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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43692

FusionGeneSummary for ZNF773_SNRPD2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF773_SNRPD2
Fusion gene ID: 43692
HgeneTgene
Gene symbol

ZNF773

SNRPD2

Gene ID

374928

6633

Gene namezinc finger protein 773small nuclear ribonucleoprotein D2 polypeptide
SynonymsZNF419BSMD2|SNRPD1|Sm-D2
Cytomap

19q13.43

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 773zinc finger protein 419Bsmall nuclear ribonucleoprotein Sm D2small nuclear ribonucleoprotein D2 polypeptide 16.5kDasnRNP core protein D2
Modification date2018052220180523
UniProtAcc

Q6PK81

P62316

Ensembl transtripts involved in fusion geneENST00000593916, ENST00000598770, 
ENST00000599847, ENST00000282292, 
ENST00000342669, ENST00000585392, 
ENST00000587367, ENST00000588599, 
ENST00000391932, ENST00000588301, 
ENST00000590212, ENST00000587579, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF773 [Title/Abstract] AND SNRPD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSNRPD2

GO:0000387

spliceosomal snRNP assembly

18984161


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-32-1970-01AZNF773chr19

58016154

+SNRPD2chr19

46190985

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000593916ENST00000342669ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000593916ENST00000585392ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000593916ENST00000587367ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000593916ENST00000588599ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000593916ENST00000391932ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000593916ENST00000588301ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000593916ENST00000590212ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-intronENST00000593916ENST00000587579ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
In-frameENST00000598770ENST00000342669ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000598770ENST00000585392ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000598770ENST00000587367ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000598770ENST00000588599ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000598770ENST00000391932ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000598770ENST00000588301ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000598770ENST00000590212ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-intronENST00000598770ENST00000587579ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
In-frameENST00000599847ENST00000342669ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000599847ENST00000585392ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000599847ENST00000587367ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000599847ENST00000588599ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000599847ENST00000391932ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000599847ENST00000588301ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000599847ENST00000590212ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-intronENST00000599847ENST00000587579ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
In-frameENST00000282292ENST00000342669ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000282292ENST00000585392ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000282292ENST00000587367ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000282292ENST00000588599ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000282292ENST00000391932ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000282292ENST00000588301ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000282292ENST00000590212ZNF773chr19

58016154

+SNRPD2chr19

46190985

-
5CDS-intronENST00000282292ENST00000587579ZNF773chr19

58016154

+SNRPD2chr19

46190985

-

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FusionProtFeatures for ZNF773_SNRPD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF773

Q6PK81

SNRPD2

P62316

May be involved in transcriptional regulation. Core component of the spliceosomal U1, U2, U4 and U5small nuclear ribonucleoproteins (snRNPs), the building blocks ofthe spliceosome. Thereby, plays an important role in the splicingof cellular pre-mRNAs. Most spliceosomal snRNPs contain a commonset of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF andSNRPG that assemble in a heptameric protein ring on the Sm site ofthe small nuclear RNA to form the core snRNP.{ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+2415_8654443DomainKRAB
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+2415_8653442DomainKRAB
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+24191_21354443Zinc fingerC2H2-type 1
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+24219_24154443Zinc fingerC2H2-type 2
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+24247_26954443Zinc fingerC2H2-type 3
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+24275_29754443Zinc fingerC2H2-type 4
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+24303_32554443Zinc fingerC2H2-type 5
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+24331_35354443Zinc fingerC2H2-type 6
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+24359_38154443Zinc fingerC2H2-type 7
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+24387_40954443Zinc fingerC2H2-type 8
HgeneZNF773chr19:58016154chr19:46190985ENST00000282292+24415_43754443Zinc fingerC2H2-type 9
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+24191_21353442Zinc fingerC2H2-type 1
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+24219_24153442Zinc fingerC2H2-type 2
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+24247_26953442Zinc fingerC2H2-type 3
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+24275_29753442Zinc fingerC2H2-type 4
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+24303_32553442Zinc fingerC2H2-type 5
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+24331_35353442Zinc fingerC2H2-type 6
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+24359_38153442Zinc fingerC2H2-type 7
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+24387_40953442Zinc fingerC2H2-type 8
HgeneZNF773chr19:58016154chr19:46190985ENST00000598770+24415_43753442Zinc fingerC2H2-type 9


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FusionGeneSequence for ZNF773_SNRPD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF773_ENST00000593916_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_111aa
MAAATLRDPAQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLGTATWCWRTXRRCGLRYPRVARARRSPSQSTKTATSP

>In-frame_ZNF773_ENST00000598770_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_111aa
MAAATLRDPAQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLGTATWCWRTXRRCGLRYPRVARARRSPSQSTKTATSP

>In-frame_ZNF773_ENST00000599847_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_112aa
MAAATLRDPAQQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLGTATWCWRTXRRCGLRYPRVARARRSPSQSTKTATS

>In-frame_ZNF773_ENST00000282292_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_112aa
MAAATLRDPAQQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLGTATWCWRTXRRCGLRYPRVARARRSPSQSTKTATS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF773_ENST00000593916_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_335nt
ATGGCGGCGGCCACGCTGAGGGACCCCGCTCAGGGCTATGTGACCTTTGAGGACGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTG
CTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGG
AGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCA

>In-frame_ZNF773_ENST00000598770_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_335nt
ATGGCGGCGGCCACGCTGAGGGACCCCGCTCAGGGCTATGTGACCTTTGAGGACGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTG
CTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGG
AGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCA

>In-frame_ZNF773_ENST00000599847_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_338nt
ATGGCGGCGGCCACGCTGAGGGACCCCGCTCAGCAGGGCTATGTGACCTTTGAGGACGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGA
TTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGC
TGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCT

>In-frame_ZNF773_ENST00000282292_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_338nt
ATGGCGGCGGCCACGCTGAGGGACCCCGCTCAGCAGGGCTATGTGACCTTTGAGGACGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGA
TTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGC
TGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF773_ENST00000593916_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_600nt
ACTCAGCTTGCCGGAAGCTGGTTGTTCGCTGCGGCGACCAGCTCCGGAAAGCGCGGTGGGGACGCGCTGTGTTCTCGCAGCTCAGAGGCG
GGTCTGAGGCTCGGTGGCGGCGCCCAGGGTGGCCCGGGCCCTTTCCTCGGTCGTTGTCTCACCGCCACAGGCTCCGATGGCGGCGGCCAC
GCTGAGGGACCCCGCTCAGGGCTATGTGACCTTTGAGGACGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCA
GAGGCTCCTCTACCGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAG
ATGTGGACTGAGGTACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGC
GGGGACTCAGTCATCGTGGTCCTGCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCT

>In-frame_ZNF773_ENST00000598770_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_580nt
GTTGTTCGCTGCGGCGACCAGCTCCGGAAAGCGCGGTGGGGACGCGCTGTGTTCTCGCAGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGG
CGCCCAGGGTGGCCCGGGCCCTTTCCTCGGTCGTTGTCTCACCGCCACAGGCTCCGATGGCGGCGGCCACGCTGAGGGACCCCGCTCAGG
GCTATGTGACCTTTGAGGACGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATG
TGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAA
GAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCATCGTGGT
CCTGCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTGCCATTGG

>In-frame_ZNF773_ENST00000599847_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_579nt
TTCGCTGCGGCGACCAGCTCCGGAAAGCGCGGTGGGGACGCGCTGTGTTCTCGCAGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCC
CAGGGTGGCCCGGGCCCTTTCCTCGGTCGTTGTCTCACCGCCACAGGCTCCGATGGCGGCGGCCACGCTGAGGGACCCCGCTCAGCAGGG
CTATGTGACCTTTGAGGACGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATGT
GATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAAG
AGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCATCGTGGTC
CTGCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTGCCATTGGT

>In-frame_ZNF773_ENST00000282292_chr19_58016154_+_SNRPD2_ENST00000342669_chr19_46190985_-_577nt
CGCTGCGGCGACCAGCTCCGGAAAGCGCGGTGGGGACGCGCTGTGTTCTCGCAGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCCCA
GGGTGGCCCGGGCCCTTTCCTCGGTCGTTGTCTCACCGCCACAGGCTCCGATGGCGGCGGCCACGCTGAGGGACCCCGCTCAGCAGGGCT
ATGTGACCTTTGAGGACGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGA
TGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAG
TGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCATCGTGGTCCT
GCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTGCCATTGGTGT


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FusionGenePPI for ZNF773_SNRPD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF773CBX5SNRPD2LSM6, RNU11, CLNS1A, WDR77, KAT5, EEF1G, GEMIN5, SMN1, SNRPE, SNRPF, SNRPD1, SF3A2, DDX20, SMN2, CDC5L, MEPCE, SRRM1, SRRM2, EGFR, ARRB2, HNRNPA1, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, SF3A1, SNRPB, SF3B1, SF3B3, SNRPD3, SNRPA1, SNRNP70, PRPF8, YBX1, SF3B6, SF3B4, SNRNP200, PRPF6, U2AF1, DHX15, PRPF19, LSM1, PRPF3, SART1, SNW1, SFPQ, SKIV2L2, DDX5, SAP18, LUC7L2, SUPT16H, NCSTN, RBM14, MAGOH, EIF4A3, SMURF1, FN1, VCAM1, LSM2, ZCCHC10, IFIT1, IFIT2, IFIT3, IL7R, METTL18, UBL4A, ITGA4, PAN2, NPM1, OS9, GRB2, AMOTL2, CRLF3, MAPRE1, PAFAH1B1, PPP1CC, RPL10AP3, YWHAH, WWOX, FUS, CEP70, CUL7, EZH2, SUZ12, EED, RNF2, DDX23, TSSC4, SNRNP40, LSM7, PRPF31, SF3A3, CHMP5, CRNKL1, HTATSF1, LUC7L, LUC7L3, PLRG1, SNRPG, SRP14, ZC3H18, RNU12, KRAS, HIST1H3E, MCM2, RC3H1, PTPN1, SNRPN, CD2BP2, PRPF4, LSM5, SART3, NCL, CYLD, EAPP, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF773_SNRPD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSNRPD2P62316DB11638ArtenimolSmall nuclear ribonucleoprotein Sm D2small moleculeapproved|investigational

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RelatedDiseases for ZNF773_SNRPD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource