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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 437

FusionGeneSummary for ACOX3_CD96

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOX3_CD96
Fusion gene ID: 437
HgeneTgene
Gene symbol

ACOX3

CD96

Gene ID

8310

10225

Gene nameacyl-CoA oxidase 3, pristanoylCD96 molecule
Synonyms-TACTILE
Cytomap

4p16.1

3q13.13-q13.2

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal acyl-coenzyme A oxidase 3BRCACoxacyl-Coenzyme A oxidase 3, pristanoylbranched-chain acyl-CoA oxidasepristanoyl-CoA oxidaseT-cell surface protein tactileT cell activation, increased late expressioncell surface antigen CD96t cell-activated increased late expression protein
Modification date2018052320180519
UniProtAcc

O15254

P40200

Ensembl transtripts involved in fusion geneENST00000356406, ENST00000413009, 
ENST00000503233, ENST00000515797, 
ENST00000352690, ENST00000283285, 
ENST00000438817, 
Fusion gene scores* DoF score7 X 7 X 3=1476 X 5 X 6=180
# samples 77
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACOX3 [Title/Abstract] AND CD96 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD96

GO:0007160

cell-matrix adhesion

17847009


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-4Z-AA7Q-01AACOX3chr4

8376705

-CD96chr3

111384374

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356406ENST00000352690ACOX3chr4

8376705

-CD96chr3

111384374

+
5CDS-intronENST00000356406ENST00000283285ACOX3chr4

8376705

-CD96chr3

111384374

+
5CDS-intronENST00000356406ENST00000438817ACOX3chr4

8376705

-CD96chr3

111384374

+
5CDS-intronENST00000413009ENST00000352690ACOX3chr4

8376705

-CD96chr3

111384374

+
5CDS-intronENST00000413009ENST00000283285ACOX3chr4

8376705

-CD96chr3

111384374

+
5CDS-intronENST00000413009ENST00000438817ACOX3chr4

8376705

-CD96chr3

111384374

+
5CDS-intronENST00000503233ENST00000352690ACOX3chr4

8376705

-CD96chr3

111384374

+
5CDS-intronENST00000503233ENST00000283285ACOX3chr4

8376705

-CD96chr3

111384374

+
5CDS-intronENST00000503233ENST00000438817ACOX3chr4

8376705

-CD96chr3

111384374

+
intron-intronENST00000515797ENST00000352690ACOX3chr4

8376705

-CD96chr3

111384374

+
intron-intronENST00000515797ENST00000283285ACOX3chr4

8376705

-CD96chr3

111384374

+
intron-intronENST00000515797ENST00000438817ACOX3chr4

8376705

-CD96chr3

111384374

+

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FusionProtFeatures for ACOX3_CD96


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACOX3

O15254

CD96

P40200

Oxidizes the CoA-esters of 2-methyl-branched fattyacids. {ECO:0000250, ECO:0000269|PubMed:9271077}. May be involved in adhesive interactions of activated Tand NK cells during the late phase of the immune response.Promotes NK cell-target adhesion by interacting with PVR presenton target cells. May function at a time after T and NK cells havepenetrated the endothelium using integrins and selectins, whenthey are actively engaging diseased cells and moving within areasof inflammation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACOX3_CD96


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACOX3_CD96


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACOX3PEX5, SMURF2, TMEM150A, FKBP6, MICU2, YTHDF1, HERC3, CENPH, HAUS7CD96UBR4, LAMB1, FAT1, HSPA1A, TMEM160, NPTX1, CLSTN1, GPR98, PXDN, GBAS, PVR, KCMF1, SQSTM1, NOMO1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACOX3_CD96


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACOX3_CD96


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCD96C0796095Opitz trigonocephaly syndrome1CTD_human;ORPHANET;UNIPROT