary for ACOX3_CD96 |
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Fusion gene information | Fusion gene name: ACOX3_CD96 | Fusion gene ID: 437 | Hgene | Tgene | Gene symbol | ACOX3 | CD96 | Gene ID | 8310 | 10225 |
Gene name | acyl-CoA oxidase 3, pristanoyl | CD96 molecule | |
Synonyms | - | TACTILE | |
Cytomap | 4p16.1 | 3q13.13-q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | peroxisomal acyl-coenzyme A oxidase 3BRCACoxacyl-Coenzyme A oxidase 3, pristanoylbranched-chain acyl-CoA oxidasepristanoyl-CoA oxidase | T-cell surface protein tactileT cell activation, increased late expressioncell surface antigen CD96t cell-activated increased late expression protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O15254 | P40200 | |
Ensembl transtripts involved in fusion gene | ENST00000356406, ENST00000413009, ENST00000503233, ENST00000515797, | ENST00000352690, ENST00000283285, ENST00000438817, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 6 X 5 X 6=180 |
# samples | 7 | 7 | |
** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACOX3 [Title/Abstract] AND CD96 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CD96 | GO:0007160 | cell-matrix adhesion | 17847009 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-4Z-AA7Q-01A | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000356406 | ENST00000352690 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
5CDS-intron | ENST00000356406 | ENST00000283285 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
5CDS-intron | ENST00000356406 | ENST00000438817 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
5CDS-intron | ENST00000413009 | ENST00000352690 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
5CDS-intron | ENST00000413009 | ENST00000283285 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
5CDS-intron | ENST00000413009 | ENST00000438817 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
5CDS-intron | ENST00000503233 | ENST00000352690 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
5CDS-intron | ENST00000503233 | ENST00000283285 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
5CDS-intron | ENST00000503233 | ENST00000438817 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
intron-intron | ENST00000515797 | ENST00000352690 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
intron-intron | ENST00000515797 | ENST00000283285 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
intron-intron | ENST00000515797 | ENST00000438817 | ACOX3 | chr4 | 8376705 | - | CD96 | chr3 | 111384374 | + |
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FusionProtFeatures for ACOX3_CD96 |
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Hgene | Tgene |
ACOX3 | CD96 |
Oxidizes the CoA-esters of 2-methyl-branched fattyacids. {ECO:0000250, ECO:0000269|PubMed:9271077}. | May be involved in adhesive interactions of activated Tand NK cells during the late phase of the immune response.Promotes NK cell-target adhesion by interacting with PVR presenton target cells. May function at a time after T and NK cells havepenetrated the endothelium using integrins and selectins, whenthey are actively engaging diseased cells and moving within areasof inflammation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACOX3_CD96 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACOX3_CD96 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACOX3 | PEX5, SMURF2, TMEM150A, FKBP6, MICU2, YTHDF1, HERC3, CENPH, HAUS7 | CD96 | UBR4, LAMB1, FAT1, HSPA1A, TMEM160, NPTX1, CLSTN1, GPR98, PXDN, GBAS, PVR, KCMF1, SQSTM1, NOMO1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACOX3_CD96 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACOX3_CD96 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CD96 | C0796095 | Opitz trigonocephaly syndrome | 1 | CTD_human;ORPHANET;UNIPROT |