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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43698

FusionGeneSummary for ZNF780A_NADSYN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF780A_NADSYN1
Fusion gene ID: 43698
HgeneTgene
Gene symbol

ZNF780A

NADSYN1

Gene ID

284323

55191

Gene namezinc finger protein 780ANAD synthetase 1
SynonymsZNF780-
Cytomap

19q13.2

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 780Aglutamine-dependent NAD(+) synthetaseNAD(+) synthaseNAD(+) synthetaseglutamine-dependent NAD synthetase
Modification date2018052220180523
UniProtAcc

O75290

Q6IA69

Ensembl transtripts involved in fusion geneENST00000450241, ENST00000414720, 
ENST00000455521, ENST00000595687, 
ENST00000594395, ENST00000340963, 
ENST00000319023, ENST00000539574, 
ENST00000530055, ENST00000526039, 
Fusion gene scores* DoF score2 X 3 X 2=129 X 9 X 5=405
# samples 211
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/405*10)=-1.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF780A [Title/Abstract] AND NADSYN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCHOLTCGA-W5-AA2X-01AZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
TCGALDCHOLTCGA-W5-AA2X-01AZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000450241ENST00000319023ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000450241ENST00000539574ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000450241ENST00000530055ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3UTRENST00000450241ENST00000526039ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000414720ENST00000319023ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000414720ENST00000539574ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000414720ENST00000530055ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3UTRENST00000414720ENST00000526039ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000455521ENST00000319023ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000455521ENST00000539574ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000455521ENST00000530055ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3UTRENST00000455521ENST00000526039ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000595687ENST00000319023ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000595687ENST00000539574ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000595687ENST00000530055ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3UTRENST00000595687ENST00000526039ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000594395ENST00000319023ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000594395ENST00000539574ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000594395ENST00000530055ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3UTRENST00000594395ENST00000526039ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000340963ENST00000319023ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000340963ENST00000539574ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000340963ENST00000530055ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
5UTR-3UTRENST00000340963ENST00000526039ZNF780Achr19

40596073

-NADSYN1chr11

71201891

+
intron-3CDSENST00000450241ENST00000319023ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3CDSENST00000450241ENST00000539574ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3CDSENST00000450241ENST00000530055ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3UTRENST00000450241ENST00000526039ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000414720ENST00000319023ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000414720ENST00000539574ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000414720ENST00000530055ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3UTRENST00000414720ENST00000526039ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000455521ENST00000319023ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000455521ENST00000539574ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000455521ENST00000530055ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3UTRENST00000455521ENST00000526039ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3CDSENST00000595687ENST00000319023ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3CDSENST00000595687ENST00000539574ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3CDSENST00000595687ENST00000530055ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3UTRENST00000595687ENST00000526039ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3CDSENST00000594395ENST00000319023ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3CDSENST00000594395ENST00000539574ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3CDSENST00000594395ENST00000530055ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
intron-3UTRENST00000594395ENST00000526039ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000340963ENST00000319023ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000340963ENST00000539574ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3CDSENST00000340963ENST00000530055ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+
5UTR-3UTRENST00000340963ENST00000526039ZNF780Achr19

40596813

-NADSYN1chr11

71201891

+

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FusionProtFeatures for ZNF780A_NADSYN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF780A

O75290

NADSYN1

Q6IA69

May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF780A_NADSYN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF780A_NADSYN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF780AMOV10, NXF1, ZNF324BNADSYN1CUTC, MYO15B, UPF1, AIP, STUB1, EGFR, FKBPL, CSGALNACT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF780A_NADSYN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNADSYN1Q6IA69DB00142Glutamic AcidGlutamine-dependent NAD(+) synthetasesmall moleculeapproved|nutraceutical

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RelatedDiseases for ZNF780A_NADSYN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource