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Fusion gene ID: 43696 |
FusionGeneSummary for ZNF77_LPCAT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF77_LPCAT2 | Fusion gene ID: 43696 | Hgene | Tgene | Gene symbol | ZNF77 | LPCAT2 | Gene ID | 58492 | 54947 |
| Gene name | zinc finger protein 77 | lysophosphatidylcholine acyltransferase 2 | |
| Synonyms | pT1 | AGPAT11|AYTL1|LysoPAFAT | |
| Cytomap | 19p13.3 | 16q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 77ZNFpT1 | lysophosphatidylcholine acyltransferase 21-AGP acyltransferase 111-AGPAT 111-acylglycerol-3-phosphate O-acyltransferase 111-acylglycerophosphocholine O-acyltransferase1-alkylglycerophosphocholine O-acetyltransferaseLPAAT-alphaLPC acyltransferase 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q15935 | Q7L5N7 | |
| Ensembl transtripts involved in fusion gene | ENST00000314531, ENST00000588050, | ENST00000262134, ENST00000565056, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 6 X 3=90 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZNF77 [Title/Abstract] AND LPCAT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LPCAT2 | GO:0036151 | phosphatidylcholine acyl-chain remodeling | 21498505 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-D8-A1XL-01A | ZNF77 | chr19 | 2944836 | - | LPCAT2 | chr16 | 55559420 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000314531 | ENST00000262134 | ZNF77 | chr19 | 2944836 | - | LPCAT2 | chr16 | 55559420 | + |
| 5CDS-intron | ENST00000314531 | ENST00000565056 | ZNF77 | chr19 | 2944836 | - | LPCAT2 | chr16 | 55559420 | + |
| 5UTR-3CDS | ENST00000588050 | ENST00000262134 | ZNF77 | chr19 | 2944836 | - | LPCAT2 | chr16 | 55559420 | + |
| 5UTR-intron | ENST00000588050 | ENST00000565056 | ZNF77 | chr19 | 2944836 | - | LPCAT2 | chr16 | 55559420 | + |
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FusionProtFeatures for ZNF77_LPCAT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF77 | LPCAT2 |
| May be involved in transcriptional regulation. | Possesses both acyltransferase and acetyltransferaseactivities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversionof the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF).Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAFprecursor. Under resting conditions, acyltransferase activity ispreferred. Upon acute inflammatory stimulus, acetyltransferaseactivity is enhanced and PAF synthesis increases. Also catalyzesthe conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:20363836,ECO:0000269|PubMed:21498505}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >LPCAT2 | chr19:2944836 | chr16:55559420 | ENST00000262134 | + | 0 | 14 | 404_415 | 57 | 545 | Calcium binding | 1 |
| Tgene | >LPCAT2 | chr19:2944836 | chr16:55559420 | ENST00000262134 | + | 0 | 14 | 441_452 | 57 | 545 | Calcium binding | 2 |
| Tgene | >LPCAT2 | chr19:2944836 | chr16:55559420 | ENST00000262134 | + | 0 | 14 | 391_426 | 57 | 545 | Domain | EF-hand 1 |
| Tgene | >LPCAT2 | chr19:2944836 | chr16:55559420 | ENST00000262134 | + | 0 | 14 | 428_463 | 57 | 545 | Domain | EF-hand 2 |
| Tgene | >LPCAT2 | chr19:2944836 | chr16:55559420 | ENST00000262134 | + | 0 | 14 | 146_151 | 57 | 545 | Motif | Note=HXXXXD motif |
| Tgene | >LPCAT2 | chr19:2944836 | chr16:55559420 | ENST00000262134 | + | 0 | 14 | 220_223 | 57 | 545 | Motif | Note=EGTC motif |
| Tgene | >LPCAT2 | chr19:2944836 | chr16:55559420 | ENST00000262134 | + | 0 | 14 | 79_544 | 57 | 545 | Topological domain | Lumenal |
| Tgene | >LPCAT2 | chr19:2944836 | chr16:55559420 | ENST00000262134 | + | 0 | 14 | 58_78 | 57 | 545 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 4_99 | 1 | 546 | Domain | KRAB |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 212_234 | 1 | 546 | Zinc finger | C2H2-type 1 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 240_262 | 1 | 546 | Zinc finger | C2H2-type 2 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 268_290 | 1 | 546 | Zinc finger | C2H2-type 3 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 296_318 | 1 | 546 | Zinc finger | C2H2-type 4 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 324_346 | 1 | 546 | Zinc finger | C2H2-type 5 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 352_374 | 1 | 546 | Zinc finger | C2H2-type 6 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 380_402 | 1 | 546 | Zinc finger | C2H2-type 7 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 408_430 | 1 | 546 | Zinc finger | C2H2-type 8 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 436_458 | 1 | 546 | Zinc finger | C2H2-type 9 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 464_486 | 1 | 546 | Zinc finger | C2H2-type 10 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 492_514 | 1 | 546 | Zinc finger | C2H2-type 11 |
| Hgene | >ZNF77 | chr19:2944836 | chr16:55559420 | ENST00000314531 | - | 1 | 4 | 520_542 | 1 | 546 | Zinc finger | C2H2-type 12 |
| Tgene | LPCAT2 | chr19:2944836 | chr16:55559420 | ENST00000262134 | + | 0 | 14 | 1_57 | 57 | 545 | Topological domain | Cytoplasmic |
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FusionGeneSequence for ZNF77_LPCAT2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF77_ENST00000314531_chr19_2944836_-_LPCAT2_ENST00000262134_chr16_55559420_+_489aa MIVLLGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPVFVAAPH STFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGA FIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPVLFANKVRNLMAEALGIPVTDHTYEDC RLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGVRKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFREY VIGLAVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDSISYEEFKSFALKHPEYAKIFTTYLDL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF77_ENST00000314531_chr19_2944836_-_LPCAT2_ENST00000262134_chr16_55559420_+_1467nt ATGATTGTCCTTCTTGGGATTATCTTGCTTCCAATTCGTGTCTTATTGGTTGCGTTAATTTTATTACTTGCATGGCCATTTGCTGCAATT TCAACAGTATGCTGTCCTGAAAAGCTGACCCACCCAATAACTGGTTGGAGGAGGAAAATTACTCAAACAGCTTTGAAATTTCTGGGTCGT GCTATGTTCTTTTCAATGGGATTTATAGTTGCTGTAAAAGGAAAGATTGCAAGTCCTTTGGAAGCACCAGTTTTTGTTGCTGCCCCTCAT TCAACATTCTTTGATGGAATTGCCTGTGTTGTAGCTGGGTTACCTTCTATGGTATCTCGAAATGAGAATGCACAAGTCCCTCTGATTGGC AGACTGTTACGGGCTGTGCAACCAGTTTTGGTGTCCCGTGTAGATCCGGATTCCCGAAAAAACACAATAAATGAAATAATAAAGCGAACA ACATCAGGAGGAGAATGGCCCCAGATACTAGTTTTCCCAGAAGGTACTTGTACTAATCGTTCCTGTTTGATTACTTTTAAACCAGGAGCC TTCATTCCAGGAGTTCCAGTGCAGCCAGTCCTCCTCAGATACCCAAACAAGCTGGATACTGTGACCTGGACATGGCAAGGATATACATTC ATTCAGCTTTGTATGCTTACTTTCTGCCAGCTCTTCACAAAGGTAGAAGTTGAGTTTATGCCAGTTCAAGTACCAAATGATGAAGAAAAA AATGATCCTGTCCTTTTTGCCAATAAAGTCCGGAATTTAATGGCAGAAGCTCTGGGAATACCAGTAACAGATCATACCTATGAAGACTGC AGATTGATGATTTCAGCAGGACAGCTAACATTGCCTATGGAAGCTGGGCTGGTGGAATTTACTAAAATTAGCCGAAAATTGAAATTAGAT TGGGATGGTGTTCGTAAGCATTTGGATGAATATGCATCTATTGCGAGTTCCTCAAAAGGAGGAAGAATTGGAATTGAAGAATTCGCCAAG TATTTAAAGTTGCCTGTTTCAGATGTCTTGAGACAACTTTTTGCACTCTTTGACAGGAACCATGATGGCAGCATTGACTTCCGAGAGTAT GTGATTGGCCTGGCTGTCTTGTGCAACCCTTCCAACACAGAGGAGATCATCCAGGTGGCATTTAAGCTGTTTGACGTTGATGAGGATGGC TACATAACGGAGGAAGAGTTCTCCACCATTCTACAGGCTTCCCTTGGAGTGCCTGACCTTGATGTTTCTGGTCTCTTCAAGGAAATAGCC CAAGGGGACTCAATTTCCTATGAGGAATTTAAAAGTTTTGCCTTAAAGCATCCAGAATATGCTAAGATATTTACAACATACCTAGACCTC CAGACGTGCCATGTGTTTTCATTACCAAAAGAAGTCCAGACAACCCCCTCCACCGCCAGTAATAAAGTCAGCCCTGAAAAGCATGAAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF77_ENST00000314531_chr19_2944836_-_LPCAT2_ENST00000262134_chr16_55559420_+_5132nt ACCCCGAGCGGCTCAGGTGTCCTGTCGTGCTCACCTGCGCCGGTCGCTGGACCGCGGGGCGCTAACCCTGGAGAGCCCAGGAGCGGGCGG GACATGATTGTCCTTCTTGGGATTATCTTGCTTCCAATTCGTGTCTTATTGGTTGCGTTAATTTTATTACTTGCATGGCCATTTGCTGCA ATTTCAACAGTATGCTGTCCTGAAAAGCTGACCCACCCAATAACTGGTTGGAGGAGGAAAATTACTCAAACAGCTTTGAAATTTCTGGGT CGTGCTATGTTCTTTTCAATGGGATTTATAGTTGCTGTAAAAGGAAAGATTGCAAGTCCTTTGGAAGCACCAGTTTTTGTTGCTGCCCCT CATTCAACATTCTTTGATGGAATTGCCTGTGTTGTAGCTGGGTTACCTTCTATGGTATCTCGAAATGAGAATGCACAAGTCCCTCTGATT GGCAGACTGTTACGGGCTGTGCAACCAGTTTTGGTGTCCCGTGTAGATCCGGATTCCCGAAAAAACACAATAAATGAAATAATAAAGCGA ACAACATCAGGAGGAGAATGGCCCCAGATACTAGTTTTCCCAGAAGGTACTTGTACTAATCGTTCCTGTTTGATTACTTTTAAACCAGGA GCCTTCATTCCAGGAGTTCCAGTGCAGCCAGTCCTCCTCAGATACCCAAACAAGCTGGATACTGTGACCTGGACATGGCAAGGATATACA TTCATTCAGCTTTGTATGCTTACTTTCTGCCAGCTCTTCACAAAGGTAGAAGTTGAGTTTATGCCAGTTCAAGTACCAAATGATGAAGAA AAAAATGATCCTGTCCTTTTTGCCAATAAAGTCCGGAATTTAATGGCAGAAGCTCTGGGAATACCAGTAACAGATCATACCTATGAAGAC TGCAGATTGATGATTTCAGCAGGACAGCTAACATTGCCTATGGAAGCTGGGCTGGTGGAATTTACTAAAATTAGCCGAAAATTGAAATTA GATTGGGATGGTGTTCGTAAGCATTTGGATGAATATGCATCTATTGCGAGTTCCTCAAAAGGAGGAAGAATTGGAATTGAAGAATTCGCC AAGTATTTAAAGTTGCCTGTTTCAGATGTCTTGAGACAACTTTTTGCACTCTTTGACAGGAACCATGATGGCAGCATTGACTTCCGAGAG TATGTGATTGGCCTGGCTGTCTTGTGCAACCCTTCCAACACAGAGGAGATCATCCAGGTGGCATTTAAGCTGTTTGACGTTGATGAGGAT GGCTACATAACGGAGGAAGAGTTCTCCACCATTCTACAGGCTTCCCTTGGAGTGCCTGACCTTGATGTTTCTGGTCTCTTCAAGGAAATA GCCCAAGGGGACTCAATTTCCTATGAGGAATTTAAAAGTTTTGCCTTAAAGCATCCAGAATATGCTAAGATATTTACAACATACCTAGAC CTCCAGACGTGCCATGTGTTTTCATTACCAAAAGAAGTCCAGACAACCCCCTCCACCGCCAGTAATAAAGTCAGCCCTGAAAAGCATGAA GAGAGTACCTCAGACAAAAAAGATGACTGAAAGCAGTATTTCCAATAAGGAAAACACAGTAGCTTTTGCTTGAAATTGTAAAGGCACTTA TTGATAATACTTTTAATGTGTTGGTAATGATGTTTAAAATTGAAAGATTTTTAAAACAAAAATGATAGATTTTCTTACTAAAAATGTTTT TATTAACCTTGCTTTTATTGGAAAAAATCAAGCAATATTTCGTTTTCTTTTGTGTTATATTGTACTTTACTGATTCATTTACTGGTGATA CATATGTTTTTATGGATTTTCCAGTTTAATTTGCATATACAAATGAATGCAATGGTCTATTGGTGAGCATTGAGCAACACTGTATAAAGT TTTAAAAATGTAAACACTTTTTAATCTACTTTCCTCTAAAAATCAATAATATTCTATTATTTCTAATCCTTTTCCACTTGGGAAATAACA ATGAAGAATCTGAGAATTTGACATCTATAACTTTACAGATTCATTTTTCCATTTAAATTTCAGTTTCTTGGATCACTGAATATGGGAAGG GAGAGCTTCACTAATTAGACGCAGCTTCTTAAGAACTTATATTCTCTTTGACATACATCTCTATTGTAGTTTTTTGTTTTGTTTTGTTTT TTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGAT TCTCGTACCTCAGACTCCCGAGTAGTTGGGATTACAGGTGCCCACCACCACACCCGACTAATTTTTGTATTTTTAGTAGCCATGTGGTTT TGCCATGTTGGCCAGGCTGGTTTCGAACTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGC CACCGTTCCCGGCCTATTGTAGATTTTCTTAACTACTTGCTAAGGAAATCATATCCTTTTACATGAACTACAGGTTTAGAACTTGGTTTT AAGACAACTGCTATGGCCAGAAGGTAAATGGGAATTGCCTTATTGAAGGTAACATTGATTGCCTAATAAGAAAATGAATTGTTTGCCACA GAGTTGAATTTAATTTGAGTTAGATAGTTCAGAATGTAGCACTTGCCCTATAAATGAATCAGATTTGTTCTATTTATATAATATTAGAAT TAATATATTATCATGTAAGTGGGAATTTTATTTTGTTAAGTGGACTCTCAAATTTTAGAACTTGTGTGAAATATCTCCCAGAAAACACAA AAGGTTTCAAGGTATCACCCAAAGCTAGGGAATCAACAAACGTACTTTATTAATGCAAGACCACAATTTAAGCCCCAGGCAGGAATCCAA CAGTAACATTTTTCCTTTAGGTTAAGCAGTAATTTTTTTGAATTGTCATTTTTAATGGGTCTCACACATGCATATTGCTAATATCATTCA TGTTTGAGGTTTTCAACAAAGAACCAATTTATTAATATAATGTACAAAAATAGTTGGTTCATTTTCTGAATTCAGTCTTTGAAATAAAAC TCCTTGTTTTGGCCGTGTTTCTGAATGTATTGGTGATTCACCCCCAAGCTAATTTTTTAAAGTCATTTTTGAAGTTGGGAAGTCTCATGA GAGATGTTGAAGTATGTATTTAATCAAGAGTCATGATTTCAAACTAGTTTTACATATTAAGCAGTTAGTGTTCTAATTTAATGGGTAAAT GTGTGTTTGGATAAATATCTGAAAATTTTATCCTTAAGTATATATAATTATTTGCCTCTTATATGTCTTAAAGCTATTTAAACAAGGTGT TAAATGAGCCAAAACAATTAAGTAATTAGAACAGTACATTTTTATCAGAGTGTCTGTCATATGCAATGAATGTATGTAATACTAAAAAAT CATGACTACTTTTATCAAAGAAAAACCACACATTAATCCTATTAATCATGAAAGCGTAGCATTGTAAATTAAAGGTTTTCTTTGAGGCTC TTGAAAGTGATCCCATTGCTTTCCTGTTTTAAAAATATTTTATGCTCTTTATTTCCACTTCTGTGAATGTGATATTTCTATTTTGTGATT ATGTTACTGAATAAACAAACTTGCTACATAAAATTCTTAGCAATTAAAAAAATTCTGATTCTGCCATTTTGTCTCAAATGTAATATACCC TTTTAATATCATATGTTTACATATTTATGAATGATTAATCATTTTTGTTTGCATTAAACTTTATGAAATGTCAGAAATGATTTTACTCTA ATGAAACTCAAATTTTGCCCAAAGTAGCAATATTCTTAAAGATGTTGAATTTTGACTGGTTGAATTTTATATAGTAACACACAAGTCGTG ATCATCAATATTATTGCAGACCAGGACTCTGCTTATATGCCTTGCTAACAAAGATTTCTTTCACAGAGGCTTTTCTCCTCTCAAGACTTA AAGTAAGAATTACATTTTATTAAGTCAGTTAAATGCACCATGGCTTCATATAGTAATATAAAAAAACTCTTTGAAGTGAGAAATATTATA TCCTAAAACCTCTAAACCACAAACATTCAATTGAAAGAGTTCTGTTGAAGGATAATGACATACTGACTGCTTACAGACCAAGTTGCTTGC ATTTTGTATGTTTAGCCCTCCTTTGCCACTGCTTTTAGAGCCTTGGAAGGCTAAGTGTGATAGTAATGCTAGCTCTAATGCATATTTAAA GGAGACTGCCTCGCTTTTAGAAGACATCTGGTCTGCTCTCTGCATGAGGCACAGCAGTAAAGCTCTTTGATTCCCAGAATCAAGAACTCT CCCCTTCAGACTATTACCGAATGCAAGGTGGTTAATTGAAGGCCACTAATTGATGCTCAAATAGAAGGATATTGACTATATTGGAACAGA TGGAGTCTCTACTACAAAAGTCTTTGGGTATTTGTTTCTTACATAGAAAATGCTAACATGAATAGAAAGATACTGGTGCAAGACCATTCC CGGGAAAGTAGACATACTTACATTTTTTTCCTTTTCTGCTCATTTGAATGAACTCAATTTTATGTTAAATTGTTATATCAGAGTGACAAA TAAGTGCTATGGCTTGATAGAAGTGAAGCTCTTCACATATATTCAAAATACATATCACAAACTTTGGTAAATAGGATAGTAATCTGAAGA ACTTTTGCCCTTTTTACCCCATTTACTGTAACTCTTGTTTCTAGGTAATCGTTCTCTCTCAACAAACTTCTCAAGCGTCTGTGTAACAAG CCACATGTTCTAACAAATTGTCTCCATCGCACTTCAACAGCCAGGTCCCTATTTTTTATAACGTATTAACCTTATTATTTTCTTATTATT TTAAAAGAATCTATGCACATTAGCAAAATTTAAAAGATAGAGAAAAATATAAACAGAAAAAATTATGTTTACTTCTACCACCCTAAATCA ACTATTATCAATTTTATACATATTTTACTCCATCTTTTTTCAAAGTTTCTTACATTTTCCAATGTCATTAAAATTCTCTGTGAATGTAAA TTTTAAAAACTGTACCTACTGTTTTTTGGAAATCTGTAACAAGCTATGTGTAATCATTCTTCTAATATTAAACATATTGTGTCCAGAATT |
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FusionGenePPI for ZNF77_LPCAT2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF77 | ELAVL1, VWCE, TRIM28 | LPCAT2 | IQCB1, HLA-DPA1, TMEM25, NTRK1, CREB3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF77_LPCAT2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF77_LPCAT2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LPCAT2 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
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