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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43697

FusionGeneSummary for ZNF77_NUP85

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF77_NUP85
Fusion gene ID: 43697
HgeneTgene
Gene symbol

ZNF77

NUP85

Gene ID

58492

79902

Gene namezinc finger protein 77nucleoporin 85
SynonymspT1FROUNT|Nup75
Cytomap

19p13.3

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 77ZNFpT1nuclear pore complex protein Nup85nucleoporin 85kDanucleoporin Nup75nucleoporin Nup85
Modification date2018052320180523
UniProtAcc

Q15935

Q9BW27

Ensembl transtripts involved in fusion geneENST00000314531, ENST00000588050, 
ENST00000245544, ENST00000541827, 
ENST00000579324, ENST00000449421, 
ENST00000579298, ENST00000447371, 
ENST00000540768, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 7 X 5=280
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF77 [Title/Abstract] AND NUP85 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA567594ZNF77chr19

2936522

-NUP85chr17

73208085

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314531ENST00000245544ZNF77chr19

2936522

-NUP85chr17

73208085

+
In-frameENST00000314531ENST00000541827ZNF77chr19

2936522

-NUP85chr17

73208085

+
5CDS-5UTRENST00000314531ENST00000579324ZNF77chr19

2936522

-NUP85chr17

73208085

+
5CDS-3UTRENST00000314531ENST00000449421ZNF77chr19

2936522

-NUP85chr17

73208085

+
5CDS-3UTRENST00000314531ENST00000579298ZNF77chr19

2936522

-NUP85chr17

73208085

+
5CDS-5UTRENST00000314531ENST00000447371ZNF77chr19

2936522

-NUP85chr17

73208085

+
5CDS-intronENST00000314531ENST00000540768ZNF77chr19

2936522

-NUP85chr17

73208085

+
intron-3CDSENST00000588050ENST00000245544ZNF77chr19

2936522

-NUP85chr17

73208085

+
intron-3CDSENST00000588050ENST00000541827ZNF77chr19

2936522

-NUP85chr17

73208085

+
intron-5UTRENST00000588050ENST00000579324ZNF77chr19

2936522

-NUP85chr17

73208085

+
intron-3UTRENST00000588050ENST00000449421ZNF77chr19

2936522

-NUP85chr17

73208085

+
intron-3UTRENST00000588050ENST00000579298ZNF77chr19

2936522

-NUP85chr17

73208085

+
intron-5UTRENST00000588050ENST00000447371ZNF77chr19

2936522

-NUP85chr17

73208085

+
intron-intronENST00000588050ENST00000540768ZNF77chr19

2936522

-NUP85chr17

73208085

+

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FusionProtFeatures for ZNF77_NUP85


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF77

Q15935

NUP85

Q9BW27

May be involved in transcriptional regulation. Essential component of the nuclear pore complex (NPC)that seems to be required for NPC assembly and maintenance(PubMed:12718872). As part of the NPC Nup107-160 subcomplex playsa role in RNA export and in tethering NUP96/Nup98 and NUP153 tothe nucleus (PubMed:12718872). The Nup107-160 complex seems to berequired for spindle assembly during mitosis (PubMed:16807356).NUP85 is required for membrane clustering of CCL2-activated CCR2(PubMed:15995708). Seems to be involved in CCR2-mediatedchemotaxis of monocytes and may link activated CCR2 to thephosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusioncascade (PubMed:15995708). {ECO:0000269|PubMed:12718872,ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-344_99103546DomainKRAB

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34212_234103546Zinc fingerC2H2-type 1
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34240_262103546Zinc fingerC2H2-type 2
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34268_290103546Zinc fingerC2H2-type 3
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34296_318103546Zinc fingerC2H2-type 4
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34324_346103546Zinc fingerC2H2-type 5
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34352_374103546Zinc fingerC2H2-type 6
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34380_402103546Zinc fingerC2H2-type 7
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34408_430103546Zinc fingerC2H2-type 8
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34436_458103546Zinc fingerC2H2-type 9
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34464_486103546Zinc fingerC2H2-type 10
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34492_514103546Zinc fingerC2H2-type 11
HgeneZNF77chr19:2936522chr17:73208085ENST00000314531-34520_542103546Zinc fingerC2H2-type 12


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FusionGeneSequence for ZNF77_NUP85


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF77_ENST00000314531_chr19_2936522_-_NUP85_ENST00000245544_chr17_73208085_+_2164nt
ACCCCGAGCGGCTCAGGTGTCCTGTCGTGCTCACCTGCGCCGGTCGCTGGACCGCGGGGCGCTAACCCTGGAGAGCCCAGGAGCGGGCGG
GACATGGACTGCGTGATCTTTGAGGAAGTGGCTGTGAACTTCACCCCAGAAGAGTGGGCATTGCTGGATCATGCTCAGAGGAGCCTCTAC
AGAGATGTGATGCTGGAGACCTGCAGGAACCTTGCCTCCTTGGATTGTTACATTTATGTTAGAACCAGTGGATCAAGTTCTCAGAGGGAC
GTTTTTGGGAATGGAATATCCAATGATGAAGAGATTGTAAAGTTCACAGGAAGTGATTCCTGGTCTATTTTTGGAGAAAATTGGAGATTT
GATAACACTGGAGATCAGCACCAAATCCCACAGAGGCATCTGAGATTGGTTCGAGTGAGTAAAAACTACCGATCAGTCATCAGAGCATGT
ATGGAGGAAATGCACCAGGTTGCAATTGCTGCTAAAGATCCAGCCAATGGCCGCCAGTTCAGCAGCCAGGTCTCCATTTTGTCAGCAATG
GAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTC
CATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATC
TTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATC
ATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCAC
GAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCT
GCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATT
GATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCC
TTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGAC
CACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCT
CATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATA
CCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATC
TTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTG
TCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGT
GACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCC
TTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTC
TCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTC
CAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCA
CTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAATGTATATAGATTTTTTTAAAAGAATAAATGTTGTTTTGCAAA

>In-frame_ZNF77_ENST00000314531_chr19_2936522_-_NUP85_ENST00000541827_chr17_73208085_+_2163nt
ACCCCGAGCGGCTCAGGTGTCCTGTCGTGCTCACCTGCGCCGGTCGCTGGACCGCGGGGCGCTAACCCTGGAGAGCCCAGGAGCGGGCGG
GACATGGACTGCGTGATCTTTGAGGAAGTGGCTGTGAACTTCACCCCAGAAGAGTGGGCATTGCTGGATCATGCTCAGAGGAGCCTCTAC
AGAGATGTGATGCTGGAGACCTGCAGGAACCTTGCCTCCTTGGATTGTTACATTTATGTTAGAACCAGTGGATCAAGTTCTCAGAGGGAC
GTTTTTGGGAATGGAATATCCAATGATGAAGAGATTGTAAAGTTCACAGGAAGTGATTCCTGGTCTATTTTTGGAGAAAATTGGAGATTT
GATAACACTGGAGATCAGCACCAAATCCCACAGAGGCATCTGAGATTGGTTCGAGTGAGTAAAAACTACCGATCAGTCATCAGAGCATGT
ATGGAGGAAATGCACCAGGTTGCAATTGCTGCTAAAGATCCAGCCAATGGCCGCCAGTTCAGCAGCCAGGTCTCCATTTTGTCAGCAATG
GAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTC
CATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATC
TTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATC
ATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCAC
GAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCT
GCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATT
GATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCC
TTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGAC
CACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCT
CATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATA
CCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATC
TTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTG
TCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGT
GACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCC
TTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTC
TCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTC
CAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCA
CTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAATGTATATAGATTTTTTTAAAAGAATAAATGTTGTTTTGCAAA


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FusionGenePPI for ZNF77_NUP85


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF77ELAVL1, VWCE, TRIM28NUP85SEH1L, NUP107, NUP43, NUP37, SEC13, EEF1G, USP36, USP49, HDAC11, EGFR, FBXO6, DCTN3, GBF1, RABL6, OBSL1, EED, CCDC183, CD274, TNFSF13B, CA14, PNKD, ENPP6, TGOLN2, NUP160, NUP98, NTRK1, IFI16, PRKDC, UNC45A, FMN1, KPNB1, ZNF740, POM121, HSP90AB1, NUDC, NUP88, RANGAP1, NUP62, NUP214, RANBP2, NUP50, NUP153, B9D2, UBE2I, FOXQ1, FAF2, UXS1, VASN, CD70, SPAST, ZNF785


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF77_NUP85


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF77_NUP85


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource